Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells

Biochemical and Biophysical Research Communications

Volumn 418, Issue 4, 2012, Pages 647-651

  Zhao, Yu ^a   Wang, Wenhui ^b   Wang, Qi ^a   Zhang, Xiaodong ^a   Ye, Lihong ^a  

^a NANKAI UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

5 LOX; Hepatocellular carcinoma; Leukotriene B4; NF B; Transcriptional activity

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 15 LIPOXYGENASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOTRIENE B4; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE SILENCING; HEPATOMA CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; LIPID METABOLISM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; UPREGULATION;

ARACHIDONATE 5-LIPOXYGENASE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; INDOLES; LEUKOTRIENE B4; LIPID METABOLISM; LIPOXYGENASE INHIBITORS; LIVER NEOPLASMS; NF-KAPPA B; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC;

EID: 84862815615     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.068     Document Type: Article

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