메뉴 건너뛰기




Volumn 18, Issue 11, 2016, Pages 3728-3741

The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus (‘Penicillium islandicum’)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROPEPTIDE; CYCLOPEPTIDE; FUNGAL PROTEIN; MYCOTOXIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDE SYNTHASE; PHENYLALANINE;

EID: 84976905121     PISSN: 14622912     EISSN: 14622920     Source Type: Journal    
DOI: 10.1111/1462-2920.13294     Document Type: Article
Times cited : (18)

References (56)
  • 1
    • 33845592512 scopus 로고    scopus 로고
    • GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin
    • Balibar, C.J., and Walsh, C.T. (2006) GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin. Biochemistry 45: 15029-15038.
    • (2006) Biochemistry , vol.45 , pp. 15029-15038
    • Balibar, C.J.1    Walsh, C.T.2
  • 2
    • 0036161991 scopus 로고    scopus 로고
    • Mutational analysis of the C-domain in nonribosomal peptide synthesis
    • Bergendahl, V., Linne, U., and Marahiel, M.A. (2002) Mutational analysis of the C-domain in nonribosomal peptide synthesis. Eur J Biochem 269: 620-629.
    • (2002) Eur J Biochem , vol.269 , pp. 620-629
    • Bergendahl, V.1    Linne, U.2    Marahiel, M.A.3
  • 3
    • 33645017788 scopus 로고    scopus 로고
    • Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis
    • Blasiak, L.C., Vaillancourt, F.H., Walsh, C.T., and Drennan, C.L. (2006) Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature 440: 368-371.
    • (2006) Nature , vol.440 , pp. 368-371
    • Blasiak, L.C.1    Vaillancourt, F.H.2    Walsh, C.T.3    Drennan, C.L.4
  • 6
    • 0034013269 scopus 로고    scopus 로고
    • Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
    • Challis, G.L., Ravel, J., and Townsend, C.A. (2000) Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol 7: 211-224.
    • (2000) Chem Biol , vol.7 , pp. 211-224
    • Challis, G.L.1    Ravel, J.2    Townsend, C.A.3
  • 8
    • 0028122932 scopus 로고
    • Mechanism of cyclosporin A biosynthesis. Evidence for synthesis via a single linear undecapeptide precursor
    • Dittmann, J., Wenger, R.M., Kleinkauf, H., and Lawen, A. (1994) Mechanism of cyclosporin A biosynthesis. Evidence for synthesis via a single linear undecapeptide precursor. J Biol Chem 269: 2841-2846.
    • (1994) J Biol Chem , vol.269 , pp. 2841-2846
    • Dittmann, J.1    Wenger, R.M.2    Kleinkauf, H.3    Lawen, A.4
  • 9
    • 25844517049 scopus 로고    scopus 로고
    • Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination
    • Dong, C., Flecks, S., Unversucht, S., Haupt, C., van Pée, K.H., and Naismith, J.H. (2005) Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Science 309: 2216-2219.
    • (2005) Science , vol.309 , pp. 2216-2219
    • Dong, C.1    Flecks, S.2    Unversucht, S.3    Haupt, C.4    Van Pée, K.H.5    Naismith, J.H.6
  • 10
    • 77956227979 scopus 로고    scopus 로고
    • Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxyalpha-amino acids
    • Duckers, N., Baer, K., Simon, S., Groger, H., and Hummel, W. (2010) Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxyalpha-amino acids. Appl Microbiol Biotechnol 88: 409-424.
    • (2010) Appl Microbiol Biotechnol , vol.88 , pp. 409-424
    • Duckers, N.1    Baer, K.2    Simon, S.3    Groger, H.4    Hummel, W.5
  • 11
    • 9244234513 scopus 로고    scopus 로고
    • Biosynthesis of nonribosomal peptides
    • Finking, R., and Marahiel, M.A. (2004) Biosynthesis of nonribosomal peptides. Annu Rev Microbiol 58: 453-488.
    • (2004) Annu Rev Microbiol , vol.58 , pp. 453-488
    • Finking, R.1    Marahiel, M.A.2
  • 12
    • 0032861512 scopus 로고    scopus 로고
    • Engineering of a novel biochemical pathway for the biosynthesis of L-2-aminobutyric acid in Escherichia coli K12
    • Fotheringham, I.G., Grinter, N., Pantaleone, D.P., Senkpeil, R.F., and Taylor, P.P. (1999) Engineering of a novel biochemical pathway for the biosynthesis of L-2-aminobutyric acid in Escherichia coli K12. Bioorg Med Chem 7: 2209-2213.
    • (1999) Bioorg Med Chem , vol.7 , pp. 2209-2213
    • Fotheringham, I.G.1    Grinter, N.2    Pantaleone, D.P.3    Senkpeil, R.F.4    Taylor, P.P.5
  • 13
    • 84920643958 scopus 로고    scopus 로고
    • Taxonomy, chemodiversity, and chemoconsistency of Aspergillus, Penicillium, and Talaromyces species
    • Frisvad, J.C. (2014) Taxonomy, chemodiversity, and chemoconsistency of Aspergillus, Penicillium, and Talaromyces species. Front Microbiol 5: 773-780.
    • (2014) Front Microbiol , vol.5 , pp. 773-780
    • Frisvad, J.C.1
  • 14
    • 0038777634 scopus 로고    scopus 로고
    • Mycotoxin production by common filamentous fungi
    • Samson, R.A., Hoekstra, E.S., and Frisvad, J.C. (eds). Utrecht: Centraalbureau voor Schimmelcultures
    • Frisvad, J.C., and Thrane, U. (2004) Mycotoxin production by common filamentous fungi. In Introduction to food-and airborne fungi. Samson, R.A., Hoekstra, E.S., and Frisvad, J.C. (eds). Utrecht: Centraalbureau voor Schimmelcultures, pp. 321-331.
    • (2004) Introduction to Food-And Airborne Fungi , pp. 321-331
    • Frisvad, J.C.1    Thrane, U.2
  • 15
    • 84867357427 scopus 로고    scopus 로고
    • Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain
    • Gao, X., Haynes, S.W., Ames, B.D., Wang, P., Vien, L.P., Walsh, C.T., and Tang, Y. (2012) Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nat Chem Biol 8: 823-830.
    • (2012) Nat Chem Biol , vol.8 , pp. 823-830
    • Gao, X.1    Haynes, S.W.2    Ames, B.D.3    Wang, P.4    Vien, L.P.5    Walsh, C.T.6    Tang, Y.7
  • 16
    • 0029018327 scopus 로고
    • Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    • Guzman, L.M., Belin, D., Carson, M.J., and Beckwith, J. (1995) Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol 177: 4121-4130.
    • (1995) J Bacteriol , vol.177 , pp. 4121-4130
    • Guzman, L.M.1    Belin, D.2    Carson, M.J.3    Beckwith, J.4
  • 17
    • 84928161840 scopus 로고    scopus 로고
    • Ironing out their differences: Dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
    • Heberling, M.M., Masman, M.F., Bartsch, S., Wybenga, G.G., Dijkstra, B.W., Marrink, S.J., and Janssen, D.B. (2015) Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase. Acs Chem Biol 10: 989-997.
    • (2015) Acs Chem Biol , vol.10 , pp. 989-997
    • Heberling, M.M.1    Masman, M.F.2    Bartsch, S.3    Wybenga, G.G.4    Dijkstra, B.W.5    Marrink, S.J.6    Janssen, D.B.7
  • 18
    • 33947694781 scopus 로고    scopus 로고
    • Natural products of filamentous fungi: Enzymes, genes, and their regulation
    • Hoffmeister, D., and Keller, N.P. (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24: 393-416.
    • (2007) Nat Prod Rep , vol.24 , pp. 393-416
    • Hoffmeister, D.1    Keller, N.P.2
  • 19
    • 0024470350 scopus 로고
    • Molecular cloning and nucleotide sequence of the gramicidin S synthetase 1 gene
    • Hori, K., Yamamoto, Y., Minetoki, T., Kurotsu, T., Kanda, M., Miura, S., et al. (1989) Molecular cloning and nucleotide sequence of the gramicidin S synthetase 1 gene. J Biochem106: 639-645.
    • (1989) J Biochem106 , pp. 639-645
    • Hori, K.1    Yamamoto, Y.2    Minetoki, T.3    Kurotsu, T.4    Kanda, M.5    Miura, S.6
  • 20
    • 0028828393 scopus 로고
    • Transformations of Penicillium islandicum and Penicillium frequentans that produce anthraquinone-related compounds
    • Huang, K.X., Iwakami, N., Fujii, I., Ebizuka, Y., and Sankawa, U. (1995) Transformations of Penicillium islandicum and Penicillium frequentans that produce anthraquinone-related compounds. Curr Genet 28: 580-584.
    • (1995) Curr Genet , vol.28 , pp. 580-584
    • Huang, K.X.1    Iwakami, N.2    Fujii, I.3    Ebizuka, Y.4    Sankawa, U.5
  • 21
    • 84924529499 scopus 로고    scopus 로고
    • High yields of active Thermus thermophilus proline dehydrogenase are obtained using maltose-binding protein as a solubility tag
    • Huijbers, M.M., and van Berkel, W.J. (2015) High yields of active Thermus thermophilus proline dehydrogenase are obtained using maltose-binding protein as a solubility tag. Biotechnol J 10: 395-403.
    • (2015) Biotechnol J , vol.10 , pp. 395-403
    • Huijbers, M.M.1    Van Berkel, W.J.2
  • 22
    • 84922927786 scopus 로고    scopus 로고
    • Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus
    • Kalb, D., Heinekamp, T., Lackner, G., Scharf, D.H., Dahse, H.M., Brakhage, A.A., and Hoffmeister, D. (2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microb 81: 1594-1600.
    • (2015) Appl Environ Microb , vol.81 , pp. 1594-1600
    • Kalb, D.1    Heinekamp, T.2    Lackner, G.3    Scharf, D.H.4    Dahse, H.M.5    Brakhage, A.A.6    Hoffmeister, D.7
  • 23
    • 0033560968 scopus 로고    scopus 로고
    • Post-translational modification of nisin. The involvement of NisB in the dehydration process
    • Karakas Sen, A., Narbad, A., Horn, N., Dodd, H.M., Parr, A.J., Colquhoun, I., and Gasson, M.J. (1999) Post-translational modification of nisin. The involvement of NisB in the dehydration process. Eur J Biochem 261: 524-532.
    • (1999) Eur J Biochem , vol.261 , pp. 524-532
    • Karakas Sen, A.1    Narbad, A.2    Horn, N.3    Dodd, H.M.4    Parr, A.J.5    Colquhoun, I.6    Gasson, M.J.7
  • 24
    • 0021340276 scopus 로고
    • A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp
    • Kawai, K., Kato, T., Mori, H., Kitamura, J., and Nozawa, Y. (1984) A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp. Toxicol Lett 20: 155-160.
    • (1984) Toxicol Lett , vol.20 , pp. 155-160
    • Kawai, K.1    Kato, T.2    Mori, H.3    Kitamura, J.4    Nozawa, Y.5
  • 25
    • 0031079973 scopus 로고    scopus 로고
    • Metabolic pathway gene clusters in filamentous fungi
    • Keller, N.P., and Hohn, T.M. (1997) Metabolic pathway gene clusters in filamentous fungi. Fungal Genet Biol 21: 17-29.
    • (1997) Fungal Genet Biol , vol.21 , pp. 17-29
    • Keller, N.P.1    Hohn, T.M.2
  • 26
    • 0027510201 scopus 로고
    • Isolation and structure of asterin, a new halogenated cyclic pentapeptide from Aster tataricus
    • Kosemura, S., Ogawa, T., and Totsuka, K. (1993) Isolation and structure of asterin, a new halogenated cyclic pentapeptide from Aster tataricus. Tetrahedron Lett 34: 1291-1294.
    • (1993) Tetrahedron Lett , vol.34 , pp. 1291-1294
    • Kosemura, S.1    Ogawa, T.2    Totsuka, K.3
  • 27
    • 33746183968 scopus 로고    scopus 로고
    • Application of the nourseothricin acetyltransferase gene (Nat1) as dominant marker for the transformation of filamentous fungi
    • Kück, U., and Hoff, B. (2006) Application of the nourseothricin acetyltransferase gene (nat1) as dominant marker for the transformation of filamentous fungi. Fungal Genet Newsl 53: 9-11.
    • (2006) Fungal Genet Newsl , vol.53 , pp. 9-11
    • Kück, U.1    Hoff, B.2
  • 29
    • 84876587454 scopus 로고    scopus 로고
    • Detecting sequence homology at the gene cluster level with MultiGeneBlast
    • Medema, M.H., Takano, E., and Breitling, R. (2013) Detecting sequence homology at the gene cluster level with MultiGeneBlast. Mol Biol Evol 30: 1218-1223.
    • (2013) Mol Biol Evol , vol.30 , pp. 1218-1223
    • Medema, M.H.1    Takano, E.2    Breitling, R.3
  • 30
    • 73449134513 scopus 로고    scopus 로고
    • In vitro reconstitution of the first steps of anatoxin-a biosynthesis in Oscillatoria PCC 6506: From free L-proline to acyl carrier protein bound dehydroproline
    • Mejean, A., Mann, S., Vassiliadis, G., Lombard, B., Loew, D., and Ploux, O. (2010) In vitro reconstitution of the first steps of anatoxin-a biosynthesis in Oscillatoria PCC 6506: from free L-proline to acyl carrier protein bound dehydroproline. Biochemistry 49: 103-113.
    • (2010) Biochemistry , vol.49 , pp. 103-113
    • Mejean, A.1    Mann, S.2    Vassiliadis, G.3    Lombard, B.4    Loew, D.5    Ploux, O.6
  • 31
    • 49049094854 scopus 로고    scopus 로고
    • Structural and conformational analysis of hydroxycyclochlorotine and cyclochlorotine, chlorinated cyclic peptides from Penicillium islandicum
    • Mizutani, K., Hirasawa, Y., Sugita-Konishi, Y., Mochizuki, N., and Morita, H. (2008) Structural and conformational analysis of hydroxycyclochlorotine and cyclochlorotine, chlorinated cyclic peptides from Penicillium islandicum. J Nat Prod 71: 1297-1300.
    • (2008) J Nat Prod , vol.71 , pp. 1297-1300
    • Mizutani, K.1    Hirasawa, Y.2    Sugita-Konishi, Y.3    Mochizuki, N.4    Morita, H.5
  • 32
    • 0027290776 scopus 로고
    • Astins A and B, antitumor cyclic pentapeptides from Aster tataricus
    • Morita, H., Nagashima, S., Takeya, K., and Itokawa, H. (1993) Astins A and B, antitumor cyclic pentapeptides from Aster tataricus. Chem Pharm Bull (Tokyo) 41: 992-993.
    • (1993) Chem Pharm Bull (Tokyo) , vol.41 , pp. 992-993
    • Morita, H.1    Nagashima, S.2    Takeya, K.3    Itokawa, H.4
  • 34
    • 39149099787 scopus 로고    scopus 로고
    • Halogenation strategies in natural product biosynthesis
    • Neumann, C.S., Fujimori, D.G., and Walsh, C.T. (2008) Halogenation strategies in natural product biosynthesis. Chem Biol 15: 99-109.
    • (2008) Chem Biol , vol.15 , pp. 99-109
    • Neumann, C.S.1    Fujimori, D.G.2    Walsh, C.T.3
  • 35
    • 84981708917 scopus 로고    scopus 로고
    • Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500)
    • Nierman, W.C., Fedorova-Abrams, N.D., and Andrianopoulos, A. (2015) Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500). Genome Announc 3: e01559-01514.
    • (2015) Genome Announc , vol.3 , pp. e01514-e01559
    • Nierman, W.C.1    Fedorova-Abrams, N.D.2    Andrianopoulos, A.3
  • 36
    • 0034598653 scopus 로고    scopus 로고
    • Acceleration of actin polymerization and rapid microfilament reorganization in cultured hepatocytes by cyclochlorotin, a hepatotoxic cyclic peptide
    • Ohmi, K., Enosawa, S., Nonomura, Y., Tatsuno, T., and Ueno, Y. (2001) Acceleration of actin polymerization and rapid microfilament reorganization in cultured hepatocytes by cyclochlorotin, a hepatotoxic cyclic peptide. Toxicon 39: 303-308.
    • (2001) Toxicon , vol.39 , pp. 303-308
    • Ohmi, K.1    Enosawa, S.2    Nonomura, Y.3    Tatsuno, T.4    Ueno, Y.5
  • 37
    • 79959936207 scopus 로고    scopus 로고
    • NRPSpredictor2-a web server for predicting NRPS adenylation domain specificity
    • Röttig, M., Medema, M.H., Blin, K., Weber, T., Rausch, C., and Kohlbacher, O. (2011) NRPSpredictor2-a web server for predicting NRPS adenylation domain specificity. Nucleic Acids Res 39: W362-W367.
    • (2011) Nucleic Acids Res , vol.39 , pp. W362-W367
    • Röttig, M.1    Medema, M.H.2    Blin, K.3    Weber, T.4    Rausch, C.5    Kohlbacher, O.6
  • 38
    • 84255201133 scopus 로고    scopus 로고
    • Phylogeny and nomenclature of the genus Talaromyces and taxa accommodated in Penicillium subgenus Biverticillium
    • Samson, R.A., Yilmaz, N., Houbraken, J., Spierenburg, H., Seifert, K.A., Peterson, S.W. et al. (2011) Phylogeny and nomenclature of the genus Talaromyces and taxa accommodated in Penicillium subgenus Biverticillium. Stud Mycol 70: 159-183.
    • (2011) Stud Mycol , vol.70 , pp. 159-183
    • Samson, R.A.1    Yilmaz, N.2    Houbraken, J.3    Spierenburg, H.4    Seifert, K.A.5    Peterson, S.W.6
  • 39
    • 84938582518 scopus 로고    scopus 로고
    • Draft genome sequence of Talaromyces islandicus (“Penicillium islandicum”) WF-38-12, a neglected mold with significant biotechnological potential
    • Schafhauser, T., Wibberg, D., Rückert, C., Winkler, A., Flor, L., van Pée, K.H. et al. (2015) Draft genome sequence of Talaromyces islandicus (“Penicillium islandicum”) WF-38-12, a neglected mold with significant biotechnological potential. J Biotechnol 211: 101-102.
    • (2015) J Biotechnol , vol.211 , pp. 101-102
    • Schafhauser, T.1    Wibberg, D.2    Rückert, C.3    Winkler, A.4    Flor, L.5    Van Pée, K.H.6
  • 40
    • 84907259451 scopus 로고    scopus 로고
    • Overproduction of ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17
    • Spohn, M., Kirchner, N., Kulik, A., Jochim, A., Wolf, F., Muenzer, P. et al. (2014) Overproduction of ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17. Antimicrob Agents Chemother 58: 6185-6196.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 6185-6196
    • Spohn, M.1    Kirchner, N.2    Kulik, A.3    Jochim, A.4    Wolf, F.5    Muenzer, P.6
  • 41
    • 0033179468 scopus 로고    scopus 로고
    • The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
    • Stachelhaus, T., Mootz, H.D., and Marahiel, M.A. (1999) The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem Biol 6: 493-505.
    • (1999) Chem Biol , vol.6 , pp. 493-505
    • Stachelhaus, T.1    Mootz, H.D.2    Marahiel, M.A.3
  • 42
  • 43
    • 84866637856 scopus 로고    scopus 로고
    • Combining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development
    • Teichert, I., Wolff, G., Kück, U., and Nowrousian, M. (2012) Combining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development. BMC Genomics 13: 511.
    • (2012) BMC Genomics , vol.13 , pp. 511
    • Teichert, I.1    Wolff, G.2    Kück, U.3    Nowrousian, M.4
  • 44
    • 0036008844 scopus 로고    scopus 로고
    • Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis
    • Thomas, M.G., Burkart, M.D., and Walsh, C.T. (2002) Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chem Biol 9: 171-184.
    • (2002) Chem Biol , vol.9 , pp. 171-184
    • Thomas, M.G.1    Burkart, M.D.2    Walsh, C.T.3
  • 45
    • 84902002754 scopus 로고    scopus 로고
    • Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus
    • Umemura, M., Nagano, N., Koike, H., Kawano, J., Ishii, T., Miyamura, Y. et al. (2014) Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus. Fungal Genet Biol 68: 23-30.
    • (2014) Fungal Genet Biol , vol.68 , pp. 23-30
    • Umemura, M.1    Nagano, N.2    Koike, H.3    Kawano, J.4    Ishii, T.5    Miyamura, Y.6
  • 46
    • 67650071917 scopus 로고
    • Isolation of two toxic agents, luteoskyrin and chlorine-containing peptide, from the metabolites of Penicillium islandicum Sopp, with some properties thereof
    • Uraguchi, K. (1961) Isolation of two toxic agents, luteoskyrin and chlorine-containing peptide, from the metabolites of Penicillium islandicum Sopp, with some properties thereof. Jpn J Exp Med 31: 19-46.
    • (1961) Jpn J Exp Med , vol.31 , pp. 19-46
    • Uraguchi, K.1
  • 47
    • 0015325993 scopus 로고
    • Chronic toxicity and carcinogenicity in mice of purified mycotoxins, luteoskyrin and cyclochlorotine
    • Uraguchi, K., Tatsuno, T., Takahash K, Saito, M., Enomoto, M., and Noguchi, Y. (1972) Chronic toxicity and carcinogenicity in mice of purified mycotoxins, luteoskyrin and cyclochlorotine. Food Cosmet Toxicol 10: 193-207.
    • (1972) Food Cosmet Toxicol , vol.10 , pp. 193-207
    • Uraguchi, K.1    Tatsuno, T.2    Takahash, K.3    Saito, M.4    Enomoto, M.5    Noguchi, Y.6
  • 48
    • 84867001758 scopus 로고    scopus 로고
    • Enzymatic chlorination and bromination
    • van Pée, K.H. (2012) Enzymatic chlorination and bromination. Method Enzymol 516: 237-257.
    • (2012) Method Enzymol , vol.516 , pp. 237-257
    • Van Pée, K.H.1
  • 49
    • 33646816419 scopus 로고    scopus 로고
    • Flavin-dependent halogenases involved in secondary metabolism in bacteria
    • van Pée, K.H., and Patallo, E.P. (2006) Flavin-dependent halogenases involved in secondary metabolism in bacteria. Appl Microbiol Biotechnol 70: 631-641.
    • (2006) Appl Microbiol Biotechnol , vol.70 , pp. 631-641
    • Van Pée, K.H.1    Patallo, E.P.2
  • 50
    • 84880149568 scopus 로고    scopus 로고
    • Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds
    • Walsh, C.T., O’Brien, R.V., and Khosla, C. (2013) Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angew Chem Int Ed Engl 52: 7098-7124.
    • (2013) Angew Chem Int Ed Engl , vol.52 , pp. 7098-7124
    • Walsh, C.T.1    O’Brien, R.V.2    Khosla, C.3
  • 51
    • 84979859096 scopus 로고    scopus 로고
    • (2015) antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters
    • Weber, T., Blin, K., Duddela, S., Krug, D., Kim, H.U., Bruccoleri, R. et al. (2015) antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res 43: W237-W243.
    • Nucleic Acids Res , vol.43 , pp. W237-W243
    • Weber, T.1    Blin, K.2    Duddela, S.3    Krug, D.4    Kim, H.U.5    Bruccoleri, R.6
  • 52
    • 84957916454 scopus 로고    scopus 로고
    • A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (Honey mushroom) toxins
    • Wick, J., Heine, D., Lackner, G., Misiek, M., Tauber, J., Jagusch, H. et al. (2015) A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Appl Environ Microb 82: 1196-1204.
    • (2015) Appl Environ Microb , vol.82 , pp. 1196-1204
    • Wick, J.1    Heine, D.2    Lackner, G.3    Misiek, M.4    Tauber, J.5    Jagusch, H.6
  • 53
    • 0037036464 scopus 로고    scopus 로고
    • Identification of peptaibols from Trichoderma virens and cloning of a peptaibol synthetase
    • Wiest, A., Grzegorski, D., Xu, B.W., Goulard, C., Rebuffat, S., Ebbole, D.J. et al. (2002) Identification of peptaibols from Trichoderma virens and cloning of a peptaibol synthetase. J Biol Chem277: 20862-20868.
    • (2002) J Biol Chem277 , pp. 20862-20868
    • Wiest, A.1    Grzegorski, D.2    Xu, B.W.3    Goulard, C.4    Rebuffat, S.5    Ebbole, D.J.6
  • 54
    • 84900564010 scopus 로고    scopus 로고
    • Molecular evolution and functional characterisation of an ancient phenylalanine ammonia-lyase gene (NnPAL1) from Nelumbo nucifera: Novel insight into the evolution of the PAL family in angiosperms
    • Wu, Z.H., Gui, S.T., Wang, S.Z., and Ding, Y. (2014) Molecular evolution and functional characterisation of an ancient phenylalanine ammonia-lyase gene (NnPAL1) from Nelumbo nucifera: novel insight into the evolution of the PAL family in angiosperms. BMC Evol Biol 14: 1-14.
    • (2014) BMC Evol Biol , vol.14 , pp. 1-14
    • Wu, Z.H.1    Gui, S.T.2    Wang, S.Z.3    Ding, Y.4
  • 56
    • 84939204823 scopus 로고    scopus 로고
    • A clinical study of acquired immunodeficiency syndrome associated Penicillium marneffeii infection from a non-endemic area in China
    • Zheng, J., Gui, X., Cao, Q., Yang, R., Yan, Y., Deng, L., and Lio, J. (2015) A clinical study of acquired immunodeficiency syndrome associated Penicillium marneffeii infection from a non-endemic area in China. PLos One 10: e0130376.
    • (2015) Plos One , vol.10
    • Zheng, J.1    Gui, X.2    Cao, Q.3    Yang, R.4    Yan, Y.5    Deng, L.6    Lio, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.