Population Pharmacokinetic Modelling of Morphine, Gabapentin and their Combination in the Rat

Pharmaceutical Research

Volumn 33, Issue 11, 2016, Pages 2630-2643

  Papathanasiou, Theodoros ^a   Juul, Rasmus Vestergaard ^a   Gabel Jensen, Charlotte ^a   Kreilgaard, Mads ^a   Lund, Trine Meldgaard ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

drug drug interactions; enterohepatic circulation; gabapentin; morphine; NONMEM

Indexed keywords

GABAPENTIN; MORPHINE; MORPHINE 3 GLUCURONIDE; 4 AMINOBUTYRIC ACID; AMINE; ANALGESIC AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; GLUCURONIDE;

ABSORPTION RATE CONSTANT; ALLOMETRY; ANIMAL EXPERIMENT; ARTICLE; CENTRAL VOLUME OF DISTRIBUTION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFICACY; EC50; ELIMINATION RATE CONSTANT; ENTEROHEPATIC CIRCULATION; IC50; LIMIT OF QUANTITATION; MALE; METABOLITE; MICHAELIS CONSTANT; NOCICEPTION; NONHUMAN; NONLINEAR SYSTEM; PERIPHERAL VOLUME OF DISTRIBUTION; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG INTERACTION; METABOLISM; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY;

AMINES; ANALGESICS; ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; DRUG INTERACTIONS; ENTEROHEPATIC CIRCULATION; GAMMA-AMINOBUTYRIC ACID; GLUCURONIDES; MODELS, BIOLOGICAL; MORPHINE; NONLINEAR DYNAMICS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84977079580     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-016-1988-z     Document Type: Article

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