CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Mogami, Sachiko ^a   Sadakane, Chiharu ^a   Nahata, Miwa ^a   Mizuhara, Yasuharu ^a   Yamada, Chihiro ^a   Hattori, Tomohisa ^a   Takeda, Hiroshi ^b,c  

^a TSUMURA AND CO   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; HERBACEOUS AGENT; RIKKUNSHITO;

ANIMAL; ANOREXIA; ANTAGONISTS AND INHIBITORS; BRAIN; COMPLICATION; MALE; MENTAL STRESS; METABOLISM; MOUSE; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANOREXIA; BRAIN; DRUGS, CHINESE HERBAL; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRESS, PSYCHOLOGICAL;

EID: 84976406770     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep27516     Document Type: Article

References (48)

1. Diefenbach, G. J. & Goethe, J. Clinical interventions for late-life anxious depression. Clin Interv Aging 1, 41-50 (2006).
2. Paykel, E. S. Life events, social support and depression. Acta Psychiatr Scand Suppl 377, 50-58 (1994).
3. Rowe, J. W. & Kahn, R. L. Human aging: usual and successful. Science 237, 143-149 (1987).
4. Seeman, T. E. & Robbins, R. J. Aging and hypothalamic-pituitary-Adrenal response to challenge in humans. Endocr Rev 15, 233-260 (1994).
5. Moschik, E. C., Mercado, C., Yoshino, T., Matsuura, K. & Watanabe, K. Usage and attitudes of physicians in Japan concerning traditional Japanese medicine (kampo medicine): a descriptive evaluation of a representative questionnaire-based survey. Evid Based Complement Alternat Med 2012, 139818 (2012).
6. Ito, A., Munakata, K., Imazu, Y. & Watanabe, K. First nationwide attitude survey of Japanese physicians on the use of traditional Japanese medicine (kampo) in cancer treatment. Evid Based Complement Alternat Med 2012, 957082 (2012).
7. Suzuki, H., Inadomi, J. M. & Hibi, T. Japanese herbal medicine in functional gastrointestinal disorders. Neurogastroenterol Motil 21, 688-696 (2009).
8. Tominaga, K. & Arakawa, T. Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application. J Gastroenterol 48, 452-462 (2013).
9. Oka, T. et al. Effects of Kampo on functional gastrointestinal disorders. Biopsychosoc Med 8, 5 (2014).
10. Suzuki, H. et al. Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia-A multicenter, double-blind, randomized, placebo-controlled study. Neurogastroenterol Motil 26, 950-961 (2014).
11. Tominaga, K. et al. A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G-PRIDE study. J Gastroenterol 49, 1392-1405 (2014).
12. Mogami, S. & Hattori, T. Beneficial effects of rikkunshito, a Japanese kampo medicine, on gastrointestinal dysfunction and anorexia in combination with Western drug: a systematic review. Evid Based Complement Alternat Med 2014, 519035 (2014).
13. Nahata, M. et al. Serotonin 2C receptor antagonism ameliorates novelty-induced hypophagia in aged mice. Psychoneuroendocrinology 38, 2051-2064 (2013).
14. Yamada, C. et al. Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice. Psychoneuroendocrinology 55C, 81-93 (2015).
15. Takeda, H. et al. Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology 134, 2004-2013 (2008).
16. Hemrick-Luecke, S. K. & Evans, D. C. Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT) (2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis. Neuropharmacology 42, 162-169 (2002).
17. Heisler, L. K. et al. Serotonin activates the hypothalamic-pituitary-Adrenal axis via serotonin 2C receptor stimulation. J Neurosci 27, 6956-6964 (2007).
18. Saegusa, Y. et al. Decreased plasma ghrelin contributes to anorexia following novelty stress. Am J Physiol Endocrinol Metab 301, E685-696 (2011).
19. Heisler, L. K. et al. Activation of central melanocortin pathways by fenfluramine. Science 297, 609-611 (2002).
20. Heisler, L. K. et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 51, 239-249 (2006).
21. Lam, D. D. et al. Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology 149, 1323-1328 (2008).
22. Kitagawa, H. et al. Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study. PLoS One 10, e0133159 (2015).
23. Yamada, C. et al. Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model. Biomed Res Int 2013, 792940 (2013).
24. Simmler, C. et al. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. J Agric Food Chem 61, 2146-2157 (2013).
25. Xiang, C. et al. From single compounds to herbal extract: a strategy to systematically characterize the metabolites of licorice in rats. Drug Metab Dispos 39, 1597-1608 (2011).
26. Kido, T. et al. Effects of rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by N(G)-nitro-Larginine. J Pharmacol Sci. 98, 161-167 (2005).
27. Heisler, L. K., Zhou, L., Bajwa, P., Hsu, J. & Tecott, L. H. Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav 6, 491-496 (2007).
28. Hotta, M., Shibasaki, T., Arai, K. & Demura, H. Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats. Brain Res 823, 221-225 (1999).
29. Zorrilla, E. P., Tache, Y. & Koob, G. F. Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends Pharmacol Sci 24, 421-427 (2003).
30. Yakabi, K. et al. Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction. Regul Pept 161, 97-105 (2010).
31. Tabuchi, M., Imamura, S., Kawakami, Z., Ikarashi, Y. & Kase, Y. The blood-brain barrier permeability of 18beta-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan. Cell Mol Neurobiol 32, 1139-1146 (2012).
32. Singh, S. P., Wahajuddin, Tewari, D., Patel, K. & Jain, G. K. Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method. Fitoterapia 82, 1206-1214 (2011).
33. Saigusa, D. et al. High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound. Anal Bioanal Chem 400, 3635-3641 (2011).
34. Li, T. et al. Simultaneous quantification of paeoniflorin, nobiletin, tangeretin, liquiritigenin, isoliquiritigenin, liquiritin and formononetin from Si-Ni-San extract in rat plasma and tissues by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr 27, 1041-1053 (2013).
35. Elahy, M. et al. Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment. Immun Ageing 12, 2 (2015).
36. Montagne, A. et al. Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302 (2015).
37. Dulawa, S. C. & Hen, R. Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci Biobehav Rev 29, 771-783 (2005).
38. Hayashi, A., Suzuki, M., Sasamata, M. & Miyata, K. Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats. Psychopharmacology (Berl) 178, 241-249 (2005).
39. Kennett, G. A. et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36, 609-620 (1997).
40. Tsubouchi, H. et al. Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion. Nutr Res 34, 876-885 (2014).
41. Wang, L. et al. Patterns of Brain Activation and Meal Reduction Induced by Abdominal Surgery in Mice and Modulation by Rikkunshito. PLoS One 10, e0139325 (2015).
42. Martinez, V. & Tache, Y. Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats. Brain Res 893, 29-35 (2001).
43. Nakade, Y. et al. Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats. Am J Physiol Regul Integr Comp Physiol 288, R427-432 (2005).
44. Kask, A. & Schioth, H. B. Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat. Brain Res. 887, 460-464 (2000).
45. Haley, T. J. & McCormick, W. G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br J Pharmacol Chemother 12, 12-15 (1957).
46. Chen, R., Lewis, K. A., Perrin, M. H. & Vale, W. W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci. USA 90, 8967-8971 (1993).
47. Chhajlani, V. Characterization of a putative alpha-MSH antagonist 153N-6 at melanocortin receptor subtypes by radioligand binding. Peptides 17, 349-351 (1996).
48. Schioth, H. B. et al. Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypes. Peptides 18, 1009-1013 (1997).