Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain

European Journal of Pharmaceutical Sciences

Volumn 82, Issue , 2016, Pages 97-105

  Papathanasiou, Theodoros ^a   Juul, Rasmus Vestergaard ^a   Heegaard, Anne Marie ^a   Kreilgaard, Mads ^a   Lund, Trine Meldgaard ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Drug drug interactions; Gabapentin; Loewe; Morphine; Postoperative pain; Synergy; Von Frey

Indexed keywords

GABAPENTIN; MORPHINE; 4 AMINOBUTYRIC ACID; AMINE; ANALGESIC AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG POTENTIATION; MALE; MONOTHERAPY; NONHUMAN; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; ANIMAL; COMBINATION DRUG THERAPY; DISEASE MODEL; HYPERALGESIA; PAIN, POSTOPERATIVE; PHYSICAL STIMULATION; SPRAGUE DAWLEY RAT;

AMINES; ANALGESICS; ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; MALE; MORPHINE; PAIN, POSTOPERATIVE; PHYSICAL STIMULATION; RATS, SPRAGUE-DAWLEY;

EID: 84948651604     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.11.015     Document Type: Article

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