Human Mesenchymal Stem Cell-Derived Microvesicles Prevent the Rupture of Intracranial Aneurysm in Part by Suppression of Mast Cell Activation via a PGE2-Dependent Mechanism

Stem Cells

Volumn 34, Issue 12, 2016, Pages 2943-2955

  Liu, Jia ^a   Kuwabara, Atsushi ^a   Kamio, Yoshinobu ^a   Hu, Shuling ^a   Park, Jeonghyun ^a   Hashimoto, Tomoki ^a   Lee, Jae Woo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Intracranial aneurysm; Mast cells; Mesenchymal stem cells; Microvesicles; Prostaglandin E2

Indexed keywords

CALCIMYCIN; CHYMASE; ELASTASE; PROSTAGLANDIN E2; PROSTANOID; TRYPTASE; ANTIINFLAMMATORY AGENT; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR 4;

ANEURYSM RUPTURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTERNALIZATION; INTRACRANIAL ANEURYSM; MAST CELL; MEMBRANE MICROPARTICLE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; ENDOCYTOSIS; GENETICS; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY;

ADMINISTRATION, INTRAVENOUS; ANEURYSM, RUPTURED; ANIMALS; ANTI-INFLAMMATORY AGENTS; BONE MARROW CELLS; CALCIMYCIN; CELL-DERIVED MICROPARTICLES; DINOPROSTONE; ENDOCYTOSIS; HUMANS; IMMUNOMODULATION; IMMUNOSUPPRESSION; INTRACRANIAL ANEURYSM; MALE; MAST CELLS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE, INBRED C57BL; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RNA, MESSENGER;

EID: 84978300315     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2448     Document Type: Article

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