PIKfyve inhibition increases exosome release and induces secretory autophagy

Cellular and Molecular Life Sciences

Volumn 73, Issue 24, 2016, Pages 4717-4737

  Hessvik, Nina Pettersen ^a,b   Øverbye, Anders ^a,b   Brech, Andreas ^a,b   Torgersen, Maria Lyngaas ^a,b   Jakobsen, Ida Seim ^a,b   Sandvig, Kirsten ^a,b   Llorente, Alicia ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Exophagy; Exosomes; Extracellular vesicles; Phosphoinositides; PIKfyve; Secretory autophagy

Indexed keywords

APILIMOD; CD63 ANTIGEN; CELL PROTEIN; EPIDERMAL GROWTH FACTOR; LC3 PROTEIN; LONG LIVED PROTEIN; NBR1 PROTEIN; PHOSPHOTRANSFERASE; PIKFYVE PROTEIN; PROTEIN P62; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WIPI2 PROTEIN; AUTOPHAGY RELATED PROTEIN; MORPHOLINE DERIVATIVE; P62 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PIKFYVE PROTEIN, HUMAN; RNA BINDING PROTEIN; TRIAZINE DERIVATIVE; UBIQUITIN;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL FRACTIONATION; CELL LABELING; CELL ORGANELLE; CELL POPULATION; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DENSITY GRADIENT; ELECTRON MICROSCOPY; ENZYME DEFICIENCY; ENZYME INHIBITION; EXOSOME; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MASS SPECTROMETRY; MULTIVESICULAR BODY; PC 3 CELL; PROSTATE CANCER CELL LINE; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; SECRETORY CELL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE SILENCING; LYSOSOME; METABOLISM; PROTEOMICS; SECRETION (PROCESS); SECRETORY PATHWAY; TUMOR CELL LINE; UBIQUITINATION; ULTRASTRUCTURE; UPREGULATION;

ANTIGENS, CD63; AUTOPHAGOSOMES; AUTOPHAGY; AUTOPHAGY-RELATED PROTEINS; CELL LINE, TUMOR; EPIDERMAL GROWTH FACTOR; EXOSOMES; GENE KNOCKDOWN TECHNIQUES; HUMANS; LYSOSOMES; MORPHOLINES; MULTIVESICULAR BODIES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEOLYSIS; PROTEOMICS; RNA-BINDING PROTEINS; SECRETORY PATHWAY; TRIAZINES; UBIQUITIN; UBIQUITINATION; UP-REGULATION;

EID: 84979243223     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-016-2309-8     Document Type: Article

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