메뉴 건너뛰기




Volumn 42, Issue 7, 2015, Pages 1052-1061

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

Author keywords

Alzheimer s disease; Imaging; Neurofibrillary tangles; PET; Tau; 18F THK 5117

Indexed keywords

6-((3-FLUORO-2-HYDROXY)PROPOXY)-2-(4-METHYLAMINOPHENYL)QUINOLINE; ANILINE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; N-METHYL-2-(4'-METHYLAMINOPHENYL)-6-HYDROXYBENZOTHIAZOLE; QUINOLINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; THK5105;

EID: 84938996337     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-015-3035-4     Document Type: Article
Times cited : (119)

References (42)
  • 1
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • COI: 1:STN:280:DyaK387gtFOiug%3D%3D, PID: 1759558
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82:239–59.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 3
    • 0023009658 scopus 로고
    • Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
    • COI: 1:CAS:528:DyaL28XitVCqsb0%3D, PID: 3084478
    • Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem. 1986;261:6084–9.
    • (1986) J Biol Chem , vol.261 , pp. 6084-6089
    • Grundke-Iqbal, I.1    Iqbal, K.2    Quinlan, M.3    Tung, Y.C.4    Zaidi, M.S.5    Wisniewski, H.M.6
  • 4
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
    • COI: 1:CAS:528:DyaL28XksFyqtrg%3D, PID: 3088567
    • Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A. 1986;83:4913–7.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.C.3    Quinlan, M.4    Wisniewski, H.M.5    Binder, L.I.6
  • 5
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • COI: 1:STN:280:DyaK2svnt1Sgug%3D%3D, PID: 9330961
    • Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging. 1997;18:351–7.
    • (1997) Neurobiol Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 6
    • 0028861585 scopus 로고
    • Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer’s disease
    • COI: 1:STN:280:DyaK2M7is1ymsw%3D%3D, PID: 7826280
    • Bierer LM, Hof PR, Purohit DP, Carlin L, Schmeidler J, Davis KL, et al. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer’s disease. Arch Neurol. 1995;52:81–8.
    • (1995) Arch Neurol , vol.52 , pp. 81-88
    • Bierer, L.M.1    Hof, P.R.2    Purohit, D.P.3    Carlin, L.4    Schmeidler, J.5    Davis, K.L.6
  • 7
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease
    • COI: 1:STN:280:DyaK2s7lvVGjsw%3D%3D, PID: 9005861
    • Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease. Ann Neurol. 1997;41:17–24. doi:10.1002/ana.410410106.
    • (1997) Ann Neurol , vol.41 , pp. 17-24
    • Gomez-Isla, T.1    Hollister, R.2    West, H.3    Mui, S.4    Growdon, J.H.5    Petersen, R.C.6
  • 8
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease
    • COI: 1:STN:280:DyaK387psFCktw%3D%3D, PID: 1549228
    • Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology. 1992;42:631–9.
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 9
    • 0019935804 scopus 로고
    • Plaques, tangles and dementia. A quantitative study
    • COI: 1:STN:280:DyaL3s%2FosV2msQ%3D%3D, PID: 7175555
    • Wilcock GK, Esiri MM. Plaques, tangles and dementia. A quantitative study. J Neurol Sci. 1982;56:343–56.
    • (1982) J Neurol Sci , vol.56 , pp. 343-356
    • Wilcock, G.K.1    Esiri, M.M.2
  • 10
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer’s disease
    • COI: 1:STN:280:DyaK38zltlGmsw%3D%3D, PID: 1822725
    • Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer’s disease. Cereb Cortex. 1991;1:103–16.
    • (1991) Cereb Cortex , vol.1 , pp. 103-116
    • Arnold, S.E.1    Hyman, B.T.2    Flory, J.3    Damasio, A.R.4    Van Hoesen, G.W.5
  • 11
    • 84857077700 scopus 로고    scopus 로고
    • Tau-targeted treatment strategies in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38Xis1OhtLc%3D, PID: 22044248
    • Gotz J, Ittner A, Ittner LM. Tau-targeted treatment strategies in Alzheimer’s disease. Br J Pharmacol. 2012;165:1246–59. doi:10.1111/j.1476-5381.2011.01713.x.
    • (2012) Br J Pharmacol , vol.165 , pp. 1246-1259
    • Gotz, J.1    Ittner, A.2    Ittner, L.M.3
  • 12
    • 84898059466 scopus 로고    scopus 로고
    • Tau-aggregation inhibitor therapy for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXjtlWit74%3D, PID: 24361915
    • Wischik CM, Harrington CR, Storey JM. Tau-aggregation inhibitor therapy for Alzheimer’s disease. Biochem Pharmacol. 2014;88:529–39. doi:10.1016/j.bcp.2013.12.008.
    • (2014) Biochem Pharmacol , vol.88 , pp. 529-539
    • Wischik, C.M.1    Harrington, C.R.2    Storey, J.M.3
  • 13
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer’s disease: strategies for disease modification
    • COI: 1:CAS:528:DC%2BC3cXlsVWjsrw%3D, PID: 20431570
    • Citron M. Alzheimer’s disease: strategies for disease modification. Nat Rev Drug Discov. 2010;9:387–98. doi:10.1038/nrd2896.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 387-398
    • Citron, M.1
  • 14
    • 78650861616 scopus 로고    scopus 로고
    • Tau aggregation is a therapeutic target for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXis1OgtQ%3D%3D, PID: 20678070
    • Takashima A. Tau aggregation is a therapeutic target for Alzheimer’s disease. Curr Alzheimer Res. 2010;7:665–9.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 665-669
    • Takashima, A.1
  • 15
    • 84890528022 scopus 로고    scopus 로고
    • Biomarker modeling of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhvFylu7fP, PID: 24360540
    • Jack Jr CR, Holtzman DM. Biomarker modeling of Alzheimer’s disease. Neuron. 2013;80:1347–58. doi:10.1016/j.neuron.2013.12.003.
    • (2013) Neuron , vol.80 , pp. 1347-1358
    • Jack, C.R.1    Holtzman, D.M.2
  • 16
    • 79956125839 scopus 로고    scopus 로고
    • Biomarkers in Alzheimer’s disease drug development
    • COI: 1:CAS:528:DC%2BC3MXmtVyjsr0%3D, PID: 21550318
    • Cummings JL. Biomarkers in Alzheimer’s disease drug development. Alzheimers Dement. 2011;7:e13–44. doi:10.1016/j.jalz.2010.06.004.
    • (2011) Alzheimers Dement , vol.7 , pp. 13-44
    • Cummings, J.L.1
  • 17
    • 0029162670 scopus 로고
    • Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer’s disease
    • COI: 1:STN:280:DyaK28%2FgtFahsA%3D%3D, PID: 7574462
    • Arai H, Terajima M, Miura M, Higuchi S, Muramatsu T, Machida N, et al. Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer’s disease. Ann Neurol. 1995;38:649–52. doi:10.1002/ana.410380414.
    • (1995) Ann Neurol , vol.38 , pp. 649-652
    • Arai, H.1    Terajima, M.2    Miura, M.3    Higuchi, S.4    Muramatsu, T.5    Machida, N.6
  • 18
    • 0034899223 scopus 로고    scopus 로고
    • Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD3MXmsVOksbw%3D, PID: 11506396
    • Itoh N, Arai H, Urakami K, Ishiguro K, Ohno H, Hampel H, et al. Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer’s disease. Ann Neurol. 2001;50:150–6.
    • (2001) Ann Neurol , vol.50 , pp. 150-156
    • Itoh, N.1    Arai, H.2    Urakami, K.3    Ishiguro, K.4    Ohno, H.5    Hampel, H.6
  • 19
    • 84887416188 scopus 로고    scopus 로고
    • [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer’s disease
    • PID: 23411393
    • Xia CF, Arteaga J, Chen G, Gangadharmath U, Gomez LF, Kasi D, et al. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer’s disease. Alzheimers Dement. 2013;9:666–76. doi:10.1016/j.jalz.2012.11.008.
    • (2013) Alzheimers Dement , vol.9 , pp. 666-676
    • Xia, C.F.1    Arteaga, J.2    Chen, G.3    Gangadharmath, U.4    Gomez, L.F.5    Kasi, D.6
  • 20
    • 84874288678 scopus 로고    scopus 로고
    • Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807
    • COI: 1:CAS:528:DC%2BC3sXjtlWlsbk%3D, PID: 23234879
    • Chien DT, Bahri S, Szardenings AK, Walsh JC, Mu F, Su MY, et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. J Alzheimers Dis. 2013;34:457–68. doi:10.3233/JAD-122059.
    • (2013) J Alzheimers Dis , vol.34 , pp. 457-468
    • Chien, D.T.1    Bahri, S.2    Szardenings, A.K.3    Walsh, J.C.4    Mu, F.5    Su, M.Y.6
  • 21
    • 84887230291 scopus 로고    scopus 로고
    • Early clinical PET imaging results with the novel PHF-Tau radioligand [F18]-T808
    • PID: 23948934
    • Chien DT, Szardenings AK, Bahri S, Walsh JC, Mu FR, Xia CF, et al. Early clinical PET imaging results with the novel PHF-Tau radioligand [F18]-T808. J Alzheimers Dis. 2014;38:171–84. doi:10.3233/Jad-130098.
    • (2014) J Alzheimers Dis , vol.38 , pp. 171-184
    • Chien, D.T.1    Szardenings, A.K.2    Bahri, S.3    Walsh, J.C.4    Mu, F.R.5    Xia, C.F.6
  • 22
    • 84884273839 scopus 로고    scopus 로고
    • Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls
    • COI: 1:CAS:528:DC%2BC3sXhsVOks7nL, PID: 24050400
    • Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 2013;79:1094–108. doi:10.1016/j.neuron.2013.07.037.
    • (2013) Neuron , vol.79 , pp. 1094-1108
    • Maruyama, M.1    Shimada, H.2    Suhara, T.3    Shinotoh, H.4    Ji, B.5    Maeda, J.6
  • 23
  • 24
    • 84881451115 scopus 로고    scopus 로고
    • Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease
    • COI: 1:CAS:528:DC%2BC3sXhsVejsr7L, PID: 23857514
    • Okamura N, Furumoto S, Harada R, Tago T, Yoshikawa T, Fodero-Tavoletti M, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013;54:1420–7. doi:10.2967/jnumed.112.117341.
    • (2013) J Nucl Med , vol.54 , pp. 1420-1427
    • Okamura, N.1    Furumoto, S.2    Harada, R.3    Tago, T.4    Yoshikawa, T.5    Fodero-Tavoletti, M.6
  • 26
    • 28044460038 scopus 로고    scopus 로고
    • Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2MXht1yks77K, PID: 16306398
    • Okamura N, Suemoto T, Furumoto S, Suzuki M, Shimadzu H, Akatsu H, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer’s disease. J Neurosci. 2005;25:10857–62. doi:10.1523/JNEUROSCI. 1738-05.2005.
    • (2005) J Neurosci , vol.25 , pp. 10857-10862
    • Okamura, N.1    Suemoto, T.2    Furumoto, S.3    Suzuki, M.4    Shimadzu, H.5    Akatsu, H.6
  • 27
    • 85027925235 scopus 로고    scopus 로고
    • Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer’s disease pathology
    • COI: 1:CAS:528:DC%2BC38XhslyjtrjN, PID: 23100049
    • Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer’s disease pathology. Eur J Nucl Med Mol Imaging. 2013;40:125–32.
    • (2013) Eur J Nucl Med Mol Imaging , vol.40 , pp. 125-132
    • Harada, R.1    Okamura, N.2    Furumoto, S.3    Tago, T.4    Maruyama, M.5    Higuchi, M.6
  • 28
    • 84901391350 scopus 로고    scopus 로고
    • Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET
    • PID: 24681664
    • Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan R, Harada R, Yates P, et al. Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET. Brain. 2014;137:1762–71.
    • (2014) Brain , vol.137 , pp. 1762-1771
    • Okamura, N.1    Furumoto, S.2    Fodero-Tavoletti, M.T.3    Mulligan, R.4    Harada, R.5    Yates, P.6
  • 29
    • 0023390305 scopus 로고
    • Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids
    • COI: 1:STN:280:DyaL2s3osFentw%3D%3D, PID: 2441141
    • Kitamoto T, Ogomori K, Tateishi J, Prusiner SB. Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest. 1987;57:230–6.
    • (1987) Lab Invest , vol.57 , pp. 230-236
    • Kitamoto, T.1    Ogomori, K.2    Tateishi, J.3    Prusiner, S.B.4
  • 30
    • 0032588781 scopus 로고    scopus 로고
    • Interaction of aluminum with PHFtau in Alzheimer’s disease neurofibrillary degeneration evidenced by desferrioxamine-assisted chelating autoclave method
    • COI: 1:CAS:528:DyaK1MXmsVCrtb8%3D, PID: 10487845
    • Murayama H, Shin RW, Higuchi J, Shibuya S, Muramoto T, Kitamoto T. Interaction of aluminum with PHFtau in Alzheimer’s disease neurofibrillary degeneration evidenced by desferrioxamine-assisted chelating autoclave method. Am J Pathol. 1999;155:877–85.
    • (1999) Am J Pathol , vol.155 , pp. 877-885
    • Murayama, H.1    Shin, R.W.2    Higuchi, J.3    Shibuya, S.4    Muramoto, T.5    Kitamoto, T.6
  • 31
    • 58749111447 scopus 로고    scopus 로고
    • Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer
    • COI: 1:CAS:528:DC%2BD1cXhtFKjur3F, PID: 18769311
    • Verdurand M, Bort G, Tadino V, Bonnefoi F, Le Bars D, Zimmer L. Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer. Nucl Med Commun. 2008;29:920–6. doi:10.1097/MNM.0b013e328304e0e1.
    • (2008) Nucl Med Commun , vol.29 , pp. 920-926
    • Verdurand, M.1    Bort, G.2    Tadino, V.3    Bonnefoi, F.4    Le Bars, D.5    Zimmer, L.6
  • 32
    • 0026700928 scopus 로고
    • Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects
    • COI: 1:STN:280:DyaK38zhslajug%3D%3D, PID: 1618936
    • Muller-Gartner HW, Links JM, Prince JL, Bryan RN, McVeigh E, Leal JP, et al. Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab. 1992;12:571–83. doi:10.1038/jcbfm.1992.81.
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 571-583
    • Muller-Gartner, H.W.1    Links, J.M.2    Prince, J.L.3    Bryan, R.N.4    McVeigh, E.5    Leal, J.P.6
  • 33
    • 54049152421 scopus 로고    scopus 로고
    • MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study
    • COI: 1:STN:280:DC%2BD1crnslCgsA%3D%3D, PID: 18765650
    • Whitwell JL, Josephs KA, Murray ME, Kantarci K, Przybelski SA, Weigand SD, et al. MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study. Neurology. 2008;71:743–9. doi:10.1212/01.wnl.0000324924.91351.7d.
    • (2008) Neurology , vol.71 , pp. 743-749
    • Whitwell, J.L.1    Josephs, K.A.2    Murray, M.E.3    Kantarci, K.4    Przybelski, S.A.5    Weigand, S.D.6
  • 34
    • 0026726282 scopus 로고
    • Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques
    • COI: 1:STN:280:DyaK38zpt1Sltw%3D%3D, PID: 1520086
    • Hof PR, Bierer LM, Perl DP, Delacourte A, Buee L, Bouras C, et al. Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques. Arch Neurol. 1992;49:946–53.
    • (1992) Arch Neurol , vol.49 , pp. 946-953
    • Hof, P.R.1    Bierer, L.M.2    Perl, D.P.3    Delacourte, A.4    Buee, L.5    Bouras, C.6
  • 35
    • 0024524812 scopus 로고
    • A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people
    • COI: 1:STN:280:DyaK3c%2Fislynsw%3D%3D, PID: 2508732
    • Kuzuhara S, Ihara Y, Toyokura Y, Shimada H. A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people. No To Shinkei. 1989;41:465–70.
    • (1989) No To Shinkei , vol.41 , pp. 465-470
    • Kuzuhara, S.1    Ihara, Y.2    Toyokura, Y.3    Shimada, H.4
  • 36
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and "preclinical" Alzheimer’s disease
    • COI: 1:STN:280:DyaK1M7ntValtQ%3D%3D, PID: 10072051
    • Price JL, Morris JC. Tangles and plaques in nondemented aging and "preclinical" Alzheimer’s disease. Ann Neurol. 1999;45:358–68.
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 37
    • 0035168927 scopus 로고    scopus 로고
    • Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD3MXosVKitrg%3D, PID: 11816784
    • Morris JC, Price JL. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer’s disease. J Mol Neurosci. 2001;17:101–18.
    • (2001) J Mol Neurosci , vol.17 , pp. 101-118
    • Morris, J.C.1    Price, J.L.2
  • 38
    • 84903202261 scopus 로고    scopus 로고
    • Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
    • PID: 11790632
    • Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, et al. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002;10:24–35.
    • (2002) Am J Geriatr Psychiatry , vol.10 , pp. 24-35
    • Shoghi-Jadid, K.1    Small, G.W.2    Agdeppa, E.D.3    Kepe, V.4    Ercoli, L.M.5    Siddarth, P.6
  • 39
    • 33845707784 scopus 로고    scopus 로고
    • PET of brain amyloid and tau in mild cognitive impairment
    • COI: 1:CAS:528:DC%2BD28XhtlGhtLvL, PID: 17182990
    • Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, et al. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med. 2006;355:2652–63. doi:10.1056/NEJMoa054625.
    • (2006) N Engl J Med , vol.355 , pp. 2652-2663
    • Small, G.W.1    Kepe, V.2    Ercoli, L.M.3    Siddarth, P.4    Bookheimer, S.Y.5    Miller, K.J.6
  • 40
    • 0035893245 scopus 로고    scopus 로고
    • Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer’s disease
    • COI: 1:STN:280:DC%2BD3MnptlejtA%3D%3D, PID: 11734604
    • Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, et al. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer’s disease. J Neurosci. 2001;21:RC189.
    • (2001) J Neurosci , vol.21 , pp. 189
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Flores-Torres, S.4    Satyamurthy, N.5    Petric, A.6
  • 41
    • 79958792912 scopus 로고    scopus 로고
    • Clinical amyloid imaging in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXnslSiu74%3D, PID: 21683932
    • Herholz K, Ebmeier K. Clinical amyloid imaging in Alzheimer’s disease. Lancet Neurol. 2011;10:667–70. doi:10.1016/S1474-4422(11)70123-5.
    • (2011) Lancet Neurol , vol.10 , pp. 667-670
    • Herholz, K.1    Ebmeier, K.2
  • 42
    • 77956384880 scopus 로고    scopus 로고
    • 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial
    • PID: 20687209
    • Vandenberghe R, Van Laere K, Ivanoiu A, Salmon E, Bastin C, Triau E, et al. 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol. 2010;68:319–29. doi:10.1002/ana.22068.
    • (2010) Ann Neurol , vol.68 , pp. 319-329
    • Vandenberghe, R.1    Van Laere, K.2    Ivanoiu, A.3    Salmon, E.4    Bastin, C.5    Triau, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.