-
1
-
-
0037129380
-
Nonalcoholic fatty liver disease
-
Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221–1231.
-
(2002)
N Engl J Med
, vol.346
, pp. 1221-1231
-
-
Angulo, P.1
-
2
-
-
0033231294
-
Association of nonalcoholic fatty liver disease with insulin resistance
-
Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999;107:450–455.
-
(1999)
Am J Med
, vol.107
, pp. 450-455
-
-
Marchesini, G1
Brizi, M2
Morselli-Labate, AM3
Bianchi, G4
Bugianesi, E5
McCullough, AJ6
-
3
-
-
0033982172
-
Prevalence of and risk factors for hepatic steatosis in Northern Italy
-
Bellentani S, Saccoccio G, Masutti F, Croce LS, Brandi G, Sasso F, et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000;132:112–117.
-
(2000)
Ann Intern Med
, vol.132
, pp. 112-117
-
-
Bellentani, S1
Saccoccio, G2
Masutti, F3
Croce, LS4
Brandi, G5
Sasso, F6
-
4
-
-
10644220306
-
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
-
Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387–1395.
-
(2004)
Hepatology
, vol.40
, pp. 1387-1395
-
-
Browning, JD1
Szczepaniak, LS2
Dobbins, R3
Nuremberg, P4
Horton, JD5
Cohen, JC6
-
5
-
-
33750002388
-
Prevalence of fatty liver in children and adolescents
-
Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics 2006;118: 1388–1393.
-
(2006)
Pediatrics
, vol.118
, pp. 1388-1393
-
-
Schwimmer, JB1
Deutsch, R2
Kahen, T3
Lavine, JE4
Stanley, C5
Behling, C.6
-
6
-
-
34247200322
-
Nonalcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines
-
Chitturi S, Farrell GC, Hashimoto E, Saibara T, Lau GK, Sollano JD. Nonalcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines. J Gastroenterol Hepatol 2007;22:778–787.
-
(2007)
J Gastroenterol Hepatol
, vol.22
, pp. 778-787
-
-
Chitturi, S1
Farrell, GC2
Hashimoto, E3
Saibara, T4
Lau, GK5
Sollano, JD.6
-
7
-
-
84866531658
-
Prevalence and risk factors for non-alcoholic fatty liver disease in Asian people who are not obese
-
Liu CJ. Prevalence and risk factors for non-alcoholic fatty liver disease in Asian people who are not obese. J Gastroenterol Hepatol 2012;27:1555–1560.
-
(2012)
J Gastroenterol Hepatol
, vol.27
, pp. 1555-1560
-
-
Liu, CJ.1
-
8
-
-
84864081494
-
Features, diagnosis, and treatment of nonalcoholic fatty liver disease
-
Torres DM, Williams CD, Harrison SA. Features, diagnosis, and treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2012;10: 837–858.
-
(2012)
Clin Gastroenterol Hepatol
, vol.10
, pp. 837-858
-
-
Torres, DM1
Williams, CD2
Harrison, SA.3
-
9
-
-
77954315951
-
Coronary flow reserve is impaired in patients with nonalcoholic fatty liver disease: association with liver fibrosis
-
Yilmaz Y, Kurt R, Yonal O, Polat N, Celikel CA, Gurdal A, et al. Coronary flow reserve is impaired in patients with nonalcoholic fatty liver disease: association with liver fibrosis. Atherosclerosis 2010;211:182–186.
-
(2010)
Atherosclerosis
, vol.211
, pp. 182-186
-
-
Yilmaz, Y1
Kurt, R2
Yonal, O3
Polat, N4
Celikel, CA5
Gurdal, A6
-
10
-
-
53549112749
-
Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?
-
Targher G, Marra F, Marchesini G. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 2008;51:1947–1953.
-
(2008)
Diabetologia
, vol.51
, pp. 1947-1953
-
-
Targher, G1
Marra, F2
Marchesini, G.3
-
11
-
-
84861197159
-
Hepatocellular carcinoma in nonalcoholic fatty liver disease: An emerging menace
-
Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in nonalcoholic fatty liver disease: An emerging menace. J Hepatol 2012;56:1384–1391.
-
(2012)
J Hepatol
, vol.56
, pp. 1384-1391
-
-
Baffy, G1
Brunt, EM2
Caldwell, SH.3
-
12
-
-
33750606061
-
Long-term follow-up of patients with NAFLD and elevated liver enzymes
-
Ekstedt M, Franzen LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865–873.
-
(2006)
Hepatology
, vol.44
, pp. 865-873
-
-
Ekstedt, M1
Franzen, LE2
Mathiesen, UL3
Thorelius, L4
Holmqvist, M5
Bodemar, G6
-
13
-
-
58849134985
-
Longterm follow-up of patients with nonalcoholic fatty liver
-
Rafiq N, Bai C, Fang Y, Srishord M, McCullough A, Gramlich T, et al. Longterm follow-up of patients with nonalcoholic fatty liver. Clin Gastroenterol Hepatol 2009;7:234–238.
-
(2009)
Clin Gastroenterol Hepatol
, vol.7
, pp. 234-238
-
-
Rafiq, N1
Bai, C2
Fang, Y3
Srishord, M4
McCullough, A5
Gramlich, T6
-
14
-
-
63049133092
-
Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
-
Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009;27:1485–1491.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1485-1491
-
-
Altekruse, SF1
McGlynn, KA2
Reichman, ME.3
-
16
-
-
43949086923
-
Cirrhosis and liver failure in nonalcoholic fatty liver disease: Molehill or mountain?
-
Charlton M. Cirrhosis and liver failure in nonalcoholic fatty liver disease: Molehill or mountain? Hepatology 2008;47:1431–1433.
-
(2008)
Hepatology
, vol.47
, pp. 1431-1433
-
-
Charlton, M.1
-
17
-
-
34250020201
-
Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
-
El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557–2576.
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, HB1
Rudolph, KL.2
-
18
-
-
0034791598
-
The spectrum of liver disease in the general population: lesson from the Dionysos study
-
Bellentani S, Tiribelli C. The spectrum of liver disease in the general population: lesson from the Dionysos study. J Hepatol 2001;35:531–537.
-
(2001)
J Hepatol
, vol.35
, pp. 531-537
-
-
Bellentani, S1
Tiribelli, C.2
-
19
-
-
33846473612
-
Nonalcoholic fatty liver disease in severely obese subjects
-
Gholam PM, Flancbaum L, Machan JT, Charney DA, Kotler DP. Nonalcoholic fatty liver disease in severely obese subjects. Am J Gastroenterol 2007; 102:399–408.
-
(2007)
Am J Gastroenterol
, vol.102
, pp. 399-408
-
-
Gholam, PM1
Flancbaum, L2
Machan, JT3
Charney, DA4
Kotler, DP.5
-
20
-
-
33750617920
-
Correlation of paired liver biopsies in morbidly obese patients with suspected nonalcoholic fatty liver disease
-
Merriman RB, Ferrell LD, Patti MG, Weston SR, Pabst MS, Aouizerat BE, et al. Correlation of paired liver biopsies in morbidly obese patients with suspected nonalcoholic fatty liver disease. Hepatology 2006;44:874–880.
-
(2006)
Hepatology
, vol.44
, pp. 874-880
-
-
Merriman, RB1
Ferrell, LD2
Patti, MG3
Weston, SR4
Pabst, MS5
Aouizerat, BE6
-
21
-
-
65549122652
-
Metabolic disturbances in non-alcoholic fatty liver disease
-
Byrne CD, Olufadi R, Bruce KD, Cagampang FR, Ahmed MH. Metabolic disturbances in non-alcoholic fatty liver disease. Clin Sci (Lond) 2009;116: 539–564.
-
(2009)
Clin Sci (Lond)
, vol.116
, pp. 539-564
-
-
Byrne, CD1
Olufadi, R2
Bruce, KD3
Cagampang, FR4
Ahmed, MH.5
-
22
-
-
78650486196
-
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
-
Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011;140:124–131.
-
(2011)
Gastroenterology
, vol.140
, pp. 124-131
-
-
Williams, CD1
Stengel, J2
Asike, MI3
Torres, DM4
Shaw, J5
Contreras, M6
-
23
-
-
84055193440
-
Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic?
-
Hashimoto E, Tokushige K. Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic? Hepatol Res 2012;42: 1–14.
-
(2012)
Hepatol Res
, vol.42
, pp. 1-14
-
-
Hashimoto, E1
Tokushige, K.2
-
24
-
-
33645963121
-
Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
-
Sanyal AJ, Banas C, Sargeant C, Luketic VA, Sterling RK, Stravitz RT, et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 2006;43:682–689.
-
(2006)
Hepatology
, vol.43
, pp. 682-689
-
-
Sanyal, AJ1
Banas, C2
Sargeant, C3
Luketic, VA4
Sterling, RK5
Stravitz, RT6
-
25
-
-
77952730428
-
The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
-
Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010;51:1972–1978.
-
(2010)
Hepatology
, vol.51
, pp. 1972-1978
-
-
Ascha, MS1
Hanouneh, IA2
Lopez, R3
Tamimi, TA4
Feldstein, AF5
Zein, NN.6
-
26
-
-
58849132440
-
Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C
-
Yatsuji S, Hashimoto E, Tobari M, Taniai M, Tokushige K, Shiratori K. Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C. J Gastroenterol Hepatol 2009;24:248–254.
-
(2009)
J Gastroenterol Hepatol
, vol.24
, pp. 248-254
-
-
Yatsuji, S1
Hashimoto, E2
Tobari, M3
Taniai, M4
Tokushige, K5
Shiratori, K.6
-
27
-
-
84984548367
-
Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan
-
Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL, et al. Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. Gastroenterology 2008;135:111–121.
-
(2008)
Gastroenterology
, vol.135
, pp. 111-121
-
-
Chen, CL1
Yang, HI2
Yang, WS3
Liu, CJ4
Chen, PJ5
You, SL6
-
28
-
-
33746514438
-
Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis
-
N’Kontchou G, Paries J, Htar MT, Ganne-Carrie N, Costentin L, Grando-Lemaire V, et al. Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis. Clin Gastroenterol Hepatol 2006;4:1062–1068.
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 1062-1068
-
-
N’Kontchou, G1
Paries, J2
Htar, MT3
Ganne-Carrie, N4
Costentin, L5
Grando-Lemaire, V6
-
29
-
-
0033019013
-
Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease
-
Caldwell SH, Oelsner DH, Iezzoni JC, Hespenheide EE, Battle EH, Driscoll CJ. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 1999;29:664–669.
-
(1999)
Hepatology
, vol.29
, pp. 664-669
-
-
Caldwell, SH1
Oelsner, DH2
Iezzoni, JC3
Hespenheide, EE4
Battle, EH5
Driscoll, CJ.6
-
30
-
-
0033797838
-
Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study
-
Poonawala A, Nair SP, Thuluvath PJ. Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 2000; 32:689–692.
-
(2000)
Hepatology
, vol.32
, pp. 689-692
-
-
Poonawala, A1
Nair, SP2
Thuluvath, PJ.3
-
31
-
-
0036894480
-
NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States
-
Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 2002;36:1349–1354.
-
(2002)
Hepatology
, vol.36
, pp. 1349-1354
-
-
Marrero, JA1
Fontana, RJ2
Su, GL3
Conjeevaram, HS4
Emick, DM5
Lok, AS.6
-
32
-
-
84857947511
-
Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: fertile soil
-
Torres DM, Harrison SA. Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: fertile soil. Semin Liver Dis 2012;32:30–38.
-
(2012)
Semin Liver Dis
, vol.32
, pp. 30-38
-
-
Torres, DM1
Harrison, SA.2
-
33
-
-
77955625142
-
Population-based risk factors and resource utilization for HCC: US perspective
-
Sanyal A, Poklepovic A, Moyneur E, Barghout V. Population-based risk factors and resource utilization for HCC: US perspective. Curr Med Res Opin 2010;26:2183–2191.
-
(2010)
Curr Med Res Opin
, vol.26
, pp. 2183-2191
-
-
Sanyal, A1
Poklepovic, A2
Moyneur, E3
Barghout, V.4
-
34
-
-
84876557053
-
Nonalcoholic fatty liver disease without cirrhosis is an emergent and independent risk factor of hepatocellular carcinoma: A population based study
-
Rahman RN, Ibdah JA. Nonalcoholic fatty liver disease without cirrhosis is an emergent and independent risk factor of hepatocellular carcinoma: A population based study. Hepatology 2012;56:241A.
-
(2012)
Hepatology
, vol.56
, pp. 241A
-
-
Rahman, RN1
Ibdah, JA.2
-
35
-
-
84856736177
-
Large-scale long-term follow-up study of Japanese patients with non-alcoholic fatty liver disease for the onset of hepatocellular carcinoma
-
Kawamura Y, Arase Y, Ikeda K, Seko Y, Imai N, Hosaka T, et al. Large-scale long-term follow-up study of Japanese patients with non-alcoholic fatty liver disease for the onset of hepatocellular carcinoma. Am J Gastroenterol 2012;107:253–261.
-
(2012)
Am J Gastroenterol
, vol.107
, pp. 253-261
-
-
Kawamura, Y1
Arase, Y2
Ikeda, K3
Seko, Y4
Imai, N5
Hosaka, T6
-
36
-
-
84869436442
-
Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review
-
e2
-
White DL, Kanwal F, El-Serag HB. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin Gastroenterol Hepatol 2012;10:1342–1359.e2.
-
(2012)
Clin Gastroenterol Hepatol
, vol.10
, pp. 1342-1359
-
-
White, DL1
Kanwal, F2
El-Serag, HB.3
-
37
-
-
77957200500
-
Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications
-
Stickel F, Hellerbrand C. Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications. Gut 2010;59: 1303–1307.
-
(2010)
Gut
, vol.59
, pp. 1303-1307
-
-
Stickel, F1
Hellerbrand, C.2
-
38
-
-
77951456114
-
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
-
Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 2010;51: 1820–1832.
-
(2010)
Hepatology
, vol.51
, pp. 1820-1832
-
-
Starley, BQ1
Calcagno, CJ2
Harrison, SA.3
-
39
-
-
7044272630
-
Hepatocellular carcinoma in cirrhosis: incidence and risk factors
-
Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004;127:S35–50.
-
(2004)
Gastroenterology
, vol.127
, pp. S35-S50
-
-
Fattovich, G1
Stroffolini, T2
Zagni, I3
Donato, F.4
-
40
-
-
0037464510
-
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
-
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625–1638.
-
(2003)
N Engl J Med
, vol.348
, pp. 1625-1638
-
-
Calle, EE1
Rodriguez, C2
Walker-Thurmond, K3
Thun, MJ.4
-
41
-
-
38949108241
-
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
-
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008;371:569–578.
-
(2008)
Lancet
, vol.371
, pp. 569-578
-
-
Renehan, AG1
Tyson, M2
Egger, M3
Heller, RF4
Zwahlen, M.5
-
42
-
-
78149386734
-
Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets
-
Severi T, van Malenstein H, Verslype C, van Pelt JF. Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. Acta Pharmacol Sin 2010;31:1409–1420.
-
(2010)
Acta Pharmacol Sin
, vol.31
, pp. 1409-1420
-
-
Severi, T1
van Malenstein, H2
Verslype, C3
van Pelt, JF.4
-
43
-
-
0036699940
-
Molecular pathogenesis of human hepatocellular carcinoma
-
Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339–346.
-
(2002)
Nat Genet
, vol.31
, pp. 339-346
-
-
Thorgeirsson, SS1
Grisham, JW.2
-
44
-
-
33747830764
-
Hepatocellular carcinoma pathogenesis: from genes to environment
-
Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6:674–687.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 674-687
-
-
Farazi, PA1
DePinho, RA.2
-
45
-
-
84857652096
-
Role of the microenvironment in hepatocellular carcinoma development and progression
-
Wu SD, Ma YS, Fang Y, Liu LL, Fu D, Shen XZ. Role of the microenvironment in hepatocellular carcinoma development and progression. Cancer Treat Rev 2012;38:218–225.
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 218-225
-
-
Wu, SD1
Ma, YS2
Fang, Y3
Liu, LL4
Fu, D5
Shen, XZ.6
-
46
-
-
33845790499
-
A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
-
Llovet JM, Chen Y, Wurmbach E, Roayaie S, Fiel MI, Schwartz M, et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 2006;131: 1758–1767.
-
(2006)
Gastroenterology
, vol.131
, pp. 1758-1767
-
-
Llovet, JM1
Chen, Y2
Wurmbach, E3
Roayaie, S4
Fiel, MI5
Schwartz, M6
-
47
-
-
0033765496
-
Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis– A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
-
Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis– A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 2000;32:970–979.
-
(2000)
Hepatology
, vol.32
, pp. 970-979
-
-
Kondo, Y1
Kanai, Y2
Sakamoto, M3
Mizokami, M4
Ueda, R5
Hirohashi, S.6
-
48
-
-
78649266473
-
Signaling networks in human hepatocarcinogenesis–novel aspects and therapeutic options
-
Breuhahn K, Schirmacher P. Signaling networks in human hepatocarcinogenesis–novel aspects and therapeutic options. Prog Mol Biol Transl Sci 2010;97:251–277.
-
(2010)
Prog Mol Biol Transl Sci
, vol.97
, pp. 251-277
-
-
Breuhahn, K1
Schirmacher, P.2
-
49
-
-
33846463379
-
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
-
Boyault S, Rickman DS, de Reynies A, Balabaud C, Rebouissou S, Jeannot E, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007;45:42–52.
-
(2007)
Hepatology
, vol.45
, pp. 42-52
-
-
Boyault, S1
Rickman, DS2
de Reynies, A3
Balabaud, C4
Rebouissou, S5
Jeannot, E6
-
50
-
-
77349092851
-
Molecular classification and novel targets in hepatocellular carcinoma: recent advancements
-
Hoshida Y, Toffanin S, Lachenmayer A, Villanueva A, Minguez B, Llovet JM. Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin Liver Dis 2010;30:35–51.
-
(2010)
Semin Liver Dis
, vol.30
, pp. 35-51
-
-
Hoshida, Y1
Toffanin, S2
Lachenmayer, A3
Villanueva, A4
Minguez, B5
Llovet, JM.6
-
51
-
-
33745552897
-
Dysregulation of growth factor signaling in human hepatocellular carcinoma
-
Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 2006;25: 3787–3800.
-
(2006)
Oncogene
, vol.25
, pp. 3787-3800
-
-
Breuhahn, K1
Longerich, T2
Schirmacher, P.3
-
52
-
-
84864480565
-
Molecularly targeted therapy for advanced hepatocellular carcinoma in 2012: current status and future perspectives
-
Zhu AX. Molecularly targeted therapy for advanced hepatocellular carcinoma in 2012: current status and future perspectives. Semin Oncol 2012; 39:493–502.
-
(2012)
Semin Oncol
, vol.39
, pp. 493-502
-
-
Zhu, AX.1
-
53
-
-
84877673233
-
A human anti-c-Met Fab fragment conjugated with doxorubicin as targeted chemotherapy for hepatocellular carcinoma
-
Chen X, Ding G, Gao Q, Sun J, Zhang Q, Du L, et al. A human anti-c-Met Fab fragment conjugated with doxorubicin as targeted chemotherapy for hepatocellular carcinoma. PLoS One 2013;8:e63093.
-
(2013)
PLoS One
, vol.8
, pp. e63093
-
-
Chen, X1
Ding, G2
Gao, Q3
Sun, J4
Zhang, Q5
Du, L6
-
54
-
-
46349103001
-
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma
-
Bengochea A, de Souza MM, Lefrancois L, Le Roux E, Galy O, Chemin I, et al. Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer 2008;99:143–150.
-
(2008)
Br J Cancer
, vol.99
, pp. 143-150
-
-
Bengochea, A1
de Souza, MM2
Lefrancois, L3
Le Roux, E4
Galy, O5
Chemin, I6
-
55
-
-
79959996152
-
A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma
-
Abu Dayyeh BK, Yang M, Fuchs BC, Karl DL, Yamada S, Sninsky JJ, et al. A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma. Gastroenterology 2011; 141:141–149.
-
(2011)
Gastroenterology
, vol.141
, pp. 141-149
-
-
Abu Dayyeh, BK1
Yang, M2
Fuchs, BC3
Karl, DL4
Yamada, S5
Sninsky, JJ6
-
56
-
-
38949184246
-
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival
-
Jiang J, Gusev Y, Aderca I, Mettler TA, Nagorney DM, Brackett DJ, et al. Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res 2008;14: 419–427.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 419-427
-
-
Jiang, J1
Gusev, Y2
Aderca, I3
Mettler, TA4
Nagorney, DM5
Brackett, DJ6
-
57
-
-
58149386462
-
Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression
-
Cheung O, Puri P, Eicken C, Contos MJ, Mirshahi F, Maher JW, et al. Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression. Hepatology 2008;48:1810–1820.
-
(2008)
Hepatology
, vol.48
, pp. 1810-1820
-
-
Cheung, O1
Puri, P2
Eicken, C3
Contos, MJ4
Mirshahi, F5
Maher, JW6
-
58
-
-
34247857663
-
Obesity, inflammation, and insulin resistance
-
Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007;132:2169–2180.
-
(2007)
Gastroenterology
, vol.132
, pp. 2169-2180
-
-
Shoelson, SE1
Herrero, L2
Naaz, A.3
-
59
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444: 860–867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, GS.1
-
60
-
-
49649096375
-
Visceral fat: a key mediator of steatohepatitis in metabolic liver disease
-
Van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008;48:449–457.
-
(2008)
Hepatology
, vol.48
, pp. 449-457
-
-
Van der Poorten, D1
Milner, KL2
Hui, J3
Hodge, A4
Trenell, MI5
Kench, JG6
-
61
-
-
0034129495
-
Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
-
Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 2000;278:E941–E948.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
, pp. E941-E948
-
-
Kelley, DE1
Thaete, FL2
Troost, F3
Huwe, T4
Goodpaster, BH.5
-
62
-
-
34047250349
-
Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
-
Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D, et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 2007;67:2497–2507.
-
(2007)
Cancer Res
, vol.67
, pp. 2497-2507
-
-
Saxena, NK1
Sharma, D2
Ding, X3
Lin, S4
Marra, F5
Merlin, D6
-
63
-
-
84866079242
-
The role of adiponectin in cancer: a review of current evidence
-
Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: a review of current evidence. Endocr Rev 2012;33:547–594.
-
(2012)
Endocr Rev
, vol.33
, pp. 547-594
-
-
Dalamaga, M1
Diakopoulos, KN2
Mantzoros, CS.3
-
64
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010;140:197–208.
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, EJ1
Lee, JH2
Yu, GY3
He, G4
Ali, SR5
Holzer, RG6
-
65
-
-
0033694535
-
Lipotoxic diseases of nonadipose tissues in obesity
-
(Suppl)
-
Unger RH, Orci L. Lipotoxic diseases of nonadipose tissues in obesity. Int J Obes Relat Metab Disord 2000;24 (Suppl):28–32.
-
(2000)
Int J Obes Relat Metab Disord
, vol.24
, pp. 28-32
-
-
Unger, RH1
Orci, L.2
-
66
-
-
53849143606
-
Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese
-
Tan CY, Vidal-Puig A. Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochem Soc Trans 2008;36:935–940.
-
(2008)
Biochem Soc Trans
, vol.36
, pp. 935-940
-
-
Tan, CY1
Vidal-Puig, A.2
-
67
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004;114:147–152.
-
(2004)
J Clin Invest
, vol.114
, pp. 147-152
-
-
Browning, JD1
Horton, JD.2
-
68
-
-
38649116056
-
Selective versus total insulin resistance: a pathogenic paradox
-
Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 2008;7:95–96.
-
(2008)
Cell Metab
, vol.7
, pp. 95-96
-
-
Brown, MS1
Goldstein, JL.2
-
69
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
-
Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008;118:829–838.
-
(2008)
J Clin Invest
, vol.118
, pp. 829-838
-
-
Postic, C1
Girard, J.2
-
71
-
-
70349249503
-
Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis
-
Fujita K, Nozaki Y, Wada K, Yoneda M, Fujimoto Y, Fujitake M, et al. Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis. Hepatology 2009;50: 772–780.
-
(2009)
Hepatology
, vol.50
, pp. 772-780
-
-
Fujita, K1
Nozaki, Y2
Wada, K3
Yoneda, M4
Fujimoto, Y5
Fujitake, M6
-
72
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, et al. Autophagy regulates lipid metabolism. Nature 2009;458:1131–1135.
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R1
Kaushik, S2
Wang, Y3
Xiang, Y4
Novak, I5
Komatsu, M6
-
73
-
-
36349024819
-
A lipidomic analysis of nonalcoholic fatty liver disease
-
Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007;46: 1081–1090.
-
(2007)
Hepatology
, vol.46
, pp. 1081-1090
-
-
Puri, P1
Baillie, RA2
Wiest, MM3
Mirshahi, F4
Choudhury, J5
Cheung, O6
-
75
-
-
43249092409
-
Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
-
Choi SS, Diehl AM. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol 2008;19:295–300.
-
(2008)
Curr Opin Lipidol
, vol.19
, pp. 295-300
-
-
Choi, SS1
Diehl, AM.2
-
76
-
-
70049089646
-
Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
-
Alkhouri N, Dixon LJ, Feldstein AE. Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol 2009;3:445–451.
-
(2009)
Expert Rev Gastroenterol Hepatol
, vol.3
, pp. 445-451
-
-
Alkhouri, N1
Dixon, LJ2
Feldstein, AE.3
-
77
-
-
43949144276
-
Noninvasive assessment of hepatic lipid composition: Advancing understanding and management of fatty liver disorders
-
Johnson NA, Walton DW, Sachinwalla T, Thompson CH, Smith K, Ruell PA, et al. Noninvasive assessment of hepatic lipid composition: Advancing understanding and management of fatty liver disorders. Hepatology 2008; 47:1513–1523.
-
(2008)
Hepatology
, vol.47
, pp. 1513-1523
-
-
Johnson, NA1
Walton, DW2
Sachinwalla, T3
Thompson, CH4
Smith, K5
Ruell, PA6
-
78
-
-
77955851425
-
Hepatic unsaturated fatty acids in patients with non-alcoholic fatty liver disease assessed by 3.0T MR spectroscopy
-
Van Werven JR, Schreuder TC, Nederveen AJ, Lavini C, Jansen PL, Stoker J. Hepatic unsaturated fatty acids in patients with non-alcoholic fatty liver disease assessed by 3.0T MR spectroscopy. Eur J Radiol 2010;75:e102–e107.
-
(2010)
Eur J Radiol
, vol.75
, pp. e102-e107
-
-
Van Werven, JR1
Schreuder, TC2
Nederveen, AJ3
Lavini, C4
Jansen, PL5
Stoker, J.6
-
79
-
-
33744948514
-
Free fatty acids induce JNKdependent hepatocyte lipoapoptosis
-
Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNKdependent hepatocyte lipoapoptosis. J Biol Chem 2006;281:12093–12101.
-
(2006)
J Biol Chem
, vol.281
, pp. 12093-12101
-
-
Malhi, H1
Bronk, SF2
Werneburg, NW3
Gores, GJ.4
-
80
-
-
77649132053
-
Mechanisms and clinical implications of hepatocyte lipoapoptosis
-
Cazanave SC, Gores GJ. Mechanisms and clinical implications of hepatocyte lipoapoptosis. Clin Lipidol 2010;5:71–85.
-
(2010)
Clin Lipidol
, vol.5
, pp. 71-85
-
-
Cazanave, SC1
Gores, GJ.2
-
81
-
-
0033836019
-
Hepatic and extrahepatic scavenger receptors: function in relation to disease
-
Terpstra V, van Amersfoort ES, van Velzen AG, Kuiper J, van Berkel TJ. Hepatic and extrahepatic scavenger receptors: function in relation to disease. Arterioscler Thromb Vasc Biol 2000;20:1860–1872.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 1860-1872
-
-
Terpstra, V1
van Amersfoort, ES2
van Velzen, AG3
Kuiper, J4
van Berkel, TJ.5
-
82
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006;116: 3015–3025.
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H1
Kokoeva, MV2
Inouye, K3
Tzameli, I4
Yin, H5
Flier, JS.6
-
83
-
-
21244472975
-
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977–990.
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S1
Kamata, H2
Luo, JL3
Leffert, H4
Karin, M.5
-
84
-
-
84856429876
-
Obesity, inflammation, and liver cancer
-
Sun B, Karin M. Obesity, inflammation, and liver cancer. J Hepatol 2012;56: 704–713.
-
(2012)
J Hepatol
, vol.56
, pp. 704-713
-
-
Sun, B1
Karin, M.2
-
85
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799–806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, AR1
Kahn, CR.2
-
86
-
-
3543072186
-
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
-
Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579–591.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 579-591
-
-
Calle, EE1
Kaaks, R.2
-
87
-
-
81855225795
-
Molecular mechanisms of cancer development in obesity
-
Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 2011;11:886–895.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 886-895
-
-
Khandekar, MJ1
Cohen, P2
Spiegelman, BM.3
-
88
-
-
85179150566
-
Effect of regular training on hepatocellular carcinoma development in hepatocyte-specific PTEN-deficient mice
-
Piguet AC. Effect of regular training on hepatocellular carcinoma development in hepatocyte-specific PTEN-deficient mice. International Liver Congress Amsterdam, 2013.
-
(2013)
International Liver Congress Amsterdam
-
-
Piguet, AC.1
-
89
-
-
79551510805
-
Obesity and cancer risk: recent review and evidence
-
Basen-Engquist K, Chang M. Obesity and cancer risk: recent review and evidence. Curr Oncol Rep 2011;13:71–76.
-
(2011)
Curr Oncol Rep
, vol.13
, pp. 71-76
-
-
Basen-Engquist, K1
Chang, M.2
-
90
-
-
34548075820
-
Long-term mortality after gastric bypass surgery
-
Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007; 357:753–761.
-
(2007)
N Engl J Med
, vol.357
, pp. 753-761
-
-
Adams, TD1
Gress, RE2
Smith, SC3
Halverson, RC4
Simper, SC5
Rosamond, WD6
-
91
-
-
84873990663
-
Review of the key results from the Swedish Obese Subjects (SOS) trial: a prospective controlled intervention study of bariatric surgery
-
Sjostrom L. Review of the key results from the Swedish Obese Subjects (SOS) trial: a prospective controlled intervention study of bariatric surgery. J Intern Med 2013;273:219–234.
-
(2013)
J Intern Med
, vol.273
, pp. 219-234
-
-
Sjostrom, L.1
-
92
-
-
84868304332
-
PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
-
Burza MA. PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals. Dig Liver Dis 2012;44: 1037–1041.
-
(2012)
Dig Liver Dis
, vol.44
, pp. 1037-1041
-
-
Burza, MA.1
-
93
-
-
77954365681
-
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease
-
Donadon V, Balbi M, Mas MD, Casarin P, Zanette G. Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. Liver Int 2010;30:750–758.
-
(2010)
Liver Int
, vol.30
, pp. 750-758
-
-
Donadon, V1
Balbi, M2
Mas, MD3
Casarin, P4
Zanette, G.5
-
94
-
-
79961216168
-
Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients
-
Nkontchou G, Cosson E, Aout M, Mahmoudi A, Bourcier V, Charif I, et al. Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients. J Clin Endocrinol Metab 2011;96:2601–2608.
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 2601-2608
-
-
Nkontchou, G1
Cosson, E2
Aout, M3
Mahmoudi, A4
Bourcier, V5
Charif, I6
-
95
-
-
77951006620
-
Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
-
Hassan MM, Curley SA, Li D, Kaseb A, Davila M, Abdalla EK, et al. Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma. Cancer 2010;116:1938–1946.
-
(2010)
Cancer
, vol.116
, pp. 1938-1946
-
-
Hassan, MM1
Curley, SA2
Li, D3
Kaseb, A4
Davila, M5
Abdalla, EK6
-
96
-
-
84855432249
-
Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: A population-based cohort study
-
Lai S-W, Chen P-C, Liao K-F, Muo C-H, Lin C-C, Sung F-C. Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: A population-based cohort study. Am J Gastroenterol 2011;107:46–52.
-
(2011)
Am J Gastroenterol
, vol.107
, pp. 46-52
-
-
Lai, S-W1
Chen, P-C2
Liao, K-F3
Muo, C-H4
Lin, C-C5
Sung, F-C.6
-
97
-
-
84874660234
-
Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies
-
Chen HP, Shieh JJ, Chang CC, Chen TT, Lin JT, Wu MS, et al. Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. Gut 2013;62:606–615.
-
(2013)
Gut
, vol.62
, pp. 606-615
-
-
Chen, HP1
Shieh, JJ2
Chang, CC3
Chen, TT4
Lin, JT5
Wu, MS6
-
98
-
-
84864072013
-
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis
-
Bhalla K, Hwang BJ, Dewi RE, Twaddel W, Goloubeva OG, Wong KK, et al. Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis. Cancer Prev Res (Phila) 2012;5:544–552.
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, pp. 544-552
-
-
Bhalla, K1
Hwang, BJ2
Dewi, RE3
Twaddel, W4
Goloubeva, OG5
Wong, KK6
-
99
-
-
84863601615
-
Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and metaanalysis
-
Zhang ZJ, Zheng ZJ, Shi R, Su Q, Jiang Q, Kip KE. Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and metaanalysis. J Clin Endocrinol Metab 2012;97:2347–2353.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 2347-2353
-
-
Zhang, ZJ1
Zheng, ZJ2
Shi, R3
Su, Q4
Jiang, Q5
Kip, KE.6
-
100
-
-
84868156060
-
Functional role of peroxisome-proliferatoractivated receptor gamma in hepatocellular carcinoma
-
Wu CW, Farrell GC, Yu J. Functional role of peroxisome-proliferatoractivated receptor gamma in hepatocellular carcinoma. J Gastroenterol Hepatol 2012;27:1665–1669.
-
(2012)
J Gastroenterol Hepatol
, vol.27
, pp. 1665-1669
-
-
Wu, CW1
Farrell, GC2
Yu, J.3
-
101
-
-
78651335893
-
Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs
-
Okumura T. Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs. J Gastroenterol 2010;45:1097–1102.
-
(2010)
J Gastroenterol
, vol.45
, pp. 1097-1102
-
-
Okumura, T.1
-
102
-
-
84881491358
-
Statins are associated with a reduced risk of hepatocellular cancer: A systematic review and metaanalysis
-
Singh S, Singh PP, Singh AG, Murad MH, Sanchez W. Statins are associated with a reduced risk of hepatocellular cancer: A systematic review and metaanalysis. Gastroenterology 2013;144:323–332.
-
(2013)
Gastroenterology
, vol.144
, pp. 323-332
-
-
Singh, S1
Singh, PP2
Singh, AG3
Murad, MH4
Sanchez, W.5
-
103
-
-
79952764351
-
MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase
-
Cao Z, Fan-Minogue H, Bellovin DI, Yevtodiyenko A, Arzeno J, Yang Q, et al. MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase. Cancer Res 2011;71: 2286–2297.
-
(2011)
Cancer Res
, vol.71
, pp. 2286-2297
-
-
Cao, Z1
Fan-Minogue, H2
Bellovin, DI3
Yevtodiyenko, A4
Arzeno, J5
Yang, Q6
-
104
-
-
28844490054
-
Statins and cancer prevention
-
Demierre MF, Higgins PD, Gruber SB, Hawk E, Lippman SM. Statins and cancer prevention. Nat Rev Cancer 2005;5:930-942.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 930-942
-
-
Demierre, MF1
Higgins, PD2
Gruber, SB3
Hawk, E4
Lippman, SM.5
-
105
-
-
55549144718
-
FXR: a metabolic regulator and cell protector
-
Wang YD, Chen WD, Moore DD, Huang W. FXR: a metabolic regulator and cell protector. Cell Res 2008;18:1087–1095.
-
(2008)
Cell Res
, vol.18
, pp. 1087-1095
-
-
Wang, YD1
Chen, WD2
Moore, DD3
Huang, W.4
-
106
-
-
33645821043
-
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
-
Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006;312:233–236.
-
(2006)
Science
, vol.312
, pp. 233-236
-
-
Huang, W1
Ma, K2
Zhang, J3
Qatanani, M4
Cuvillier, J5
Liu, J6
-
107
-
-
57149118460
-
Nuclear bile acid receptor FXR protects against intestinal tumorigenesis
-
Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A. Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res 2008; 68:9589–9594.
-
(2008)
Cancer Res
, vol.68
, pp. 9589-9594
-
-
Modica, S1
Murzilli, S2
Salvatore, L3
Schmidt, DR4
Moschetta, A.5
-
108
-
-
84867305638
-
FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model
-
Deuschle U, Schuler J, Schulz A, Schluter T, Kinzel O, Abel U, et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One 2012;7:e43044.
-
(2012)
PLoS One
, vol.7
, pp. e43044
-
-
Deuschle, U1
Schuler, J2
Schulz, A3
Schluter, T4
Kinzel, O5
Abel, U6
-
109
-
-
79959491395
-
Increased activation of the Wnt/beta-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice
-
Wolfe A, Thomas A, Edwards G, Jaseja R, Guo GL, Apte U. Increased activation of the Wnt/beta-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice. J Pharmacol Exp Ther 2011;338:12–21.
-
(2011)
J Pharmacol Exp Ther
, vol.338
, pp. 12-21
-
-
Wolfe, A1
Thomas, A2
Edwards, G3
Jaseja, R4
Guo, GL5
Apte, U.6
-
110
-
-
84874503997
-
Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer
-
Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, et al. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology 2013;57:1098–1106.
-
(2013)
Hepatology
, vol.57
, pp. 1098-1106
-
-
Jiang, Y1
Iakova, P2
Jin, J3
Sullivan, E4
Sharin, V5
Hong, IH6
-
111
-
-
16544371307
-
The epidemiology of alcoholic liver disease
-
Mann RE, Smart RG, Govoni R. The epidemiology of alcoholic liver disease. Alcohol Res Health 2003;27:209–219.
-
(2003)
Alcohol Res Health
, vol.27
, pp. 209-219
-
-
Mann, RE1
Smart, RG2
Govoni, R.3
-
112
-
-
84862743466
-
Risk for hepatocellular carcinoma in patients with alcoholic cirrhosis: a Danish nationwide cohort study
-
Jepsen P, Ott P, Andersen PK, Sorensen HT, Vilstrup H. Risk for hepatocellular carcinoma in patients with alcoholic cirrhosis: a Danish nationwide cohort study. Ann Intern Med 2012;156:841–847.
-
(2012)
Ann Intern Med
, vol.156
, pp. 841-847
-
-
Jepsen, P1
Ott, P2
Andersen, PK3
Sorensen, HT4
Vilstrup, H.5
-
113
-
-
44949096255
-
Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management
-
Fung J, Lai CL, But D, Wong D, Cheung TK, Yuen MF. Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management. Am J Gastroenterol 2008;103:1421–1426.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 1421-1426
-
-
Fung, J1
Lai, CL2
But, D3
Wong, D4
Cheung, TK5
Yuen, MF.6
-
114
-
-
33644506166
-
Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005
-
Yim HJ, Lok AS. Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005. Hepatology 2006;43:S173–181.
-
(2006)
Hepatology
, vol.43
, pp. S173-S181
-
-
Yim, HJ1
Lok, AS.2
-
115
-
-
0033584440
-
The prevalence of hepatitis C virus infection in the United States, 1988 through 1994
-
Alter MJ, Kruszon-Moran D, Nainan OV, McQuillan GM, Gao F, Moyer LA, et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 1999;341:556–562.
-
(1999)
N Engl J Med
, vol.341
, pp. 556-562
-
-
Alter, MJ1
Kruszon-Moran, D2
Nainan, OV3
McQuillan, GM4
Gao, F5
Moyer, LA6
-
116
-
-
17344370538
-
Prognosis of chronic hepatitis C: results of a large, prospective cohort study
-
Niederau C, Lange S, Heintges T, Erhardt A, Buschkamp M, Hurter D, et al. Prognosis of chronic hepatitis C: results of a large, prospective cohort study. Hepatology 1998;28:1687–1695.
-
(1998)
Hepatology
, vol.28
, pp. 1687-1695
-
-
Niederau, C1
Lange, S2
Heintges, T3
Erhardt, A4
Buschkamp, M5
Hurter, D6
|