The role of iron metabolism as a mediator of macrophage inflammation and lipid handling in atherosclerosis

Frontiers in Pharmacology

Volumn 5 AUG, Issue , 2014, Pages

  Habib, Anwer ^a   Finn, Aloke V ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; CD163 ANTIGEN; CHOLESTEROL; FERROPORTIN; HEMOGLOBIN; HEPCIDIN; HYDROXYL RADICAL; INTERLEUKIN 10; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; IRON; LIPID; MANNOSE RECEPTOR; PROCOLLAGEN C PROTEINASE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL DIFFERENTIATION; CELL FUNCTION; CHOLESTEROL TRANSPORT; CYTOKINE PRODUCTION; FOAM CELL; HUMAN; INFLAMMATION; IRON METABOLISM; LIPID METABOLISM; LIPID OXIDATION; LIPID PEROXIDATION; LIPID TRANSPORT; MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN BINDING; SHORT SURVEY; SIGNAL TRANSDUCTION; TISSUE INJURY;

EID: 84906249472     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00195     Document Type: Short Survey

References (36)

1. R.R. Crichton, S. Wilmet, R. Legssyer, and R.J. Ward, Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. Journal of inorganic biochemistry 91 (2002) 9-18.
2. H. Yoshida, and R. Kisugi, Mechanisms of LDL oxidation. Clinica chimica acta; international journal of clinical chemistry 411 (2010) 1875-82.
3. G. Balla, H.S. Jacob, J.W. Eaton, J.D. Belcher, and G.M. Vercellotti, Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arteriosclerosis and thrombosis: a journal of vascular biology / American Heart Association 11 (1991) 1700-11.
4. V. Jeney, J. Balla, A. Yachie, Z. Varga, G.M. Vercellotti, J.W. Eaton, and G. Balla, Prooxidant and cytotoxic effects of circulating heme. Blood 100 (2002) 879-87.
5. Y.I. Miller, S.M. Altamentova, and N. Shaklai, Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin. Biochemistry 36 (1997) 12189-98.
6. G. Camejo, C. Halberg, A. Manschik-Lundin, E. Hurt-Camejo, B. Rosengren, H. Olsson, G.I. Hansson, G.B. Forsberg, and B. Ylhen, Hemin binding and oxidation of lipoproteins in serum: mechanisms and effect on the interaction of LDL with human macrophages. Journal of lipid research 39 (1998) 755-66.
7. E. Nagy, J.W. Eaton, V. Jeney, M.P. Soares, Z. Varga, Z. Galajda, J. Szentmiklosi, G. Mehes, T. Csonka, A. Smith, G.M. Vercellotti, G. Balla, and J. Balla, Red cells, hemoglobin, heme, iron, and atherogenesis. Arteriosclerosis, thrombosis, and vascular biology 30 (2010) 1347-53.
8. G. Silva, V. Jeney, A. Chora, R. Larsen, J. Balla, and M.P. Soares, Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells. The Journal of biological chemistry 284 (2009) 29582-95.
9. G. Balla, H.S. Jacob, J. Balla, M. Rosenberg, K. Nath, F. Apple, J.W. Eaton, and G.M. Vercellotti, Ferritin: a cytoprotective antioxidant strategem of endothelium. The Journal of biological chemistry 267 (1992) 18148-53.
10. K. Sakakura, M. Nakano, F. Otsuka, E. Ladich, F.D. Kolodgie, and R. Virmani, Pathophysiology of atherosclerosis plaque progression. Heart, lung & circulation 22 (2013) 399-411.
11. C. Smith, M.J. Mitchinson, O.I. Aruoma, and B. Halliwell, Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions. The Biochemical journal 286 ( Pt 3) (1992) 901-5.
12. M.B. Juckett, J. Balla, G. Balla, J. Jessurun, H.S. Jacob, and G.M. Vercellotti, Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro. The American journal of pathology 147 (1995) 782-9.
13. J.H. Pang, M.J. Jiang, Y.L. Chen, F.W. Wang, D.L. Wang, S.H. Chu, and L.Y. Chau, Increased ferritin gene expression in atherosclerotic lesions. The Journal of clinical investigation 97 (1996) 2204-12.
14. M. Miller, and G.M. Hutchins, Hemochromatosis, multiorgan hemosiderosis, and coronary artery disease. JAMA: the journal of the American Medical Association 272 (1994) 231- 3.
15. C. Ellervik, A. Tybjaerg-Hansen, P. Grande, M. Appleyard, and B.G. Nordestgaard, Hereditary hemochromatosis and risk of ischemic heart disease: a prospective study and a case-control study. Circulation 112 (2005) 185-93.
16. E.A. Kirk, J.W. Heinecke, and R.C. LeBoeuf, Iron overload diminishes atherosclerosis in apoE-deficient mice. The Journal of clinical investigation 107 (2001) 1545-53.
17. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, D.M. Ward, T. Ganz, and J. Kaplan, Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-3.
18. T. Ganz, Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102 (2003) 783-8.
19. L. Wang, L. Harrington, E. Trebicka, H.N. Shi, J.C. Kagan, C.C. Hong, H.Y. Lin, J.L. Babitt, and B.J. Cherayil, Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. The Journal of clinical investigation 119 (2009) 3322-8.
20. F.D. Kolodgie, H.K. Gold, A.P. Burke, D.R. Fowler, H.S. Kruth, D.K. Weber, A. Farb, L.J. Guerrero, M. Hayase, R. Kutys, J. Narula, A.V. Finn, and R. Virmani, Intraplaque hemorrhage and progression of coronary atheroma. The New England journal of medicine 349 (2003) 2316-25.
21. F. Vallelian, T. Pimenova, C.P. Pereira, B. Abraham, M.G. Mikolajczyk, G. Schoedon, R. Zenobi, A.I. Alayash, P.W. Buehler, and D.J. Schaer, The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways. Free radical biology & medicine 45 (2008) 1150-8.
22. R. Ross, Atherosclerosis--an inflammatory disease. The New England journal of medicine 340 (1999) 115-26.
23. P. Libby, Molecular bases of the acute coronary syndromes. Circulation 91 (1995) 2844-50.
24. S. Gordon, Alternative activation of macrophages. Nature reviews. Immunology 3 (2003) 23-35.
25. J.J. Boyle, H.A. Harrington, E. Piper, K. Elderfield, J. Stark, R.C. Landis, and D.O. Haskard, Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. The American journal of pathology 174 (2009) 1097-108.
26. A.V. Finn, M. Nakano, R. Polavarapu, V. Karmali, O. Saeed, X. Zhao, S. Yazdani, F. Otsuka, T. Davis, A. Habib, J. Narula, F.D. Kolodgie, and R. Virmani, Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques. Journal of the American College of Cardiology 59 (2012) 166- 77.
27. J.J. Boyle, M. Johns, J. Lo, A. Chiodini, N. Ambrose, P.C. Evans, J.C. Mason, and D.O. Haskard, Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage. Arteriosclerosis, thrombosis, and vascular biology 31 (2011) 2685-91.
28. M.A. Bouhlel, B. Derudas, E. Rigamonti, R. Dievart, J. Brozek, S. Haulon, C. Zawadzki, B. Jude, G. Torpier, N. Marx, B. Staels, and G. Chinetti-Gbaguidi, PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell metabolism 6 (2007) 137-43.
29. J.J. Boyle, M. Johns, T. Kampfer, A.T. Nguyen, L. Game, D.J. Schaer, J.C. Mason, and D.O. Haskard, Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection. Circulation research 110 (2012) 20-33.
30. G. Bories, S. Colin, J. Vanhoutte, B. Derudas, C. Copin, M. Fanchon, M. Daoudi, L. Belloy, S. Haulon, C. Zawadzki, B. Jude, B. Staels, and G. Chinetti-Gbaguidi, Liver X receptor activation stimulates iron export in human alternative macrophages. Circulation research 113 (2013) 1196-205.
31. G. Chinetti-Gbaguidi, M. Baron, M.A. Bouhlel, J. Vanhoutte, C. Copin, Y. Sebti, B. Derudas, T. Mayi, G. Bories, A. Tailleux, S. Haulon, C. Zawadzki, B. Jude, and B. Staels, Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARgamma and LXRalpha pathways. Circulation research 108 (2011) 985-95.
32. O. Saeed, F. Otsuka, R. Polavarapu, V. Karmali, D. Weiss, T. Davis, B. Rostad, K. Pachura, L. Adams, J. Elliott, W.R. Taylor, J. Narula, F. Kolodgie, R. Virmani, C.C. Hong, and A.V. Finn, Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology 32 (2012) 299-307.
33. P.B. Yu, C.C. Hong, C. Sachidanandan, J.L. Babitt, D.Y. Deng, S.A. Hoyng, H.Y. Lin, K.D. Bloch, and R.T. Peterson, Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology 4 (2008) 33-41.
34. J.H. Boergermann, J. Kopf, P.B. Yu, and P. Knaus, Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology 42 (2010) 1802-7.
35. M. Derwall, R. Malhotra, C.S. Lai, Y. Beppu, E. Aikawa, J.S. Seehra, W.M. Zapol, K.D. Bloch, and P.B. Yu, Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology 32 (2012) 613-22.
36. J.J. Li, X. Meng, H.P. Si, C. Zhang, H.X. Lv, Y.X. Zhao, J.M. Yang, M. Dong, K. Zhang, S.X. Liu, X.Q. Zhao, F. Gao, X.L. Liu, T.X. Cui, and Y. Zhang, Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis. Arteriosclerosis, thrombosis, and vascular biology 32 (2012) 1158-66.