메뉴 건너뛰기




Volumn , Issue , 2016, Pages S73-S81

Renal Transporter-Mediated Drug-Drug Interactions: Are They Clinically Relevant?

Author keywords

active tubular secretion; cimetidine; MATE; metabolomics; metformin; methotrexate; probenecid

Indexed keywords

ANTIARRHYTHMIC AGENT; CIMETIDINE; CREATININE; FEXOFENADINE; METFORMIN; METHOTREXATE; PROBENECID; TOXIN;

EID: 84979022057     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1002/jcph.735     Document Type: Article
Times cited : (35)

References (92)
  • 2
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters
    • Dresser MJ, Leabman MK, Giacomini KM. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J Pharm Sci. 2001;90(4):397–421.
    • (2001) J Pharm Sci , vol.90 , Issue.4 , pp. 397-421
    • Dresser, M.J.1    Leabman, M.K.2    Giacomini, K.M.3
  • 3
    • 1342344851 scopus 로고    scopus 로고
    • Transporters and renal drug elimination
    • Lee W, Kim RB. Transporters and renal drug elimination. Annu Rev Pharmacol Toxicol. 2004;44:137–166.
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 137-166
    • Lee, W.1    Kim, R.B.2
  • 5
    • 77954846109 scopus 로고    scopus 로고
    • Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state
    • Feng B, LaPerle JL, Chang G, Varma MV. Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state. Expert Opin Drug Metab Toxicol. 2010;6(8):939–952.
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , Issue.8 , pp. 939-952
    • Feng, B.1    LaPerle, J.L.2    Chang, G.3    Varma, M.V.4
  • 6
    • 84946733480 scopus 로고    scopus 로고
    • Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters
    • Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V. Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters. Clin J Am Soc Nephrol. 2015;10(11):2039–2049.
    • (2015) Clin J Am Soc Nephrol , vol.10 , Issue.11 , pp. 2039-2049
    • Nigam, S.K.1    Wu, W.2    Bush, K.T.3    Hoenig, M.P.4    Blantz, R.C.5    Bhatnagar, V.6
  • 7
    • 70349345913 scopus 로고    scopus 로고
    • Glut9 is a major regulator of urate homeostasis, and its genetic inactivation induces hyperuricosuria and urate nephropathy
    • Preitner F, Bonny O, Laverriere A, et al. Glut9 is a major regulator of urate homeostasis, and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci USA. 2009;106(36):15501–15506.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.36 , pp. 15501-15506
    • Preitner, F.1    Bonny, O.2    Laverriere, A.3
  • 9
    • 84858820185 scopus 로고    scopus 로고
    • Renal drug-drug interactions: what we have learned and where we are going
    • Lepist EI, Ray AS. Renal drug-drug interactions: what we have learned and where we are going. Expert Opin Drug Metab Toxicol. 2012;8(4):433–448.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , Issue.4 , pp. 433-448
    • Lepist, E.I.1    Ray, A.S.2
  • 10
    • 0020454235 scopus 로고
    • Pharmacokinetics of probenecid following oral doses to human volunteers
    • Selen A, Amidon GL, Welling PG. Pharmacokinetics of probenecid following oral doses to human volunteers. J Pharm Sci. 1982;71(11):1238–1242.
    • (1982) J Pharm Sci , vol.71 , Issue.11 , pp. 1238-1242
    • Selen, A.1    Amidon, G.L.2    Welling, P.G.3
  • 11
    • 0014284549 scopus 로고
    • Apparent effect of probenecid on the distribution of penicillins in man
    • Gibaldi M, Schwartz MA. Apparent effect of probenecid on the distribution of penicillins in man. Clin Pharmacol Ther. 1968;9(3):345–349.
    • (1968) Clin Pharmacol Ther , vol.9 , Issue.3 , pp. 345-349
    • Gibaldi, M.1    Schwartz, M.A.2
  • 12
    • 0029000871 scopus 로고
    • Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients
    • Cundy KC, Petty BG, Flaherty J, et al. Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 1995;39(6):1247–1252.
    • (1995) Antimicrob Agents Chemother , vol.39 , Issue.6 , pp. 1247-1252
    • Cundy, K.C.1    Petty, B.G.2    Flaherty, J.3
  • 13
    • 85043093560 scopus 로고    scopus 로고
    • Vistide prescribing info
    • Vistide prescribing info. http://www.accessdata.fda.gov/drugsatfda_docs/label/1999/020638s003lbl.pdf.
  • 14
    • 0020325272 scopus 로고
    • Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans
    • Laskin OL, de Miranda P, King DH, et al. Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans. Antimicrob Agents Chemother. 1982;21(5):804–807.
    • (1982) Antimicrob Agents Chemother , vol.21 , Issue.5 , pp. 804-807
    • Laskin, O.L.1    de Miranda, P.2    King, D.H.3
  • 15
    • 0024519265 scopus 로고
    • Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination
    • Ko H, Cathcart KS, Griffith DL, Peters GR, Adams WJ. Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination. Antimicrob Agents Chemother. 1989;33(3):356–361.
    • (1989) Antimicrob Agents Chemother , vol.33 , Issue.3 , pp. 356-361
    • Ko, H.1    Cathcart, K.S.2    Griffith, D.L.3    Peters, G.R.4    Adams, W.J.5
  • 16
    • 0025055624 scopus 로고
    • The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers
    • Inotsume N, Nishimura M, Nakano M, Fujiyama S, Sato T. The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers. J Clin Pharmacol. 1990;30(1):50–56.
    • (1990) J Clin Pharmacol , vol.30 , Issue.1 , pp. 50-56
    • Inotsume, N.1    Nishimura, M.2    Nakano, M.3    Fujiyama, S.4    Sato, T.5
  • 17
    • 11344279702 scopus 로고    scopus 로고
    • Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics
    • Yasui-Furukori N, Uno T, Sugawara K, Tateishi T. Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics. Clin Pharmacol Ther. 2005;77(1):17–23.
    • (2005) Clin Pharmacol Ther , vol.77 , Issue.1 , pp. 17-23
    • Yasui-Furukori, N.1    Uno, T.2    Sugawara, K.3    Tateishi, T.4
  • 18
    • 0017652767 scopus 로고
    • Effects of probenecid on furosemide kinetics and natriuresis in man
    • Honari J, Blair AD, Cutler RE. Effects of probenecid on furosemide kinetics and natriuresis in man. Clin Pharmacol Ther. 1977;22(4):395–401.
    • (1977) Clin Pharmacol Ther , vol.22 , Issue.4 , pp. 395-401
    • Honari, J.1    Blair, A.D.2    Cutler, R.E.3
  • 19
    • 0017645455 scopus 로고
    • Effect of probenecid on the blood levels and urinary excretion of cefamandole
    • Griffith RS, Black HR, Brier GL, Wolny JD. Effect of probenecid on the blood levels and urinary excretion of cefamandole. Antimicrob Agents Chemother. 1977;11(5):809–812.
    • (1977) Antimicrob Agents Chemother , vol.11 , Issue.5 , pp. 809-812
    • Griffith, R.S.1    Black, H.R.2    Brier, G.L.3    Wolny, J.D.4
  • 21
    • 63849121023 scopus 로고    scopus 로고
    • Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells
    • Tsuda M, Terada T, Ueba M, et al. Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells. J Pharmacol Exp Ther. 2009;329(1):185–191.
    • (2009) J Pharmacol Exp Ther , vol.329 , Issue.1 , pp. 185-191
    • Tsuda, M.1    Terada, T.2    Ueba, M.3
  • 22
    • 84905508974 scopus 로고    scopus 로고
    • Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
    • Lepist EI, Zhang X, Hao J, et al. Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat. Kidney Int. 2014;86(2):350–357.
    • (2014) Kidney Int , vol.86 , Issue.2 , pp. 350-357
    • Lepist, E.I.1    Zhang, X.2    Hao, J.3
  • 23
    • 0033957482 scopus 로고    scopus 로고
    • Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide
    • Abel S, Nichols DJ, Brearley CJ, Eve MD. Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide. Br J Clin Pharmacol. 2000;49(1):64–71.
    • (2000) Br J Clin Pharmacol , vol.49 , Issue.1 , pp. 64-71
    • Abel, S.1    Nichols, D.J.2    Brearley, C.J.3    Eve, M.D.4
  • 24
  • 25
    • 0020635466 scopus 로고
    • Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs
    • Somogyi A, McLean A, Heinzow B. Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs. Eur J Clin Pharmacol. 1983;25(3):339–345.
    • (1983) Eur J Clin Pharmacol , vol.25 , Issue.3 , pp. 339-345
    • Somogyi, A.1    McLean, A.2    Heinzow, B.3
  • 26
    • 0023204364 scopus 로고
    • Reduction of metformin renal tubular secretion by cimetidine in man
    • Somogyi A, Stockley C, Keal J, Rolan P, Bochner F. Reduction of metformin renal tubular secretion by cimetidine in man. Br J Clin Pharmacol. 1987;23(5):545–551.
    • (1987) Br J Clin Pharmacol , vol.23 , Issue.5 , pp. 545-551
    • Somogyi, A.1    Stockley, C.2    Keal, J.3    Rolan, P.4    Bochner, F.5
  • 27
    • 0026606632 scopus 로고
    • Stereoselective inhibition of pindolol renal clearance by cimetidine in humans
    • Somogyi AA, Bochner F, Sallustio BC. Stereoselective inhibition of pindolol renal clearance by cimetidine in humans. Clin Pharmacol Ther. 1992;51(4):379–387.
    • (1992) Clin Pharmacol Ther , vol.51 , Issue.4 , pp. 379-387
    • Somogyi, A.A.1    Bochner, F.2    Sallustio, B.C.3
  • 28
    • 0034025366 scopus 로고    scopus 로고
    • Effect of cimetidine and probenecid on pilsicainide renal clearance in humans
    • Shiga T, Hashiguchi M, Urae A, Kasanuki H, Rikihisa T. Effect of cimetidine and probenecid on pilsicainide renal clearance in humans. Clin Pharmacol Ther. 2000;67(3):222–228.
    • (2000) Clin Pharmacol Ther. , vol.67 , Issue.3 , pp. 222-228
    • Shiga, T.1    Hashiguchi, M.2    Urae, A.3    Kasanuki, H.4    Rikihisa, T.5
  • 31
    • 0018703481 scopus 로고
    • Pharmacokinetics of metformin after intravenous and oral administration to man
    • Pentikainen PJ, Neuvonen PJ, Penttila A. Pharmacokinetics of metformin after intravenous and oral administration to man. Eur J Clin Pharmacol. 1979;16(3):195–202.
    • (1979) Eur J Clin Pharmacol , vol.16 , Issue.3 , pp. 195-202
    • Pentikainen, P.J.1    Neuvonen, P.J.2    Penttila, A.3
  • 32
    • 79956333806 scopus 로고    scopus 로고
    • Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects
    • Kusuhara H, Ito S, Kumagai Y, et al. Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects. Clin Pharmacol Ther. 2011;89(6):837–844.
    • (2011) Clin Pharmacol Ther , vol.89 , Issue.6 , pp. 837-844
    • Kusuhara, H.1    Ito, S.2    Kumagai, Y.3
  • 33
    • 84885148050 scopus 로고    scopus 로고
    • Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters
    • Grun B, Kiessling MK, Burhenne J, et al. Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters. Br J Clin Pharmacol. 2013;76(5):787–796.
    • (2013) Br J Clin Pharmacol , vol.76 , Issue.5 , pp. 787-796
    • Grun, B.1    Kiessling, M.K.2    Burhenne, J.3
  • 34
    • 84922084054 scopus 로고    scopus 로고
    • N(1)-Methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction
    • Muller F, Pontones CA, Renner B, et al. N(1)-Methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction. Eur J Clin Pharmacol. 2015;71(1):85–94.
    • (2015) Eur J Clin Pharmacol , vol.71 , Issue.1 , pp. 85-94
    • Muller, F.1    Pontones, C.A.2    Renner, B.3
  • 36
    • 84936960124 scopus 로고    scopus 로고
    • The effect of dolutegravir on the pharmacokinetics of metformin in healthy subjects
    • Zong J, Borland J, Jerva F, Wynne B, Choukour M, Song I. The effect of dolutegravir on the pharmacokinetics of metformin in healthy subjects. J Int AIDS Soc. 2014;17(4 suppl 3):19584.
    • (2014) J Int AIDS Soc , vol.17 , Issue.4 , pp. 19584
    • Zong, J.1    Borland, J.2    Jerva, F.3    Wynne, B.4    Choukour, M.5    Song, I.6
  • 37
    • 84903141985 scopus 로고    scopus 로고
    • Effects of proton pump inhibitors on metformin pharmacokinetics and pharmacodynamics
    • Kim A, Chung I, Yoon SH, et al. Effects of proton pump inhibitors on metformin pharmacokinetics and pharmacodynamics. Drug Metab Dispos. 2014;42(7):1174–1179.
    • (2014) Drug Metab Dispos , vol.42 , Issue.7 , pp. 1174-1179
    • Kim, A.1    Chung, I.2    Yoon, S.H.3
  • 38
    • 84895075413 scopus 로고    scopus 로고
    • The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects
    • Ding Y, Jia Y, Song Y, et al. The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects. Eur J Clin Pharmacol. 2014;70(2):141–146.
    • (2014) Eur J Clin Pharmacol , vol.70 , Issue.2 , pp. 141-146
    • Ding, Y.1    Jia, Y.2    Song, Y.3
  • 39
    • 84940200906 scopus 로고    scopus 로고
    • Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin
    • Chen EC, Liang X, Yee SW, et al. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015;88(1):75–83.
    • (2015) Mol Pharmacol , vol.88 , Issue.1 , pp. 75-83
    • Chen, E.C.1    Liang, X.2    Yee, S.W.3
  • 40
    • 84862066298 scopus 로고    scopus 로고
    • Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics
    • Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ. Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics. Drug Metab Dispos. 2012;40(6):1170–1177.
    • (2012) Drug Metab Dispos , vol.40 , Issue.6 , pp. 1170-1177
    • Higgins, J.W.1    Bedwell, D.W.2    Zamek-Gliszczynski, M.J.3
  • 41
    • 0031695302 scopus 로고    scopus 로고
    • Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers
    • Robbins DK, Castles MA, Pack DJ, Bhargava VO, Weir SJ. Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers. Biopharm Drug Dispos. 1998;19(7):455–463.
    • (1998) Biopharm Drug Dispos , vol.19 , Issue.7 , pp. 455-463
    • Robbins, D.K.1    Castles, M.A.2    Pack, D.J.3    Bhargava, V.O.4    Weir, S.J.5
  • 42
    • 77952239982 scopus 로고    scopus 로고
    • Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability
    • Lappin G, Shishikura Y, Jochemsen R, et al. Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability. Eur J Pharm Sci. 2010;40(2):125–131.
    • (2010) Eur J Pharm Sci , vol.40 , Issue.2 , pp. 125-131
    • Lappin, G.1    Shishikura, Y.2    Jochemsen, R.3
  • 43
    • 33645798634 scopus 로고    scopus 로고
    • Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid
    • Tahara H, Kusuhara H, Maeda K, Koepsell H, Fuse E, Sugiyama Y. Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. Drug Metab Dispos. 2006;34(5):743–747.
    • (2006) Drug Metab Dispos , vol.34 , Issue.5 , pp. 743-747
    • Tahara, H.1    Kusuhara, H.2    Maeda, K.3    Koepsell, H.4    Fuse, E.5    Sugiyama, Y.6
  • 44
    • 61449246570 scopus 로고    scopus 로고
    • The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine
    • Matsushima S, Maeda K, Inoue K, et al. The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine. Drug Metab Dispos. 2009;37(3):555–559.
    • (2009) Drug Metab Dispos , vol.37 , Issue.3 , pp. 555-559
    • Matsushima, S.1    Maeda, K.2    Inoue, K.3
  • 45
    • 0017862739 scopus 로고
    • Clinical pharmacokinetics of methotrexate
    • Shen DD, Azarnoff DL. Clinical pharmacokinetics of methotrexate. Clin Pharmacokinet. 1978;3(1):1–13.
    • (1978) Clin Pharmacokinet , vol.3 , Issue.1 , pp. 1-13
    • Shen, D.D.1    Azarnoff, D.L.2
  • 46
    • 0028792273 scopus 로고
    • The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg
    • Kremer JM, Hamilton RA. The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg. J Rheumatol. 1995;22(11):2072–2077.
    • (1995) J Rheumatol , vol.22 , Issue.11 , pp. 2072-2077
    • Kremer, J.M.1    Hamilton, R.A.2
  • 47
    • 0018091529 scopus 로고
    • Prolongation and enhancement of serum methotrexate concentrations by probenecid
    • Aherne GW, Piall E, Marks V, Mould G, White WF. Prolongation and enhancement of serum methotrexate concentrations by probenecid. Br Med J. 1978;1(6120):1097–1099.
    • (1978) Br Med J , vol.1 , Issue.6120 , pp. 1097-1099
    • Aherne, G.W.1    Piall, E.2    Marks, V.3    Mould, G.4    White, W.F.5
  • 48
    • 0037157552 scopus 로고    scopus 로고
    • Drug points: Severe myalgia from an interaction between treatments with pantoprazole and methotrexate
    • Troger U, Stotzel B, Martens-Lobenhoffer J, Gollnick H, Meyer FP. Drug points: Severe myalgia from an interaction between treatments with pantoprazole and methotrexate. BMJ. 2002;324(7352):1497.
    • (2002) BMJ , vol.324 , Issue.7352 , pp. 1497
    • Troger, U.1    Stotzel, B.2    Martens-Lobenhoffer, J.3    Gollnick, H.4    Meyer, F.P.5
  • 49
    • 0023283255 scopus 로고
    • Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole
    • Frain JB. Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole. J Rheumatol. 1987;14(1):176–177.
    • (1987) J Rheumatol , vol.14 , Issue.1 , pp. 176-177
    • Frain, J.B.1
  • 50
    • 0022474766 scopus 로고
    • Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole
    • Thomas MH, Gutterman LA. Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole. J Rheumatol. 1986;13(2):440–441.
    • (1986) J Rheumatol , vol.13 , Issue.2 , pp. 440-441
    • Thomas, M.H.1    Gutterman, L.A.2
  • 51
    • 0031824961 scopus 로고    scopus 로고
    • Methotrexate and trimethoprim: a fatal interaction
    • Steuer A, Gumpel JM. Methotrexate and trimethoprim: a fatal interaction. Br J Rheumatol. 1998;37(1):105–106.
    • (1998) Br J Rheumatol , vol.37 , Issue.1 , pp. 105-106
    • Steuer, A.1    Gumpel, J.M.2
  • 52
    • 0033811761 scopus 로고    scopus 로고
    • Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole
    • Yang CH, Yang LJ, Jaing TH, Chan HL. Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole. Int J Dermatol. 2000;39(8):621–623.
    • (2000) Int J Dermatol , vol.39 , Issue.8 , pp. 621-623
    • Yang, C.H.1    Yang, L.J.2    Jaing, T.H.3    Chan, H.L.4
  • 53
    • 84876695671 scopus 로고    scopus 로고
    • Methotrexate and trimethoprim-sulphamethoxazole: extremely serious and life-threatening combination
    • Al-Quteimat OM, Al-Badaineh MA. Methotrexate and trimethoprim-sulphamethoxazole: extremely serious and life-threatening combination. J Clin Pharmacol Ther. 2013;38(3):203–205.
    • (2013) J Clin Pharmacol Ther , vol.38 , Issue.3 , pp. 203-205
    • Al-Quteimat, O.M.1    Al-Badaineh, M.A.2
  • 54
    • 77954429186 scopus 로고    scopus 로고
    • Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review
    • Bourre-Tessier J, Haraoui B. Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review. J Rheumatol. 2010;37(7):1416–1421.
    • (2010) J Rheumatol , vol.37 , Issue.7 , pp. 1416-1421
    • Bourre-Tessier, J.1    Haraoui, B.2
  • 55
    • 0025094392 scopus 로고
    • Interaction between trimethoprim-sulfamethoxazole and methotrexate in children with leukemia
    • Ferrazzini G, Klein J, Sulh H, Chung D, Griesbrecht E, Koren G. Interaction between trimethoprim-sulfamethoxazole and methotrexate in children with leukemia. J Pediatr. 1990;117(5):823–826.
    • (1990) J Pediatr , vol.117 , Issue.5 , pp. 823-826
    • Ferrazzini, G.1    Klein, J.2    Sulh, H.3    Chung, D.4    Griesbrecht, E.5    Koren, G.6
  • 56
    • 0027170585 scopus 로고
    • Pancytopenia associated with low dose methotrexate therapy. A regional survey
    • al-Awadhi A, Dale P, McKendry RJ. Pancytopenia associated with low dose methotrexate therapy. A regional survey. J Rheumatol. 1993;20(7):1121–1125.
    • (1993) J Rheumatol. , vol.20 , Issue.7 , pp. 1121-1125
    • al-Awadhi, A.1    Dale, P.2    McKendry, R.J.3
  • 57
    • 0026656407 scopus 로고
    • Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man
    • Smith DA, Rasmussen HS, Stopher DA, Walker DK. Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man. Xenobiotica. 1992;22(6):709–719.
    • (1992) Xenobiotica , vol.22 , Issue.6 , pp. 709-719
    • Smith, D.A.1    Rasmussen, H.S.2    Stopher, D.A.3    Walker, D.K.4
  • 58
    • 0018750834 scopus 로고
    • Digoxin-quinidine interaction pharmacokinetic evaluation
    • Hager WD, Fenster P, Mayersohn M, et al. Digoxin-quinidine interaction pharmacokinetic evaluation. N Engl J Med. 1979;300(22):1238–1241.
    • (1979) N Engl J Med , vol.300 , Issue.22 , pp. 1238-1241
    • Hager, W.D.1    Fenster, P.2    Mayersohn, M.3
  • 59
    • 0020059844 scopus 로고
    • The long-term effect of verapamil on plasma digoxin concentration and renal digoxin clearance in healthy subjects
    • Pedersen KE, Dorph-Pedersen A, Hvidt S, Klitgaard NA, Pedersen KK. The long-term effect of verapamil on plasma digoxin concentration and renal digoxin clearance in healthy subjects. Eur J Clin Pharmacol. 1982;22(2):123–127.
    • (1982) Eur J Clin Pharmacol , vol.22 , Issue.2 , pp. 123-127
    • Pedersen, K.E.1    Dorph-Pedersen, A.2    Hvidt, S.3    Klitgaard, N.A.4    Pedersen, K.K.5
  • 60
    • 0031443240 scopus 로고    scopus 로고
    • Itraconazole decreases renal clearance of digoxin
    • Jalava KM, Partanen J, Neuvonen PJ. Itraconazole decreases renal clearance of digoxin. Ther Drug Monit. 1997;19(6):609–613.
    • (1997) Ther Drug Monit , vol.19 , Issue.6 , pp. 609-613
    • Jalava, K.M.1    Partanen, J.2    Neuvonen, P.J.3
  • 61
    • 0036206004 scopus 로고    scopus 로고
    • Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney
    • Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, Endou H. Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol. 2002;13(4):848–857.
    • (2002) J Am Soc Nephrol , vol.13 , Issue.4 , pp. 848-857
    • Kojima, R.1    Sekine, T.2    Kawachi, M.3    Cha, S.H.4    Suzuki, Y.5    Endou, H.6
  • 62
    • 0036260663 scopus 로고    scopus 로고
    • Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
    • Enomoto A, Takeda M, Shimoda M, et al. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002;301(3):797–802.
    • (2002) J Pharmacol Exp Ther , vol.301 , Issue.3 , pp. 797-802
    • Enomoto, A.1    Takeda, M.2    Shimoda, M.3
  • 63
    • 84861152254 scopus 로고    scopus 로고
    • A role for the organic anion transporter OAT3 in renal creatinine secretion in mice
    • Vallon V, Eraly SA, Rao SR, et al. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012;302(10):F1293–F1299.
    • (2012) Am J Physiol Renal Physiol , vol.302 , Issue.10 , pp. F1293-F1299
    • Vallon, V.1    Eraly, S.A.2    Rao, S.R.3
  • 65
    • 33344454764 scopus 로고    scopus 로고
    • Tissue distribution and ontogeny of organic cation transporters in mice
    • Alnouti Y, Petrick JS, Klaassen CD. Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metab Dispos. 2006;34(3):477–482.
    • (2006) Drug Metab Dispos , vol.34 , Issue.3 , pp. 477-482
    • Alnouti, Y.1    Petrick, J.S.2    Klaassen, C.D.3
  • 66
    • 84888431020 scopus 로고    scopus 로고
    • The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo
    • Hume WE, Shingaki T, Takashima T, et al. The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo. Bioorg Med Chem. 2013;21(24):7584–7590.
    • (2013) Bioorg Med Chem , vol.21 , Issue.24 , pp. 7584-7590
    • Hume, W.E.1    Shingaki, T.2    Takashima, T.3
  • 67
    • 84961203300 scopus 로고    scopus 로고
    • Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse
    • Shingaki T, Hume WE, Takashima T, et al. Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse. Pharm Res. 2015;32(8):2538–2547.
    • (2015) Pharm Res , vol.32 , Issue.8 , pp. 2538-2547
    • Shingaki, T.1    Hume, W.E.2    Takashima, T.3
  • 68
    • 84855995429 scopus 로고    scopus 로고
    • Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
    • Ito S, Kusuhara H, Yokochi M, et al. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. J Pharmacol Exp Ther. 2012;340(2):393–403.
    • (2012) J Pharmacol Exp Ther , vol.340 , Issue.2 , pp. 393-403
    • Ito, S.1    Kusuhara, H.2    Yokochi, M.3
  • 69
    • 1542434260 scopus 로고    scopus 로고
    • Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine
    • Rollot F, Nazal EM, Chauvelot-Moachon L, et al. Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine. Clin Infect Dis. 2003;37(12):e174–e176.
    • (2003) Clin Infect Dis , vol.37 , Issue.12 , pp. e174-e176
    • Rollot, F.1    Nazal, E.M.2    Chauvelot-Moachon, L.3
  • 70
    • 33749531758 scopus 로고    scopus 로고
    • Mechanism of active renal tubular efflux of tenofovir
    • Ray AS, Cihlar T, Robinson KL, et al. Mechanism of active renal tubular efflux of tenofovir. Antimicrob Agents Chemother. 2006;50(10):3297–3304.
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.10 , pp. 3297-3304
    • Ray, A.S.1    Cihlar, T.2    Robinson, K.L.3
  • 71
    • 33846420624 scopus 로고    scopus 로고
    • Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir
    • Imaoka T, Kusuhara H, Adachi M, Schuetz JD, Takeuchi K, Sugiyama Y. Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol. 2007;71(2):619–627.
    • (2007) Mol Pharmacol , vol.71 , Issue.2 , pp. 619-627
    • Imaoka, T.1    Kusuhara, H.2    Adachi, M.3    Schuetz, J.D.4    Takeuchi, K.5    Sugiyama, Y.6
  • 72
    • 34147173854 scopus 로고    scopus 로고
    • Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors
    • Cihlar T, Ray AS, Laflamme G, et al. Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors. Antiviral Therapy. 2007;12(2):267–272.
    • (2007) Antiviral Therapy , vol.12 , Issue.2 , pp. 267-272
    • Cihlar, T.1    Ray, A.S.2    Laflamme, G.3
  • 73
    • 34948854765 scopus 로고    scopus 로고
    • Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro
    • Tong L, Phan TK, Robinson KL, et al. Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro. Antimicrob Agents Chemother. 2007;51(10):3498–3504.
    • (2007) Antimicrob Agents Chemother , vol.51 , Issue.10 , pp. 3498-3504
    • Tong, L.1    Phan, T.K.2    Robinson, K.L.3
  • 74
    • 77957929019 scopus 로고    scopus 로고
    • Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity
    • Nakamura T, Yonezawa A, Hashimoto S, Katsura T, Inui K. Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity. Biochem Pharmacol. 2010;80(11):1762–1767.
    • (2010) Biochem Pharmacol , vol.80 , Issue.11 , pp. 1762-1767
    • Nakamura, T.1    Yonezawa, A.2    Hashimoto, S.3    Katsura, T.4    Inui, K.5
  • 75
    • 84884722995 scopus 로고    scopus 로고
    • Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs)
    • Li Q, Guo D, Dong Z, et al. Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs). Toxicol Appl Pharmacol. 2013;273(1):100–109.
    • (2013) Toxicol Appl Pharmacol , vol.273 , Issue.1 , pp. 100-109
    • Li, Q.1    Guo, D.2    Dong, Z.3
  • 76
    • 82955240616 scopus 로고    scopus 로고
    • Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice
    • Li Q, Peng X, Yang H, Wang H, Shu Y. Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice. Mol Pharm. 2011;8(6):2476–2483.
    • (2011) Mol Pharm , vol.8 , Issue.6 , pp. 2476-2483
    • Li, Q.1    Peng, X.2    Yang, H.3    Wang, H.4    Shu, Y.5
  • 77
    • 0022372166 scopus 로고
    • Limitations of creatinine as a filtration marker in glomerulopathic patients
    • Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int. 1985;28(5):830–838.
    • (1985) Kidney Int , vol.28 , Issue.5 , pp. 830-838
    • Shemesh, O.1    Golbetz, H.2    Kriss, J.P.3    Myers, B.D.4
  • 78
    • 28444444126 scopus 로고    scopus 로고
    • Effects of renal failure on drug transport and metabolism
    • Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006;109(1-2):1–11.
    • (2006) Pharmacol Ther , vol.109 , Issue.1-2 , pp. 1-11
    • Sun, H.1    Frassetto, L.2    Benet, L.Z.3
  • 79
    • 1642539149 scopus 로고    scopus 로고
    • Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases
    • Sakurai Y, Motohashi H, Ueo H, et al. Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004;21(1):61–67.
    • (2004) Pharm Res , vol.21 , Issue.1 , pp. 61-67
    • Sakurai, Y.1    Motohashi, H.2    Ueo, H.3
  • 82
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States, 2011–2012
    • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA. 2014;311(8):806–814.
    • (2014) JAMA , vol.311 , Issue.8 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 83
    • 0032861050 scopus 로고    scopus 로고
    • A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?
    • Andreev E, Koopman M, Arisz L. A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible? J Intern Med. 1999;246(3):247–252.
    • (1999) J Intern Med , vol.246 , Issue.3 , pp. 247-252
    • Andreev, E.1    Koopman, M.2    Arisz, L.3
  • 84
    • 84982134755 scopus 로고    scopus 로고
    • Creatinine as an endogenous marker for renal function – emerging role of transporters in the overall assessment of renal toxicity
    • Arya V, Yang X, Balimane P, et al. Creatinine as an endogenous marker for renal function – emerging role of transporters in the overall assessment of renal toxicity. Abstract PII-012. Clin Pharmacol Ther. 2014;95(suppl 1):S65.
    • (2014) Clin Pharmacol Ther , vol.95 , pp. S65
    • Arya, V.1    Yang, X.2    Balimane, P.3
  • 85
    • 85043096079 scopus 로고    scopus 로고
    • Edurant
    • Edurant. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002264/WC500118874.pdf.
  • 86
    • 84961122890 scopus 로고    scopus 로고
    • The effect of nizatidine, a MATE2K selective inhibitor, on the pharmacokinetics and pharmacodynamics of metformin in healthy volunteers
    • Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. The effect of nizatidine, a MATE2K selective inhibitor, on the pharmacokinetics and pharmacodynamics of metformin in healthy volunteers. Clin Pharmacokinet. 2016;55(4):495–506.
    • (2016) Clin Pharmacokinet , vol.55 , Issue.4 , pp. 495-506
    • Morrissey, K.M.1    Stocker, S.L.2    Chen, E.C.3    Castro, R.A.4    Brett, C.M.5    Giacomini, K.M.6
  • 87
    • 84940392415 scopus 로고    scopus 로고
    • Characterization of organic anion transporter 2 (SLC22A7): a highly efficient transporter for creatinine and species-dependent renal tubular expression
    • Shen H, Liu T, Morse BL, et al. Characterization of organic anion transporter 2 (SLC22A7): a highly efficient transporter for creatinine and species-dependent renal tubular expression. Drug Metab Dispos. 2015;43(7):984–993.
    • (2015) Drug Metab Dispos , vol.43 , Issue.7 , pp. 984-993
    • Shen, H.1    Liu, T.2    Morse, B.L.3
  • 88
    • 84891624684 scopus 로고    scopus 로고
    • Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins
    • Kato K, Mori H, Kito T, et al. Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins. Pharm Res. 2014;31(1):136–147.
    • (2014) Pharm Res , vol.31 , Issue.1 , pp. 136-147
    • Kato, K.1    Mori, H.2    Kito, T.3
  • 89
    • 84903977464 scopus 로고    scopus 로고
    • OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
    • Chen L, Shu Y, Liang X, et al. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci USA. 2014;111(27):9983–9988.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.27 , pp. 9983-9988
    • Chen, L.1    Shu, Y.2    Liang, X.3
  • 90
    • 84867869728 scopus 로고    scopus 로고
    • N-Methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K)
    • Ito S, Kusuhara H, Kumagai Y, et al. N-Methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K). Clin Pharmacol Ther. 2012;92(5):635–641.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.5 , pp. 635-641
    • Ito, S.1    Kusuhara, H.2    Kumagai, Y.3
  • 91
    • 84964694744 scopus 로고    scopus 로고
    • Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis: a randomized clinical trial
    • Pardanani A, Harrison C, Cortes JE, et al. Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis: a randomized clinical trial. JAMA Oncol. 2015;1(5):643–651.
    • (2015) JAMA Oncol , vol.1 , Issue.5 , pp. 643-651
    • Pardanani, A.1    Harrison, C.2    Cortes, J.E.3
  • 92
    • 84907912086 scopus 로고    scopus 로고
    • The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy
    • Zhang Q, Zhang Y, Diamond S, et al. The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy. Drug Metab Dispos. 2014;42(10):1656–1662.
    • (2014) Drug Metab Dispos , vol.42 , Issue.10 , pp. 1656-1662
    • Zhang, Q.1    Zhang, Y.2    Diamond, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.