GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin

Biochemistry

Volumn 45, Issue 50, 2006, Pages 15029-15038

  Balibar, Carl J ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ESCHERICHIA COLI; METABOLITES; NITROGEN COMPOUNDS; REDOX REACTIONS; TOXIC MATERIALS;

DIKETOPIPERAZINE (DKP) SCAFFOLDS; ENZYME INTERMEDIATES; INTRAMOLECULAR CYCLIZATION; PHOSPHOPANTETHEINE PROSTHETIC GROUPS;

ENZYMES;

CARBON; DIPEPTIDE DERIVATIVE; FUNGAL ENZYME; GLIOTOXIN; MYCOTOXIN; PANTETHEINE PHOSPHATE; PEPTIDE SYNTHASE; PHENYLALANINE; PHENYLSERINE; PIPERAZINEDIONE; PROTEIN GLIP; SERINE; SULFUR; THIOL ESTER HYDROLASE;

ARTICLE; ASPERGILLUS FUMIGATUS; ASPERGILLUS FUMIGATUS AF293; CONTROLLED STUDY; CYCLIZATION; DISULFIDE BOND; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME RELEASE; ENZYME STRUCTURE; ENZYME SYNTHESIS; ESCHERICHIA COLI; FUNGAL STRAIN; METABOLITE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; STRUCTURE ACTIVITY RELATION; THIOLATION;

ASPERGILLUS FUMIGATUS; ENZYME ACTIVATION; ESCHERICHIA COLI; FUNGAL PROTEINS; GLIOTOXIN; MUTATION; PEPTIDE SYNTHASES; PIPERAZINES; PROTEIN STRUCTURE, TERTIARY;

ASPERGILLUS FUMIGATUS; ASPERGILLUS FUMIGATUS AF293; ESCHERICHIA COLI;

EID: 33845592512     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061845b     Document Type: Article

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