Quercetin-Loaded Solid Lipid Nanoparticle Dispersion with Improved Physicochemical Properties and Cellular Uptake

AAPS PharmSciTech

Volumn 18, Issue 3, 2017, Pages 875-883

  Vijayakumar, Ajay ^a   Baskaran, Rengarajan ^a   Jang, Young Soo ^a   Oh, Seung Hyun ^a   Yoo, Bong Kyu ^a  

^a Gachon University College of Medicine   (South Korea)

Author keywords

chitosan; quercetin; solid lipid nanoparticles; surface coating; tripalmitin

Indexed keywords

CHITOSAN; CRYSTALLIN; DISTILLED WATER; LIPID; NANOCARRIER; PHOSPHATIDYLCHOLINE; QUERCETIN; SOLID LIPID NANOPARTICLE; TRIPALMITIN; DRUG CARRIER; EXCIPIENT; NANOPARTICLE; TRIACYLGLYCEROL;

ARTICLE; CACO-2 CELL LINE; CELL TRANSPORT; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISPERSITY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL; SURFACE PROPERTY; ULTRASOUND; ZETA POTENTIAL; CHEMISTRY; HUMAN; MEDICINAL CHEMISTRY; PROCEDURES; TUMOR CELL LINE;

CACO-2 CELLS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG CARRIERS; EXCIPIENTS; HUMANS; LECITHINS; LIPIDS; NANOPARTICLES; PARTICLE SIZE; QUERCETIN; TRIGLYCERIDES;

EID: 84976503878     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-016-0573-4     Document Type: Article

References (45)

1. Muller RH, MaEder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery—sa review of the state of the art. Eur J Pharm Biopharm. 2000;50(1):161–77.
2. Mehnert W, Mader K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2001;47(2):165–96.
3. Kakkar Thukral D, Dumoga S, Mishra AK. Solid lipid nanoparticles: promising therapeutic nanocarriers for drug delivery. Curr Drug Deliv. 2014;11(6):771–91.
4. Q-y X, Wang M, Chen F, Gong T, Y-l J, Z-r Z, et al. Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch Pharm Res. 2007;30(4):519–25.
5. Muller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs—a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol. 2004;113(1):151–70.
6. Mukherjee S, Ray S, Thakur R. Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian J Pharm Sci. 2009;71(4):349.
7. Pardeike J, Hommoss A, Müller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm. 2009;366(1):170–84.
8. Uner M, Yener G. Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int J Nanomedicine. 2007;2(3):289.
9. Abdelbary G, Fahmy RH. Diazepam-loaded solid lipid nanoparticles: design and characterization. AAPS PharmSciTech. 2009;10(1):211–9.
10. Kalepu S, Manthina M, Padavala V. Oral lipid-based drug delivery systems—an overview. Acta Pharm Sin B. 2013;3(6):361–72.
11. Severino P, Andreani T, Macedo AS, Fangueiro JF, Santana MHA, Silva AM, et al. Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. J Drug Deliv. 2011;2012.
12. Aditya N, Macedo AS, Doktorovova S, Souto EB, Kim S, Chang P-S, et al. Development and evaluation of lipid nanocarriers for quercetin delivery: a comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE). LWT - Food Sci Technol. 2014;59(1):115–21.
13. Dok-Go H, Lee KH, Kim HJ, Lee EH, Lee J, Song YS, et al. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 2003;965(1):130–6.
14. Jung E-G, Han K-I, Kwon H-J, Patnaik BB, Kim W-J, Hur GM, et al. Anti-inflammatory activity of sappanchalcone isolated from Caesalpinia sappan L. in a collagen-induced arthritis mouse model. Arch Pharm Res. 2015;38(6):973–83.
15. Kim HH, Kim DH, Kim MH, Oh MH, Kim SR, Park KJ, et al. Flavonoid constituents in the leaves of Myrica rubra sieb. et zucc. with anti-inflammatory activity. Arch Pharm Res. 2013;36(12):1533–40.
16. Rotelli AE, Guardia T, Juarez AO, De la Rocha NE, Pelzer LE. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res. 2003;48(6):601–6.
17. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585(2):325–37.
18. Cai X, Fang Z, Dou J, Yu A, Zhai G. Bioavailability of quercetin: problems and promises. Curr Med Chem. 2013;20(20):2572–82.
19. Nagpal K, Singh SK, Mishra DN. Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull. 2010;58(11):1423–30.
20. Yang T, Nyiawung D, Silber A, Hao J, Lai L, Bai S. Comparative studies on chitosan and polylactic-co-glycolic acid incorporated nanoparticles of low molecular weight heparin. AAPS PharmSciTech. 2012;13(4):1309–18.
21. Piyakulawat P, Praphairaksit N, Chantarasiri N, Muangsin N. Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac. AAPS PharmSciTech. 2007;8(4):120–30.
22. Dash M, Chiellini F, Ottenbrite RM, Chiellini E. Chitosan—a versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci. 2011;36(8):981–1014.
23. Lee KD, Choi S-H, Kim DH, Lee H-Y, Choi K-C. Self-organized nanoparticles based on chitosan-folic acid and dextran succinate-doxorubicin conjugates for drug targeting. Arch Pharm Res. 2014;37(12):1546–53.
24. Luo Y, Teng Z, Li Y, Wang Q. Solid lipid nanoparticles for oral drug delivery: chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake. Carbohydr Polym. 2015;122:221–9.
25. Madheswaran T, Baskaran R, Sundaramoorthy P, Yoo BK. Enhanced skin permeation of 5α-reductase inhibitors entrapped into surface-modified liquid crystalline nanoparticles. Arch Pharm Res. 2015;38(4):534–42.
26. Tran TH, Guo Y, Song D, Bruno RS, Lu X. Quercetin‐containing self‐nanoemulsifying drug delivery system for improving oral bioavailability. J Pharm Sci. 2014;103(3):840–52.
27. Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech. 2011;12(1):62–76.
28. Mishra A, Vuddanda PR, Singh S. Intestinal lymphatic delivery of praziquantel by solid lipid nanoparticles: formulation design, in vitro and in vivo studies. J Nanotech. 2014;2014.
29. Svensson O, Thuresson K, Arnebrant T. Interactions between chitosan-modified particles and mucin-coated surfaces. J Colloid Interface Sci. 2008;325(2):346–50.
30. Madheswaran T, Baskaran R, Thapa RK, Rhyu JY, Choi HY, Kim JO, et al. Design and in vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery. AAPS PharmSciTech. 2013;14(1):45–52.
31. Baskaran R, Madheswaran T, Sundaramoorthy P, Kim HM, Yoo BK. Entrapment of curcumin into monoolein-based liquid crystalline nanoparticle dispersion for enhancement of stability and anticancer activity. Int J Nanomedicine. 2014;9:3119.
32. Jain S, Jain AK, Pohekar M, Thanki K. Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications for drug-induced cardiotoxicity and nephrotoxicity. Free Radic Biol Med. 2013;65:117–30.
33. Censi R, Martena V, Hoti E, Malaj L, Di Martino P. Permeation and skin retention of quercetin from microemulsions containing Transcutol® P. Drug Dev Ind Pharm. 2012;38(9):1128–33.
34. Azuma K, Ippoushi K, Ito H, Higashio H, Terao J. Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J Agric Food Chem. 2002;50(6):1706–12.
35. Pizzol CD, Filippin-Monteiro FB, Restrepo JAS, Pittella F, Silva AH, Alves de Souza P, et al. Influence of surfactant and lipid type on the physicochemical properties and biocompatibility of solid lipid nanoparticles. Int J Environ Res Public Health. 2014;11(8):8581–96.
36. Awad TS, Helgason T, Weiss J, Decker EA, McClements DJ. Effect of omega-3 fatty acids on crystallization, polymorphic transformation and stability of tripalmitin solid lipid nanoparticle suspensions. Cryst Growth Des. 2009;9(8):3405–11.
37. Patel MR, Martin‐Gonzalez S, Fernanda M. Characterization of ergocalciferol loaded solid lipid nanoparticles. J Food Sci. 2012;77(1):N8–13.
38. Hu X, Lin X, Gu Y, Liu Z, Tang Y, Zhang Y, et al. Biocompatible riboflavin laurate long-acting injectable nanosuspensions allowing sterile filtration. Drug Deliv. 2014;21(5):351–61.
39. Lakkadwala S, Nguyen S, Lawrence J, Nauli SM, Nesamony J. Physico-chemical characterisation, cytotoxic activity, and biocompatibility studies of tamoxifen-loaded solid lipid nanoparticles prepared via a temperature-modulated solidification method. J Microencapsul. 2014;31(6):590–9.
40. Sabnis S, Rege P, Block LH. Use of chitosan in compressed tablets of diclofenac sodium: inhibition of drug release in an acidic environment. Pharm Dev Technol. 1997;2(3):243–55.
41. Lopez-León T, Carvalho E, Seijo B, Ortega-Vinuesa J, Bastos-González D. Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior. J Colloid Interface Sci. 2005;283(2):344–51.
42. Li N, Zhuang C, Wang M, Sun X, Nie S, Pan W. Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. Int J Pharm. 2009;379(1):131–8.
43. Abouelmagd SA, Ku YJ, Yeo Y. Low molecular weight chitosan-coated polymeric nanoparticles for sustained and pH-sensitive delivery of paclitaxel. J Drug Target. 2015;23(7-8):725–35.
44. Bang S, Hwang I, Yu Y, Kwon H, Kim D, Park HJ. Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems. J Microencapsul. 2011;28(7):595–604.
45. Honary S, Zahir F. Effect of zeta potential on the properties of nano-drug delivery systems—a review (part 1). Trop J Pharm Res. 2013;12(2):255–64.