Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma

Experimental Hematology and Oncology

Volumn 4, Issue 1, 2015, Pages

  Koerber, Ruth Miriam ^a   Held, Stefanie Andrea Erika ^a   Heine, Annkristin ^a   Kotthoff, Philipp ^a   Daecke, Solveig Nora ^a   Bringmann, Anita ^a   Brossart, Peter ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Apoptosis; Multiple myeloma; Piceatannol; Plasmacell malignancy; R406; Signal transduction Bay61 3606; Spleen tyrosine kinase (Syk); Syk inhibitors; Tyrosine kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BAY 61 3606; CASPASE 3; CYTOCHROME C; DACTOLISIB; FOSTAMATINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PICEATANNOL; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG TARGETING; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MULTIPLE MYELOMA; MULTIPLE MYELOMA CELL LINE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; U266 CELL LINE; WESTERN BLOTTING;

EID: 84978022740     PISSN: None     EISSN: 21623619     Source Type: Journal    
DOI: 10.1186/s40164-015-0016-z     Document Type: Article

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