The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers

Clinical Pharmacokinetics

Volumn 55, Issue 4, 2016, Pages 495-506

  Morrissey, Kari M ^a,b   Stocker, Sophie L ^a,c   Chen, Eugene C ^a,b   Castro, Richard A ^a   Brett, Claire M ^a   Giacomini, Kathleen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENENTECH INC   (United States)

^c ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IOHEXOL; METFORMIN; MOXIFLOXACIN; NIZATIDINE; NORFLOXACIN; ONDANSETRON; ORGANIC CATION TRANSPORTER; RANITIDINE; ANTIDIABETIC AGENT; MATE2-K PROTEIN, HUMAN;

ADULT; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CATION TRANSPORT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG POTENCY; DRUG URINE LEVEL; FEMALE; HALF LIFE TIME; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; ORAL GLUCOSE TOLERANCE TEST; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RENAL CLEARANCE; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUME OF DISTRIBUTION; ADOLESCENT; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; DRUG INTERACTION; KIDNEY; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; CELL LINE; CROSS-OVER STUDIES; DRUG INTERACTIONS; FEMALE; HALF-LIFE; HEK293 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; KIDNEY; MALE; METFORMIN; MIDDLE AGED; NIZATIDINE; ORGANIC CATION TRANSPORT PROTEINS; YOUNG ADULT;

EID: 84961122890     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-015-0332-9     Document Type: Article

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