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Volumn 27, Issue 7, 2016, Pages 1199-1206

Biomarkers associated with checkpoint inhibitors

Author keywords

Biomarkers; Cancer; Checkpoint inhibitors; Immunotherapy

Indexed keywords

BIOLOGICAL MARKER; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; IPILIMUMAB; LACTATE DEHYDROGENASE; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TUMOR ANTIGEN; ANTIIDIOTYPIC ANTIBODY; CD274 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CTLA4 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84977071049     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdw181     Document Type: Article
Times cited : (142)

References (72)
  • 1
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12: 252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 2
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • Selby MJ, Engelhardt JJ, Quigley M et al. Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res 2013; 1: 32-42.
    • (2013) Cancer Immunol Res , vol.1 , pp. 32-42
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3
  • 3
    • 84893489025 scopus 로고    scopus 로고
    • PD-1 as a potential target in cancer therapy
    • McDermott DF, Atkins MB. PD-1 as a potential target in cancer therapy. Cancer Med 2013; 2: 662-673.
    • (2013) Cancer Med , vol.2 , pp. 662-673
    • McDermott, D.F.1    Atkins, M.B.2
  • 4
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
    • Wolchok JD, Neyns B, Linette G et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 2010; 11: 155-164.
    • (2010) Lancet Oncol , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3
  • 5
    • 84899974090 scopus 로고    scopus 로고
    • Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma
    • Kelderman S, Heemskerk B, van Tinteren H et al. Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma. Cancer Immunol Immunother 2014; 63: 449-458.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 449-458
    • Kelderman, S.1    Heemskerk, B.2    van Tinteren, H.3
  • 6
    • 77950258677 scopus 로고    scopus 로고
    • Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting
    • Ku GY, Yuan J, Page DB et al. Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting. Cancer 2010; 116: 1767-1775.
    • (2010) Cancer , vol.116 , pp. 1767-1775
    • Ku, G.Y.1    Yuan, J.2    Page, D.B.3
  • 7
    • 84878432797 scopus 로고    scopus 로고
    • Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival
    • Delyon J et al. Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival. Ann Oncol 2013; 24: 1697-1703.
    • (2013) Ann Oncol , vol.24 , pp. 1697-1703
    • Delyon, J.1
  • 8
    • 77950285080 scopus 로고    scopus 로고
    • Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab.
    • Berman DM, Wolchok J, Weber J et al. Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab. J Clin Oncol 2009; 27.
    • (2009) J Clin Oncol , pp. 27
    • Berman, D.M.1    Wolchok, J.2    Weber, J.3
  • 9
    • 84878875962 scopus 로고    scopus 로고
    • Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10mg/kg within an expanded access programme
    • Di Giacomo AM, Calabrò L, Danielli R et al. Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10mg/kg within an expanded access programme. Cancer Immunol Immunother 2013; 62: 1021-1028.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1021-1028
    • Di Giacomo, A.M.1    Calabrò, L.2    Danielli, R.3
  • 10
    • 84924267914 scopus 로고    scopus 로고
    • Pretreatment levels of absolute and relative eosinophil count to improve overall survival (OS) in patients with metastatic melanoma under treatment with ipilimumab, an anti CTLA-4 antibody.
    • Schindler K, Harmankaya K, Postow M et al. Pretreatment levels of absolute and relative eosinophil count to improve overall survival (OS) in patients with metastatic melanoma under treatment with ipilimumab, an anti CTLA-4 antibody. In ASCO Annual Meeting, 2013.
    • (2013) In ASCO Annual Meeting
    • Schindler, K.1    Harmankaya, K.2    Postow, M.3
  • 11
    • 84929192743 scopus 로고    scopus 로고
    • Ipilimumab-dependent cellmediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
    • Romano E, Kusio-Kobialka M, Foukas PG et al. Ipilimumab-dependent cellmediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Proc Natl Acad Sci USA 2015; 112: 6140-6145.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 6140-6145
    • Romano, E.1    Kusio-Kobialka, M.2    Foukas, P.G.3
  • 12
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti- PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria J-C, Kowanetz M et al. Predictive correlates of response to the anti- PD-L1 antibody MPDL3280A in cancer patients. Nature 2014; 515: 563-567.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J-C.2    Kowanetz, M.3
  • 13
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T, Eder JP, Fine GD et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014; 515: 558-562.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3
  • 14
    • 54449091476 scopus 로고    scopus 로고
    • CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
    • Liakou CI et al. CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci USA 2008; 105: 14987-14992.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14987-14992
    • Liakou, C.I.1
  • 15
    • 62449309334 scopus 로고    scopus 로고
    • Anti-CTLA-4 therapy results in higher CD4+ ICOShi T cell frequency and IFN-levels in both nonmalignant and malignant prostate tissues
    • Chen H, Liakou CI, Kamat A et al. Anti-CTLA-4 therapy results in higher CD4+ ICOShi T cell frequency and IFN-levels in both nonmalignant and malignant prostate tissues. Proc Natl Acad Sci USA 2009; 106: 2729-2734.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2729-2734
    • Chen, H.1    Liakou, C.I.2    Kamat, A.3
  • 16
    • 77952337834 scopus 로고    scopus 로고
    • Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial
    • Carthon BC, Wolchok JD, Yuan J et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res 2010; 16: 2861-2871.
    • (2010) Clin Cancer Res , vol.16 , pp. 2861-2871
    • Carthon, B.C.1    Wolchok, J.D.2    Yuan, J.3
  • 17
    • 84902825664 scopus 로고    scopus 로고
    • Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients
    • Cha E, Klinger M, Hou Y et al. Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Sci Transl Med 2014; 6: 238ra70.
    • (2014) Sci Transl Med , vol.6
    • Cha, E.1    Klinger, M.2    Hou, Y.3
  • 18
    • 84907284200 scopus 로고    scopus 로고
    • Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response
    • Kvistborg P, Philips D, Kelderman S et al. Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response. Sci Transl Med 2014; 6: 254ra128.
    • (2014) Sci Transl Med , vol.6
    • Kvistborg, P.1    Philips, D.2    Kelderman, S.3
  • 19
    • 84997755141 scopus 로고    scopus 로고
    • Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma
    • Postow MA, Manuel M, Wong P et al. Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma. J Immunother Cancer 2015; 3: 23.
    • (2015) J Immunother Cancer , vol.3 , pp. 23
    • Postow, M.A.1    Manuel, M.2    Wong, P.3
  • 20
    • 80053648839 scopus 로고    scopus 로고
    • Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
    • Yuan J, Adamow M, Ginsberg BA et al. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proc Natl Acad Sci USA 2011; 108: 16723-16728.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16723-16728
    • Yuan, J.1    Adamow, M.2    Ginsberg, B.A.3
  • 21
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • Attia P. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005; 23: 6043-6053.
    • (2005) J Clin Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1
  • 22
    • 42149169184 scopus 로고    scopus 로고
    • Mechanisms of regulatory T-cell suppression-a diverse arsenal for a moving target
    • Sojka DK, Huang Y-H, Fowell DJ. Mechanisms of regulatory T-cell suppression-a diverse arsenal for a moving target. Immunology 2008; 124: 13-22.
    • (2008) Immunology , vol.124 , pp. 13-22
    • Sojka, D.K.1    Huang, Y.-H.2    Fowell, D.J.3
  • 23
    • 84155163015 scopus 로고    scopus 로고
    • Ipilimumab increases activated T cells and enhances humoral immunity in patients with advanced melanoma
    • Weber JS, Hamid O, Chasalow SD et al. Ipilimumab increases activated T cells and enhances humoral immunity in patients with advanced melanoma. J Immunother 2012; 35: 89-97.
    • (2012) J Immunother , vol.35 , pp. 89-97
    • Weber, J.S.1    Hamid, O.2    Chasalow, S.D.3
  • 24
    • 27844458057 scopus 로고    scopus 로고
    • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study
    • Maker AV et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005; 12: 1005-1016.
    • (2005) Ann Surg Oncol , vol.12 , pp. 1005-1016
    • Maker, A.V.1
  • 25
    • 84903818245 scopus 로고    scopus 로고
    • Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma
    • Simeone E et al. Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma. Cancer Immunol Immunother 2014; 63: 675-683.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 675-683
    • Simeone, E.1
  • 26
    • 84894639687 scopus 로고    scopus 로고
    • Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab
    • Tarhini AA, Edington H, Butterfield LH et al. Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab. PLoS One 2014; 9: e87705.
    • (2014) PLoS One , vol.9
    • Tarhini, A.A.1    Edington, H.2    Butterfield, L.H.3
  • 27
    • 84929223574 scopus 로고    scopus 로고
    • Immunologic correlates in the course of treatment with immunomodulating antibodies
    • Weide B, Di Giacomo AM, Fonsatti E, Zitvogel L. Immunologic correlates in the course of treatment with immunomodulating antibodies. Semin Oncol 2015; 42: 448-458.
    • (2015) Semin Oncol , vol.42 , pp. 448-458
    • Weide, B.1    Di Giacomo, A.M.2    Fonsatti, E.3    Zitvogel, L.4
  • 28
    • 84896523643 scopus 로고    scopus 로고
    • Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production
    • Pico de Coaña Y, Poschke I, Gentilcore G et al. Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production. Cancer Immunol Res 2013; 1: 158-162.
    • (2013) Cancer Immunol Res , vol.1 , pp. 158-162
    • Pico de Coaña, Y.1    Poschke, I.2    Gentilcore, G.3
  • 29
    • 84970047228 scopus 로고    scopus 로고
    • Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab.
    • Martens A, Wistuba-Hamprecht K, Geukes Foppen MH et al. Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab. Clin Cancer Res 2016, doi:10.1158/1078- 0432.CCR-15-2412
    • (2016) Clin Cancer Res
    • Martens, A.1    Wistuba-Hamprecht, K.2    Geukes Foppen, M.H.3
  • 30
    • 84911445469 scopus 로고    scopus 로고
    • Computational algorithm-driven evaluation of monocytic myeloidderived suppressor cell frequency for prediction of clinical outcomes
    • Kitano S et al. Computational algorithm-driven evaluation of monocytic myeloidderived suppressor cell frequency for prediction of clinical outcomes. Cancer Immunol Res 2014; 2: 812-821.
    • (2014) Cancer Immunol Res , vol.2 , pp. 812-821
    • Kitano, S.1
  • 31
    • 84924340539 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25
    • Hannani D et al. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Cell Res 2015; 25: 208-224.
    • (2015) Cell Res , vol.25 , pp. 208-224
    • Hannani, D.1
  • 32
    • 84875343764 scopus 로고    scopus 로고
    • Single-center experience with ipilimumab in an expanded access program for patients with pretreated advanced melanoma
    • Wilgenhof S et al. Single-center experience with ipilimumab in an expanded access program for patients with pretreated advanced melanoma. J Immunother 2013; 36: 215-222.
    • (2013) J Immunother , vol.36 , pp. 215-222
    • Wilgenhof, S.1
  • 33
    • 84921456279 scopus 로고    scopus 로고
    • Combination therapy with anti-CTLA-4 and anti- PD-1 leads to distinct immunologic changes in vivo
    • Das R, Verma R, Sznol M et al. Combination therapy with anti-CTLA-4 and anti- PD-1 leads to distinct immunologic changes in vivo. J Immunol 2014; 194: 950-959.
    • (2014) J Immunol , vol.194 , pp. 950-959
    • Das, R.1    Verma, R.2    Sznol, M.3
  • 34
    • 82155168544 scopus 로고    scopus 로고
    • A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
    • Hamid O, Schmidt H, Nissan A et al. A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 2011; 9: 204.
    • (2011) J Transl Med , vol.9 , pp. 204
    • Hamid, O.1    Schmidt, H.2    Nissan, A.3
  • 35
    • 42949105127 scopus 로고    scopus 로고
    • Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
    • Hodi FS, Butler M, Oble DA et al. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci USA 2008; 105: 3005-3010.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3005-3010
    • Hodi, F.S.1    Butler, M.2    Oble, D.A.3
  • 36
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh PC, Harview CL, Yearley JH et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014; 515: 568-571.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3
  • 38
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A, Makarov V, Merghoub T et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014; 371: 2189-2199.
    • (2014) N Engl J Med , vol.371 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 39
    • 84943516465 scopus 로고    scopus 로고
    • Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
    • Van Allen EM, Miao D, Schilling B et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 2015; 350: 207-211.
    • (2015) Science , vol.350 , pp. 207-211
    • Van Allen, E.M.1    Miao, D.2    Schilling, B.3
  • 40
    • 84928761118 scopus 로고    scopus 로고
    • Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015; 348: 124-128.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 41
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • Le DT, Uram JN, Wang H et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015; 372: 2509-2520.
    • (2015) N Engl J Med , vol.372 , pp. 2509-2520
    • Le, D.T.1    Uram, J.N.2    Wang, H.3
  • 42
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366: 2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 43
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon EB, Rizvi NA, Hui R et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015; 372: 2018-2028.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 44
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015; 372: 320-330.
    • (2015) N Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 45
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • Robert C, Schachter J, Long GV et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015; 372: 2521-2532.
    • (2015) N Engl J Med , vol.372 , pp. 2521-2532
    • Robert, C.1    Schachter, J.2    Long, G.V.3
  • 46
    • 84928342005 scopus 로고    scopus 로고
    • Peripheral and tumor immune correlates in patients with advanced melanoma treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) monotherapy or in combination with ipilimumab
    • Postow MA, Cardona DM, Taube JM et al. Peripheral and tumor immune correlates in patients with advanced melanoma treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) monotherapy or in combination with ipilimumab. J Transl Med 2014; 12: O8.
    • (2014) J Transl Med , vol.12
    • Postow, M.A.1    Cardona, D.M.2    Taube, J.M.3
  • 47
    • 84907973066 scopus 로고    scopus 로고
    • Clinical efficacy and correlation with tumor PDL1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475
    • Kefford R, Ribas A, Hamid O et al. Clinical efficacy and correlation with tumor PDL1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. ASCO Annual Meeting J Clin Oncol 2014; 32:5s (Suppl): abstr 3005.
    • (2014) ASCO Annual Meeting J Clin Oncol , vol.32 , Issue.5
    • Kefford, R.1    Ribas, A.2    Hamid, O.3
  • 48
    • 84947704341 scopus 로고    scopus 로고
    • Long-term efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001
    • Daud A, Ribas A, Robert C et al. Long-term efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001. ASCO Meet Abstr 2015; 33: 9005.
    • (2015) ASCO Meet Abstr , vol.33 , pp. 9005
    • Daud, A.1    Ribas, A.2    Robert, C.3
  • 49
    • 84939227614 scopus 로고    scopus 로고
    • Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers
    • Carbognin L, Pilotto S, Milella M et al. Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PLoS One 2015; 10: e0130142.
    • (2015) PLoS One , vol.10
    • Carbognin, L.1    Pilotto, S.2    Milella, M.3
  • 50
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • Ji R-R, Chasalow SD, Wang L et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother 2012; 61: 1019-1031.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1019-1031
    • Ji, R-R.1    Chasalow, S.D.2    Wang, L.3
  • 51
    • 84961221351 scopus 로고    scopus 로고
    • Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
    • Hugo W, Zaretsky JM, Sun L et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 2016; 165: 35-44.
    • (2016) Cell , vol.165 , pp. 35-44
    • Hugo, W.1    Zaretsky, J.M.2    Sun, L.3
  • 52
    • 80051694786 scopus 로고    scopus 로고
    • The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy
    • Fu T, He Q, Sharma P. The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy. Cancer Res 2011; 71: 5445-5454.
    • (2011) Cancer Res , vol.71 , pp. 5445-5454
    • Fu, T.1    He, Q.2    Sharma, P.3
  • 53
    • 77954230122 scopus 로고    scopus 로고
    • Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells
    • Vonderheide RH, LoRusso PM, Khalil M et al. Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Clin Cancer Res 2010; 16: 3485-3494.
    • (2010) Clin Cancer Res , vol.16 , pp. 3485-3494
    • Vonderheide, R.H.1    LoRusso, P.M.2    Khalil, M.3
  • 54
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009; 9: 162-174.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 55
    • 84899709874 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications
    • Diaz-Montero CM, Finke J, Montero AJ. Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications. Semin Oncol 2014; 41: 174-184.
    • (2014) Semin Oncol , vol.41 , pp. 174-184
    • Diaz-Montero, C.M.1    Finke, J.2    Montero, A.J.3
  • 56
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • Balch CM, Gershenwald JE, Soong S-J et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009; 27: 6199-6206.
    • (2009) J Clin Oncol , vol.27 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.-J.3
  • 57
    • 58249134743 scopus 로고    scopus 로고
    • Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms
    • discussion 371-372
    • Ruffini E, Asioli S, Filosso PL et al. Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms. Ann Thorac Surg 2009; 87: 365-371; discussion 371-372.
    • (2009) Ann Thorac Surg , vol.87 , pp. 365-371
    • Ruffini, E.1    Asioli, S.2    Filosso, P.L.3
  • 58
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov LB, Nik-Zainal S, Wedge DC et al. Signatures of mutational processes in human cancer. Nature 2013; 500: 415-421.
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 59
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • Rooney MS, Shukla SA, Wu CJ, Getz G, Hacohen N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 2015; 160: 48-61.
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 60
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Chiarion-Sileni V, Gonzalez R et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 2015; 373: 1270-1271.
    • (2015) N Engl J Med , vol.373 , pp. 1270-1271
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 61
    • 85016873692 scopus 로고    scopus 로고
    • The role of indoleamine 2, 3- dioxygenase in immune suppression and autoimmunity
    • Mbongue JC, Nicholas DA, Torrez TW et al. The role of indoleamine 2, 3- dioxygenase in immune suppression and autoimmunity. Vaccines 2015; 3: 703-729.
    • (2015) Vaccines , vol.3 , pp. 703-729
    • Mbongue, J.C.1    Nicholas, D.A.2    Torrez, T.W.3
  • 62
    • 33947532866 scopus 로고    scopus 로고
    • Differential regulation of indoleamine 2,3- dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells
    • Jung ID, Lee C-M, Jeong Y-I et al. Differential regulation of indoleamine 2,3- dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells. FEBS Lett 2007; 581: 1449-1456.
    • (2007) FEBS Lett , vol.581 , pp. 1449-1456
    • Jung, I.D.1    Lee, C.-M.2    Jeong, Y.-I.3
  • 63
    • 12144251098 scopus 로고    scopus 로고
    • The role of IFN-gamma and TNF-alpharesponsive regulatory elements in the synergistic induction of indoleamine dioxygenase
    • Robinson CM, Hale PT, Carlin JM. The role of IFN-gamma and TNF-alpharesponsive regulatory elements in the synergistic induction of indoleamine dioxygenase. J Interferon Cytokine Res 2005; 25: 20-30.
    • (2005) J Interferon Cytokine Res , vol.25 , pp. 20-30
    • Robinson, C.M.1    Hale, P.T.2    Carlin, J.M.3
  • 64
    • 84953309212 scopus 로고    scopus 로고
    • Immune-related adverse events with immune checkpoint blockade: a comprehensive review
    • Michot JM, Bigenwald C, Champiat S et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer 2016; 54: 139-148.
    • (2016) Eur J Cancer , vol.54 , pp. 139-148
    • Michot, J.M.1    Bigenwald, C.2    Champiat, S.3
  • 65
    • 84929201793 scopus 로고    scopus 로고
    • Correlation of absolute and relative eosinophil counts with immune-related adverse events in melanoma patients treated with ipilimumab.
    • Schindler K, Harmankaya K, Kuk D et al. Correlation of absolute and relative eosinophil counts with immune-related adverse events in melanoma patients treated with ipilimumab. ASCO Meet Abstr 2014; 32.
    • (2014) ASCO Meet Abstr , pp. 32
    • Schindler, K.1    Harmankaya, K.2    Kuk, D.3
  • 66
    • 84856769074 scopus 로고    scopus 로고
    • Evaluation of serum IL-17 levels during ipilimumab therapy: correlation with colitis.
    • Callahan MK, Yang A, Tandon S et al. Evaluation of serum IL-17 levels during ipilimumab therapy: correlation with colitis. ASCO Meet Abstr 2011; 29.
    • (2011) ASCO Meet Abstr , pp. 29
    • Callahan, M.K.1    Yang, A.2    Tandon, S.3
  • 67
    • 84875132942 scopus 로고    scopus 로고
    • Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immunerelated gastrointestinal adverse events
    • Shahabi V, Berman D, Chasalow SD et al. Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immunerelated gastrointestinal adverse events. J Transl Med 2013; 11: 75.
    • (2013) J Transl Med , vol.11 , pp. 75
    • Shahabi, V.1    Berman, D.2    Chasalow, S.D.3
  • 68
    • 78650428877 scopus 로고    scopus 로고
    • Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma
    • Berman D, Parker SM, Siegel J et al. Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immun 2010; 10: 11.
    • (2010) Cancer Immun , vol.10 , pp. 11
    • Berman, D.1    Parker, S.M.2    Siegel, J.3
  • 69
    • 36748999428 scopus 로고    scopus 로고
    • Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
    • Downey SG et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res 2007; 13: 6681-6688.
    • (2007) Clin Cancer Res , vol.13 , pp. 6681-6688
    • Downey, S.G.1
  • 70
    • 78651345254 scopus 로고    scopus 로고
    • Releasing the brake on the immune system: ipilimumab in melanoma and other tumors
    • Tarhini A, Lo E, Minor DR. Releasing the brake on the immune system: ipilimumab in melanoma and other tumors. Cancer Biother Radiopharm 2010; 25: 601-613.
    • (2010) Cancer Biother Radiopharm , vol.25 , pp. 601-613
    • Tarhini, A.1    Lo, E.2    Minor, D.R.3
  • 71
    • 61349114199 scopus 로고    scopus 로고
    • Ipilimumab: controversies in its development, utility and autoimmune adverse events
    • Weber J. Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunol Immunother 2009; 58: 823-830.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 823-830
    • Weber, J.1
  • 72
    • 84901246811 scopus 로고    scopus 로고
    • Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort.
    • Ascierto PA et al. Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort. J Transl Med 2014; 12: 116.
    • (2014) J Transl Med , vol.12 , pp. 116
    • Ascierto, P.A.1


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