Nicotine directly induces endoplasmic reticulum stress response in rat placental trophoblast giant cells

Toxicological Sciences

Volumn 151, Issue 1, 2016, Pages 23-34

  Wong, Michael K ^a   Holloway, Alison C ^b   Hardy, Daniel B ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Endoplasmic reticulum stress; Nicotine; Placenta; Rcho 1; Tauroursodeoxycholic acid; Trophoblast giant cell

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MECAMYLAMINE; MESSENGER RNA; NICOTINE; PERK PROTEIN; PL 1 PROTEIN; PROSTAGLANDIN F; PROTEIN; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PERK KINASE; PROTEIN KINASE R; TAUROCHENODEOXYCHOLIC ACID;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE TARGETING; GIANT CELL; NONHUMAN; PLACENTA; PLACENTA INSUFFICIENCY; PROTEIN FOLDING; RAT; REAL TIME POLYMERASE CHAIN REACTION; TROPHOBLAST; WESTERN BLOTTING; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME FACTOR;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION REGULATION; GIANT CELLS; MECAMYLAMINE; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PHOSPHORYLATION; RATS; RECEPTORS, NICOTINIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; TAUROCHENODEOXYCHOLIC ACID; TIME FACTORS; TROPHOBLASTS;

EID: 84978794974     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw019     Document Type: Article

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