Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development

Atherosclerosis

Volumn 251, Issue , 2016, Pages 282-290

  Fang, Shaohong ^a   Xu, Yanwen ^a   Zhang, Yun ^a   Tian, Jiangtian ^a   Li, Ji ^a   Li, Zhaoying ^a   He, Zhongze ^a   Chai, Ruikai ^a   Liu, Fang ^a   Zhang, Tongshuai ^a   Yang, Shuang ^a   Pei, Chunying ^a   Liu, Xinxin ^a   Lin, Peng ^a   Xu, Hongwei ^a   Yu, Bo ^a   Li, Hulun ^a   Sun, Bo ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; IRGM Irgm1; Macrophage; Polarization

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; GUANOSINE TRIPHOSPHATASE; IMMUNITY RELATED GUANOSINE TRIPHOSPHATASE1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; INTERFERON REGULATORY FACTOR 5; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN; IFI1 PROTEIN, MOUSE; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 1; IRF1 PROTEIN, MOUSE; IRGM PROTEIN, HUMAN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; ARTERY; ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL DIET; CONTROLLED STUDY; EXPERIMENTAL ATHEROSCLEROSIS; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MACROPHAGE FUNCTION; MACROPHAGE POLARIZATION; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PERITONEUM MACROPHAGE; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SURGERY; ADULT; AGED; ANIMAL; APOLIPOPROTEIN E KNOCKOUT MOUSE; ATHEROSCLEROSIS; BLOOD; C57BL MOUSE; CELL POLARITY; CYTOLOGY; GENETICS; MACROPHAGE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ATHEROSCLEROSIS; CELL POLARITY; CHOLESTEROL; FEMALE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTORS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT, APOE; MIDDLE AGED; PLAQUE, ATHEROSCLEROTIC;

EID: 84978800238     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2016.07.011     Document Type: Article

References (35)

1. [1] Moore, K.J., Tabas, I., Macrophages in the pathogenesis of atherosclerosis. Cell 145 (2011), 341–355.
2. [2] Hansson, G.K., Hermansson, A., The immune system in atherosclerosis. Nat. Immunol. 12 (2011), 204–212.
3. [3] Swirski, F.K., Nahrendorf, M., Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science 339 (2013), 161–166.
4. [4] Allahverdian, S., Pannu, P.S., Francis, G.A., Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation. Cardiovasc. Res. 95 (2012), 165–172.
5. [5] Mosser, D.M., Edwards, J.P., Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8 (2008), 958–969.
6. [6] Mosser, D.M., The many faces of macrophage activation. J. Leukoc. Biol. 73 (2003), 209–212.
7. [7] Murray, P.J., Wynn, T.A., Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11 (2011), 723–737.
8. [8] Verreck, F.A., de Boer, T., Langenberg, D.M., Hoeve, M.A., Kramer, M., Vaisberg, E., et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 4560–4565.
9. [9] Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., et al. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J. Clin. investigation 121 (2011), 985–997.
10. [10] Modolell, M., Corraliza, I.M., Link, F., Soler, G., Eichmann, K., Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur. J. Immunol. 25 (1995), 1101–1104.
11. [11] Gordon, S., Martinez, F.O., Alternative activation of macrophages: mechanism and functions. Immunity 32 (2010), 593–604.
12. [12] Jetten, N., Verbruggen, S., Gijbels, M.J., Post, M.J., De Winther, M.P., Donners, M.M., Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. Angiogenesis 17 (2014), 109–118.
13. [13] Lee, C.G., Homer, R.J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J. Exp. Med. 194 (2001), 809–821.
14. [14] Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A., Locati, M., The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25:12 (2004), 677–686.
15. [15] Xu, J.W., Zhang, H., Chen, L., Zhang, D.H., Jia, M.J., Wu, H.W., Xu Wu, G.L., Schistosoma japonicum infection induces macrophage polarization. J.Biomed. Res. 28:4 (2014), 299–308.
16. [16] Mantovani, A., Garlanda, C., Locati, M., Macrophage diversity and polarization in atherosclerosis: a question of balance. Arteriosclerosis, thrombosis, Vasc. Biol. 29 (2009), 1419–1423.
17. [17] Krausgruber, T., Blazek, K., Smallie, T., Alzabin, S., Lockstone, H., Sahgal, N., et al. Irf5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat. Immunol. 12 (2011), 231–238.
18. [18] Takaoka, A., Yanai, H., Kondo, S., Duncan, G., Negishi, H., Mizutani, T., et al. Integral role of Irf-5 in the gene induction programme activated by Toll-like receptors. Nature 434 (2005), 243–249.
19. [19] Xu, H., Zhu, J., Smith, S., Foldi, J., Zhao, B., Chung, A.Y., et al. Notch-RBP-J signaling regulates the transcription factor Irf8 to promote inflammatory macrophage polarization. Nat. Immunol. 13 (2012), 642–650.
20. [20] Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat. Immunol. 11 (2010), 936–944.
21. [21] Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A., Locati, M., The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25 (2004), 677–686.
22. [22] Habib, A., Finn, A.V., The role of iron metabolism as a mediator of macrophage inflammation and lipid handling in atherosclerosis. Front. Pharmacol., 5, 2014, 195.
23. [23] Bories, G., Colin, S., Vanhoutte, J., Derudas, B., Copin, C., Fanchon, M., et al. Liver X receptor activation stimulates iron export in human alternative macrophages. Circul. Res. 113 (2013), 1196–1205.
24. [24] Chistiakov, D.A., Bobryshev, Y.V., Nikiforov, N.G., Elizova, N.V., Sobenin, I.A., Orekhov, A.N., Macrophage phenotypic plasticity in atherosclerosis: the associated features and the peculiarities of the expression of inflammatory genes. Int. J. Cardiol. 184 (2015), 436–445.
25. [25] MacMicking, J.D., IFN-inducible GTPases and immunity to intracellular pathogens. Trends Immunol. 25 (2004), 601–609.
26. [26] Taylor, G.A., Feng, C.G., Sher, A., p47 GTPases: regulators of immunity to intracellular pathogens. Nat. Rev. Immunol. 4 (2004), 100–109.
27. [27] Taylor, G.A., IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens. Cell. Microbiol. 9 (2007), 1099–1107.
28. [28] Singh, S.B., Davis, A.S., Taylor, G.A., Deretic, V., Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313 (2006), 1438–1441.
29. [29] Henry, S.C., Traver, M., Daniell, X., Indaram, M., Oliver, T., Taylor, G.A., Regulation of macrophage motility by Irgm1. J. Leukoc. Biol. 87 (2010), 333–343.
30. [30] Henry, S.C., Daniell, X., Indaram, M., Whitesides, J.F., Sempowski, G.D., Howell, D., et al. Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). J. Immunol. 179 (2007), 6963–6972.
31. [31] Xia, F., Li, R., Wang, C., Yang, S., Tian, L., Dong, H., et al. Irgm1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis. Sci. Rep., 3, 2013, 1867.
32. [32] Kirbis, S., Breskvar, U.D., Sabovic, M., Zupan, I., Sinkovic, A., Inflammation markers in patients with coronary artery disease–comparison of intracoronary and systemic levels. Wien. Klin. Wochenschr. 122:Suppl. 2 (2010), 31–34.
33. [33] Sierra-Filardi, E., Vega, M.A., Sanchez-Mateos, P., Corbi, A.L., Puig-Kroger, A., Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release. Immunobiology 215 (2010), 788–795.
34. [34] Lapaque, N., Takeuchi, O., Corrales, F., Akira, S., Moriyon, I., Howard, J.C., et al. Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides. Cell. Microbiol. 8 (2006), 401–413.
35. [35] Bafica, A., Feng, C.G., Santiago, H.C., Aliberti, J., Cheever, A., Thomas, K.E., et al. The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. J. Immunol. 179 (2007), 5514–5522.