PGE 2-EP 2 signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB

British Journal of Pharmacology

Volumn 163, Issue 6, 2011, Pages 1237-1249

  Aoki, T ^a   Nishimura, M ^a   Matsuoka, T ^a   Yamamoto, K ^b   Furuyashiki, T ^a   Kataoka, H ^a   Kitaoka, S ^a   Ishibashi, R ^a   Ishibazawa, A ^b   Miyamoto, S ^a   Morishita, R ^c   Ando, J ^b   Hashimoto, N ^d   Nozaki, K ^e   Narumiya, S ^a,f  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^e SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

cerebral aneurysm; COX 2; EP 2; inflammation; NF B; prostaglandin

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ARTERY ANEURYSM; CHRONIC INFLAMMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE; HEMODYNAMIC STRESS; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN E RECEPTOR 2 GENE; PROTEIN EXPRESSION; RAT; SHEAR STRESS; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM;

ANIMALS; CHEMOKINE CCL2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; HUMANS; INFLAMMATION; INTRACRANIAL ANEURYSM; MICE; MICE, KNOCKOUT; NF-KAPPA B; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; SIGNAL TRANSDUCTION;

EID: 79959714950     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01358.x     Document Type: Article

References (51)

1. Alexander SPH, Mathie A, Peters JA, (2009). Guide to receptors and channels (GRAC), 4th edition (2009). Br J Pharmacol 158 (Suppl. 1): S1-S254.
2. Alnaes MS, Isaksen J, Mardal KA, Romner B, Morgan MK, Ingebrigtsen T, (2007). Computation of hemodynamics in the circle of Willis. Stroke 38: 2500-2505. (Pubitemid 47329629)
3. Aoki T, Nishimura M, (2010). Targeting chronic inflammation in cerebral aneurysms: focusing on NF-κB as a putative target of medical therapy. Expert Opin Ther Targets 14: 265-273.
4. Aoki T, Kataoka H, Morimoto M, Nozaki K, Hashimoto N, (2007a). Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Stroke 38: 162-169. (Pubitemid 46035622)
5. Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, et al,. (2007b). NF-κB is a key mediator of cerebral aneurysm formation. Circulation 116: 2830-2840. (Pubitemid 350291225)
6. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Hashimoto N, (2008a). Gene expression profile of the intima and media of experimentally induced cerebral aneurysms in rats by laser-microdissection and microarray techniques. Int J Mol Med 22: 595-603.
7. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Hashimoto N, (2008b). Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Stroke 39: 1276-1285. (Pubitemid 351440702)
8. Aoki T, Moriwaki T, Takagi Y, Kataoka H, Yang J, Nozaki K, et al,. (2008c). The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation. Int J Mol Med 21: 453-459. (Pubitemid 351802640)
9. Aoki T, Kataoka H, Ishibashi R, Nakagami H, Nozaki K, Morishita R, et al,. (2009a). Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor κB pathway. Neurosurgery 64: 357-365.
10. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Egashira K, Hashimoto N, (2009b). Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation. Stroke 40: 942-951.
11. 2 receptors in abdominal aortic aneurysm and human aortic smooth muscle cells. J Vasc Surg 38: 354-359. (Pubitemid 41123262)
12. Breyer RM, Bagdassarian CK, Myers SA, Breyer MD, (2001). Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 41: 661-690. (Pubitemid 32385902)
13. Chyatte D, Bruno G, Desai S, Todor DR, (1999). Inflammation and intracranial aneurysms. Neurosurgery 45: 1137-1146.
14. Cornuz J, Sidoti PC, Tevaearai H, Egger M, (2004). Risk factors for asymptomatic abdominal aortic aneurysm: systematic review and meta-analysis of population-based screening studies. Eur J Public Health 14: 343-349. (Pubitemid 40186442)
15. Everts B, Wahrborg P, Hedner T, (2000). COX-2-Specific inhibitors-the emergence of a new class of analgesic and anti-inflammatory drugs. Clin Rheumatol 19: 331-343.
16. Feigin VL, Rinkel GJ, Lawes CM, Algra A, Bennett DA, van Gijn J, et al,. (2005). Risk factors for subarachnoid hemorrhage: an updated systematic review of epidemiological studies. Stroke 36: 2773-2780.
17. Fukuda S, Hashimoto N, Naritomi H, Nagata I, Nozaki K, Kondo S, et al,. (2000). Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase. Circulation 101: 2532-2538. (Pubitemid 30366259)
18. Funk CD, FitzGerald GA, (2007). COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol 50: 470-479. (Pubitemid 350146448)
19. van Gijn J, Kerr RS, Rinkel GJ, (2007). Subarachnoid haemorrhage. Lancet 369: 306-318. (Pubitemid 46136491)
20. Hashimoto N, Handa H, Hazama F, (1978). Experimentally induced cerebral aneurysms in rats. Surg Neurol 10: 3-8. (Pubitemid 8369658)
21. Hashimoto N, Handa H, Nagata I, Hazama F, (1980). Experimentally induced cerebral aneurysms in rats: part V. Relation of hemodynamics in the circle of Willis to formation of aneurysms. Surg Neurol 13: 41-45. (Pubitemid 10212073)
22. 2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms. J Vasc Surg 25: 810-815. (Pubitemid 27227676)
23. Inoue H, Tada Y, Miwa Y, Yokota C, Miyagi M, Sasaguri T, (2002). Transcriptional and posttranscriptional regulation of cycloocygenase-2 expression by fluid shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol 22: 1415-1420.
24. Ishibashi R, Aoki T, Nishimura M, Hashimoto N, Miyamoto S, (2010). Contribution of mast cells to cerebral aneurysm formation. Curr Neurovasc Res 7: 113-124.
25. Jayaraman T, Berenstein V, Li X, Mayer J, Silane M, Shin YS, et al,. (2005). Tumor necrosis factor alpha is a key modulator of inflammation in cerebral aneurysms. Neurosurgery 57: 558-564.
26. Juni P, Nartey L, Reichenbach S, Sterchi R, Dieppe PA, Egger M, (2004). Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 364: 2021-2029. (Pubitemid 39593078)
27. King VL, Trivedi DB, Gitlin JM, Loftin CD, (2006). Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler Thromb Vasc Biol 26: 1137-1143. (Pubitemid 43732124)
28. Kobayashi T, Narumiya S, (2002). Function of prostanoid receptors: studies on knockout mice. Prostaglandins Other Lipid Mediat 68-69: 557-573. (Pubitemid 35247420)
29. 2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest 114: 784-794. (Pubitemid 39578737)
30. Liao JK, Laufs U, (2005). Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45: 89-118. (Pubitemid 40261799)
31. Linn FH, Rinkel GE, Algra A, van Gijn J, (1996). Incidence of subarachnoid hemorrhage. Stroke 27: 625-629.
32. Meng H, Wang Z, Hoi Y, Gao L, Metaxa E, Swartz DD, et al,. (2007). Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke 38: 1924-1931. (Pubitemid 46847270)
33. Miralles M, Wester W, Sicard GA, Thompson R, Reilly JM, (1999). Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase. J Vasc Surg 29: 884-892.
34. Morimoto M, Miyamoto S, Mizoguchi A, Kume N, Kita T, Hashimoto N, (2002). Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes. Stroke 33: 1911-1915. (Pubitemid 34761084)
35. Morishita R, Tomita N, Kaneda Y, Ogihara T, (2004). Molecular therapy to inhibit NFκB activation by transcription factor decoy oligonucleotides. Curr Opin Pharmacol 4: 139-146. (Pubitemid 38444048)
36. Moriwaki T, Takagi Y, Sadamasa N, Aoki T, Nozaki K, Hashimoto N, (2006). Impaired progression of cerebral aneurysms in interleukin-1β-deficient mice. Stroke 37: 900-905. (Pubitemid 43731929)
37. Mukherjee D, Nissen SE, Topol EJ, (2001). Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA 286: 954-959. (Pubitemid 33010342)
38. Murakami M, Nakatani Y, Tanioka T, Kudo I, (2002). Prostaglandin E synthase. Prostaglandins Other Lipid Mediat 68-69: 383-399. (Pubitemid 35247409)
39. Nakatani H, Hashimoto N, Kang Y, Yamazoe N, Kikuchi H, Yamaguchi S, et al,. (1991). Cerebral blood flow patterns at major vessel bifurcations and aneurysms in rats. J Neurosurg 74: 258-262.
40. Narumiya S, Sugimoto Y, Ushikubi F, (1999). Prostanoid receptors: structures, properties, and functions. Physiol Rev 79: 1193-1226. (Pubitemid 29473315)
41. Ogasawara A, Arakawa T, Kaneda T, Takuma T, Sato T, Kaneko H, et al,. (2001). Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP β, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells. J Biol Chem 276: 7048-7054.
42. Sadamasa N, Nozaki K, Hashimoto N, (2003). Disruption of gene for inducible nitric oxide synthase reduces progression of cerebral aneurysms. Stroke 34: 2980-2984. (Pubitemid 37517781)
43. Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN, Runge MS, (1997). Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272: 601-608. (Pubitemid 27021200)
44. Δ716 knockout mice. Nat Med 7: 1048-1051. (Pubitemid 32937386)
45. Sugimoto Y, Narumiya S, (2007). Prostaglandin E receptors. J Biol Chem 282: 11613-11617. (Pubitemid 47100657)
46. Takagi Y, Ishikawa M, Nozaki K, Yoshimura S, Hashimoto N, (2002). Increased expression of phosphorylated c-Jun amino-terminal kinase and phosphorylated c-Jun in human cerebral aneurysms: role of the c-Jun amino-terminal kinase/c-Jun pathway in apoptosis of vascular walls. Neurosurgery 51: 997-1002.
47. Takeuchi S, Karino T, (2009). Flow patterns and distributions of fluid velocity and wall shear stress in the human internal carotid and middle cerebral arteries. Surg Neurol 73: 174-185.
48. Tilley SL, Coffman TM, Koller BH, (2001). Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108: 15-23. (Pubitemid 32634916)
49. Topper JN, Cai J, Falb D, Gimbrone MA Jr, (1996). Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 93: 10417-10422.
50. Wiebers DO, Whisnant JP, Huston J, III, Meissner I, Brown RD, Jr, Piepgras DG, et al,. (2003). Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362: 103-110. (Pubitemid 36831019)
51. Yamamoto K, Sokabe T, Matsumoto T, Yoshimura K, Shibata M, Ohura N, et al,. (2006). Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med 12: 133-137. (Pubitemid 43050088)