Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: A randomized, double-blind, placebo-controlled dose-finding study

Pain

Volumn 156, Issue 12, 2015, Pages 2438-2448

  Lunn, Troels Haxholdt ^a,b   Husted, Henrik ^b,c   Laursen, Mogens Berg ^b,d   Hansen, Lars Tambour ^b,e   Kehlet, Henrik ^b,f  

^a HVIDOVRE HOSPITAL   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c Mental Health Center Glostrup   (Denmark)

^d AALBORG UNIVERSITY HOSPITAL   (Denmark)

^e Department of Orthopedic Surgery   (Denmark)

^f University of Copenhagen   (Denmark)

Author keywords

Dose finding; Gabapentin; Postoperative pain; RCT; Total knee arthroplasty; Total knee replacement

Indexed keywords

CELECOXIB; GABAPENTIN; KETOBEMIDONE; MORPHINE; ONDANSETRON; OXYCODONE; PARACETAMOL; PLACEBO; SUFENTANIL; ZOLPIDEM; 4 AMINOBUTYRIC ACID; AMINE; ANALGESIC AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; HYPNOTIC SEDATIVE AGENT; NARCOTIC ANALGESIC AGENT;

ADULT; AGED; ANALGESIA; ANALGESIC ACTIVITY; ANXIETY; ARTICLE; BALANCE IMPAIRMENT; CLINICAL EXAMINATION; CONCENTRATION LOSS; CONFUSION; CONTROLLED STUDY; DEPRESSION; DIPLOPIA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; FATIGUE; FEMALE; HEADACHE; HUMAN; HYPOTENSION; LENGTH OF STAY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MOBILIZATION; NAUSEA; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTOCOL COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; RESPONSE TIME; SEDATION; SIDE EFFECT; SLEEP DISORDER; SLEEP QUALITY; TOTAL KNEE ARTHROPLASTY; VISUAL ANALOG SCALE; VISUAL DISORDER; VOMITING; CHEMICALLY INDUCED; COMBINATION DRUG THERAPY; DOSE RESPONSE; KNEE REPLACEMENT; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; SLEEP; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMINES; ANALGESICS; ANALGESICS, OPIOID; ARTHROPLASTY, REPLACEMENT, KNEE; CYCLOHEXANECARBOXYLIC ACIDS; DIZZINESS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; MORPHINE; NAUSEA; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; SLEEP; TREATMENT OUTCOME; VOMITING;

EID: 84953777994     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000309     Document Type: Article

References (36)

1. Andersen LO, Gaarn-Larsen L, Kristensen BB, Husted H, Otte KS, Kehlet H. Subacute and function after fast-track hip and knee arthroplasty. Anaesthesia 2009;64:508-13.
2. Andersen LO, Kehlet H. Analgesic efficacy of local infiltration analgesia in hip and knee arthroplasty: a systematic review. Br J Anaesth 2014;113: 360-74.
3. Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet 2010;49:661-9.
4. Box GEP, Cox DR. An analysis of transformations. J R Stat Soc Series B Stat Methodol 1964;26:211-52.
5. Buvanendran A, Kroin JS. Multimodal analgesia for controlling acute postoperative pain. Curr Opin Anaesthesiol 2009;22:588-93.
6. Buvanendran A, Kroin JS, La Valle CJ, Kari M, Moric M, Tuman KJ. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth Analg 2010;110:199-207.
7. Carr AJ, Robertsson O, Graves S, Price AJ, Arden NK, Judge A, Beard DJ. Knee replacement. Lancet 2012;379:1331-40.
8. Clarke HA, Katz J, McGartney CJL, Stratford P, Kennedy D, Pagé MG, Awad IT, Gollish J, Kay J. Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block. Br J Anaesth 2014;113:855-64.
9. Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J. The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. Anesth Analg 2012;115:428-42.
10. Clarke H, Pereira S, Kennedy D, Gilron I, Katz J, Gollish J, Kay J. Gabapentin decreases morphine consumption and improves functional recovery following total knee arthroplasty. Pain Res Manag 2009;14: 217-22.
11. Dahl JB, Nielsen RV, Wetterslev J, Nikolajsen L, Hamunen K, Kontinen VK, Hansen MS, Kjer JJ, Mathiesen O.Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. Acta Anesthesiol Scand 2014;58: 1165-81.
12. Dahl JB, Rasmussen LS. Comparison of two active analgesic interventions: a suggestion for an "approximated placebo control". Acta Anaesthesiol Scand 2012;56:669-71.
13. Hayashida K, DeGoes S, Curry R, Eisenach JC. Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology 2007;106:557-62.
14. Ho KY, Gan TJ, Habib AS. Gabapentin and postoperative pain-a systematic review of randomized controlled trials. PAIN 2006;126: 91-101.
15. Hurley RW, Cohen SP, Williams KA, Rowlingson AJ, Wu CL. The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis. Reg Anesth Pain Med 2006;31:237-47.
16. Husted H, Lunn TH, Troelsen A, Gaarn-Larsen L, Kristensen BB, Kehlet H. Why still in hospital after fast-track hip and knee arthroplasty? Acta Orthop 2011;82:679-84.
17. Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. Lancet 2003;362:1921-8.
18. Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 2008;248:189-98.
19. Khan ZH, Rahimi M, Makarem J, Khan RH. Optimal dose of pre-incision/post-incision gabapentin for pain relief following lumbar laminectomy: a randomized study. Acta Anaesthesiol Scand 2011; 55:306-12.
20. Lewis GN, Rice DA, McNair PJ, Kluger M. Predictors of persistent pain after total knee arthroplasty: a systematic review and meta-analysis. Br J Anaesth 2015;114:551-61.
21. Mathiesen O, Moiniche S, Dahl JB. Gabapentin and postoperative pain: a qualitative and quantitative systematic review, with focus on procedure. BMC Anesthesiol 2007;7:6.
22. Mathiesen O, Wetterslev J, Kontinen VK, Pommergaard HC, Nikolajsen L, Rosenberg J, Hansen MS, Hamunen K, Kjer JJ, Dahl JB. Adverse effects of perioperative paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. Acta Anaesthesiol Scand 2014; 58:1182-98.
23. Menigaux C, Adam F, Guignard B, Sessler DI, Chauvin M. Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg 2005;100:1394-9.
24. Mishriky BM, Waldron NH, Habib AS. Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis. Br J Anaesth 2015;114:10-31.
25. Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, Singh RB, Singh U, Singh PK. Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. J Neurosurg Anesthesiol 2005;17:65-8.
26. Paul JE, Nantha-Aree M, Buckley N, Cheng J, Thabane L, Tidy A, DeBeer J, Winemaker M, Wismer D, Punthakee D, Avram V. Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial. Can J Anaesth 2013;60:423-31.
27. Peng PW, Wijeysundera DN, Li CC. Use of gabapentin for perioperative pain control-a meta-analysis. Pain Res Manag 2007;12:85-92.
28. Schmidt PC, Ruchelli G, Mackey SC, Carroll IR. Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain. Anesthesiology 2013;119:1215-21.
29. Seib RK, Paul JE. Preoperative gabapentin for postoperative analgesia: a meta-analysis. Can J Anaesth 2006;53:461-9.
30. Srikandarajah S, Gilron I. Systematic review of movement-evoked pain versus pain at rest in postsurgical clinical trials and meta-analyses: a fundamental distinction requiring standardized measurement. PAIN 2011;152:1734-9.
31. Straube S, Derry S, Moore RA, Wiffen PJ, McQuay HJ. Single dose oral gabapentin for established acute postoperative pain in adults. Cochrane Database Syst Rev 2010;5:CD008183.
32. Sullivan MJ, Scott BR, Pivik J. The pain catastrophizing scale: development and validation. Psychol Assess 1995;7:524-32.
33. Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg 2007;104:1545-56.
34. Weinbroum AA. Non-opioid IV adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoids. Pharmacol Res 2012;65:411-29.
35. White PF, Kehlet H. Improving postoperative pain management: what are the unresolved issues? Anesthesiology 2010;112:220-5.
36. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983;67:361-70.