Enhanced skin permeation of 5α-reductase inhibitors entrapped into surface-modified liquid crystalline nanoparticles

Archives of Pharmacal Research

Volumn 38, Issue 4, 2015, Pages 534-542

  Madheswaran, Thiagarajan ^a   Baskaran, Rengarajan ^b   Sundaramoorthy, Pasupathi ^b   Yoo, Bong Kyu ^b  

^a Yeungnam University   (South Korea)

^b Gachon University College of Medicine   (South Korea)

Author keywords

Chitosan; Dutasteride; Finasteride; Liquid crystalline nanoparticles; Skin permeation

Indexed keywords

NANOPARTICLE; STEROID 5ALPHA REDUCTASE INHIBITOR;

ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HUMAN; KERATINOCYTE; LIQUID CRYSTAL; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PIG; SKIN ABSORPTION; SURFACE PROPERTY;

5-ALPHA REDUCTASE INHIBITORS; ANIMALS; CELL SURVIVAL; HUMANS; KERATINOCYTES; LIQUID CRYSTALS; NANOPARTICLES; ORGAN CULTURE TECHNIQUES; SKIN ABSORPTION; SURFACE PROPERTIES; SWINE;

EID: 84939884579     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-014-0464-8     Document Type: Article

References (31)

1. Azzouni, F., N. Zeitouni, and J. Mohler. 2013. Role of 5α-reductase inhibitors in androgen-stimulated skin disorders. Journal of Drugs in Dermatology 12: e30-e35.
2. Banka, N., M. Bunagan, and J. Shapiro. 2013. Pattern hair loss in men: diagnosis and medical treatment. Dermatologic Clinics 31: 129-140.
3. Blumeyer, A., A. Tosti, A. Messenger, P. Reygagne, V. del Marmol, P.I. Spuls, M. Trakatelli, A. Finner, F. Kiesewetter, R. Trüeb, R. Rzany, and U. Blume-Peytavi. 2011. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. Journal der Deutschen Dermatologischen Gesellschaft 9: S1-S57.
4. Boyapati, A., and R. Sinclair. 2013. Combination therapy with finasteride and low-dose dutasteride in the treatment of androgenetic alopecia. Australasian Journal of Dermatology 54: 49-51.
5. Cevc, G., and U. Vierl. 2010. Nanotechnology and the transdermal route: a state of the art review and critical appraisal. Journal of Controlled Release 141: 277-299.
6. Chang, D.P., M. Jankunec, J. Barauskas, F. Tiberg, and T. Nylander. 2012. Adsorption of lipid liquid crystalline nanoparticles on cationic, hydrophilic, and hydrophobic surfaces. ACS Applied Materials and Interfaces 4: 2643-2651.
7. Farshi, S., P. Mansouri, and F. Rafie. 2012. A randomized double blind, vehicle controlled bilateral comparison study of the efficacy and safety of finasteride 0.5% solution in combination with intense pulsed light in the treatment of facial hirsutism. Journal of Cosmetic and Laser Therapy 87: 193-199.
8. Guo, C., J. Wang, F. Cao, R.J. Lee, and G. Zhai. 2010. Lyotropic liquid crystal systems in drug delivery. Drug Discovery Today 15: 1032-1040.
9. Gupta, A.K., and A. Charrette. 2014. The efficacy and safety of 5α-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit-risk assessment of finasteride and dutasteride. Journal of Dermatological Treatment 25: 156-161.
10. Gur, S., P.J. Kadowitz, and W.J. Hellstrom. 2013. Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation. Expert Opinion on Drug Safety 12: 81-90.
11. Hajheydari, Z., J. Akbari, M. Saeedi, and L. Shokoohi. 2009. Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian Journal of Dermatology, Venereology and Leprology 75: 47-51.
12. Inui, S., and S. Itami. 2011. Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla. Journal of Dermatological Science 61: 1-6.
13. Inui, S., and S. Itami. 2013. Androgen actions on the human hair follicle: perspectives. Experimental Dermatology 22: 168-171.
14. Jepps, O.G., Y. Dancik, Y.G. Anissimov, and M.S. Roberts. 2013. Modeling the human skin barrier: Towards a better understanding of dermal absorption. Advanced Drug Delivery Reviews 65: 152-168.
15. Kulkarni, C.V., W. Wachter, G. Iglesias-Salto, W. Engelskirchen, and S. Ahualli. 2011. Monoolein: a magic lipid? Physical Chemistry Chemical Physics: PCCP 13: 3004-3021.
16. Lapteva, M., and Y.N. Kalia. 2013. Microstructured bicontinuous phase formulations: their characterization and application in dermal and transdermal drug delivery. Expert opinion on drug delivery 10: 1043-1059.
17. Liu, H., S. Chen, Y. Zhou, X. Che, Z. Bao, S. Li, and J. Xu. 2013. The effect of surface charge of glycerol monooleate-based nanoparticles on the round window membrane permeability and cochlear distribution. Journal of Drug Targeting 21: 846-854.
18. Madheswaran, T., R. Baskaran, R.K. Thapa, J.Y. Rhyu, H.Y. Choi, J.O. Kim, C.S. Yong, and B.K. Yoo. 2013a. Design and in vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery. AAPS PharmSciTech 14: 45-52.
19. Madheswaran, T., R. Baskaran, C.S. Yong, and B.K. Yoo. 2013b. Enhanced topical delivery of finasteride using glyceryl monooleate-based liquid crystalline nanoparticles stabilized by cremophor surfactants. AAPS PharmSciTech 15: 44-51.
20. Mulet, X., B.J. Boyd, and C.J. Drummond. 2013. Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions. Journal of Colloid and Interface Science 393: 1-20.
21. Murgia, S., A.M. Falchi, M. Mano, S. Lampis, R. Angius, A.M. Carnerup, J. Schmidt, G. Diaz, M. Giacca, and Y. Talmon. 2010. Nanoparticles from lipid-based liquid crystals: emulsifier influence on morphology and cytotoxicity. Journal of Physical Chemistry B 114: 3518-3525.
22. Mysore, V. 2012. Finasteride and sexual side effects. Indian Dermatology Online Journal 3: 62-65.
23. Park, S.H., B.B. Das, F. Casagrande, Y. Tian, H.J. Nothnagel, M. Chu, H. Kiefer, K. Maier, A.A. De Angelis, and F.M. Marassi. 2012. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature 491: 779-783.
24. Prow, T.W., J.E. Grice, L.L. Lin, R. Faye, M. Butler, W. Becker, E.M.T. Wurm, C. Yoong, T.A. Robertson, H.P. Soyer, and M.S. Roberts. 2011. Nanoparticles and microparticles for skin drug delivery. Advanced Drug Delivery Reviews 63: 470-491.
25. Ridolfi, D.M., P.D. Marcato, G.Z. Justo, L. Cordi, D. Machado, and N. Durán. 2012. Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin. Colloids and Surfaces B: Biointerfaces 93: 36-40.
26. Rojanasakul, Y., L.Y. Wang, M. Bhat, D.D. Glover, C.J. Malanga, and J.K. Ma. 1992. The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit. Pharmaceutical Research 9: 1029-1034.
27. Svensson, O., K. Thuresson, and T. Arnebrant. 2008. Interactions between chitosan-modified particles and mucin-coated surfaces. Journal of Colloid and Interface Science 325: 346-350.
28. de Valente Duarte Sousa, I.C., and A. Tosti. 2013. New investigational drugs for androgenetic alopecia. Expert Opinion on Investigational Drugs 22: 573-589.
29. Van Neste, D., V. Fuh, P. Sanchez-Pedreno, E. Lopez-Bran, H. Wolff, D. Whiting, J. Roberts, D. Kopera, J.J. Stene, S. Calvieri, A. Tosti, E. Prens, M. Guarrera, P. Kanojia, W. He, and K.D. Kaufman. 2000. Finasteride increases anagen hair in men with androgenetic alopecia. British Journal of Dermatology 143: 804-810.
30. Piemi, Youenang. 1999. M. P., Korner, D., Benita, S., and Marty, J. P., Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. Journal of Controlled Release 58: 177-187.
31. Zhang, J., and B. Michniak-Kohn. 2011. Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine. International Journal of Pharmaceutics 421: 34-44.