The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets

Diabetologia

Volumn 59, Issue 10, 2016, Pages 2166-2171

  Meier, Daniel T ^a,b   Entrup, Leon ^a,b   Templin, Andrew T ^a,b   Hogan, Meghan F ^a,b   Mellati, Mahnaz ^a,b   Zraika, Sakeneh ^a,b   Hull, Rebecca L ^a,b   Kahn, Steven E ^a,b  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Amylin; Amyloid; Beta cell; Insulin secretion; Islet; Islet amyloid polypeptide; Toxicity; Type 2 diabetes

Indexed keywords

AMYLIN; AMYLOID; INSULIN; LEVO GLUCOSE; S20G HUMAN ISLET AMYLOID POLYPEPTIDE; UNCLASSIFIED DRUG; GLUCOSE;

AMYLOIDOGENICITY; AMYLOIDOSIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BETA CELL AREA; CELL CULTURE; CELL ISOLATION; CELL LOSS; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENE MUTATION; GENOTYPE; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; WILD TYPE; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; MUTATION; PANCREAS ISLET;

AMYLOID; ANIMALS; APOPTOSIS; FEMALE; GLUCOSE; HUMANS; IN VITRO TECHNIQUES; INSULIN; INSULIN-SECRETING CELLS; ISLET AMYLOID POLYPEPTIDE; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MUTATION;

EID: 84978117019     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4045-x     Document Type: Article

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