High glucose concentration favors the selective secretion of islet amyloid polypeptide through a constitutive secretory pathway in human pancreatic islets

Pancreas

Volumn 22, Issue 3, 2001, Pages 307-310

  Gasa, R ^a,b   Gomis, R ^a,b   Casamitjana, R ^a,b   Novials, A ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Fundació Sardà Farriol ^*  (Spain)

Author keywords

Brefeldin A; Constitutive secretion; Diabetes; Human pancreatic islets; Islet amyloid polypeptide

Indexed keywords

AMYLIN; BREFELDIN A; EGTAZIC ACID; GLUCOSE; INSULIN; MESSENGER RNA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INSULIN RELEASE; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM;

AMYLOID; ANIMALS; BLOOD GLUCOSE; BREFELDIN A; CELLS, CULTURED; EGTAZIC ACID; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; RNA, MESSENGER;

EID: 0035086993     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200104000-00013     Document Type: Article

References (13)

1. Amylin compared with calcitonin-gene related peptide: Structure, biology and relevance to metabolic disease
2. Islet amyloid: A long recognised but underappreciated pathological feature of type 2 diabetes
3. Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway
4. Brefeldin A inhibits formation of constitutive secretory vesicles and immature secretory granules from the trans-Golgi network
5. Human islet function after automatic isolation and bovine serum albumin gradient purification
6. Regulation of islet amyloid polypeptide in human pancreatic islets
7. Co-secretion of amylin and insulin from isolated rat pancreas
8. Evidence for cosecretion of islet amyloid polypeptide and insulin by β cells
9. Newly synthesised proinsulin/insulin and stored insulin are released from pancreatic islets via a regulated rather than a constitutive pathway
10. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the B cell function
11. Signals related to glucose metabolism regulate islet amyloid polypeptide gene expression in human pancreatic islets
12. Human islet amyloid polypeptide expression in COS-1 cells: An in vitro model of intracellular amyloidogenesis
13. Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide