Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20

Molecular Cell

Volumn 63, Issue 2, 2016, Pages 249-260

  Li, Heng ^a,b   Lim, Kah Suan ^c   Kim, Hyungjin ^d   Hinds, Thomas R ^a   Jo, Ukhyun ^d   Mao, Haibin ^a,b   Weller, Caroline E ^b   Sun, Ji ^a   Chatterjee, Champak ^b   D'Andrea, Alan D ^c   Zheng, Ning ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEUBIQUITINASE; PROTEIN; UBIQUITIN SPECIFIC PROTEASE 12; UNCLASSIFIED DRUG; USP1 ASSOCIATED FACTOR 1; WD40 EPEAT CONTAINING PROTEIN WDR20; CARRIER PROTEIN; COUMARIN DERIVATIVE; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PROTEIN BINDING; UBIQUITIN; UBIQUITIN C-TERMINAL 7-AMIDO-4-METHYLCOUMARIN; UBIQUITIN THIOLESTERASE; USP1 ASSOCIATED FACTOR 1, HUMAN; USP12 PROTEIN, HUMAN; WDR20 PROTEIN, HUMAN;

ALLOSTERISM; ARTICLE; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME REGULATION; ENZYME SUBSTRATE; HUMAN; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; UBIQUITINATION; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HYDROLYSIS; KINETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; BINDING SITES; CARRIER PROTEINS; COUMARINS; HEK293 CELLS; HUMANS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRANSFECTION; UBIQUITIN THIOLESTERASE; UBIQUITINATION; UBIQUITINS;

EID: 84978511594     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.05.031     Document Type: Article

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