Enhanced in vitro production of amyloid-like fibrils from mutant (s20g) islet amyloid polypeptide

Amyloid

Volumn 8, Issue 4, 2001, Pages 242-249

  Ma, Z ^a   Westermark, G T ^a   Sakagashira, S ^a   Sanke, T ^a   Gustavsson, A ^a   Sakamoto, H ^a   Engstrom U ^a   Nanjo, K ^a   Westermark, P ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Dye fluorescence; Fibrillogenesis; Islet amyloid epolypeptide; Mutation; Type 2 diabetes

Indexed keywords

ACETIC ACID; AMYLIN; AMYLOID PROTEIN; CONGO RED; THIOFLAVINE;

AMINO ACID SUBSTITUTION; ARTICLE; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; JAPAN; LANGERHANS CELL; MISSENSE MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; STAINING;

EID: 0035672526     PISSN: 13506129     EISSN: None     Source Type: Journal    
DOI: 10.3109/13506120108993820     Document Type: Article

References (34)

1. The pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults
2. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: Quantitative changes in the pancreas in type 2 diabetes
3. Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and β-cell dysfunction
4. vy/a mice expressing human islet amyloid polypeptide
5. Extensive islet amyloid formation is induced by development of type II diabetes mellitus and contributes to its progression: Pathogenesis of diabetes in a mouse model
6. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
7. The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles
8. Islet amyloid polypeptide: Pinpointing amino acid residues linked to amyloid fibril
9. Effects of sequential proline substitutions on amyloid formation by human amylin20-29
10. Islet amyloid polypeptide (amylin): No evidence of an abnormal precursor sequence in 25 Type 2 (non-insulin-dependent) diabetic patients
11. The islet amyloid polypeptide gene and non-insulin-dependent diabetes mellitus in south Indians
12. Islet amyloid polypeptide gene: No evidence of abnormal promoter region in thirty-five type 2 diabetic patients
13. Missense mutation of amylin gene (S20G) in Japanese NIDDM patients
14. Acceleration of AA-amyloidosis by amyloid-like synthetic fibrils
15. On the binding of Congo red by amyloid
16. Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: Detection of amyloid aggregation in solution
17. Thioflavine T interaction with amyloid β-sheet structures
18. Quantification of b -sheet amyloid fibril structures with thioflavine T
19. Effects of beta cell granule components on human islet amyloid polypeptide fibril formation
20. Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP molecule in the amyloidogenesis
21. Staining methods for identification of amyloid in tissue
22. Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP
23. Fine structure of islets of Langerhans in insular amyloidosis
24. Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with species-specific occurrence of age-related diabetes mellitus
25. Interspecies sequence variations affect the kinetics and thermodynamics of amyloid formation: Peptide models of pancreatic amyloid
26. Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide
27. A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation
28. Islet amyloid polypeptide: Synthetic peptides for study of the pathogenesis of islet amyloid
29. Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin
30. Transthyretin mutations in health and disease
31. Setting the standards: Quality control in the secretory pathway
32. Insulin and islet amyloid polypeptide 'amylin' form stable molecular complexes in vitro affecting fibril formation
33. B cell granule peptides affect human islet amyloid polypeptide (IAPP) fibril formation in vitro
34. Human aging is associated with parallel reductions in insulin and amylin release