Probe depth matters in dermal microdialysis sampling of benzoic acid after topical application: An ex vivo study in human skin

Skin Pharmacology and Physiology

Volumn 25, Issue 1, 2011, Pages 9-16

  Holmgaard, R ^a,c   Benfeldt, E ^c   Bangsgaard, N ^c   Sorensen, J A ^b   Brosen, K ^a   Nielsen, F ^a   Nielsen, J B ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Benzoic acid; Dermal microdialysis; Ex vivo study; Probe depth; Skin penetration; Topical drug administration

Indexed keywords

BENZOIC ACID;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DERMAL MICRODIALYSIS; DERMIS; DIALYSATE; DRUG EXPOSURE; DRUG PENETRATION; EX VIVO STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTERMETHOD COMPARISON; MICRODIALYSIS; PRIORITY JOURNAL; SKIN; SKIN PENETRATION;

ADMINISTRATION, CUTANEOUS; AREA UNDER CURVE; BENZOIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DERMIS; FEMALE; HUMANS; MICRODIALYSIS; REPRODUCIBILITY OF RESULTS; SKIN ABSORPTION;

EID: 80051630639     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000330491     Document Type: Article

References (34)

1. Franz TJ: Percutaneous absorption. On the relevance of in vitro data. J Invest Dermatol 1975; 64: 190-195.
2. Bronaugh RL, Stewart RF: Methods for in vitro percutaneous absorption studies IV: The flow-through diffusion cell. J Pharm Sci 1985; 74:64-67. (Pubitemid 15155372)
3. Bito L, Davson H, Levin E, Murray M, Snider N: The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog. J Neurochem 1966; 13: 1057-1067.
4. Benfeldt E, Serup J, Menne T: Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharma-cokinetics using microdialysis and non-invasive quantification of barrier function. Br J Dermatol 1999; 140: 739-748. (Pubitemid 29191402)
5. Brunner M, Derendorf H, Muller M: Micro-dialysis for in vivo pharmacokinetic/phar-macodynamic characterization of anti-infective drugs. Curr Opin Pharmacol 2005; 5: 495-499. (Pubitemid 41258566)
6. Chaurasia CS, Muller M, Bashaw ED, Benfeldt E, Bolinder J, Bullock R, Bungay PM, DeLange EC, Derendorf H, Elmquist WF, Hammarlund-Udenaes M, Joukhadar C, Kellogg DL, Jr., Lunte CE, Nordstrom CH, Rollema H, Sawchuk RJ, Cheung BW, Shah VP, Stahle L, Ungerstedt U, Welty DF, Yeo H: AAPS-FDA workshop white paper: Microdi-alysis Principles, Application and Regulatory Perspectives. Pharm Res 2007; 24:1014-1025. (Pubitemid 46675390)
7. Benfeldt E, Hansen SH, Volund A, Menne T, Shah VP: Bioequivalence of topical formulations in humans: evaluation by dermal mi-crodialysis sampling and the dermatophar-macokinetic method. J Invest Dermatol 2007; 127:170-178. (Pubitemid 46005675)
8. Tettey-Amlalo RN, Kanfer I, Skinner MF, Benfeldt E, Verbeeck RK: Application of dermal microdialysis for the evaluation of bio-equivalence of a ketoprofen topical gel. Eur J Pharm Sci 2009; 36:219-225.
9. Ungerstedt U: Measurement of neurotrans-mitter release in microdialysis; in Marsden CA (ed): Measurement of Neurotransmitter Release in vivo. Chichester, Wiley, 1984, pp 81-105.
10. Benfeldt E, Serup J, Menne T: Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human der-mis. Acta Derm Venereol 1999; 79: 338-342. (Pubitemid 29414963)
11. Ault JM, Lunte CE, Meltzer NM, Riley CM: Microdialysis sampling for the investigation of dermal drug transport. Pharm Res 1992; 9: 1256-1261.
12. Lionberger RA: FDA critical path initiatives: opportunities for generic drug development. AAPS J 2008; 10:103-109.
13. Groth L, García Ortiz P, Benfeldt E: Micro-dialysis methodology for sampling in the skin; in Serup J, Jemec GBE, Grove G (eds): Handbook of Non-Invasive Methods and the Skin. Boca Raton, CRC Press, 2006, pp 443-454.
14. Schmidt S, Banks R, Kumar V, Rand KH, Derendorf H: Clinical microdialysis in skin and soft tissues: an update. J Clin Pharmacol 2008; 48: 351-364. (Pubitemid 351257772)
15. Holmgaard R, Nielsen JB, Benfeldt E: Micro-dialysis sampling for investigations of bio-availability and bioequivalence of topically administered drugs: current state and future perspectives. Skin Pharmacol Physiol 2010; 23: 225-243.
16. Holmgaard R, Nielsen JB: Dermal Absorption of Pesticides-Evaluation and Prevention. Danish Ministry of the Environment, 2009 (http://www2.mst.dk/udgiv/ publica-tions/2009/978-87-7052-980-8/pdf/978-87-7052-981-5.pdf).
17. Nielsen JB, Nielsen F: Topical use of tea tree oil reduces the dermal absorption of benzoic acid and methiocarb. Arch Dermatol Res 2006; 297: 395-402. (Pubitemid 43288214)
18. van de Sandt JJ, van Burgsteden JA, Cage S, Carmichael PL, Dick I, Kenyon S, Korinth G, Larese F, Limasset JC, Maas WJ, Montomoli L, Nielsen JB, Payan JP, Robinson E, Sartorelli P, Schaller KH, Wilkinson SC, Williams FM: In vitro predictions of skin absorption of caffeine, testosterone, and ben-zoic acid: a multi-centre comparison study. Regul Toxicol Pharmacol 2004; 39:271-281. (Pubitemid 38596765)
19. Nielsen JB, Sorensen JA, Nielsen F: The usual suspects-influence of physicochemical properties on lag time, skin deposition, and percutaneous penetration of nine model compounds. J Toxicol Environ Health A 2009; 72:315-323.
20. Ortiz PG, Hansen SH, Shah VP, Sonne J, Benfeldt E: Are marketed topical metronida-zole creams bioequivalent? Evaluation by in vivo microdialysis sampling and tape stripping methodology. Skin Pharmacol Physiol 2011; 24:44-53.
21. Benfeldt E, Serup J: Effect of barrier perturbation on cutaneous penetration of salicylic acid in hairless rats: in vivo pharmacokinet-ics using microdialysis and non-invasive quantification of barrier function. Arch Dermatol Res 1999; 291:517-526. (Pubitemid 29484133)
22. Simonsen L, Jorgensen A, Benfeldt E, Groth L: Differentiated in vivo skin penetration of salicylic compounds in hairless rats measured by cutaneous microdialysis. Eur J Pharm Sci 2004; 21: 379-388. (Pubitemid 38156176)
23. Benfeldt E: In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects. Acta Derm Venereol Suppl (Stockh) 1999; 206:1-59.
24. Muller M, Schmid R, Wagner O, von Osten B, Shayganfar H, Eichler HG: In-vivo characterization of transdermal drug transport by microdialysis. J Control Release 1995; 37: 49-57.
25. Laurent A, Mistretta F, Bottigioli D, Dahel K, Goujon C, Nicolas JF, Hennino A, Laurent PE: Echographic measurement of skin thickness in adults by high frequency ultrasound to assess the appropriate microneedle length for intradermal delivery of vaccines. Vaccine 2007; 25:6423-6430. (Pubitemid 47096751)
26. Ortiz PG, Hansen SH, Shah VP, Menne T, Benfeldt E: The effect of irritant dermatitis on cutaneous bioavailability of a metronida-zole formulation, investigated by microdial-ysis and dermatopharmacokinetic method. Contact Dermatitis 2008; 59: 23-30. (Pubitemid 351990043)
27. Ortiz PG, Hansen SH, VP Shah, Menne T, Benfeldt E: Impact of adult atopic dermatitis on topical drug penetration: assessment by cutaneous microdialysis and tape stripping. Acta Derm Venereol 2009; 89:33-38.
28. Larsen RH, Nielsen F, Sorensen JA, Nielsen JB: Dermal penetration of fentanyl: inter-and intraindividual variations. Pharmacol Toxicol 2003; 93: 244-248. (Pubitemid 37521962)
29. McCleverty D, Lyons R, Henry B: Microdi-alysis sampling and the clinical determination of topical dermal bioequivalence. Int J Pharm 2006; 308:1-7. (Pubitemid 43097228)
30. Gattu S, Maibach HI: Modest but increased penetration through damaged skin: an over-v iew of the in vivo huma n model. Skin Pharmacol Physiol 2011; 24:2-9.
31. Benveniste H, Huttemeier PC: Microdialysis-theory and application. Prog Neurobiol 1990; 35: 195-215.
32. Lafontan M, Arner P: Application of in situ microdialysis to measure metabolic and vascular responses in adipose tissue. Trends Pharmacol Sci 1996; 17:309-313. (Pubitemid 26302704)
33. Clough GF, Boutsiouki P, Church MK, Michel CC: Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin. J Pharmacol Exp Ther 2002; 302: 681-686. (Pubitemid 34787236)
34. Braverman IM, Yen A: Ultrastructure of the human dermal microcirculation. II. The capillary loops of the dermal papillae. J Invest Dermatol 1977; 68:44-52. (Pubitemid 8019016)