PPARβ/δ Agonist Provides Neuroprotection by Suppression of IRE1α–Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson’s Disease

Molecular Neurobiology

Volumn 53, Issue 6, 2016, Pages 3822-3831

  Tong, Qiang ^a   Wu, Liang ^b   Gao, Qing ^b   Ou, Zhou ^b   Zhu, Dongya ^a   Zhang, Yingdong ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

ER stress; Neuroprotection; Parkinson s disease; PPAR

Indexed keywords

CASPASE 12; DIHYDROXYPHENYLACETIC ACID; DOPAMINE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HOMOVANILLIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PROTEIN IRE1; PROTEIN IRE1 ALPHA; UNCLASSIFIED DRUG; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; IRE1ALPHA PROTEIN, RAT; MULTIENZYME COMPLEX; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; ROTENONE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR ASSESSMENT; BINDING AFFINITY; CATALEPSY; CATALEPSY TEST; CATECHOLAMINE DEPLETION; CELL ACTIVATION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; EXPERIMENTAL BEHAVIORAL TEST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOKINESIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOCOMOTION; MALE; MESENCEPHALON; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PARKINSON DISEASE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUNEL ASSAY; WESTERN BLOTTING; AGONISTS; ANIMAL; DISEASE MODEL; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; MOTOR ACTIVITY; NEOSTRIATUM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CASPASE 12; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINERGIC NEURONS; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MOTOR ACTIVITY; MULTIENZYME COMPLEXES; NEOSTRIATUM; NEUROPROTECTION; PARKINSON DISEASE; PPAR DELTA; PPAR-BETA; PROTEIN-SERINE-THREONINE KINASES; RATS, SPRAGUE-DAWLEY; ROTENONE; SIGNAL TRANSDUCTION; THIAZOLES;

EID: 84979049888     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9309-9     Document Type: Article

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