Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model

Anesthesiology

Volumn 101, Issue 3, 2004, Pages 759-765

  Smiley, Matthew M ^a   Lu, Ying ^a   Vera Portocarrero, Louis P ^b   Zidan, Amr ^c   Westlund, Karin N ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; CALCIUM CHANNEL N TYPE; GABAPENTIN; METHOHEXITAL; MORPHINE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BILE DUCT; CEREBROSPINAL FLUID; CONTROLLED STUDY; DOSE RESPONSE; HINDLIMB; LAPAROTOMY; LOW DRUG DOSE; MALE; NOCICEPTION; NONHUMAN; PANCREAS DUCT; PANCREATITIS; PRIORITY JOURNAL; RAT; REARING; SUBARACHNOID SPACE; VISCERAL PAIN;

EID: 4344611099     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200409000-00026     Document Type: Article

References (55)

1. Dougherty PM, Staats PS: Intrathecal drug therapy for chronic pain: From basic science to clinical practice. ANESTHESIOLOGY 1999; 91:1891-918
2. Woolf CJ, Max MB: Mechanism-based pain diagnosis: Issues for analgesic drag development. ANESTHESIOLOGY 2001; 95:241-9
3. Schnell SH, Weaver MF: Addiction and pain. Am J Addict. 2003; 12 Suppl 2:S27-35
4. Leon-Casasola OA: Cellular mechanisms of opioid tolerance and the clinical approach to the opioid tolerant patient in the postoperative period. Best Pract Res Clin. Anaesthesiol 2002; 16:521-5
5. Yamamuro M, Kusaka K, Kato M, Takahashi M: Celiac plexus block in cancer pain management. Tohoku J Exp. Med 2000; 192:1-18
6. McHale A, Buechter KJ, Colin I Jr, O'Leary JP: Surgical management of chronic pain from chronic pancreatitis. Am. Surg 1997; 63:1119-22
7. Hirshberg RM, Al Chaer ED, Lawand NB, Westlund KN, Willis WD: Is there a pathway in the posterior funiculus that signals visceral pain? Pain 1996; 67:291-305
8. Westlund KN: Visceral nociception. Curr. Rev. Pain 2000; 4:478-87
9. Blackshaw LA, Gebhart GF: The pharmacology of gastrointestinal nociceptive pathways. Curr Opin Pharmacol 2002; 2:642-9
10. Martin TJ, Eisenach JC: Pharmacology of opioid and nonopioid analgesics in chronic pain states. J Pharmacol. Exp. Ther 2001; 299:811-7
11. Lu Y, Vera-Portocarrero LP, Westlund KN: Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. ANESTHESIOLOGY 2003; 98:734-40
12. Hwang JH, Yaksh TL: The effect of spinal GABA receptor agonists on tactile allodynia in a surgically induced neuropathic pain model in the rat. Pain 1997; 70:15-22
13. Dirig DM, Yaksh TL: Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. J Pharmacol. Exp. Ther 1995; 275:219-27
14. Birch PJ, Dekker LV, James IF, Southan A, Cronk D: Strategies to identify ion channel modulators: current and novel approaches to target neuropathic-pain. Drug Discov Today 2004; 9:410-8
15. Labaille T, Mazoit JX, Paqueron X, Franco D, Benhamou D: The clinical efficacy and pharmacokinetics of intraperitoneal ropivacaine for laparoscopic cholecystectomy. Anesth Analg 2002; 94:100-5
16. McCleane G: Pharmacological management of neuropathic pain. CNS Drugs 2003; 17:1031-43
17. Smith MA, Yancey DL: Sensitivity to the effects of opioids in rats with free access to exercise wheels: Mu-opioid tolerance and physical dependence. Psychopharmacology (Berl) 2003; 168:426-34
18. Piquet CY, Mallaret MP, Lemoigne AH, Barjhoux CE, Danel VC, Vincent FH: Respiratory depression following administration of intrathecal bupivacaine to an opioid-dependent patient. Ann Pharmacother 1998; 32:653-5
19. Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN: The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 1996; 271:5768-76
20. Taylor CP, Gee NS, Su TZ, Kocsis JD, Welly DF, Brown JP, Dooley DJ, Boden P, Singh L: A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998; 29:233-49
21. Gu Y, Huang LY: Gabapentin actions on Ar-methyl-D-aspartate receptor channels are protein kinase C-dependent. Pain 2001; 93:85-92
22. Gu Y, Huang LY: Gabapentin potentiates N-methyl-D-aspartate receptor mediated currents in rat GABAergic dorsal horn neurons. Neurosci Lett 2002; 324:177-80
23. Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR: Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther 2002; 303:1199-205
24. Cheng JK, Lai YJ, Chen CC, Cheng CR, Chiou LC: Magnesium chloride and ruthenium red attenuate the antiallodynic effect of intrathecal gabapentin in a rat model of postoperative pain. ANESTHESIOLOGY 2003; 98:1472-9
25. Maneuf YP, Gonzalez MI, Sutton KS, Chung FZ, Pinnock RD, Lee K: Cellular and molecular action of the putative GABA-mimetic, gabapentin. Cell Mol. Life Sci 2003; 60:742-50
26. Rao ML, Clarenbach P, Vahlensieck M, Kratzschmar S: Gabapentin augments whole blood serotonin in healthy young men. J. Neural Transm 1988; 73:129-34
27. Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB: A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. ANESTHESIOLOGY 2002; 97:560-4
28. Dirks J, Petersen KL, Rowbotham MC, Dahl JB: Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization. ANESTHESIOLOGY 2002; 97:102-7
29. Rose MA, Kam PC: Gabapentin: pharmacology and its use in pain management. Anaesthesia 2002; 57:451-62
30. Field MJ, Holloman EF, McCleary S, Hughes J, Singh L: Evaluation of gabapentin and S(+)-3-isoburylgaba in a rat model of postoperative pain. J Pharmacol Exp Ther 1997; 282:1242-6
31. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J, Singh L: Gabapentin (neurontin) and S(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br. J Pharmacol 1997; 121:1513-22
32. Lu Y, Westlund KN: Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats. J Pharmacol Exp Ther 1999; 290:214-9
33. Shimoyama M, Shimoyama N, Inturrisi CE, Elliott KJ: Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test. Pain 1997; 72:375-82
34. Backonja M, Beydoun A, Edwards KR, Schwanz SL, Fonseca V, Hes M, LaMoreaux L, Garofalo E: Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 1998; 280:1831-6
35. Kaneko M, Mestre C, Sanchez EH, Hammond DL: Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther 2000; 292:743-51
36. Fox A, Gentry C, Patel S, Kesingland A, Bevan S: Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea pig. Pain 2003; 105:355-62
37. Matthews EA, Dickenson AH: A combination of gabapentin and morphine mediates enhanced inhibitory effects on dorsal horn neuronal responses in a rat model of neuropathy. ANESTHESIOLOGY 2002; 96:633-40
38. Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G: Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg 2000; 91:185-91
39. Chandler A, Williams JE: Gabapentin, an adjuvant treatment for neuropathic pain in a cancer hospital. J Pain Symptom Manage 2000; 20:82-6
40. Caraceni A, Zecca E, Martini C, De Conno F: Gabapentin as an adjuvant to opioid analgesia for neuropathic cancer pain. J Pain Symptom Manage 1999; 17:441-5
41. Feng Y, Cui M, Willis WD: Gabapentin markedly reduces acetic acid-induced visceral nociception. ANESTHESIOLOGY 2003; 98:729-33
42. Grabow TS, Dougherty PM: Gabapentin produces dose-dependent antinociception in the orofacial formalin test in the rat. Reg Anesth. Pain Med 2002; 27:277-83
43. Dierking G, Duedahl TH, Rasmussen ML, Fomsgaard JS, Moiniche S, Romsing J, Dahl JB: Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: A randomized, double-blind trial. Acta Anaesthesiol Scand 2004; 48:322-7
44. Gilron I, Biederman J, Jhamandas K, Hong M: Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests. ANESTHESIOLOGY 2003; 98:1288-92
45. Houghton AK, Wang CC, Westlund KN: Do nociceptive signals from the pancreas travel in the dorsal column? Pain 2001; 89:207-20
46. Yaksh TL, Rudy TA: Chronic catheterization of spinal subarachnoid space. Physiol Behav 1976; 17:1031-6
47. Wang CC, Willis WD, Westlund KN: Ascending projections from the area around the spinal cord central canal: A Phaseolus vulgaris leukoagglutinin study in rats. J Comp Neurol 1999; 415:341-67
48. Wang CC, Westlund KN: Responses of rat dorsal column neurons to pancreatic nociceptive stimulation. Neuroreport 2001; 12:2527-30
49. Craft RM, Carlisi VJ, Mattia A, Herman RM, Porreca F: Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat. Pain 1993; 55:205-15
50. Bennett MI, Simpson KH: Gabapentin in the treatment of neuropathic pain. Palliat Med 2004; 18:5-11
51. Shimoyama M, Shimoyama N, Hori Y: Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain 2000; 85:405-14
52. Martin DJ, McClelland D, Herd MB, Sutton KG, Hall MD, Lee K, Pinnock RD, Scott RH: Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression. Neuropharmacology 2002; 42:353-66
53. Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH: Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones. Br. J Pharmacol 2002; 135:257-65
54. Omote K, Sonoda H, Kawamata M, Iwasaki H, Namiki A: Potentiation of antinociceptive effects of morphine by calcium-channel blockers at the level of the spinal cord. ANESTHESIOLOGY 1993; 79:746-52
55. Omote K, Kawamata M, Satoh O, Iwasaki H, Namiki A: Spinal antinociceptive action of an N-Type voltage-dependent calcium channel blocker and the synergistic interaction with morphine. ANESTHESIOLOGY 1996; 84:636-43