Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer

Journal of Cellular and Molecular Medicine

Volumn 19, Issue 5, 2015, Pages 1085-1093

  Jiang, Zhenming ^a   Kong, Chuize ^a   Zhang, Zhe ^a   Zhu, Yuyan ^a   Zhang, Yuxi ^a   Chen, Xi ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bladder cancer; Caspase 3; Dicer; PKC

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; CALPHOSTIN C; CARBAZOLE DERIVATIVE; CASPASE 3; ENZYME INHIBITOR; NAPHTHALENE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PRKCA PROTEIN, HUMAN; PROTEIN KINASE C ALPHA; RIBONUCLEASE III;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; BLADDER TUMOR; DOWN REGULATION; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CARBAZOLES; CASPASE 3; CELL LINE, TUMOR; DOWN-REGULATION; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; NAPHTHALENES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE C-ALPHA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASE III; RNA INTERFERENCE; URINARY BLADDER NEOPLASMS;

EID: 84928431677     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12503     Document Type: Article

References (25)

1. Liou LS. Urothelial cancer biomarkers for detection and surveillance. Urology. 2006; 14: 25-33.
2. Smaldone MC, Jacobs BL, Smaldone AM, et al. Long-term results of selective partial cystectomy for invasive urothelial bladder carcinoma. Urology. 2008; 14: 613-6.
3. Mellor H, Parker PJ. The extended protein kinase C superfamily. Biochem J. 1998; 332: 281-92.
4. Harfe BD, McManus MT, Mansfield JH, et al. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci USA. 2005; 102: 10898-903.
5. Nakagawa A, Shi Y, Kage-Nakadai E, et al. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science. 2010; 328: 327-34.
6. Bubeník J, Baresová M, Viklický V, et al. Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen. Int J Cancer. 1973; 11: 765-73.
7. Quentmeier H, Zaborski M, Drexler HG. The human bladder carcinoma cell line 5637 constitutively secretes functional cytokines. Leuk Res. 1997; 21: 343-50.
8. Brömme HJ, Holtz J. Apoptosis in the heart: when and why? Mol Cell Biochem. 1996; 163-164: 261-75.
9. Bogerd HP, Whisnant AW, Kennedy EM, et al. Derivation and characterization of Dicer- and microRNA-deficient human cells. RNA. 2014; 20: 923-37.
10. Liu J, Kong CZ, Gong DX, et al. PKC α regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer. BMC Cancer. 2014; 14: 93.
11. Matskevich AA, Moelling K. Stimuli-dependent cleavage of Dicer during apoptosis. Biochem J. 2008; 412: 527-34.
12. Zhang B, Chen H, Zhang L, et al. A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene. 2014; 33: 3099-108.
13. Jafarnejad SM, Ardekani GS, Ghaffari M, et al. Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion. Oncogene. 2013; 32: 2131-9.
14. Lin RJ, Lin YC, Chen J, et al. microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res. 2010; 70: 7841-50.
15. Khoshnaw SM, Rakha EA, Abdel-Fatah TM, et al. Loss of Dicer expression is associated with breast cancer progression and recurrence. Breast Cancer Res Treat. 2012; 135: 403-13.
16. Chiosea S, Jelezcova E, Chandran U, et al. Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res. 2007; 67: 2345-50.
17. Faggad A, Budczies J, Tchernitsa O, et al. Prognostic significance of Dicer expression in ovarian cancer-link to global microRNA changes and oestrogen receptor expression. J Pathol. 2010; 220: 382-91.
18. Rajendran G, Dutta D, Hong J. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem. 2013; 288: 24351-62.
19. Serova M, Ghoul A, Benhadji KA, et al. Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. Mol Cancer Ther. 2008; 7: 915-22.
20. Muller PA, Trinidad AG, Caswell PT, et al. Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. J Biol Chem. 2014; 289: 122-32.
21. Delphin C, Huang KP, Scotto C, et al. The in vitro phosphorylation of p53 by calcium-dependent protein kinase C-characterization of a protein-kinase-C-binding site on p53. Eur J Biochem. 1997; 245: 684-92.
22. Smith SD, Enge M, Bao W, et al. Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo. J Biol Chem. 2012; 287: 29336-47.
23. Tokumaru S, Suzuki M, Yamada H, et al. Let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis. 2008; 29: 2073-7.
24. Chen SN, Gurha P, Lombardi R, et al. The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ Res. 2014; 114: 454-68.
25. Chaulk SG, Lattanzi VJ, Hiemer SE, et al. The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7. J Biol Chem. 2014; 289: 1886-91.