The value of glucocorticoid co-therapy in different rheumatic diseases - positive and adverse effects

Arthritis Research and Therapy

Volumn 16, Issue , 2014, Pages

  van der Goes, Marlies C ^a   Jacobs, Johannes W ^a   Bijlsma, Johannes W ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AZATHIOPRINE; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CYCLOSPORIN; ETANERCEPT; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOMODULATING AGENT; INFLIXIMAB; LEFLUNOMIDE; METHOTREXATE; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PREDNISONE; PROTON PUMP INHIBITOR; TRIAMCINOLONE HEXACETONIDE; VITAMIN D; ANTIINFLAMMATORY AGENT; IMMUNOSUPPRESSIVE AGENT;

ACNE; ADRENAL INSUFFICIENCY; AKATHISIA; ANTIINFLAMMATORY ACTIVITY; BONE DENSITY; BONE NECROSIS; CARDIOVASCULAR DISEASE; CATARACT; COMBINATION DRUG THERAPY; CORTICOSTEROID INDUCED OSTEOPOROSIS; CUSHING SYNDROME; DEPRESSION; DERMATOMYOSITIS; DIABETES MELLITUS; DRUG DOSE REDUCTION; DRUG INTERMITTENT THERAPY; DRUG MEGADOSE; DRUG PULSE THERAPY; ECCHYMOSIS; EDEMA; FLUID RETENTION; GIANT CELL ARTERITIS; GLAUCOMA; GOUT; HIRSUTISM; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INSOMNIA; INSULIN RESISTANCE; INTESTINE PERFORATION; INTRAOCULAR PRESSURE; JUVENILE RHEUMATOID ARTHRITIS; LOW DRUG DOSE; MENTAL DISEASE; MIXED CONNECTIVE TISSUE DISEASE; MOON FACE; MORNING DOSAGE; MYOPATHY; MYOSITIS; OBESITY; OPPORTUNISTIC INFECTION; OSTEOARTHRITIS; OSTEOPOROSIS; PANCREATITIS; PATIENT EDUCATION; PNEUMOCYSTOSIS; POLYMYOSITIS; PREGNANT WOMAN; PRENATAL DRUG EXPOSURE; PSORIATIC ARTHRITIS; PSYCHOSIS; REACTIVE ARTHRITIS; REMISSION; REVIEW; RHEUMATIC DISEASE; RHEUMATIC FEVER; RHEUMATIC POLYMYALGIA; RHEUMATOID ARTHRITIS; SIDE EFFECT; SJOEGREN SYNDROME; SKIN ATROPHY; SKIN BRUISING; STOMACH ULCER; STRIA; SUBCAPSULAR CATARACT; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; SYSTEMIC VASCULITIS; TRANSACTIVATION; VASCULITIS; WEIGHT GAIN; WOUND HEALING IMPAIRMENT; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS; RHEUMATIC DISEASES;

ANTI-INFLAMMATORY AGENTS; CUSHING SYNDROME; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOSUPPRESSIVE AGENTS; PITUITARY-ADRENAL SYSTEM; PREGNANCY; PREGNANCY COMPLICATIONS; RECEPTORS, GLUCOCORTICOID; RHEUMATIC DISEASES;

EID: 84978832858     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4686     Document Type: Review

References (130)

1. Hench PS, Kendall EC, Slocumb CH, Polley HF: The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Mayo Clin Proc. 1949, 24: 181-197.
2. Bertsias G, Ioannidis JP, Boletis J, Bombardieri S, Cervera R, Dostal C, Font J, Gilboe IM, Houssiau F, Huizinga T, Isenberg D, Kallenberg CG, Khamashta M, Piette JC, Schneider M, Smolen J, Sturfelt G, Tincani A, van Vollenhoven R, Gordon C, Boumpas DT, Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics: EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics. Ann Rheum Dis. 2008, 67: 195-205. 10.1136/ard.2007.070367.
3. Hatemi G, Silman A, Bang D, Bodaghi B, Chamberlain AM, Gul A, Houman MH, Kotter I, Olivieri I, Salvarani C, Sfikakis PP, Siva A, Stanford MR, Stübiger N, Yurdakul S, Yazici H: EULAR Expert Committee: EULAR recommendations for the management of Behcet disease. Ann Rheum Dis. 2008, 67: 1656-1662. 10.1136/ard.2007.080432.
4. Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, Hauser T, Hellmich B, Jayne D, Kallenberg CG, Merkel PA, Raspe H, Salvarani C, Scott DG, Stegeman C, Watts R, Westman K, Witter J, Yazici H, Luqmani R, European Vasculitis Study Group: EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis. 2009, 68: 310-317. 10.1136/ard.2008.088096.
5. Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, Hauser T, Hellmich B, Jayne D, Kallenberg CG, Merkel PA, Raspe H, Salvarani C, Scott DG, Stegeman C, Watts R, Westman K, Witter J, Yazici H, Luqmani R, European Vasculitis Study Group: EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis. 2009, 68: 318-323. 10.1136/ard.2008.088351.
6. Gorter SL, Bijlsma JW, Cutolo M, Gomez-Reino J, Kouloumas M, Smolen JS, Landewe R: Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2010, 69: 1010-1014. 10.1136/ard.2009.127332.
7. Luijten RK, Fritsch-Stork RD, Bijlsma JW, Derksen RH: The use of glucocorticoids in systemic lupus erythematosus. After 60 years still more an art than science. Autoimmun Rev. 2013, 12: 617-628. 10.1016/j.autrev.2012.12.001.
8. Thiele K, Buttgereit F, Huscher D, Zink A: Current use of glucocorticoids in patients with rheumatoid arthritis in Germany. Arthritis Rheum. 2005, 53: 740-747. 10.1002/art.21467.
9. Buttgereit F, Seibel MJ, Bijlsma JW: Glucocorticoids. Clinical Immunology: Principles and Practice. 2008, Amsterdam: Elsevier Health Sciences, Chapter 87: 3
10. Sokka T, Toloza S, Cutolo M, Kautiainen H, Makinen H, Gogus F, Skakic V, Badsha H, Peets T, Baranauskaite A, Géher P, Ujfalussy I, Skopouli FN, Mavrommati M, Alten R, Pohl C, Sibilia J, Stancati A, Salaffi F, Romanowski W, Zarowny-Wierzbinska D, Henrohn D, Bresnihan B, Minnock P, Knudsen LS, Jacobs JW, Calvo-Alen J, Lazovskis J, Pinheiro Gda R, Karateev D: Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study. Arthritis Res Ther. 2009, 11: R7-
11. Fardet L, Petersen I, Nazareth I: Prevalence of long-term oral glucocorticoid prescriptions in UK over the past 20 years. Rheumatology (Oxford). 2011, 50: 1982-1990. 10.1093/rheumatology/ker017.
12. Walsh LJ, Wong CA, Pringle M, Tattersfield AE: Use of oral corticosteroids in the community and the prevention of secondary osteoporosis: a cross sectional study. BMJ. 1996, 313: 344-346. 10.1136/bmj.313.7053.344.
13. Ramsey-Goldman R: Missed opportunities in physician management of glucocorticoid-induced osteoporosis?. Arthritis Rheum. 2002, 46: 3115-3120. 10.1002/art.10619.
14. Buttgereit F, Wehling M, Burmester GR: A new hypothesis of modular glucocorticoid actions: steroid treatment of rheumatic diseases revisited. Arthritis Rheum. 1998, 41: 761-767. 10.1002/1529-0131(199805)41:5<761::AID-ART2>3.0.CO;2-M.
15. Buttgereit F, Straub RH, Wehling M, Burmester GR: Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action. Arthritis Rheum. 2004, 50: 3408-3417. 10.1002/art.20583.
16. Croxtall JD, Choudhury Q, Flower RJ: Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 2000, 130: 289-298. 10.1038/sj.bjp.0703272.
17. Rhen T, Cidlowski JA: Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N Engl J Med. 2005, 353: 1711-1723. 10.1056/NEJMra050541.
18. Stahn C, Buttgereit F: Genomic and nongenomic effects of glucocorticoids. Nat Clin Pract Rheumatol. 2008, 4: 525-533.
19. Coutinho AE, Chapman KE: The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011, 335: 2-13. 10.1016/j.mce.2010.04.005.
20. Buttgereit F, da Silva JA, Boers M, Burmester GR, Cutolo M, Jacobs J, Kirwan J, Kohler L, Van Riel P, Vischer T, Bijlsma JW: Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology. Ann Rheum Dis. 2002, 61: 718-722. 10.1136/ard.61.8.718.
21. Buttgereit F, Burmester GR, Straub RH, Seibel MJ, Zhou H: Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis Rheum. 2011, 63: 1-9.
22. Clark AR: Anti-inflammatory functions of glucocorticoid-induced genes. Mol Cell Endocrinol. 2007, 275: 79-97. 10.1016/j.mce.2007.04.013.
23. Kleiman A, Tuckermann JP: Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice. Mol Cell Endocrinol. 2007, 275: 98-108. 10.1016/j.mce.2007.05.009.
24. Hernandez-Rodriguez J, Cid MC, Lopez-Soto A, Espigol-Frigole G, Bosch X: Treatment of polymyalgia rheumatica: a systematic review. Arch Intern Med. 2009, 169: 1839-1850. 10.1001/archinternmed.2009.352.
25. Ferraccioli G, Salaffi F, De Vita S, Casatta L, Bartoli E: Methotrexate in polymyalgia rheumatica: preliminary results of an open, randomized study. J Rheumatol. 1996, 23: 624-628.
26. Caporali R, Cimmino MA, Ferraccioli G, Gerli R, Klersy C, Salvarani C, Montecucco C: Prednisone plus methotrexate for polymyalgia rheumatica: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2004, 141: 493-500. 10.7326/0003-4819-141-7-200410050-00005.
27. van der Veen MJ, Dinant HJ, van Booma-Frankfort C, van Albada-Kuipers GA, Bijlsma JW: Can methotrexate be used as a steroid sparing agent in the treatment of polymyalgia rheumatica and giant cell arteritis?. Ann Rheum Dis. 1996, 55: 218-223. 10.1136/ard.55.4.218.
28. De Silva M, Hazleman BL: Azathioprine in giant cell arteritis/polymyalgia rheumatica: a double-blind study. Ann Rheum Dis. 1986, 45: 136-138. 10.1136/ard.45.2.136.
29. Salvarani C, Macchioni P, Manzini C, Paolazzi G, Trotta A, Manganelli P, Cimmino M, Gerli R, Catanoso MG, Boiardi L, Cantini F, Klersy C, Hunder GG: Infliximab plus prednisone or placebo plus prednisone for the initial treatment of polymyalgia rheumatica: a randomized trial. Ann Intern Med. 2007, 146: 631-639. 10.7326/0003-4819-146-9-200705010-00005.
30. Hoffman GS, Cid MC, Hellmann DB, Guillevin L, Stone JH, Schousboe J, Cohen P, Calabrese LH, Dickler H, Merkel PA, Fortin P, Flynn JA, Locker GA, Easley KA, Schned E, Hunder GG, Sneller MC, Tuggle C, Swanson H, Hernández-Rodríguez J, Lopez-Soto A, Bork D, Hoffman DB, Kalunian K, Klashman D, Wilke WS, Scheetz RJ, Mandell BF, Fessler BJ, Kosmorsky G: A multicenter, randomized, double-blind, placebo-controlled trial of adjuvant methotrexate treatment for giant cell arteritis. Arthritis Rheum. 2002, 46: 1309-1318. 10.1002/art.10262.
31. Spiera RF, Mitnick HJ, Kupersmith M, Richmond M, Spiera H, Peterson MG, Paget SA: A prospective, double-blind, randomized, placebo controlled trial of methotrexate in the treatment of giant cell arteritis (GCA). Clin Exp Rheumatol. 2001, 19: 495-501.
32. Jover JA, Hernandez-Garcia C, Morado IC, Vargas E, Banares A, Fernandez-Gutierrez B: Combined treatment of giant-cell arteritis with methotrexate and prednisone. a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001, 134: 106-114. 10.7326/0003-4819-134-2-200101160-00010.
33. Schaufelberger C, Mollby H, Uddhammar A, Bratt J, Nordborg E: No additional steroid-sparing effect of cyclosporine A in giant cell arteritis. Scand J Rheumatol. 2006, 35: 327-329. 10.1080/03009740500474537.
34. Martinez-Taboada VM, Rodriguez-Valverde V, Carreno L, Lopez-Longo J, Figueroa M, Belzunegui J, Mola EM, Bonilla G: A double-blind placebo controlled trial of etanercept in patients with giant cell arteritis and corticosteroid side effects. Ann Rheum Dis. 2008, 67: 625-630.
35. Hoffman GS, Cid MC, Rendt-Zagar KE, Merkel PA, Weyand CM, Stone JH, Salvarani C, Xu W, Visvanathan S, Rahman MU: Infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis: a randomized trial. Ann Intern Med. 2007, 146: 621-630. 10.7326/0003-4819-146-9-200705010-00004.
36. Diamantopoulos AP, Hetland H, Myklebust G: Leflunomide as a corticosteroid-sparing agent in giant cell arteritis and polymyalgia rheumatica: a case series. BioMed Res Int. 2013, 2013: 120638-
37. Weusten BL, Jacobs JW, Bijlsma JW: Corticosteroid pulse therapy in active rheumatoid arthritis. Semin Arthritis Rheum. 1993, 23: 183-192. 10.1016/S0049-0172(05)80039-3.
38. Janssens HJ, Janssen M, van de Lisdonk EH, van Riel PL, van Weel C: Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trial. Lancet. 2008, 371: 1854-1860. 10.1016/S0140-6736(08)60799-0.
39. Criswell LA, Saag KG, Sems KM, Welch V, Shea B, Wells G, Suarez-Almazor ME: Moderate-term, low-dose corticosteroids for rheumatoid arthritis. Cochrane Database Syst Rev. 2000, 2: CD001158-
40. Gotzsche PC, Johansen HK: Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis. Cochrane Database Syst Rev. 2004, 3: CD000189
41. Buttgereit F, Doering G, Schaeffler A, Witte S, Sierakowski S, Gromnica-Ihle E, Jeka S, Krueger K, Szechinski J, Alten R: Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet. 2008, 371: 205-214. 10.1016/S0140-6736(08)60132-4.
42. Pincus T, Sokka T, Castrejon I, Cutolo M: Decline of mean initial prednisone dosage from 10.3 to 3.6 mg/day to treat rheumatoid arthritis between 1980 and 2004 in one clinical setting, with long-term effectiveness of dosages less than 5 mg/day. Arthritis Care Res (Hoboken). 2013, 65: 729-736. 10.1002/acr.21899.
43. Kirwan JR: The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The Arthritis and Rheumatism Council Low-Dose Glucocorticoid Study Group. N Engl J Med. 1995, 333: 142-146. 10.1056/NEJM199507203330302.
44. Boers M, Verhoeven AC, Markusse HM, van de Laar MA, Westhovens R, van Denderen JC, van Zeben D, Dijkmans BA, Peeters AJ, Jacobs P, van den Brink HR, Schouten HJ, van der Heijde DM, Boonen A, van der Linden S: Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet. 1997, 350: 309-318. 10.1016/S0140-6736(97)01300-7.
45. Hansen M, Podenphant J, Florescu A, Stoltenberg M, Borch A, Kluger E, Sorensen SF, Hansen TM: A randomised trial of differentiated prednisolone treatment in active rheumatoid arthritis. Clinical benefits and skeletal side effects. Ann Rheum Dis. 1999, 58: 713-718. 10.1136/ard.58.11.713.
46. van Everdingen AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW: Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med. 2002, 136: 1-12. 10.7326/0003-4819-136-1-200201010-00006.
47. Svensson B, Boonen A, Albertsson K, van der Heijde D, Keller C, Hafstrom I: Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial. Arthritis Rheum. 2005, 52: 3360-3370. 10.1002/art.21298.
48. Wassenberg S, Rau R, Steinfeld P, Zeidler H: Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 2005, 52: 3371-3380. 10.1002/art.21421.
49. Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, van Zeben D, Kerstens PJ, Hazes JM, Zwinderman AH, Peeters AJ, de Jonge-Bok JM, Mallée C, de Beus WM, de Sonnaville PB, Ewals JA, Breedveld FC, Dijkmans BA: Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial. Ann Intern Med. 2007, 146: 406-415. 10.7326/0003-4819-146-6-200703200-00005.
50. Kirwan JR, Bijlsma JW, Boers M, Shea BJ: Effects of glucocorticoids on radiological progression in rheumatoid arthritis. Cochrane Database Syst Rev. 2007, 1: CD006356-
51. Choy EH, Smith CM, Farewell V, Walker D, Hassell A, Chau L, Scott DL: Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis. Ann Rheum Dis. 2008, 67: 656-663.
52. Bakker MF, Jacobs JW, Welsing PM, Verstappen SM, Tekstra J, Ton E, Geurts MA, van der Werf JH, van Albada-Kuipers GA, Jahangier-de Veen ZN, van der Veen MJ, Verhoef CM, Lafeber FP, Bijlsma JW, Utrecht Rheumatoid Arthritis Cohort Study Group: Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial. Ann Intern Med. 2012, 156: 329-339. 10.7326/0003-4819-156-5-201203060-00004.
53. Hafstrom I, Albertsson K, Boonen A, van der Heijde D, Landewe R, Svensson B: Remission achieved after 2 years treatment with low-dose prednisolone in addition to disease-modifying anti-rheumatic drugs in early rheumatoid arthritis is associated with reduced joint destruction still present after 4 years: an open 2-year continuation study. Ann Rheum Dis. 2009, 68: 508-513. 10.1136/ard.2008.087833.
54. Jacobs JW, van Everdingen AA, Verstappen SM, Bijlsma JW: Followup radiographic data on patients with rheumatoid arthritis who participated in a two-year trial of prednisone therapy or placebo. Arthritis Rheum. 2006, 54: 1422-1428. 10.1002/art.21809.
55. Landewe RB, Boers M, Verhoeven AC, Westhovens R, van de Laar MA, Markusse HM, van Denderen JC, Westedt ML, Peeters AJ, Dijkmans BA, Jacobs P, Boonen A, van der Heijde DM, van der Linden S: COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum. 2002, 46: 347-356. 10.1002/art.10083.
56. Smolen JS, Landewe R, Breedveld FC, Buch M, Burmester G, Dougados M, Emery P, Gaujoux-Viala C, Gossec L, Nam J, Ramiro S, Winthrop K, de Wit M, Aletaha D, Betteridge N, Bijlsma JW, Boers M, Buttgereit F, Combe B, Cutolo M, Damjanov N, Hazes JM, Kouloumas M, Kvien TK, Mariette X, Pavelka K, van Riel PL, Rubbert-Roth A, Scholte-Voshaar M, Scott DL: EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis. 2014, 73: 492-509.
57. Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O'Dell J, Winthrop KL, Beukelman T, Bridges SL, Chatham WW, Paulus HE, Suarez-Almazor M, Bombardier C, Dougados M, Khanna D, King CM, Leong AL, Matteson EL, Schousboe JT, Moynihan E, Kolba KS, Jain A, Volkmann ER, Agrawal H, Bae S, Mudano AS, Patkar NM, Saag KG: 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012, 64: 625-639. 10.1002/acr.21641.
58. Boers M, Kirwan JR, Bijlsma JW: American College of Rheumatology treatment guidelines continue to omit guidance on glucocorticoids: comment on the article by Singh et al. Arthritis Care Res (Hoboken). 2012, 64: 1622-
59. Gaffney K, Ledingham J, Perry JD: Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response. Ann Rheum Dis. 1995, 54: 379-381. 10.1136/ard.54.5.379.
60. Blyth T, Hunter JA, Stirling A: Pain relief in the rheumatoid knee after steroid injection. A single-blind comparison of hydrocortisone succinate, and triamcinolone acetonide or hexacetonide. Br J Rheumatol. 1994, 33: 461-463. 10.1093/rheumatology/33.5.461.
61. Chakravarty K, Pharoah PD, Scott DG: A randomized controlled study of post-injection rest following intra-articular steroid therapy for knee synovitis. Br J Rheumatol. 1994, 33: 464-468. 10.1093/rheumatology/33.5.464.
62. McCarty DJ, Harman JG, Grassanovich JL, Qian C: Treatment of rheumatoid joint inflammation with intrasynovial triamcinolone hexacetonide. J Rheumatol. 1995, 22: 1631-1635.
63. Bijlsma JWJ, Buttgereit F, Jacobs JWG: Systemic and intra-articular glucocorticoids in rheumatoid arthritis. Rheumatoid Arthritis. 2007, Oxford: Oxford University Press, 337-353. 2
64. Saag KG, Koehnke R, Caldwell JR, Brasington R, Burmeister LF, Zimmerman B, Kohler JA, Furst DE: Low dose long-term corticosteroid therapy in rheumatoid arthritis: an analysis of serious adverse events. Am J Med. 1994, 96: 115-123. 10.1016/0002-9343(94)90131-7.
65. Huscher D, Thiele K, Gromnica-Ihle E, Hein G, Demary W, Dreher R, Zink A, Buttgereit F: Dose-related patterns of glucocorticoid-induced side effects. Ann Rheum Dis. 2009, 68: 1119-1124. 10.1136/ard.2008.092163.
66. Bijlsma JW, Saag KG, Buttgereit F, da Silva JA: Developments in glucocorticoid therapy. Rheum Dis Clin North Am. 2005, 31: 1-17. 10.1016/j.rdc.2004.10.003. vii
67. Da Silva JA, Jacobs JW, Kirwan JR, Boers M, Saag KG, Ines LB, de Koning EJ, Buttgereit F, Cutolo M, Capell H, Rau R, Bijlsma JW: Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data. Ann Rheum Dis. 2006, 65: 285-293. 10.1136/ard.2005.038638.
68. Hoes JN, Jacobs JW, Boers M, Boumpas D, Buttgereit F, Caeyers N, Choy EH, Cutolo M, Da Silva JA, Esselens G, Guillevin L, Hafstrom I, Kirwan JR, Rovensky J, Russell A, Saag KG, Svensson B, Westhovens R, Zeidler H, Bijlsma JW: EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis. 2007, 66: 1560-1567. 10.1136/ard.2007.072157.
69. van der Goes MC, Jacobs JW, Boers M, Andrews T, Blom-Bakkers MA, Buttgereit F, Caeyers N, Cutolo M, Da Silva JA, Guillevin L, Kirwan JR, Rovensky J, Severijns G, Webber S, Westhovens R, Bijlsma JW: Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice. Ann Rheum Dis. 2010, 69: 1913-1919. 10.1136/ard.2009.124958.
70. Duru N, van der Goes MC, Jacobs JW, Andrews T, Boers M, Buttgereit F, Caeyers N, Cutolo M, Halliday S, Da Silva JA, Kirwan JR, Ray D, Rovensky J, Severijns G, Westhovens R, Bijlsma JW: EULAR evidence-based and consensus-based recommendations on the management of medium to high-dose glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis. 2013, 72: 1905-1913. 10.1136/annrheumdis-2013-203249.
71. van Staa TP, Leufkens HG, Cooper C: The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int. 2002, 13: 777-787. 10.1007/s001980200108.
72. Keller C, Hafstrom I, Svensson B: Bone mineral density in women and men with early rheumatoid arthritis. Scand J Rheumatol. 2001, 30: 213-220. 10.1080/030097401316909558.
73. Shenstone BD, Mahmoud A, Woodward R, Elvins D, Palmer R, Ring EF, Bhalla AK: Longitudinal bone mineral density changes in early rheumatoid arthritis. Br J Rheumatol. 1994, 33: 541-545. 10.1093/rheumatology/33.6.541.
74. Book C, Karlsson M, Akesson K, Jacobsson L: Disease activity and disability but probably not glucocorticoid treatment predicts loss in bone mineral density in women with early rheumatoid arthritis. Scand J Rheumatol. 2008, 37: 248-254. 10.1080/03009740801998747.
75. Forslind K, Keller C, Svensson B, Hafstrom I: Reduced bone mineral density in early rheumatoid arthritis is associated with radiological joint damage at baseline and after 2 years in women. J Rheumatol. 2003, 30: 2590-2596.
76. Gough AK, Lilley J, Eyre S, Holder RL, Emery P: Generalised bone loss in patients with early rheumatoid arthritis. Lancet. 1994, 344: 23-27. 10.1016/S0140-6736(94)91049-9.
77. van der Goes MC, Jacobs JW, Jurgens MS, Bakker MF, van der Veen MJ, van der Werf JH, Welsing PM, Bijlsma JW: Are changes in bone mineral density different between groups of early rheumatoid arthritis patients treated according to a tight control strategy with or without prednisone if osteoporosis prophylaxis is applied?. Osteoporos Int. 2013, 24: 1429-1436. 10.1007/s00198-012-2073-z.
78. Bezerra MC, Carvalho JF, Prokopowitsch AS, Pereira RM: RANK, RANKL and osteoprotegerin in arthritic bone loss. Braz J Med Biol Res. 2005, 38: 161-170. 10.1590/S0100-879X2005000200004.
79. Miyasaka N, Sato K, Goto M, Sasano M, Natsuyama M, Inoue K, Nishioka K: Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction. Arthritis Rheum. 1988, 31: 480-486. 10.1002/art.1780310404.
80. Mabilleau G, Pascaretti-Grizon F, Basle MF, Chappard D: Depth and volume of resorption induced by osteoclasts generated in the presence of RANKL, TNF-alpha/IL-1 or LIGHT. Cytokine. 2012, 57: 294-299. 10.1016/j.cyto.2011.11.014.
81. Jacobs JW, Geenen R, Evers AW, van Jaarsveld CH, Kraaimaat FW, Bijlsma JW: Short term effects of corticosteroid pulse treatment on disease activity and the wellbeing of patients with active rheumatoid arthritis. Ann Rheum Dis. 2001, 60: 61-64. 10.1136/ard.60.1.61.
82. Jurgens MS, Jacobs JW, Geenen R, Bossema ER, Bakker MF, Bijlsma JW, van Albada-Kuipers IA, Ehrlich JC, Lafeber FP, Welsing PM: Increase of body mass index in a tight controlled methotrexate-based strategy with prednisone in early rheumatoid arthritis: side effect of the prednisone or better control of disease activity?. Arthritis Care Res (Hoboken). 2013, 65: 88-93.
83. van der Goes MC, Jacobs JW, Boers M, Andrews T, Blom-Bakkers MA, Buttgereit F, Caeyers N, Choy EH, Cutolo M, Da Silva JA, Guillevin L, Holland M, Kirwan JR, Rovensky J, Saag KG, Severijns G, Webber S, Westhovens R, Bijlsma JW: Patient and rheumatologist perspectives on glucocorticoids: an exercise to improve the implementation of the European League Against Rheumatism (EULAR) recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis. 2010, 69: 1015-1021. 10.1136/ard.2009.114579.
84. Saltiel AR, Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001, 414: 799-806. 10.1038/414799a.
85. Peters MJ, Symmons DP, McCarey D, Dijkmans BA, Nicola P, Kvien TK, McInnes IB, Haentzschel H, Gonzalez-Gay MA, Provan S, Semb A, Sidiropoulos P, Kitas G, Smulders YM, Soubrier M, Szekanecz Z, Sattar N, Nurmohamed MT: EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis. 2010, 69: 325-331. 10.1136/ard.2009.113696.
86. Ku IA, Imboden JB, Hsue PY, Ganz P: Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circ J. 2009, 73: 977-985. 10.1253/circj.CJ-09-0274.
87. Hajer GR, van Haeften TW, Visseren FL: Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008, 29: 2959-2971. 10.1093/eurheartj/ehn387.
88. Dessein PH, Joffe BI: Insulin resistance and impaired beta cell function in rheumatoid arthritis. Arthritis Rheum. 2006, 54: 2765-2775. 10.1002/art.22053.
89. Chung CP, Oeser A, Solus JF, Gebretsadik T, Shintani A, Avalos I, Sokka T, Raggi P, Pincus T, Stein CM: Inflammation-associated insulin resistance: differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms. Arthritis Rheum. 2008, 58: 2105-2112. 10.1002/art.23600.
90. Shahin D, Eltoraby E, Mesbah A, Houssen M: Insulin resistance in early untreated rheumatoid arthritis patients. Clin Biochem. 2010, 43: 661-665. 10.1016/j.clinbiochem.2010.01.012.
91. den Uyl D, van Raalte DH, Nurmohamed MT, Lems WF, Bijlsma JW, Hoes JN, Dijkmans BA, Diamant M: Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction. Arthritis Rheum. 2012, 64: 639-646. 10.1002/art.33378.
92. Hoes JN, van der Goes MC, van Raalte DH, van der Zijl NJ, den Uyl D, Lems WF, Lafeber FP, Jacobs JW, Welsing PM, Diamant M, Bijlsma JW: Glucose tolerance, insulin sensitivity and beta-cell function in patients with rheumatoid arthritis treated with or without low-to-medium dose glucocorticoids. Ann Rheum Dis. 2011, 70: 1887-1894. 10.1136/ard.2011.151464.
93. Charmandari E, Nicolaides NC, Chrousos GP: Adrenal insufficiency. Lancet. 2014, 383: 2152-2167. 10.1016/S0140-6736(13)61684-0.
94. EMPIRE Rheumatism Council: multi-centre controlled trial comparing cortisone acetate and acetyl salicylic acid in the long-term treatment of rheumatoid arthritis; results of three years' treatment. Ann Rheum Dis. 1957, 16: 277-289.
95. A COMPARISON of prednisolone with aspirin on other analgesics in the treatment of rheumatoid arthritis. Ann Rheum Dis. 1959, 18: 173-188.
96. Dixon WG, Kezouh A, Bernatsky S, Suissa S: The influence of systemic glucocorticoid therapy upon the risk of non-serious infection in older patients with rheumatoid arthritis: a nested case-control study. Ann Rheum Dis. 2011, 70: 956-960. 10.1136/ard.2010.144741.
97. Dixon WG, Abrahamowicz M, Beauchamp ME, Ray DW, Bernatsky S, Suissa S, Sylvestre MP: Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis. Ann Rheum Dis. 2012, 71: 1128-1133. 10.1136/annrheumdis-2011-200702.
98. Widdifield J, Bernatsky S, Paterson JM, Gunraj N, Thorne JC, Pope J, Cividino A, Bombardier C: Serious infections in a population-based cohort of 86,039 seniors with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013, 65: 353-361. 10.1002/acr.21812.
99. Crowson CS, Hoganson DD, Fitz-Gibbon PD, Matteson EL: Development and validation of a risk score for serious infection in patients with rheumatoid arthritis. Arthritis Rheum. 2012, 64: 2847-2855. 10.1002/art.34530.
100. Yale SH, Limper AH: Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy. Mayo Clin Proc. 1996, 71: 5-13. 10.4065/71.1.5.
101. Belard E, Semb S, Ruhwald M, Werlinrud AM, Soborg B, Jensen FK, Thomsen H, Brylov A, Hetland ML, Nordgaard-Lassen I, Ravn P: Prednisolone treatment affects the performance of the QuantiFERON gold in-tube test and the tuberculin skin test in patients with autoimmune disorders screened for latent tuberculosis infection. Inflamm Bowel Dis. 2011, 17: 2340-2349. 10.1002/ibd.21605.
102. van Assen S, Agmon-Levin N, Elkayam O, Cervera R, Doran MF, Dougados M, Emery P, Geborek P, Ioannidis JP, Jayne DR, Kallenberg CG, Müller-Ladner U, Shoenfeld Y, Stojanovich L, Valesini G, Wulffraat NM, Bijl M: EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011, 70: 414-422. 10.1136/ard.2010.137216.
103. Garcia Rodriguez LA, Hernandez-Diaz S: The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents. Arthritis Res. 2001, 3: 98-101. 10.1186/ar146.
104. Piper JM, Ray WA, Daugherty JR, Griffin MR: Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med. 1991, 114: 735-740. 10.7326/0003-4819-114-9-735.
105. Deeks JJ, Smith LA, Bradley MD: Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. BMJ. 2002, 325: 619-10.1136/bmj.325.7365.619.
106. Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS: Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Longterm Arthritis Safety Study. JAMA. 2000, 284: 1247-1255. 10.1001/jama.284.10.1247.
107. Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, Day R, Ferraz MB, Hawkey CJ, Hochberg MC, Kvien TK, Schnitzer TJ, VIGOR Study Group: Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. 2000, 343: 1520-1528. 10.1056/NEJM200011233432103. 2 pp following 1528
108. Cooper C, Kirwan JR: The risks of local and systemic corticosteroid administration. Baillieres Clin Rheumatol. 1990, 4: 305-332. 10.1016/S0950-3579(05)80023-8.
109. Carnahan MC, Goldstein DA: Ocular complications of topical, peri-ocular, and systemic corticosteroids. Curr Opin Ophthalmol. 2000, 11: 478-483. 10.1097/00055735-200012000-00016.
110. Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P: Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000, 2: CD000952-
111. Homik J, Cranney A, Shea B, Tugwell P, Wells G, Adachi R, Suarez-Almazor M: Bisphosphonates for steroid induced osteoporosis. Cochrane Database Syst Rev. 2000, 2: CD001347-
112. Amin S, Lavalley MP, Simms RW, Felson DT: The comparative efficacy of drug therapies used for the management of corticosteroid-induced osteoporosis: a meta-regression. J Bone Miner Res. 2002, 17: 1512-1526. 10.1359/jbmr.2002.17.8.1512.
113. de Nijs RN, Jacobs JW, Lems WF, Laan RF, Algra A, Huisman AM, Buskens E, de Laet CE, Oostveen AC, Geusens PP, Bruyn GA, Dijkmans BA, Bijlsma JW, STOP Investigators: Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis. N Engl J Med. 2006, 355: 675-684. 10.1056/NEJMoa053569.
114. de Nijs RN, Jacobs JW, Algra A, Lems WF, Bijlsma JW: Prevention and treatment of glucocorticoid-induced osteoporosis with active vitamin D3 analogues: a review with meta-analysis of randomized controlled trials including organ transplantation studies. Osteoporos Int. 2004, 15: 589-602. 10.1007/s00198-004-1614-5.
115. Richy F, Schacht E, Bruyere O, Ethgen O, Gourlay M, Reginster JY: Vitamin D analogs versus native vitamin D in preventing bone loss and osteoporosis-related fractures: a comparative meta-analysis. Calcif Tissue Int. 2005, 76: 176-186. 10.1007/s00223-004-0005-4.
116. ®. [http://www.shef.ac.uk/FRAX/]
117. Grossman JM, Gordon R, Ranganath VK, Deal C, Caplan L, Chen W, Curtis JR, Furst DE, McMahon M, Patkar NM, Volkmann E, Saag KG: American College of Rheumatology 2010 recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Care Res (Hoboken). 2010, 62: 1515-1526. 10.1002/acr.20295.
118. van Staa TP, Geusens P, Pols HA, de Laet C, Leufkens HG, Cooper C: A simple score for estimating the long-term risk of fracture in patients using oral glucocorticoids. QJM. 2005, 98: 191-198. 10.1093/qjmed/hci029.
119. Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A: Case finding for the management of osteoporosis with FRAX - assessment and intervention thresholds for the UK. Osteoporos Int. 2008, 19: 1395-1408. 10.1007/s00198-008-0712-1.
120. Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E: FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008, 19: 385-397. 10.1007/s00198-007-0543-5.
121. McCloskey E, Kanis JA: FRAX updates 2012. Curr Opin Rheumatol. 2012, 24: 554-560. 10.1097/BOR.0b013e328356d2f5.
122. Park-Wyllie L, Mazzotta P, Pastuszak A, Moretti ME, Beique L, Hunnisett L, Friesen MH, Jacobson S, Kasapinovic S, Chang D, Diav-Citrin O, Chitayat D, Nulman I, Einarson TR, Koren G: Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology. 2000, 62: 385-392. 10.1002/1096-9926(200012)62:6<385::AID-TERA5>3.0.CO;2-Z.
123. Temprano KK, Bandlamudi R, Moore TL: Antirheumatic drugs in pregnancy and lactation. Semin Arthritis Rheum. 2005, 35: 112-121. 10.1016/j.semarthrit.2005.05.002.
124. Schacke H, Berger M, Rehwinkel H, Asadullah K: Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index. Mol Cell Endocrinol. 2007, 275: 109-117. 10.1016/j.mce.2007.05.014.
125. Strehl C, Spies CM, Buttgereit F: Pharmacodynamics of glucocorticoids. Clin Exp Rheumatol. 2011, 29: S13-S18.
126. Reuter KC, Grunwitz CR, Kaminski BM, Steinhilber D, Radeke HH, Stein J: Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis. J Pharmacol Exp Ther. 2012, 341: 68-80. 10.1124/jpet.111.183947.
127. Hoes JN, Jacobs JW, Buttgereit F, Bijlsma JW: Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis. Nat Rev Rheumatol. 2010, 6: 693-702. 10.1038/nrrheum.2010.179.
128. Huisman AM, Jacobs JW, Buttgereit F, Bijlsma JW: New developments in glucocorticoid therapy: selective glucocorticoid receptor agonists, nitrosteroids and liposomal glucocorticoids. Ned Tijdschr Geneeskd. 2006, 150: 476-480.
129. Jacobs JW, van der Goes MC, Buttgereit F: Glucocorticoids in rheumatic diseases. EULAR Textbook on Rheumatic Diseases. Edited by: Bijlsma JWJ. 2012, London: BMJ Group, 1218-1233.
130. Kuchuk NO, Hoes JN, Bijlsma JW, Jacobs JW: Glucocorticoid-induced osteoporosis: an overview. Int J Clin Rheumatol. 2014, 9: 311-326. 10.2217/ijr.14.24.