메뉴 건너뛰기




Volumn 318, Issue 3, 2004, Pages 691-697

LY294002 inhibits interferon-gamma-stimulated inducible nitric oxide synthase expression in BV2 microglial cells

Author keywords

Interferon gamma; LY294002; Microglia; Nitric oxide

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GAMMA INTERFERON; INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; UNCLASSIFIED DRUG;

EID: 2442554039     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.04.082     Document Type: Article
Times cited : (26)

References (33)
  • 3
    • 0027090310 scopus 로고
    • Activation of transcription by IFN-gamma: Tyrosine phosphorylation of a 91-kDa DNA binding protein
    • Shuai K., Schindler C., Prezioso V.R., Darnell J.E. Jr. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kDa DNA binding protein. Science. 258:1992;1808-1812
    • (1992) Science , vol.258 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell Jr., J.E.4
  • 4
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell J.E. Jr., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1994;1415-1421
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 5
    • 0028979707 scopus 로고
    • Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process
    • Greenlund A.C., Morales M.O., Viviano B.L., Yan H., Krolewski J., Schreiber R.D. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity. 2:1995;677-687
    • (1995) Immunity , vol.2 , pp. 677-687
    • Greenlund, A.C.1    Morales, M.O.2    Viviano, B.L.3    Yan, H.4    Krolewski, J.5    Schreiber, R.D.6
  • 6
    • 0028097932 scopus 로고
    • Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene
    • Pine R., Canova A., Schindler C. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. EMBO J. 13:1994;158-167
    • (1994) EMBO J. , vol.13 , pp. 158-167
    • Pine, R.1    Canova, A.2    Schindler, C.3
  • 9
    • 0027368278 scopus 로고
    • Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
    • Lowenstein C., Alley E., Raval P., Snowman A., Snyder S., Russell S., Murphy W. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. PNAS. 90:1993;9730-9734
    • (1993) PNAS , vol.90 , pp. 9730-9734
    • Lowenstein, C.1    Alley, E.2    Raval, P.3    Snowman, A.4    Snyder, S.5    Russell, S.6    Murphy, W.7
  • 10
    • 0027255749 scopus 로고
    • Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
    • Xie Q., Whisnant R., Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp. Med. 177:1993;1779-1784
    • (1993) J. Exp. Med. , vol.177 , pp. 1779-1784
    • Xie, Q.1    Whisnant, R.2    Nathan, C.3
  • 11
    • 0028106830 scopus 로고
    • Role of interferon regulatory factor 1 in induction of nitric oxide synthase
    • Martin E., Nathan C., Xie Q.W. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:1994;977-984
    • (1994) J. Exp. Med. , vol.180 , pp. 977-984
    • Martin, E.1    Nathan, C.2    Xie, Q.W.3
  • 12
    • 0027523467 scopus 로고
    • Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide- stimulated transcription from the murine IP-10 promoter
    • Ohmori Y., Hamilton T. Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J. Biol. Chem. 268:1993;6677-6688
    • (1993) J. Biol. Chem. , vol.268 , pp. 6677-6688
    • Ohmori, Y.1    Hamilton, T.2
  • 13
    • 0029034506 scopus 로고
    • The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha
    • Ohmori Y., Hamilton T. The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha. J. Immunol. 154:1995;5235-5244
    • (1995) J. Immunol. , vol.154 , pp. 5235-5244
    • Ohmori, Y.1    Hamilton, T.2
  • 14
    • 0030890933 scopus 로고    scopus 로고
    • Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
    • Order
    • Ahmed N.N., Grimes H.L., Bellacosa A., Chan T.O., Tsichlis P.N. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA. 94:1997;3627-3632. Order
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3627-3632
    • Ahmed, N.N.1    Grimes, H.L.2    Bellacosa, A.3    Chan, T.O.4    Tsichlis, P.N.5
  • 17
    • 0028856331 scopus 로고
    • When is a lipid kinase not a lipid kinase? When it is a protein kinase
    • Hunter T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell. 83:1995;1-4
    • (1995) Cell , vol.83 , pp. 1-4
    • Hunter, T.1
  • 18
    • 0028883178 scopus 로고
    • Phospholipid signaling
    • Divecha N., Irvine R.F. Phospholipid signaling. Cell. 80:1995;269-278
    • (1995) Cell , vol.80 , pp. 269-278
    • Divecha, N.1    Irvine, R.F.2
  • 19
    • 0033563141 scopus 로고    scopus 로고
    • Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages
    • Diaz-Guerra M.J., Castrillo A., Martin-Sanz P., Bosca L. Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages. J. Immunol. 162:1999;6184-6190
    • (1999) J. Immunol. , vol.162 , pp. 6184-6190
    • Diaz-Guerra, M.J.1    Castrillo, A.2    Martin-Sanz, P.3    Bosca, L.4
  • 20
    • 0033548627 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells
    • Pahan K., Raymond J.R., Singh I. Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells. J. Biol. Chem. 274:1999;7528-7536
    • (1999) J. Biol. Chem. , vol.274 , pp. 7528-7536
    • Pahan, K.1    Raymond, J.R.2    Singh, I.3
  • 21
    • 0030946256 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29
    • Wright K., Ward S.G., Kolios G., Westwick J. Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29. J. Biol. Chem. 272:1997;12626-12633
    • (1997) J. Biol. Chem. , vol.272 , pp. 12626-12633
    • Wright, K.1    Ward, S.G.2    Kolios, G.3    Westwick, J.4
  • 22
    • 0032534586 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: Differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production
    • Salh B., Wagey R., Marotta A., Tao J.S., Pelech S. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J. Immunol. 161:1998;6947-6954
    • (1998) J. Immunol. , vol.161 , pp. 6947-6954
    • Salh, B.1    Wagey, R.2    Marotta, A.3    Tao, J.S.4    Pelech, S.5
  • 23
    • 0037204864 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse Bv2 microglial cells
    • Han I.O., Kim K.W., Ryu J.H., Kim W.K. p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse Bv2 microglial cells. Neurosci. Lett. 325:2002;9-12
    • (2002) Neurosci. Lett. , vol.325 , pp. 9-12
    • Han, I.O.1    Kim, K.W.2    Ryu, J.H.3    Kim, W.K.4
  • 24
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 25
    • 0041837502 scopus 로고    scopus 로고
    • Synergistic expression of inducible nitric oxide synthase by phorbol ester and interferon-gamma is mediated through NF-kappaB and ERK in microglial cells
    • Han I.O., Kim H.S., Kim H.C., Joe E.H., Kim W.K. Synergistic expression of inducible nitric oxide synthase by phorbol ester and interferon-gamma is mediated through NF-kappaB and ERK in microglial cells. J. Neurosci. Res. 73:2003;659-669
    • (2003) J. Neurosci. Res. , vol.73 , pp. 659-669
    • Han, I.O.1    Kim, H.S.2    Kim, H.C.3    Joe, E.H.4    Kim, W.K.5
  • 26
    • 0032703254 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced microglial activation in culture: Temporal profiles of morphological change and release of cytokines and nitric oxide
    • Nakamura Y., Si Q.S., Kataoka K. Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide. Neurosci. Res. 35:1999;95-100
    • (1999) Neurosci. Res. , vol.35 , pp. 95-100
    • Nakamura, Y.1    Si, Q.S.2    Kataoka, K.3
  • 28
    • 0031587403 scopus 로고    scopus 로고
    • Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages
    • Park Y.C., Lee C.H., Kang H.S., Chung H.T., Kim H.D. Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages. Biochem. Biophys. Res. Commun. 240:1997;692-696
    • (1997) Biochem. Biophys. Res. Commun. , vol.240 , pp. 692-696
    • Park, Y.C.1    Lee, C.H.2    Kang, H.S.3    Chung, H.T.4    Kim, H.D.5
  • 29
    • 0031591592 scopus 로고    scopus 로고
    • Upstream NF-kappaB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-gamma plus lipopolysaccharide-induced RAW 264.7 macrophages
    • Kim Y.M., Lee B.S., Yi K.Y., Paik S.G. Upstream NF-kappaB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-gamma plus lipopolysaccharide-induced RAW 264.7 macrophages. Biochem. Biophys. Res. Commun. 236:1997;655-660
    • (1997) Biochem. Biophys. Res. Commun. , vol.236 , pp. 655-660
    • Kim, Y.M.1    Lee, B.S.2    Yi, K.Y.3    Paik, S.G.4
  • 30
    • 0033546410 scopus 로고    scopus 로고
    • Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription
    • Saura M., Zaragoza C., Bao C., McMillan A., Lowenstein C.J. Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription. J. Mol. Biol. 289:1999;459-471
    • (1999) J. Mol. Biol. , vol.289 , pp. 459-471
    • Saura, M.1    Zaragoza, C.2    Bao, C.3    McMillan, A.4    Lowenstein, C.J.5
  • 31
    • 0032759325 scopus 로고    scopus 로고
    • The CIS/SOCS proteins: A family of cytokine-inducible regulators of signaling
    • Gisselbrecht S. The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling. Eur. Cytokine Netw. 10:1999;463-470
    • (1999) Eur. Cytokine Netw. , vol.10 , pp. 463-470
    • Gisselbrecht, S.1
  • 32
    • 0032567353 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
    • Song M.M., Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273:1998;35056-35062
    • (1998) J. Biol. Chem. , vol.273 , pp. 35056-35062
    • Song, M.M.1    Shuai, K.2
  • 33
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
    • Sizemore N., Leung S., Stark G.R. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol. Cell. Biol. 19:1999;4798-4805
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.