α2-Macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity

Journal of Immunology

Volumn 182, Issue 9, 2009, Pages 5770-5777

  Raymond, Wilfred W ^a   Su, Sharon ^c   Makarova, Anastasia ^d   Wilson, Todd M ^f   Carter, Melody C ^f   Metcalfe, Dean D ^f   Caughey, George H ^a,b,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Veterans Health Research Institute   (United States)

^e SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; ANGIOTENSIN I; ANGIOTENSIN II; CAPTOPRIL; CATHEPSIN G; CHYMASE; CHYMOSTATIN; CHYMOTRYPSIN; DIPEPTIDYL CARBOXYPEPTIDASE; PEPTIDASE; SERINE PROTEINASE INHIBITOR; CMA1 PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ADULT; ARTICLE; CELL INTERACTION; CLINICAL ARTICLE; COMBINATORIAL CHEMISTRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRANULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FEMALE; HUMAN; HYDROLYSIS; MALE; MAST CELL; MASTOCYTOSIS; MICROTITER PLATE ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SYSTEMIC MASTOCYTOSIS; BIOSYNTHESIS; BLOOD; CHILD; COMPARATIVE STUDY; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYMOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PILOT STUDY; PROTEIN BINDING; SECRETION; SERUM;

ADULT; ALPHA-MACROGLOBULINS; ANGIOTENSIN II; CHILD; CHYMASES; ENZYME ACTIVATION; ENZYME STABILITY; HUMANS; MAST CELLS; MASTOCYTOSIS; PILOT PROJECTS; PROTEIN BINDING; RECOMBINANT PROTEINS; SERUM; SUBSTRATE SPECIFICITY;

EID: 66949181206     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900127     Document Type: Article

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