The blood-brain barrier permeability of 18b-glycyrrhetinic acid, a major metabolite of glycyrrhizin in glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan

Cellular and Molecular Neurobiology

Volumn 32, Issue 7, 2012, Pages 1139-1146

  Tabuchi, Masahiro ^a   Imamura, Sachiko ^a   Kawakami, Zenji ^a   Ikarashi, Yasushi ^a   Kase, Yoshio ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

18b Glycyrrhetinic acid; Blood brain barrier; Glycyrrhiza root; Glycyrrhizin; Yokukansan

Indexed keywords

ANGELICA ACUTILOBA EXTRACT; ATRACTYLODES EXTRACT; BUPLEURUM ROOT EXTRACT; CARBAMAZEPINE; CNIDIUM RHIZOME EXTRACT; FLAVONOID; GLYCYRRHETINIC ACID; GLYCYRRHIZA URALENSIS EXTRACT; GLYCYRRHIZIC ACID; ISOLIQUIRITIGENIN; ISOLIQUIRITIN; ISOLIQUIRITIN APIOSIDE; LIQUIRITIGENIN; LIQUIRITIN; LIQUIRITIN APIOSIDE; PLANT EXTRACT; PORIA COCOS EXTRACT; PSYCHOTROPIC AGENT; UNCARIA RHYNCHOPHILLA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; COCULTURE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISTRIBUTION; DRUG PENETRATION; ENDOTHELIUM CELL; GLYCYRRHIZA; IN VITRO STUDY; IN VIVO STUDY; JAPAN; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PERICYTE; PLANT ROOT; PRIORITY JOURNAL; RAT; TRADITIONAL MEDICINE; UNCARIA; UNCARIA RHYNCHOPHILLA;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; DRUGS, CHINESE HERBAL; GLYCYRRHETINIC ACID; GLYCYRRHIZA; GLYCYRRHIZIC ACID; JAPAN; MALE; MEDICINE, EAST ASIAN TRADITIONAL; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY;

GLYCYRRHIZA; RATTUS;

EID: 84867580336     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-012-9839-x     Document Type: Article

References (25)

1. Abbott NJ, Rönnbäck L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7:41-53
2. Akao T, Hayashi T, Kobashi K, Kanaoka M, Kato H, Kobayashi M, Takeda S, Oyama T (1994) Intestinal bacterial hydrolysis is indispensable to absorption of 18b-glycyrrhetic acid after oral administration of glycyrrhizin in rats. J Pharm Pharmacol 46:135-137
3. Cantelli-Forti G, Maffei F, Hrelia P, Bugamelli F, Bernardi M, D'Intino P, Maranesi M, Raggi MA (1994) Interaction of licorice on glycyrrhizin pharmacokinetics. Environ Health Perspect 102:65-68
4. Cecchelli R, Berezowski V, Lundquist S, Culot M, Renftel M, Dehouck MP, Fenart L (2007) Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 6:650-661
5. De Vries HE, Blom-Roosemalen MCM, De Boer AG, Van Berkel TJC, Breimer DD, Kuiper J (1996) Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro. J Pharm Exp Ther 277:1418-1423
6. Deli MA, A ́ braha'm CS, Kataoka Y, Niwa M (2005) Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell Mol Neurobiol 25:59-127
7. Gaillard PJ, De Boer AG (2000) Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drug. Eur J Pharm Sci 12:95-102
8. Gaillard PJ, De Boer AG, Breimer DD (2003) Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro. Microvasc Res 65:24-31
9. Hattori M, Sakamoto T, Yamagishi T, Sakamoto K, Konishi K, Kobashi K, Namba T (1985) Metabolism of glycyrrhizin by human intestinal flora. II. Isolation and characterization of human intestinal bacteria capable of metabolizing glycyrrhizin and related compounds. Chem Pharm Bull 33:210-217
10. Ikarashi Y, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S (2009) Effects of Yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. Biol Pharm Bull 32:1701-1709
11. Imamura S, Tabuchi M, Kushida H, Nishi A, Kanno H, Yamaguchi T, Sekiguchi K, Ikarashi Y, Kase Y (2011) The blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansan. Cell Mol Neurobiol 31:787-793
12. Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H (2005) A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry 66:248-252
13. Jang EY, Choe ES, Hwang M, Kim SC, Lee JR, Kim SG, Jeon JP, Buono RJ, Yang CH (2008) Isoliquiritigenin suppresses cocaineinduced extracellular dopamine release in rat brain through GABAB receptor. Eur J Pharmacol 587:124-128
14. Joó F (1996) Endothelial cells of the brain and other organ systems: some similarities and differences. Prog Neurobiol 48:255-273
15. Kawakami Z, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, Kase Y (2009) Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. Neuroscience 159:1397-1407
16. Kawakami Z, Ikarashi Y, Kase Y (2010) Glycyrrhizin and its metabolite 18b-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes. Eur J Pharmacol 626:154-158
17. Kis B, Deli MA, Kobayashi H,A ́ braha'm CS, Yanagita T, Kaiya H, Isse T, Nishi R, Gotoh S, Kangawa K, Wada A, Greenwood J, Niwa M, Yamashita H, Ueta Y (2001) Adrenomedullin regulates blood- brain barrier functions in vitro. Neuroreport 12:4139-4142
18. Mizukami K, Asada T, Kinoshita T, Tanaka K, Sonohara K, Nakai R, Yamaguchi K, Hanyu H, Kanaya K, Takao T, Okada M, Kudo S, Kotoku H, Iwakiri M, Kurita H, Miyamura T, Kawasaki Y, Omori K, Shiozaki K, Odawara T, Suzuki T, Yamada S, Nakamura Y, Toba K (2009) A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. Int J Neuropsychopharmacol 12:191-199
19. Monji A, Takita M, Samejima T, Takaishi T, Hashimoto K, Matsunaga H, Oda M, Sumida Y, Mizoguchi Y, Kato T (2009) Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 33:308-311
20. Nakagawa S, Deli MA, Nakao S, Honda M, Hayashi K, Nakaoke R, Kataoka Y, Niwa M (2007) Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells. Cell Mol Neurobiol 27:687-694
21. Nakagawa S, Deli MA, Kawaguchi H, Shimizudani T, Shimono T, Kittel A ́, Tanaka K, Niwa M (2009) A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochem Int 54:253-263
22. Redzic Z (2011) Molecular biology of the blood-brain and the blood- cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS 8:3
23. Takeda S, Ishihara K, Wakui Y, Amagaya S, Maruno M, Akao T, Kobashi K (1996) Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis. J Pharm Pharmacol 48:902-905
24. Veszelka S, Pa'sztó i M, Farkas AE, Krizbai I, Dung NTK, Niwa M, A ́ braha'm CS, Deli MA (2007) Pentosan polysulfate protects brain endothelial cells against bacterial lipopolysaccharideinduced damages. Neurochem Int 50:219-228
25. Wang Z, Kurosaki Y, Nakayama T, Kimura T (1994) Mechanism of gastrointestinal absorption of glycyrrhizin in rats. Biol Pharm Bull 17:1399-1403 Zlokovic BV (2008) The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57:178-201