Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease

Brain Pathology

Volumn 26, Issue 4, 2016, Pages 533-541

  Miners, J Scott ^a   Palmer, Jennifer C ^a   Love, Seth ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Alzheimer's disease; amyloid ; blood flow; endothelin 1; oxygenation; precuneus

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ANGIOTENSIN II; BIOLOGICAL MARKER; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN 1; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME 2; MYELIN ASSOCIATED GLYCOPROTEIN; PROTEOLIPID PROTEIN; PROTEOLIPID PROTEIN 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTERIOLE; ARTICLE; BRAIN ATHEROSCLEROSIS; BRAIN PERFUSION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PRECUNEUS; UPREGULATION; VASCULAR AMYLOIDOSIS; VASOCONSTRICTION; VERY ELDERLY; WHITE MATTER;

EID: 84978472879     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12331     Document Type: Article

References (61)

1. Ashby EL, Miners JS, Kumar S, Walter J, Love S, Kehoe PG (2015) Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia. Neuropathol Appl Neurobiol 41:428–444.
2. Asllani I, Habeck C, Scarmeas N, Borogovac A, Brown TR, Stern Y (2008) Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's disease. J Cereb Blood Flow Metab 28:725–36.
3. Barker R, Ashby EL, Wellington D, Barrow VM, Palmer JC, Kehoe PG et al (2014) Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia. Brain 137:1524–1532.
4. Barker R, Wellington D, Esiri MM, Love S (2013) Assessing white matter ischemic damage in dementia patients by measurement of myelin proteins. J Cereb Blood Flow Metab 33:1050–1057.
5. Barua NU, Miners JS, Bienemann AS, Wyatt MJ, Welser K, Tabor AB et al (2012) Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy. J Alzheimers Dis 32:43–56.
6. Benzinger TL, Blazey T, Jack CR, Jr., Koeppe RA, Su Y, Xiong C, Raichle ME et al (2013) Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc Natl Acad Sci USA 110:E4502–E4509.
7. Binnewijzend MA, Kuijer JP, Benedictus MR, van der Flier WM, Wink AM, Wattjes MP et al (2013) Cerebral blood flow measured with 3D pseudocontinuous arterial spin-labeling MR imaging in Alzheimer disease and mild cognitive impairment: a marker for disease severity. Radiology 267:221–230.
8. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112:389–404.
9. Brun A, Englund E (1986) Brain changes in dementia of Alzheimer's type relevant to new imaging diagnostic methods. Prog Neuropsychopharmacol Biol Psychiatry 10:297–308.
10. Brun A, Gustafson L, Englund E (1990) Subcortical pathology of Alzheimer's disease. Adv Neurol 51:73–77.
11. Chalmers K, Wilcock GK, Love S (2003) APOE e4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Ab protein. Neuropathol Appl Neurobiol 29:231–238.
12. Chui HC, Zheng L, Reed BR, Vinters HV, Mack WJ (2012) Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review. Alzheimers Res Ther 4:1.
13. Dai W, Lopez OL, Carmichael OT, Becker JT, Kuller LH, Gach HM (2009) Mild cognitive impairment and alzheimer disease: patterns of altered cerebral blood flow at MR imaging. Radiology 250:856–866.
14. den Abeelen AS, Lagro J, van Beek AH, Claassen JA (2014) Impaired cerebral autoregulation and vasomotor reactivity in sporadic Alzheimer's disease. Curr Alzheimer Res 11:11–17.
15. Elesber AA, Bonetti PO, Woodrum JE, Zhu XY, Lerman LO, Younkin SG, Lerman A (2006) Bosentan preserves endothelial function in mice overexpressing APP. Neurobiol Aging 27:446–450.
16. Ellis RJ, Olichney JM, Thal LJ, Mirra SS, Morris JC, Beekly D, Heyman A (1996) Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV. Neurology 46:1592–1596.
17. Englund E (1998) Neuropathology of white matter changes in Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord 9(Suppl 1):6–12.
18. Esiri MM, Wilcock GK (1986) Cerebral amyloid angiopathy in dementia and old age. J Neurol Neurosurg Psychiatry 49:1221–1226.
19. Gentile MT, Vecchione C, Maffei A, Aretini A, Marino G, Poulet R et al (2004) Mechanisms of soluble β-amyloid impairment of endothelial function. J Biol Chem 279:48135–48142.
20. Hawkes CA, Gatherer M, Sharp MM, Dorr A, Yuen HM, Kalaria R et al (2013) Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain. Aging Cell 12:224–236.
21. Hawkes CA, Hartig W, Kacza J, Schliebs R, Weller RO, Nicoll JA, Carare RO (2011) Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathol 121:431–443.
22. Hawkes CA, Jayakody N, Johnston DA, Bechmann I, Carare RO (2014) Failure of perivascular drainage of β-amyloid in cerebral amyloid angiopathy. Brain Pathol 24:396–403.
23. Hughes TM, Kuller LH, Barinas-Mitchell EJ, McDade EM, Klunk WE, Cohen AD et al (2014) Arterial stiffness and β-amyloid progression in nondemented elderly adults. JAMA Neurol 71:562–568.
24. Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5:347–360.
25. Jochemsen HM, van der Flier WM, Ashby EL, Teunissen CE, Jones RE, Wattjes MP et al (2015) Angiotensin-converting enzyme in cerebrospinal fluid and risk of brain atrophy. J Alzheimers Dis 44:153–162.
26. Kalaria RN (2000) The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging 21:321–330.
27. Kester MI, Goos JD, Teunissen CE, Benedictus MR, Bouwman FH, Wattjes MP et al (2014) Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers. JAMA Neurol 71:855–862.
28. Langbaum JB, Chen K, Caselli RJ, Lee W, Reschke C, Bandy D et al (2010) Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele. Arch Neurol 67:462–468.
29. Love S, Nicoll JA, Hughes A, Wilcock GK (2003) APOE and cerebral amyloid angiopathy in the elderly. Neuroreport 14:1535–1536.
30. Matsuda H (2001) Cerebral blood flow and metabolic abnormalities in Alzheimer's disease. Ann Nucl Med 15:85–92.
31. Miners JS, Ashby E, Van Helmond Z, Chalmers KA, Palmer LE, Love S, Kehoe PG (2008) Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 34:181–193.
32. Miners JS, Jones R, Love S (2014) Differential changes in Aβ42 and Aβ40 with age. J Alzheimers Dis 40:727–735.
33. Miners JS, Palmer JC, Tayler H, Palmer LE, Ashby E, Kehoe PG, Love S (2014) Aβdegradation or cerebral perfusion? Divergent effects of multifunctional enzymes. Front Aging Neurosci 6:238.
34. Miners JS, van Helmond Z, Raiker M, Love S, Kehoe PG (2010) ACE variants and association with brain Aβ levels in Alzheimer's disease. Am J Transl Res 3:73–80.
35. Miners S, Ashby E, Baig S, Harrison R, Tayler H, Speedy E et al (2009) Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes. Am J Transl Res 1:163–177.
36. Miners S, Moulding H, de Silva R, Love S (2014) Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies. Brain Pathol 24:334–343.
37. Mondello S, Buki A, Barzo P, Randall J, Provuncher G, Hanlon D et al (2014) CSF and plasma amyloid-β temporal profiles and relationships with neurological status and mortality after severe traumatic brain injury. Sci Rep 4:6446.
38. Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW et al (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol 123:1–11.
39. Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C (2002) Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am J Physiol Heart Circ Physiol 283:H315–H323.
40. Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C (2002) Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol Dis 9:61–68.
41. Niwa K, Porter VA, Kazama K, Cornfield D, Carlson GA, Iadecola C (2001) Aβ-peptides enhance vasoconstriction in cerebral circulation. Am J Physiol Heart Circ Physiol 281:H2417–H2424.
42. Olichney JM, Hansen LA, Galasko D, Saitoh T, Hofstetter CR, Katzman R, Thal LJ (1996) The apolipoprotein E ϵ4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant. Neurology 47:190–196.
43. Pacheco-Quinto J, Eckman EA (2013) Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes. J Biol Chem 288:5606–5615.
44. Palmer J, Love S (2011) Endothelin receptor antagonists: potential in Alzheimer's disease. Pharmacol Res 63:525–531.
45. Palmer JC, Baig S, Kehoe PG, Love S (2009) Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Aβ. Am J Pathol 175:262–270.
46. Palmer JC, Barker R, Kehoe PG, Love S (2012) Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β. J Alzheimers Dis 29:853–861.
47. Palmer JC, Kehoe PG, Love S (2010) Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia. Neuropathol Appl Neurobiol 36:487–497.
48. Palmer JC, Tayler HM, Love S (2013) Endothelin-converting enzyme-1 activity, endothelin-1 production, and free radical-dependent vasoconstriction in Alzheimer's disease. J Alzheimers Dis 36:577–587.
49. Park L, Koizumi K, El Jamal S, Zhou P, Previti ML, Van Nostrand WE et al (2014) Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke 45:1815–1821.
50. Peca S, McCreary CR, Donaldson E, Kumarpillai G, Shobha N, Sanchez K et al (2013) Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy. Neurology 81:1659–1665.
51. Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ (1997) Degradation of amyloid β-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem 272:6641–6666.
52. Ruitenberg A, den Heijer T, Bakker SL, van Swieten JC, Koudstaal PJ, Hofman A, Breteler MM (2005) Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol 57:789–794.
53. Sakamoto S, Ishii K, Sasaki M, Hosaka K, Mori T, Matsui M et al (2002) Differences in cerebral metabolic impairment between early and late onset types of Alzheimer's disease. J Neurol Sci 200:27–32.
54. Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ et al (2007) Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain 130:2310–2319.
55. Swirski M, Miners JS, de Silva R, Lashley T, Ling H, Holton J et al (2014) Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease. Alzheimers Res Ther 6:77.
56. Thomas T, Miners S, Love S (2015) Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer's disease and vascular dementia. Brain 138:1059–1069.
57. van Helmond Z, Miners JS, Kehoe PG, Love S (2010) Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease. Brain Pathol 20:787–793.
58. van Helmond Z, Miners JS, Kehoe PG, Love S (2010) Oligomeric Aβ in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy. Brain Pathol 20:468–480.
59. Weller RO, Hawkes CA, Kalaria RN, Werring DJ, Carare RO (2015) White matter changes in dementia: role of impaired drainage of interstitial fluid. Brain Pathol 25:63–78.
60. Weller RO, Subash M, Preston SD, Mazanti I, Carare RO (2008) Perivascular drainage of amyloid-β peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 18:253–266.
61. Zetterberg H, Mortberg E, Song L, Chang L, Provuncher GK, Patel PP et al (2011) Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PLoS One 6:e28263.