-
1
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711-723
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
2
-
-
84859393995
-
CTLA-4 blockade with ipilimumab: Long-term follow-up of 177 patients with metastatic melanoma
-
Prieto PA, Yang JC, Sherry RM, Hughes MS, Kammula US, White DE et al (2012) CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res 18:2039-2047
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2039-2047
-
-
Prieto, P.A.1
Yang, J.C.2
Sherry, R.M.3
Hughes, M.S.4
Kammula, U.S.5
White, D.E.6
-
3
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507-2516
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
-
4
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358-365
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
Jouary, T.4
Gutzmer, R.5
Millward, M.6
-
5
-
-
84875235432
-
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 study
-
Ascierto PA, Schadendorf D, Berking C, Agarwala SS, van Herpen CM, Queirolo P et al (2013) MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol 14:249-256
-
(2013)
Lancet Oncol
, vol.14
, pp. 249-256
-
-
Ascierto, P.A.1
Schadendorf, D.2
Berking, C.3
Agarwala, S.S.4
Van Herpen, C.M.5
Queirolo, P.6
-
6
-
-
84874777853
-
Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor
-
Kim KB, Kefford R, Pavlick AC, Infante JR, Ribas A, Sosman JA et al (2013) Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. J Clin Oncol 31:482-489
-
(2013)
J Clin Oncol
, vol.31
, pp. 482-489
-
-
Kim, K.B.1
Kefford, R.2
Pavlick, A.C.3
Infante, J.R.4
Ribas, A.5
Sosman, J.A.6
-
7
-
-
0035100888
-
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
-
DOI 10.1067/mcp.2001.113989
-
Atkinson AJ, Magnuson WG, Colbern WA, DeGrutolla VG, DeMets DL, Downing GJ et al (2001) Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69:89-95 (Pubitemid 32225406)
-
(2001)
Clinical Pharmacology and Therapeutics
, vol.69
, Issue.3
, pp. 89-95
-
-
Atkinson Jr., A.J.1
Colburn, W.A.2
DeGruttola, V.G.3
DeMets, D.L.4
Downing, G.J.5
Hoth, D.F.6
Oates, J.A.7
Peck, C.C.8
Schooley, R.T.9
Spilker, B.A.10
Woodcock, J.11
Zeger, S.L.12
-
9
-
-
80053371253
-
Defining the critical hurdles in cancer immunotherapy
-
Fox BA, Schendel DJ, Butterfield LH, Aamdal S, Allison JP, Ascierto PA et al (2011) Defining the critical hurdles in cancer immunotherapy. J Transl Med 9:214
-
(2011)
J Transl Med
, vol.9
, pp. 214
-
-
Fox, B.A.1
Schendel, D.J.2
Butterfield, L.H.3
Aamdal, S.4
Allison, J.P.5
Ascierto, P.A.6
-
10
-
-
52649088779
-
CTLA-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: Surrogate marker of efficacy of tremelimumab?
-
Menard C, Ghiringhelli F, Roux S, Chaput N, Mateus C, Grohmann U et al (2008) CTLA-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab? Clin Cancer Res 14:5242-5249
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5242-5249
-
-
Menard, C.1
Ghiringhelli, F.2
Roux, S.3
Chaput, N.4
Mateus, C.5
Grohmann, U.6
-
11
-
-
79951831113
-
Extended dose ipilimumab with a peptide vaccine: Immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma
-
Sarnaik A, Yu B, Yu D, Morelli D, Hall M, Bogle D et al (2011) Extended dose ipilimumab with a peptide vaccine: immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma. Clin Cancer Res 17:896-906
-
(2011)
Clin Cancer Res
, vol.17
, pp. 896-906
-
-
Sarnaik, A.1
Yu, B.2
Yu, D.3
Morelli, D.4
Hall, M.5
Bogle, D.6
-
12
-
-
78649237899
-
Evaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanoma
-
abstr 2609
-
Marshall MA, Ribas A, Huang B (2010) Evaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanoma. J Clin Oncol 28: abstr 2609
-
(2010)
J Clin Oncol
, vol.28
-
-
Marshall, M.A.1
Ribas, A.2
Huang, B.3
-
13
-
-
77950258677
-
Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: Lymphocyte count after 2 doses correlates with survival
-
Ku GY, Yuan J, Page DB, Schroeder SE, Panageas KS, Carvajal RD et al (2010) Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival. Cancer 116:1767-1775
-
(2010)
Cancer
, vol.116
, pp. 1767-1775
-
-
Ku, G.Y.1
Yuan, J.2
Page, D.B.3
Schroeder, S.E.4
Panageas, K.S.5
Carvajal, R.D.6
-
14
-
-
84871320184
-
Immunological and Biological Changes During Ipilimumab Treatment and their Correlation with Clinical Response and Survival
-
abst 8573
-
Simeone E, Gentilcore G, Romano A, Daponte A, Caraco C, Grimaldi AM, et al (2012) Immunological and Biological Changes During Ipilimumab Treatment and their Correlation with Clinical Response and Survival. J Clin Oncol 30 (suppl). abst 8573
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Simeone, E.1
Gentilcore, G.2
Romano, A.3
Daponte, A.4
Caraco, C.5
Grimaldi, A.M.6
-
15
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD, Hoos A, O'Day S, Weber JS, Hamid O, Lebbé C et al (2009) Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 15:7412-7420
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
Weber, J.S.4
Hamid, O.5
Lebbé, C.6
-
16
-
-
77955526258
-
Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment
-
Ascierto PA, Napolitano M, Celentano E, Simeone E, Gentilcore G, Daponte A et al (2010) Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment. J Transl Med 8:76
-
(2010)
J Transl Med
, vol.8
, pp. 76
-
-
Ascierto, P.A.1
Napolitano, M.2
Celentano, E.3
Simeone, E.4
Gentilcore, G.5
Daponte, A.6
-
17
-
-
39149104690
-
Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials
-
DOI 10.1200/JCO.2007.12.7837
-
Korn EL, Liu PY, Lee SJ, Chapman JA, Niedzwiecki D, Suman VJ et al (2008) Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. J Clin Oncol 26:527-534 (Pubitemid 351264344)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.4
, pp. 527-534
-
-
Korn, E.L.1
Liu, P.-Y.2
Lee, S.J.3
Chapman, J.-A.W.4
Niedzwiecki, D.5
Suman, V.J.6
Moon, J.7
Sondak, V.K.8
Atkins, M.B.9
Eisenhauer, E.A.10
Parulekar, W.11
Markovic, S.N.12
Saxman, S.13
Kirkwood, J.M.14
-
18
-
-
84874830056
-
Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types
-
Ascierto PA, Kalos M, Schaer DA, Callahan MK, Wolchok JD (2013) Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types. Clin Cancer Res 19:1009-1020
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1009-1020
-
-
Ascierto, P.A.1
Kalos, M.2
Schaer, D.A.3
Callahan, M.K.4
Wolchok, J.D.5
-
19
-
-
48549100241
-
Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade
-
Breunis WB, Tarazona-Santos E, Chen R, Kiley M, Rosenberg SA, Chanock SJ (2008) Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade. J Immunother 31:586-590
-
(2008)
J Immunother
, vol.31
, pp. 586-590
-
-
Breunis, W.B.1
Tarazona-Santos, E.2
Chen, R.3
Kiley, M.4
Rosenberg, S.A.5
Chanock, S.J.6
-
20
-
-
82155168544
-
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
-
Hamid O, Schmidt H, Nissan A, Ridolfi L, Aamdal S, Hansson J et al (2011) A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 9:204
-
(2011)
J Transl Med
, vol.9
, pp. 204
-
-
Hamid, O.1
Schmidt, H.2
Nissan, A.3
Ridolfi, L.4
Aamdal, S.5
Hansson, J.6
-
21
-
-
84863672266
-
Biomarkers on melanoma patient T cells associated with ipilimumab treatment
-
Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D et al (2012) Biomarkers on melanoma patient T cells associated with ipilimumab treatment. J Transl Med 10:146
-
(2012)
J Transl Med
, vol.10
, pp. 146
-
-
Wang, W.1
Yu, D.2
Sarnaik, A.3
Yu, B.4
Hall, M.5
Morelli, D.6
-
22
-
-
80053648839
-
Integrated NY-ESO-1 antibody and CD8 + T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
-
Yuan J, Adamow M, Ginsberg BA, Rasalan TS, Ritter E, Gallardo HF et al (2011) Integrated NY-ESO-1 antibody and CD8 + T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proc Natl Acad Sci USA 108:16723-16728
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16723-16728
-
-
Yuan, J.1
Adamow, M.2
Ginsberg, B.A.3
Rasalan, T.S.4
Ritter, E.5
Gallardo, H.F.6
-
23
-
-
84878432797
-
Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: An early increase in lymphocyte and eosinophil counts is associated with improved survival
-
Delyon J, Mateus C, Lefeuvre D, Lanoy E, Zitvogel L, Chaput N et al (2013) Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival. Ann Oncol 24:1697-1703
-
(2013)
Ann Oncol
, vol.24
, pp. 1697-1703
-
-
Delyon, J.1
Mateus, C.2
Lefeuvre, D.3
Lanoy, E.4
Zitvogel, L.5
Chaput, N.6
-
24
-
-
84878875962
-
Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10 mg/kg within an expanded access programme
-
Di Giacomo AM, Calabro L, Danielli R, Fonsatti E, Bertocci E, Pesce I et al (2013) Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10 mg/kg within an expanded access programme. Cancer Immunol Immunother 62:1021-1028
-
(2013)
Cancer Immunol Immunother
, vol.62
, pp. 1021-1028
-
-
Di Giacomo, A.M.1
Calabro, L.2
Danielli, R.3
Fonsatti, E.4
Bertocci, E.5
Pesce, I.6
-
25
-
-
84875343764
-
Single-center experience with ipilimumab in an expanded access program for patients with pretreated advanced melanoma
-
Wilgenhof S, Du FS, Vandenbroucke F, Everaert H, Salmon I, Liénard D et al (2013) Single-center experience with ipilimumab in an expanded access program for patients with pretreated advanced melanoma. J Immunother 36:215-222
-
(2013)
J Immunother
, vol.36
, pp. 215-222
-
-
Wilgenhof, S.1
Du, F.S.2
Vandenbroucke, F.3
Everaert, H.4
Salmon, I.5
Liénard, D.6
-
26
-
-
84903814426
-
Pharmacodynamic effect of ipilimumab on absolute lymphocyte count (ALC) and association with overall survival in patients with advanced melanoma
-
abstr 9052
-
Postow MA, Chasalow SD, Yuan J, Kuk D, Panageas KS, Cheng M et al (2013) Pharmacodynamic effect of ipilimumab on absolute lymphocyte count (ALC) and association with overall survival in patients with advanced melanoma. J Clin Oncol 31: abstr 9052
-
(2013)
J Clin Oncol
, vol.31
-
-
Postow, M.A.1
Chasalow, S.D.2
Yuan, J.3
Kuk, D.4
Panageas, K.S.5
Cheng, M.6
-
27
-
-
74949143594
-
Final version of 2009 AJCC melanoma staging and classification
-
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR et al (2009) Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 27:6199-6206
-
(2009)
J Clin Oncol
, vol.27
, pp. 6199-6206
-
-
Balch, C.M.1
Gershenwald, J.E.2
Soong, S.J.3
Thompson, J.F.4
Atkins, M.B.5
Byrd, D.R.6
-
28
-
-
9244249813
-
Predictors of clinical response to interleukin-2-based immunotherapy in melanoma patients: A French multiinstitutional study
-
Tartour E, Blay JY, Dorval T, Escudier B, Mosseri V, Douillard JY et al (1996) Predictors of clinical response to interleukin-2-based immunotherapy in melanoma patients: a French multiinstitutional study. J Clin Oncol 14:1697-1703 (Pubitemid 26134229)
-
(1996)
Journal of Clinical Oncology
, vol.14
, Issue.5
, pp. 1697-1703
-
-
Tartour, E.1
Blay, J.Y.2
Dorval, T.3
Escudier, B.4
Mosseri, V.5
Douillard, J.Y.6
Deneux, L.7
Gorin, I.8
Negrier, S.9
Mathiot, C.10
Pouillart, P.11
Fridman, W.H.12
-
29
-
-
84891628090
-
Serum lactate dehydrogenase (LDH) as a prognostic selection criterion for ipilimumab treatment in metastatic melanoma
-
abstr 3036
-
Blank CU, Kelderman S, van Tinteren H, Heemskerk B, van den Brom R, Hospers GA et al (2013) Serum lactate dehydrogenase (LDH) as a prognostic selection criterion for ipilimumab treatment in metastatic melanoma. J Clin Oncol 31: abstr 3036
-
(2013)
J Clin Oncol
, vol.31
-
-
Blank, C.U.1
Kelderman, S.2
Van Tinteren, H.3
Heemskerk, B.4
Van Den Brom, R.5
Hospers, G.A.6
-
30
-
-
84874882829
-
CTLA-4 defines distinct T cell signaling populations in healthy donors and metastatic melanoma patients
-
abstr 760
-
Hotson D, Conroy A, Evensen E, Gentilcore G, Simeone E, Esposito A et al (2012) CTLA-4 defines distinct T cell signaling populations in healthy donors and metastatic melanoma patients. J Immunother 11: abstr 760
-
(2012)
J Immunother
, vol.11
-
-
Hotson, D.1
Conroy, A.2
Evensen, E.3
Gentilcore, G.4
Simeone, E.5
Esposito, A.6
-
31
-
-
79959742164
-
Prognostic role of FOXP3 + regulatory T cells infiltrating human carcinomas: The paradox of colorectal cancer
-
Ladoire S, Martin F, Ghiringhelli F (2011) Prognostic role of FOXP3 + regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immunol Immunother 60:909-918
-
(2011)
Cancer Immunol Immunother
, vol.60
, pp. 909-918
-
-
Ladoire, S.1
Martin, F.2
Ghiringhelli, F.3
|