Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3′UTR in human liver cells

Acta Pharmacologica Sinica

Volumn 37, Issue 7, 2016, Pages 898-907

  Gao, Yu En ^a   Wang, Yuan ^a   Chen, Fu Quan ^a   Feng, Jin Yan ^a   Yang, Guang ^a   Feng, Guo Xing ^a   Yang, Zhe ^a   Ye, Li Hong ^a   Zhang, Xiao Dong ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

Chang liver cells; DGCR8; Drosha; hairpin; human liver L O2 cells; mRNA 3'UTR; post transcriptional regulation; PPP2CA; PTEN

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN PHOSPHATASE PPP2CA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; DEAD BOX PROTEIN; DGCR8 PROTEIN, HUMAN; DICER1 PROTEIN, HUMAN; DROSHA PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2CA PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; RIBONUCLEASE III; RNA BINDING PROTEIN;

3' UNTRANSLATED REGION; ANGIOGENESIS; APOPTOSIS; ARTICLE; BIOINFORMATICS; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID METABOLISM; LIVER CELL; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; RNA PROCESSING; WESTERN BLOTTING; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM;

3' UNTRANSLATED REGIONS; CELL PROLIFERATION; CELLS, CULTURED; DEAD-BOX RNA HELICASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; HUMANS; PROTEIN PHOSPHATASE 2; PTEN PHOSPHOHYDROLASE; RIBONUCLEASE III; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS;

EID: 84977110898     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2016.18     Document Type: Article

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