ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein

Chemistry and Biology

Volumn 21, Issue 11, 2014, Pages 1564-1574

  Chen, John J ^a   Genereux, Joseph C ^a   Qu, Song ^a   Hulleman, John D ^a,b   Shoulders, Matthew D ^a,c   Wiseman, R Luke ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; AMYLOID PROTEIN; PREALBUMIN; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ADP-RIBOSYLATION FACTOR 6; DIHYDROFOLATE REDUCTASE; HYBRID PROTEIN;

ANIMAL CELL; ARTICLE; CELL AGGREGATION; DEGRADATION; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR SPACE; FAMILIAL AMYLOIDOSIS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; TRANSCRIPTION INITIATION; UNFOLDED PROTEIN RESPONSE; AMINO ACID SUBSTITUTION; BIOSYNTHESIS; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; KINETICS; METABOLISM; PROTEIN STABILITY; SECRETION (PROCESS);

ADP-RIBOSYLATION FACTORS; AMINO ACID SUBSTITUTION; ENDOPLASMIC RETICULUM; HEK293 CELLS; HEP G2 CELLS; HUMANS; KINETICS; PREALBUMIN; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; TRANSFECTION; UNFOLDED PROTEIN RESPONSE;

EID: 84911868259     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.09.009     Document Type: Article

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