-
1
-
-
84865222310
-
Defining the mode of tumour growth by clonal analysis
-
[1] Driessens, G., Beck, B., Caauwe, A., Simons, B.D., Blanpain, C., Defining the mode of tumour growth by clonal analysis. Nature 488 (2012), 527–530.
-
(2012)
Nature
, vol.488
, pp. 527-530
-
-
Driessens, G.1
Beck, B.2
Caauwe, A.3
Simons, B.D.4
Blanpain, C.5
-
2
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
[2] Vogelstein, B., Fearon, E.R., Hamilton, S.R., Kern, S.E., Preisinger, A.C., Leppert, M., et al. Genetic alterations during colorectal-tumor development. N Engl J Med 319 (1988), 525–532.
-
(1988)
N Engl J Med
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
Fearon, E.R.2
Hamilton, S.R.3
Kern, S.E.4
Preisinger, A.C.5
Leppert, M.6
-
3
-
-
84994435466
-
Hypoxic microenvironment as determinant of Cancer stem cells evolution
-
[3] Carnero, A., Lleonart, M.E., Hypoxic microenvironment as determinant of Cancer stem cells evolution. Inside Cell, 1, 2015.
-
(2015)
Inside Cell
, vol.1
-
-
Carnero, A.1
Lleonart, M.E.2
-
4
-
-
52549087785
-
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
-
[4] Visvader, J.E., Lindeman, G.J., Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8 (2008), 755–768.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 755-768
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
5
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
[5] Bao, S., Wu, Q., McLendon, R.E., Hao, Y., Shi, Q., Hjelmeland, A.B., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444 (2006), 756–760.
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
Hao, Y.4
Shi, Q.5
Hjelmeland, A.B.6
-
6
-
-
84867212473
-
Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells
-
[6] Chow, E.K., Fan, L.L., Chen, X., Bishop, J.M., Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells. Hepatology 56 (2012), 1331–1341.
-
(2012)
Hepatology
, vol.56
, pp. 1331-1341
-
-
Chow, E.K.1
Fan, L.L.2
Chen, X.3
Bishop, J.M.4
-
7
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
[7] Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367 (1994), 645–648.
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
-
8
-
-
84951750638
-
CD133 overexpression correlates with clinicopathological features of gastric cancer patients and its impact on survival: a systematic review and meta-analysis
-
[8] Yiming, L., Yunshan, G., Bo, M., Yu, Z., Tao, W., Gengfang, L., et al. CD133 overexpression correlates with clinicopathological features of gastric cancer patients and its impact on survival: a systematic review and meta-analysis. Oncotarget 6 (2015), 42019–42027.
-
(2015)
Oncotarget
, vol.6
, pp. 42019-42027
-
-
Yiming, L.1
Yunshan, G.2
Bo, M.3
Yu, Z.4
Tao, W.5
Gengfang, L.6
-
9
-
-
80053174609
-
CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers
-
[9] Olsson, E., Honeth, G., Bendahl, P.O., Saal, L.H., Gruvberger-Saal, S., Ringner, M., et al. CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. BMC Cancer, 11, 2011, 418.
-
(2011)
BMC Cancer
, vol.11
, pp. 418
-
-
Olsson, E.1
Honeth, G.2
Bendahl, P.O.3
Saal, L.H.4
Gruvberger-Saal, S.5
Ringner, M.6
-
10
-
-
84866431367
-
Biomarker and pharmacologic evaluation of the gamma-secretase inhibitor PF-03084014 in breast cancer models
-
[10] Zhang, C.C., Pavlicek, A., Zhang, Q., Lira, M.E., Painter, C.L., Yan, Z., et al. Biomarker and pharmacologic evaluation of the gamma-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res 18 (2012), 5008–5019.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5008-5019
-
-
Zhang, C.C.1
Pavlicek, A.2
Zhang, Q.3
Lira, M.E.4
Painter, C.L.5
Yan, Z.6
-
11
-
-
50649125794
-
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor
-
[11] Osipo, C., Patel, P., Rizzo, P., Clementz, A.G., Hao, L., Golde, T.E., et al. ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene 27 (2008), 5019–5032.
-
(2008)
Oncogene
, vol.27
, pp. 5019-5032
-
-
Osipo, C.1
Patel, P.2
Rizzo, P.3
Clementz, A.G.4
Hao, L.5
Golde, T.E.6
-
12
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
[12] Sekulic, A., Migden, M.R., Oro, A.E., Dirix, L., Lewis, K.D., Hainsworth, J.D., et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med 366 (2012), 2171–2179.
-
(2012)
N Engl J Med
, vol.366
, pp. 2171-2179
-
-
Sekulic, A.1
Migden, M.R.2
Oro, A.E.3
Dirix, L.4
Lewis, K.D.5
Hainsworth, J.D.6
-
13
-
-
38349165576
-
Identification of cells initiating human melanomas
-
[13] Schatton, T., Murphy, G.F., Frank, N.Y., Yamaura, K., Waaga-Gasser, A.M., Gasser, M., et al. Identification of cells initiating human melanomas. Nature 451 (2008), 345–349.
-
(2008)
Nature
, vol.451
, pp. 345-349
-
-
Schatton, T.1
Murphy, G.F.2
Frank, N.Y.3
Yamaura, K.4
Waaga-Gasser, A.M.5
Gasser, M.6
-
14
-
-
84884846749
-
The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis
-
[14] Wouters, J., Stas, M., Gremeaux, L., Govaere, O., Van den Broeck, A., Maes, H., et al. The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis. PLoS ONE, 8, 2013, e76550.
-
(2013)
PLoS ONE
, vol.8
, pp. e76550
-
-
Wouters, J.1
Stas, M.2
Gremeaux, L.3
Govaere, O.4
Van den Broeck, A.5
Maes, H.6
-
15
-
-
20144364789
-
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
-
[15] Frank, N.Y., Margaryan, A., Huang, Y., Schatton, T., Waaga-Gasser, A.M., Gasser, M., et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res 65 (2005), 4320–4333.
-
(2005)
Cancer Res
, vol.65
, pp. 4320-4333
-
-
Frank, N.Y.1
Margaryan, A.2
Huang, Y.3
Schatton, T.4
Waaga-Gasser, A.M.5
Gasser, M.6
-
16
-
-
84905444205
-
CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance
-
[16] Yoon, C., Park do J, Schmidt B, Thomas NJ, Lee HJ, Kim TS, J., et al. CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance. Clin Cancer Res 20 (2014), 3974–3988.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 3974-3988
-
-
Yoon, C.1
Park do J, Schmidt B, Thomas NJ, Lee HJ, Kim TS, J.2
-
17
-
-
84883244302
-
Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo
-
[17] Huang, J., Li, C., Wang, Y., Lv, H., Guo, Y., Dai, H., et al. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clin Immunol 149 (2013), 156–168.
-
(2013)
Clin Immunol
, vol.149
, pp. 156-168
-
-
Huang, J.1
Li, C.2
Wang, Y.3
Lv, H.4
Guo, Y.5
Dai, H.6
-
18
-
-
84943145003
-
Human renal normal, tumoral, and cancer stem cells express membrane-bound interleukin-15 isoforms displaying different functions
-
[18] Azzi, S., Gallerne, C., Romei, C., Le Coz, V., Gangemi, R., Khawam, K., et al. Human renal normal, tumoral, and cancer stem cells express membrane-bound interleukin-15 isoforms displaying different functions. Neoplasia 17 (2015), 509–517.
-
(2015)
Neoplasia
, vol.17
, pp. 509-517
-
-
Azzi, S.1
Gallerne, C.2
Romei, C.3
Le Coz, V.4
Gangemi, R.5
Khawam, K.6
-
19
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
[19] Olive, K.P., Jacobetz, M.A., Davidson, C.J., Gopinathan, A., McIntyre, D., Honess, D., et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324 (2009), 1457–1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
-
20
-
-
84866021276
-
Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells
-
[20] Domingo-Domenech, J., Vidal, S.J., Rodriguez-Bravo, V., Castillo-Martin, M., Quinn, S.A., Rodriguez-Barrueco, R., et al. Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells. Cancer Cell 22 (2012), 373–388.
-
(2012)
Cancer Cell
, vol.22
, pp. 373-388
-
-
Domingo-Domenech, J.1
Vidal, S.J.2
Rodriguez-Bravo, V.3
Castillo-Martin, M.4
Quinn, S.A.5
Rodriguez-Barrueco, R.6
-
21
-
-
84863938543
-
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
-
[21] Gurney, A., Axelrod, F., Bond, C.J., Cain, J., Chartier, C., Donigan, L., et al. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci USA 109 (2012), 11717–11722.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 11717-11722
-
-
Gurney, A.1
Axelrod, F.2
Bond, C.J.3
Cain, J.4
Chartier, C.5
Donigan, L.6
-
22
-
-
84922611324
-
Suppression of cancer relapse and metastasis by inhibiting cancer stemness
-
[22] Li, Y., Rogoff, H.A., Keates, S., Gao, Y., Murikipudi, S., Mikule, K., et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci USA 112 (2015), 1839–1844.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 1839-1844
-
-
Li, Y.1
Rogoff, H.A.2
Keates, S.3
Gao, Y.4
Murikipudi, S.5
Mikule, K.6
-
23
-
-
84978268586
-
A phase II study to assess vismodegib in the neoadjuvant treatment of locally advanced basal cell carcinoma (laBCC): the Vismodegib Neoadjuvant (VISMONEO) study
-
[23] L.M., A phase II study to assess vismodegib in the neoadjuvant treatment of locally advanced basal cell carcinoma (laBCC): the Vismodegib Neoadjuvant (VISMONEO) study. J Clin Oncol, 32, 2014.
-
(2014)
J Clin Oncol
, vol.32
-
-
L.M.1
-
24
-
-
85006576907
-
A phase 1 dose-escalation study of BBI503, a first-in-class cancer stemness kinase inhibitor in adult patients with advanced solid tumors
-
[24] Scott, A.L., William Jeffery Edenfield, D.J., Stephenson, Joe, Keller, Deborah, Hitron, Matthew, Li, Wei, et al. A phase 1 dose-escalation study of BBI503, a first-in-class cancer stemness kinase inhibitor in adult patients with advanced solid tumors. J Clin Oncol, 32, 2014, 2527.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2527
-
-
Scott, A.L.1
William Jeffery Edenfield, D.J.2
Stephenson, J.3
Keller, D.4
Hitron, M.5
Li, W.6
-
25
-
-
84978265278
-
Phase 1 extension study of BBI503, a first-in-class cancer stemness kinase inhibitor, in patients with advanced colorectal cancer
-
[25] Derek, J., Jonker, S.A.L., Gregory, Michael Cote, Keuth, Flaherty, Fuchs, Charles S., Rashmi, Chugh, et al. Phase 1 extension study of BBI503, a first-in-class cancer stemness kinase inhibitor, in patients with advanced colorectal cancer. J Clin Oncol, 33, 2015, 3615.
-
(2015)
J Clin Oncol
, vol.33
, pp. 3615
-
-
Derek, J.1
Jonker, S.A.L.2
Gregory, M.C.3
Keuth, F.4
Fuchs, C.S.5
Rashmi, C.6
-
26
-
-
84864018642
-
Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors
-
[26] Tolcher, A.W., Messersmith, W.A., Mikulski, S.M., Papadopoulos, K.P., Kwak, E.L., Gibbon, D.G., et al. Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. J Clin Oncol 30 (2012), 2348–2353.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2348-2353
-
-
Tolcher, A.W.1
Messersmith, W.A.2
Mikulski, S.M.3
Papadopoulos, K.P.4
Kwak, E.L.5
Gibbon, D.G.6
-
27
-
-
84920509474
-
A Phase I, dose-finding study in patients with advanced solid malignancies of the oral gamma-secretase inhibitor PF-03084014
-
[27] Messersmith, W.A., Shapiro, G.I., Cleary, J.M., Jimeno, A., Dasari, A., Huang, B, et al. A Phase I, dose-finding study in patients with advanced solid malignancies of the oral gamma-secretase inhibitor PF-03084014. Clin Cancer Res, 2015, 60–67.
-
(2015)
Clin Cancer Res
, pp. 60-67
-
-
Messersmith, W.A.1
Shapiro, G.I.2
Cleary, J.M.3
Jimeno, A.4
Dasari, A.5
Huang, B.6
-
28
-
-
84879487108
-
Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockade
-
[28] Chu, Q., Orr, B.A., Semenkow, S., Bar, E.E., Eberhart, C.G., Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockade. Clin Cancer Res 19 (2013), 3224–3233.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3224-3233
-
-
Chu, Q.1
Orr, B.A.2
Semenkow, S.3
Bar, E.E.4
Eberhart, C.G.5
-
29
-
-
34447310236
-
Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis
-
[discussion 31]
-
[29] Shibuya, M., Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. Angiogenesis 9 (2006), 225–230 [discussion 31].
-
(2006)
Angiogenesis
, vol.9
, pp. 225-230
-
-
Shibuya, M.1
-
30
-
-
84883185608
-
A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
-
[30] Sahebjam, S., Bedard, P.L., Castonguay, V., Chen, Z., Reedijk, M., Liu, G., et al. A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503). Br J Cancer 109 (2013), 943–949.
-
(2013)
Br J Cancer
, vol.109
, pp. 943-949
-
-
Sahebjam, S.1
Bedard, P.L.2
Castonguay, V.3
Chen, Z.4
Reedijk, M.5
Liu, G.6
-
31
-
-
12444279265
-
On the origin of cancer cells
-
[31] Warburg, O., On the origin of cancer cells. Science 123 (1956), 309–314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
32
-
-
84942849998
-
Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition
-
[32] Lee, E., Yang, J., Ku, M., Kim, N.H., Park, Y., Park, C.B., et al. Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition. Cell Death Dis, 6, 2015, e1805.
-
(2015)
Cell Death Dis
, vol.6
, pp. e1805
-
-
Lee, E.1
Yang, J.2
Ku, M.3
Kim, N.H.4
Park, Y.5
Park, C.B.6
-
33
-
-
84921816801
-
Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells
-
[33] Shibuya, K., Okada, M., Suzuki, S., Seino, M., Seino, S., Takeda, H., et al. Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells. Oncotarget 6 (2015), 651–661.
-
(2015)
Oncotarget
, vol.6
, pp. 651-661
-
-
Shibuya, K.1
Okada, M.2
Suzuki, S.3
Seino, M.4
Seino, S.5
Takeda, H.6
-
34
-
-
84937468857
-
How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
-
[34] Lincet, H., Icard, P., How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?. Oncogene 34 (2015), 3751–3759.
-
(2015)
Oncogene
, vol.34
, pp. 3751-3759
-
-
Lincet, H.1
Icard, P.2
-
35
-
-
84857975015
-
Metformin: multi-faceted protection against cancer
-
[35] Del Barco, S., Vazquez-Martin, A., Cufi, S., Oliveras-Ferraros, C., Bosch-Barrera, J., Joven, J., et al. Metformin: multi-faceted protection against cancer. Oncotarget 2 (2011), 896–917.
-
(2011)
Oncotarget
, vol.2
, pp. 896-917
-
-
Del Barco, S.1
Vazquez-Martin, A.2
Cufi, S.3
Oliveras-Ferraros, C.4
Bosch-Barrera, J.5
Joven, J.6
-
36
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
[36] Kondoh, H., Lleonart, M.E., Gil, J., Wang, J., Degan, P., Peters, G., et al. Glycolytic enzymes can modulate cellular life span. Cancer Res 65 (2005), 177–185.
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
-
37
-
-
33846420629
-
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
-
[37] Kondoh, H., Lleonart, M.E., Nakashima, Y., Yokode, M., Tanaka, M., Bernard, D., et al. A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid Redox Signal 9 (2007), 293–299.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 293-299
-
-
Kondoh, H.1
Lleonart, M.E.2
Nakashima, Y.3
Yokode, M.4
Tanaka, M.5
Bernard, D.6
-
38
-
-
84946903513
-
Oxidative stress inhibits distant metastasis by human melanoma cells
-
[38] Piskounova, E., Agathocleous, M., Murphy, M.M., Hu, Z., Huddlestun, S.E., Zhao, Z., et al. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature, 2015.
-
(2015)
Nature
-
-
Piskounova, E.1
Agathocleous, M.2
Murphy, M.M.3
Hu, Z.4
Huddlestun, S.E.5
Zhao, Z.6
-
39
-
-
35148842462
-
MAP17 enhances the malignant behavior of tumor cells through ROS increase
-
[39] Guijarro, M.V., Leal, J.F., Blanco-Aparicio, C., Alonso, S., Fominaya, J., Lleonart, M., et al. MAP17 enhances the malignant behavior of tumor cells through ROS increase. Carcinogenesis 28 (2007), 2096–2104.
-
(2007)
Carcinogenesis
, vol.28
, pp. 2096-2104
-
-
Guijarro, M.V.1
Leal, J.F.2
Blanco-Aparicio, C.3
Alonso, S.4
Fominaya, J.5
Lleonart, M.6
-
40
-
-
84942155861
-
MAP17 (PDZKIP1) expression determines sensitivity to the proteasomal inhibitor bortezomib by preventing cytoprotective autophagy and NFkappaB activation in breast cancer
-
[40] Munoz-Galvan, S., Gutierrez, G., Perez, M., Carnero, A., MAP17 (PDZKIP1) expression determines sensitivity to the proteasomal inhibitor bortezomib by preventing cytoprotective autophagy and NFkappaB activation in breast cancer. Mol Cancer Ther 14 (2015), 1454–1465.
-
(2015)
Mol Cancer Ther
, vol.14
, pp. 1454-1465
-
-
Munoz-Galvan, S.1
Gutierrez, G.2
Perez, M.3
Carnero, A.4
-
41
-
-
84953872444
-
Disruption of the ribosomal P complex leads to stress-induced autophagy
-
[41] Artero-Castro, A., Perez-Alea, M., Feliciano, A., Leal, J.A., Genestar, M., Castellvi, J., et al. Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy 11 (2015), 1499–1519.
-
(2015)
Autophagy
, vol.11
, pp. 1499-1519
-
-
Artero-Castro, A.1
Perez-Alea, M.2
Feliciano, A.3
Leal, J.A.4
Genestar, M.5
Castellvi, J.6
-
42
-
-
24944486664
-
Resistance to paclitaxel is proportional to cellular total antioxidant capacity
-
[42] Ramanathan, B., Jan, K.Y., Chen, C.H., Hour, T.C., Yu, H.J., Pu, Y.S., Resistance to paclitaxel is proportional to cellular total antioxidant capacity. Cancer Res 65 (2005), 8455–8460.
-
(2005)
Cancer Res
, vol.65
, pp. 8455-8460
-
-
Ramanathan, B.1
Jan, K.Y.2
Chen, C.H.3
Hour, T.C.4
Yu, H.J.5
Pu, Y.S.6
-
43
-
-
64749093574
-
Association of reactive oxygen species levels and radioresistance in cancer stem cells
-
[43] Diehn, M., Cho, R.W., Lobo, N.A., Kalisky, T., Dorie, M.J., Kulp, A.N., et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458 (2009), 780–783.
-
(2009)
Nature
, vol.458
, pp. 780-783
-
-
Diehn, M.1
Cho, R.W.2
Lobo, N.A.3
Kalisky, T.4
Dorie, M.J.5
Kulp, A.N.6
-
44
-
-
84864987692
-
Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon
-
[44] Kim, H.M., Haraguchi, N., Ishii, H., Ohkuma, M., Okano, M., Mimori, K., et al. Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon. Ann Surg Oncol 19:Suppl 3 (2012), S539–S548.
-
(2012)
Ann Surg Oncol
, vol.19
, pp. S539-S548
-
-
Kim, H.M.1
Haraguchi, N.2
Ishii, H.3
Ohkuma, M.4
Okano, M.5
Mimori, K.6
-
45
-
-
0027326559
-
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes
-
[45] Uchida, K., Szweda, L.I., Chae, H.Z., Stadtman, E.R., Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Proc Natl Acad Sci USA 90 (1993), 8742–8746.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8742-8746
-
-
Uchida, K.1
Szweda, L.I.2
Chae, H.Z.3
Stadtman, E.R.4
-
46
-
-
0026644834
-
Cyclophosphamide resistance in medulloblastoma
-
[46] Friedman, H.S., Colvin, O.M., Kaufmann, S.H., Ludeman, S.M., Bullock, N., Bigner, D.D., et al. Cyclophosphamide resistance in medulloblastoma. Cancer Res 52 (1992), 5373–5378.
-
(1992)
Cancer Res
, vol.52
, pp. 5373-5378
-
-
Friedman, H.S.1
Colvin, O.M.2
Kaufmann, S.H.3
Ludeman, S.M.4
Bullock, N.5
Bigner, D.D.6
-
47
-
-
79960401862
-
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
-
[47] Wei, H., Wei, S., Gan, B., Peng, X., Zou, W., Guan, J.L., Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 25 (2011), 1510–1527.
-
(2011)
Genes Dev
, vol.25
, pp. 1510-1527
-
-
Wei, H.1
Wei, S.2
Gan, B.3
Peng, X.4
Zou, W.5
Guan, J.L.6
-
48
-
-
84906283311
-
Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1
-
[48] Choi, D.S., Blanco, E., Kim, Y.S., Rodriguez, A.A., Zhao, H., Huang, T.H., et al. Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1. Stem Cells 32 (2014), 2309–2323.
-
(2014)
Stem Cells
, vol.32
, pp. 2309-2323
-
-
Choi, D.S.1
Blanco, E.2
Kim, Y.S.3
Rodriguez, A.A.4
Zhao, H.5
Huang, T.H.6
-
49
-
-
78650599928
-
What is the malignant nature of human ductal carcinoma in situ?
-
[49] Espina, V., Liotta, L.A., What is the malignant nature of human ductal carcinoma in situ?. Nat Rev Cancer 11 (2011), 68–75.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 68-75
-
-
Espina, V.1
Liotta, L.A.2
-
50
-
-
84925281259
-
Autophagy contributes to the enrichment and survival of colorectal cancer stem cells under oxaliplatin treatment
-
[50] Yang, H.Z., Ma, Y., Zhou, Y., Xu, L.M., Chen, X.J., Ding, W.B., et al. Autophagy contributes to the enrichment and survival of colorectal cancer stem cells under oxaliplatin treatment. Cancer Lett 361 (2015), 128–136.
-
(2015)
Cancer Lett
, vol.361
, pp. 128-136
-
-
Yang, H.Z.1
Ma, Y.2
Zhou, Y.3
Xu, L.M.4
Chen, X.J.5
Ding, W.B.6
-
51
-
-
84880202019
-
Autolysosomal beta-catenin degradation regulates Wnt-autophagy-p62 crosstalk
-
[51] Petherick, K.J., Williams, A.C., Lane, J.D., Ordonez-Moran, P., Huelsken, J., Collard, T.J., et al. Autolysosomal beta-catenin degradation regulates Wnt-autophagy-p62 crosstalk. EMBO J 32 (2013), 1903–1916.
-
(2013)
EMBO J
, vol.32
, pp. 1903-1916
-
-
Petherick, K.J.1
Williams, A.C.2
Lane, J.D.3
Ordonez-Moran, P.4
Huelsken, J.5
Collard, T.J.6
-
52
-
-
84883211035
-
Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
-
[52] Wang, Y., Han, C., Lu, L., Magliato, S., Wu, T., Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology 58 (2013), 995–1010.
-
(2013)
Hepatology
, vol.58
, pp. 995-1010
-
-
Wang, Y.1
Han, C.2
Lu, L.3
Magliato, S.4
Wu, T.5
-
53
-
-
84925442031
-
Involvement of autophagy in melatonin-induced cytotoxicity in glioma-initiating cells
-
[53] Martin, V., Sanchez-Sanchez, A.M., Puente-Moncada, N., Gomez-Lobo, M., Alvarez-Vega, M.A., Antolin, I., et al. Involvement of autophagy in melatonin-induced cytotoxicity in glioma-initiating cells. J Pineal Res 57 (2014), 308–316.
-
(2014)
J Pineal Res
, vol.57
, pp. 308-316
-
-
Martin, V.1
Sanchez-Sanchez, A.M.2
Puente-Moncada, N.3
Gomez-Lobo, M.4
Alvarez-Vega, M.A.5
Antolin, I.6
-
54
-
-
84861882582
-
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells
-
[54] Tsuyada, A., Chow, A., Wu, J., Somlo, G., Chu, P., Loera, S., et al. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res 72 (2012), 2768–2779.
-
(2012)
Cancer Res
, vol.72
, pp. 2768-2779
-
-
Tsuyada, A.1
Chow, A.2
Wu, J.3
Somlo, G.4
Chu, P.5
Loera, S.6
-
55
-
-
84931275698
-
Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties
-
[55] Bhuvanalakshmi, G., Arfuso, F., Millward, M., Dharmarajan, A., Warrier, S., Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties. PLoS ONE, 10, 2015, e0127517.
-
(2015)
PLoS ONE
, vol.10
, pp. e0127517
-
-
Bhuvanalakshmi, G.1
Arfuso, F.2
Millward, M.3
Dharmarajan, A.4
Warrier, S.5
-
56
-
-
84948735803
-
CD40 controls CXCR5-induced recruitment of myeloid-derived suppressor cells to gastric cancer
-
[56] Ding, Y., Shen, J., Zhang, G., Chen, X., Wu, J., Chen, W., CD40 controls CXCR5-induced recruitment of myeloid-derived suppressor cells to gastric cancer. Oncotarget 6 (2015), 38901–38911.
-
(2015)
Oncotarget
, vol.6
, pp. 38901-38911
-
-
Ding, Y.1
Shen, J.2
Zhang, G.3
Chen, X.4
Wu, J.5
Chen, W.6
-
57
-
-
84963722251
-
Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell
-
[57] Wang, Z., Sun, J., Feng, Y., Tian, X., Wang, B., Zhou, Y., Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell. Tumour Biol, 2016.
-
(2016)
Tumour Biol
-
-
Wang, Z.1
Sun, J.2
Feng, Y.3
Tian, X.4
Wang, B.5
Zhou, Y.6
-
58
-
-
84949599509
-
BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia
-
[58] Chen, S.S., Chang, B.Y., Chang, S., Tong, T., Ham, S., Sherry, B., et al. BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia. Leukemia 30 (2016), 833–843.
-
(2016)
Leukemia
, vol.30
, pp. 833-843
-
-
Chen, S.S.1
Chang, B.Y.2
Chang, S.3
Tong, T.4
Ham, S.5
Sherry, B.6
-
59
-
-
84954209322
-
The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells
-
[59] Boyle, S.T., Ingman, W.V., Poltavets, V., Faulkner, J.W., Whitfield, R.J., McColl, S.R., et al. The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells. Oncogene 35 (2016), 105–115.
-
(2016)
Oncogene
, vol.35
, pp. 105-115
-
-
Boyle, S.T.1
Ingman, W.V.2
Poltavets, V.3
Faulkner, J.W.4
Whitfield, R.J.5
McColl, S.R.6
-
60
-
-
84927574151
-
Inhibitors of BCR signalling interrupt the survival signal mediated by the micro-environment in mantle cell lymphoma
-
[60] Bernard, S., Danglade, D., Gardano, L., Laguillier, C., Lazarian, G., Roger, C., et al. Inhibitors of BCR signalling interrupt the survival signal mediated by the micro-environment in mantle cell lymphoma. Int J Cancer 136 (2015), 2761–2774.
-
(2015)
Int J Cancer
, vol.136
, pp. 2761-2774
-
-
Bernard, S.1
Danglade, D.2
Gardano, L.3
Laguillier, C.4
Lazarian, G.5
Roger, C.6
-
61
-
-
84897451152
-
A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor
-
[61] Burke, R.T., Meadows, S., Loriaux, M.M., Currie, K.S., Mitchell, S.A., Maciejewski, P., et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget 5 (2014), 908–915.
-
(2014)
Oncotarget
, vol.5
, pp. 908-915
-
-
Burke, R.T.1
Meadows, S.2
Loriaux, M.M.3
Currie, K.S.4
Mitchell, S.A.5
Maciejewski, P.6
-
62
-
-
4344707313
-
Quantifying transient hypoxia in human tumor xenografts by flow cytometry
-
[62] Bennewith, K.L., Durand, R.E., Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Res 64 (2004), 6183–6189.
-
(2004)
Cancer Res
, vol.64
, pp. 6183-6189
-
-
Bennewith, K.L.1
Durand, R.E.2
-
63
-
-
84928139478
-
CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer
-
[63] Cheah, M.T., Chen, J.Y., Sahoo, D., Contreras-Trujillo, H., Volkmer, A.K., Scheeren, F.A., et al. CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer. Proc Natl Acad Sci USA 112 (2015), 4725–4730.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 4725-4730
-
-
Cheah, M.T.1
Chen, J.Y.2
Sahoo, D.3
Contreras-Trujillo, H.4
Volkmer, A.K.5
Scheeren, F.A.6
-
64
-
-
84891121499
-
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4
-
[64] Volonte, A., Di Tomaso, T., Spinelli, M., Todaro, M., Sanvito, F., Albarello, L., et al. Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4. J Immunol 192 (2014), 523–532.
-
(2014)
J Immunol
, vol.192
, pp. 523-532
-
-
Volonte, A.1
Di Tomaso, T.2
Spinelli, M.3
Todaro, M.4
Sanvito, F.5
Albarello, L.6
-
65
-
-
76649113726
-
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
-
[65] Ginestier, C., Liu, S., Diebel, M.E., Korkaya, H., Luo, M., Brown, M., et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Investig 120 (2010), 485–497.
-
(2010)
J Clin Investig
, vol.120
, pp. 485-497
-
-
Ginestier, C.1
Liu, S.2
Diebel, M.E.3
Korkaya, H.4
Luo, M.5
Brown, M.6
-
66
-
-
67649864077
-
Natural killer cells kill human melanoma cells with characteristics of cancer stem cells
-
[66] Pietra, G., Manzini, C., Vitale, M., Balsamo, M., Ognio, E., Boitano, M., et al. Natural killer cells kill human melanoma cells with characteristics of cancer stem cells. Int Immunol 21 (2009), 793–801.
-
(2009)
Int Immunol
, vol.21
, pp. 793-801
-
-
Pietra, G.1
Manzini, C.2
Vitale, M.3
Balsamo, M.4
Ognio, E.5
Boitano, M.6
-
67
-
-
4744357460
-
Overview of interleukin-2 function, production and clinical applications
-
[67] Gaffen, S.L., Liu, K.D., Overview of interleukin-2 function, production and clinical applications. Cytokine 28 (2004), 109–123.
-
(2004)
Cytokine
, vol.28
, pp. 109-123
-
-
Gaffen, S.L.1
Liu, K.D.2
-
68
-
-
84868255419
-
Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?
-
[68] Klebanoff, C.A., Gattinoni, L., Restifo, N.P., Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?. J Immunother 35 (2012), 651–660.
-
(2012)
J Immunother
, vol.35
, pp. 651-660
-
-
Klebanoff, C.A.1
Gattinoni, L.2
Restifo, N.P.3
-
69
-
-
84975105592
-
CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer
-
[69] Byrne, K.T., Vonderheide, R.H., CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. Cell Rep 15 (2016), 2719–2732.
-
(2016)
Cell Rep
, vol.15
, pp. 2719-2732
-
-
Byrne, K.T.1
Vonderheide, R.H.2
-
70
-
-
84928174677
-
Therapy-induced tumour secretomes promote resistance and tumour progression
-
[70] Obenauf, A.C., Zou, Y., Ji, A.L., Vanharanta, S., Shu, W., Shi, H., et al. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature 520 (2015), 368–372.
-
(2015)
Nature
, vol.520
, pp. 368-372
-
-
Obenauf, A.C.1
Zou, Y.2
Ji, A.L.3
Vanharanta, S.4
Shu, W.5
Shi, H.6
-
71
-
-
77749317560
-
Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
-
[71] Saito, Y., Uchida, N., Tanaka, S., Suzuki, N., Tomizawa-Murasawa, M., Sone, A., et al. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nat Biotechnol 28 (2010), 275–280.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 275-280
-
-
Saito, Y.1
Uchida, N.2
Tanaka, S.3
Suzuki, N.4
Tomizawa-Murasawa, M.5
Sone, A.6
-
72
-
-
44049100934
-
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
-
[72] Li, X., Lewis, M.T., Huang, J., Gutierrez, C., Osborne, C.K., Wu, M.F., et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 100 (2008), 672–679.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 672-679
-
-
Li, X.1
Lewis, M.T.2
Huang, J.3
Gutierrez, C.4
Osborne, C.K.5
Wu, M.F.6
-
73
-
-
44649133215
-
A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes
-
[73] Liu, Y., Lu, W.L., Guo, J., Du, J., Li, T., Wu, J.W., et al. A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes. J Controlled Release 129 (2008), 18–25.
-
(2008)
J Controlled Release
, vol.129
, pp. 18-25
-
-
Liu, Y.1
Lu, W.L.2
Guo, J.3
Du, J.4
Li, T.5
Wu, J.W.6
-
74
-
-
68749099671
-
Identification of selective inhibitors of cancer stem cells by high-throughput screening
-
[74] Gupta, P.B., Onder, T.T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R.A., et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 (2009), 645–659.
-
(2009)
Cell
, vol.138
, pp. 645-659
-
-
Gupta, P.B.1
Onder, T.T.2
Jiang, G.3
Tao, K.4
Kuperwasser, C.5
Weinberg, R.A.6
-
75
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
[75] Hirsch, H.A., Iliopoulos, D., Tsichlis, P.N., Struhl, K., Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69 (2009), 7507–7511.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
76
-
-
56449084185
-
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells
-
[76] Tazzari, P.L., Tabellini, G., Ricci, F., Papa, V., Bortul, R., Chiarini, F., et al. Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res 68 (2008), 9394–9403.
-
(2008)
Cancer Res
, vol.68
, pp. 9394-9403
-
-
Tazzari, P.L.1
Tabellini, G.2
Ricci, F.3
Papa, V.4
Bortul, R.5
Chiarini, F.6
-
77
-
-
80052662217
-
Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
-
[77] Piggott, L., Omidvar, N., Marti Perez, S., Eberl, M., Clarkson, R.W., Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Res, 13, 2011, R88.
-
(2011)
Breast Cancer Res
, vol.13
, pp. R88
-
-
Piggott, L.1
Omidvar, N.2
Marti Perez, S.3
Eberl, M.4
Clarkson, R.W.5
-
78
-
-
84900000022
-
CD44v8-10 is a cancer-specific marker for gastric cancer stem cells
-
[78] Lau, W.M., Teng, E., Chong, H.S., Lopez, K.A., Tay, A.Y., Salto-Tellez, M., et al. CD44v8-10 is a cancer-specific marker for gastric cancer stem cells. Cancer Res 74 (2014), 2630–2641.
-
(2014)
Cancer Res
, vol.74
, pp. 2630-2641
-
-
Lau, W.M.1
Teng, E.2
Chong, H.S.3
Lopez, K.A.4
Tay, A.Y.5
Salto-Tellez, M.6
-
79
-
-
84906779006
-
The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells
-
[79] Yao, H.J., Zhang, Y.G., Sun, L., Liu, Y., The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells. Biomaterials 35 (2014), 9208–9223.
-
(2014)
Biomaterials
, vol.35
, pp. 9208-9223
-
-
Yao, H.J.1
Zhang, Y.G.2
Sun, L.3
Liu, Y.4
-
80
-
-
84879604991
-
Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles
-
[80] Liu, Q., Li, R.T., Qian, H.Q., Wei, J., Xie, L., Shen, J., et al. Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles. Biomaterials 34 (2013), 7191–7203.
-
(2013)
Biomaterials
, vol.34
, pp. 7191-7203
-
-
Liu, Q.1
Li, R.T.2
Qian, H.Q.3
Wei, J.4
Xie, L.5
Shen, J.6
-
81
-
-
79952335251
-
Interaction of mesalasine (5-ASA) with translational initiation factors eIF4 partially explains 5-ASA anti-inflammatory and anti-neoplastic activities
-
[81] Lyakhovich, A., Michlmayr, A., Bakulina, A., Gerner, C., Oehler, R., Gasche, C., Interaction of mesalasine (5-ASA) with translational initiation factors eIF4 partially explains 5-ASA anti-inflammatory and anti-neoplastic activities. Med Chem 7 (2011), 92–98.
-
(2011)
Med Chem
, vol.7
, pp. 92-98
-
-
Lyakhovich, A.1
Michlmayr, A.2
Bakulina, A.3
Gerner, C.4
Oehler, R.5
Gasche, C.6
-
82
-
-
84920078382
-
Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis
-
[82] Kantara, C., O'Connell, M.R., Luthra, G., Gajjar, A., Sarkar, S., Ullrich, R.L., et al. Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis. Lab Invest 95 (2015), 100–112.
-
(2015)
Lab Invest
, vol.95
, pp. 100-112
-
-
Kantara, C.1
O'Connell, M.R.2
Luthra, G.3
Gajjar, A.4
Sarkar, S.5
Ullrich, R.L.6
-
83
-
-
84933279009
-
A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia
-
[83] Diaz-Padilla, I., Wilson, M.K., Clarke, B.A., Hirte, H.W., Welch, S.A., Mackay, H.J., et al. A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia. Gynecol Oncol 137 (2015), 216–222.
-
(2015)
Gynecol Oncol
, vol.137
, pp. 216-222
-
-
Diaz-Padilla, I.1
Wilson, M.K.2
Clarke, B.A.3
Hirte, H.W.4
Welch, S.A.5
Mackay, H.J.6
-
84
-
-
84921498604
-
Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933
-
[84] Lee, S.M., Moon, J., Redman, B.G., Chidiac, T., Flaherty, L.E., Zha, Y., et al. Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933. Cancer 121 (2015), 432–440.
-
(2015)
Cancer
, vol.121
, pp. 432-440
-
-
Lee, S.M.1
Moon, J.2
Redman, B.G.3
Chidiac, T.4
Flaherty, L.E.5
Zha, Y.6
-
85
-
-
84896391556
-
A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
-
[85] Richter, S., Bedard, P.L., Chen, E.X., Clarke, B.A., Tran, B., Hotte, S.J., et al. A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575). Invest New Drugs 32 (2014), 243–249.
-
(2014)
Invest New Drugs
, vol.32
, pp. 243-249
-
-
Richter, S.1
Bedard, P.L.2
Chen, E.X.3
Clarke, B.A.4
Tran, B.5
Hotte, S.J.6
-
86
-
-
84989350415
-
A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma
-
[86] Papayannidis, C., DeAngelo, D.J., Stock, W., Huang, B., Shaik, M.N., Cesari, R., et al. A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. Blood Cancer J, 5, 2015, e350.
-
(2015)
Blood Cancer J
, vol.5
, pp. e350
-
-
Papayannidis, C.1
DeAngelo, D.J.2
Stock, W.3
Huang, B.4
Shaik, M.N.5
Cesari, R.6
-
87
-
-
85014951347
-
Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the gamma-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
-
[87] Knoechel, B., Bhatt, A., Pan, L., Pedamallu, C.S., Severson, E., Gutierrez, A., et al. Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the gamma-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud, 1, 2015, a000539.
-
(2015)
Cold Spring Harb Mol Case Stud
, vol.1
, pp. a000539
-
-
Knoechel, B.1
Bhatt, A.2
Pan, L.3
Pedamallu, C.S.4
Severson, E.5
Gutierrez, A.6
-
88
-
-
84929331637
-
Discovery of clinical candidate BMS-906024: a potent pan-notch inhibitor for the treatment of leukemia and solid tumors
-
[88] Gavai, A.V., Quesnelle, C., Norris, D., Han, W.C., Gill, P., Shan, W., et al. Discovery of clinical candidate BMS-906024: a potent pan-notch inhibitor for the treatment of leukemia and solid tumors. ACS Med Chem Lett 6 (2015), 523–527.
-
(2015)
ACS Med Chem Lett
, vol.6
, pp. 523-527
-
-
Gavai, A.V.1
Quesnelle, C.2
Norris, D.3
Han, W.C.4
Gill, P.5
Shan, W.6
-
89
-
-
84940482116
-
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032
-
[89] Robinson, G.W., Orr, B.A., Wu, G., Gururangan, S., Lin, T., Qaddoumi, I., et al. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. J Clin Oncol 33 (2015), 2646–2654.
-
(2015)
J Clin Oncol
, vol.33
, pp. 2646-2654
-
-
Robinson, G.W.1
Orr, B.A.2
Wu, G.3
Gururangan, S.4
Lin, T.5
Qaddoumi, I.6
-
90
-
-
79954611501
-
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
-
[90] LoRusso, P.M., Rudin, C.M., Reddy, J.C., Tibes, R., Weiss, G.J., Borad, M.J., et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res 17 (2011), 2502–2511.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2502-2511
-
-
LoRusso, P.M.1
Rudin, C.M.2
Reddy, J.C.3
Tibes, R.4
Weiss, G.J.5
Borad, M.J.6
-
91
-
-
84919456263
-
Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28
-
[91] Le, P.N., McDermott, J.D., Jimeno, A., Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28. Pharmacol Ther 146 (2015), 1–11.
-
(2015)
Pharmacol Ther
, vol.146
, pp. 1-11
-
-
Le, P.N.1
McDermott, J.D.2
Jimeno, A.3
-
92
-
-
80053542413
-
Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8(+) T cells
-
[92] Visus, C., Wang, Y., Lozano-Leon, A., Ferris, R.L., Silver, S., Szczepanski, M.J., et al. Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8(+) T cells. Clin Cancer Res 17 (2011), 6174–6184.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6174-6184
-
-
Visus, C.1
Wang, Y.2
Lozano-Leon, A.3
Ferris, R.L.4
Silver, S.5
Szczepanski, M.J.6
-
93
-
-
84878765030
-
Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer
-
[93] Yang, D.R., Ding, X.F., Luo, J., Shan, Y.X., Wang, R., Lin, S.J., et al. Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer. J Biol Chem 288 (2013), 16476–16483.
-
(2013)
J Biol Chem
, vol.288
, pp. 16476-16483
-
-
Yang, D.R.1
Ding, X.F.2
Luo, J.3
Shan, Y.X.4
Wang, R.5
Lin, S.J.6
-
94
-
-
65449177238
-
NK cells recognize and kill human glioblastoma cells with stem cell-like properties
-
[94] Castriconi, R., Daga, A., Dondero, A., Zona, G., Poliani, P.L., Melotti, A., et al. NK cells recognize and kill human glioblastoma cells with stem cell-like properties. J Immunol 182 (2009), 3530–3539.
-
(2009)
J Immunol
, vol.182
, pp. 3530-3539
-
-
Castriconi, R.1
Daga, A.2
Dondero, A.3
Zona, G.4
Poliani, P.L.5
Melotti, A.6
-
95
-
-
84873537569
-
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
-
[95] Kim, S.Y., Kang, J.W., Song, X., Kim, B.K., Yoo, Y.D., Kwon, Y.T., et al. Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal 25 (2013), 961–969.
-
(2013)
Cell Signal
, vol.25
, pp. 961-969
-
-
Kim, S.Y.1
Kang, J.W.2
Song, X.3
Kim, B.K.4
Yoo, Y.D.5
Kwon, Y.T.6
-
96
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
-
[96] Ansell, S.M., Lesokhin, A.M., Borrello, I., Halwani, A., Scott, E.C., Gutierrez, M., et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med 372 (2015), 311–319.
-
(2015)
N Engl J Med
, vol.372
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
Halwani, A.4
Scott, E.C.5
Gutierrez, M.6
-
97
-
-
33749515476
-
Targeting of CD44 eradicates human acute myeloid leukemic stem cells
-
[97] Jin, L., Hope, K.J., Zhai, Q., Smadja-Joffe, F., Dick, J.E., Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 12 (2006), 1167–1174.
-
(2006)
Nat Med
, vol.12
, pp. 1167-1174
-
-
Jin, L.1
Hope, K.J.2
Zhai, Q.3
Smadja-Joffe, F.4
Dick, J.E.5
-
98
-
-
84874857331
-
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab
-
[98] Ithimakin, S., Day, K.C., Malik, F., Zen, Q., Dawsey, S.J., Bersano-Begey, T.F., et al. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res 73 (2013), 1635–1646.
-
(2013)
Cancer Res
, vol.73
, pp. 1635-1646
-
-
Ithimakin, S.1
Day, K.C.2
Malik, F.3
Zen, Q.4
Dawsey, S.J.5
Bersano-Begey, T.F.6
-
99
-
-
80052446521
-
Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours
-
[99] Nicol, A.J., Tokuyama, H., Mattarollo, S.R., Hagi, T., Suzuki, K., Yokokawa, K., et al. Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours. Br J Cancer 105 (2011), 778–786.
-
(2011)
Br J Cancer
, vol.105
, pp. 778-786
-
-
Nicol, A.J.1
Tokuyama, H.2
Mattarollo, S.R.3
Hagi, T.4
Suzuki, K.5
Yokokawa, K.6
-
100
-
-
0033587721
-
CD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells
-
[100] Bonnet, D., Warren, E.H., Greenberg, P.D., Dick, J.E., Riddell, S.R., CD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. Proc Natl Acad Sci USA 96 (1999), 8639–8644.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8639-8644
-
-
Bonnet, D.1
Warren, E.H.2
Greenberg, P.D.3
Dick, J.E.4
Riddell, S.R.5
|