Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer's Disease Brain

ACS Chemical Neuroscience

Volumn 7, Issue 7, 2016, Pages 897-911

  Cai, Lisheng ^a   Qu, Baoxi ^b   Hurtle, Bryan T ^a   Dadiboyena, Sureshbabu ^a   Diaz Arrastia, Ramon ^b   Pike, Victor W ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Alzheimer's disease; in vitro assay; PET; Radioligand; tangle; tau

Indexed keywords

18F THK 523; FLORTAUCIPIR F 18; RADIOLIGAND; UNCLASSIFIED DRUG; 2-(4'-(METHYLAMINO)PHENYL)-6-HYDROXYBENZOTHIAZOLE; 2-(4-AMINOPHENYL)-6-(2-FLUOROETHOXY)QUINOLINE; 7-(6-FLUOROPYRIDIN-3-YL)-5H-PYRIDO(4,3-B)INDOLE; ANILINE DERIVATIVE; CARBOLINE DERIVATIVE; QUINOLINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TAU PROTEIN; THIAZOLE DERIVATIVE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LIGAND BINDING; NEUROFIBRILLARY TANGLE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; AUTORADIOGRAPHY; BRAIN; CHEMISTRY; DIAGNOSIS; DIAGNOSTIC IMAGING; DOSE RESPONSE; DRUG EFFECTS; FEMALE; MALE; METABOLISM; PATHOLOGY; RADIOASSAY; SYNTHESIS;

ALZHEIMER DISEASE; ANILINE COMPOUNDS; AUTORADIOGRAPHY; BINDING SITES; BRAIN; CARBOLINES; DIAGNOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; NEUROFIBRILLARY TANGLES; POSITRON-EMISSION TOMOGRAPHY; QUINOLINES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; TAU PROTEINS; THIAZOLES;

EID: 84979520766     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00051     Document Type: Article

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