-
1
-
-
2442563304
-
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
-
Loftus EV Jr: Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004; 126: 1504-1517.
-
(2004)
Gastroenterology
, vol.126
, pp. 1504-1517
-
-
Loftus, E.V.1
-
2
-
-
84902125741
-
Incidence of pediatric inflammatory bowel disease in Saudi Arabia: A multicenter national study
-
El Mouzan MI, Saadah O, Al-Saleem K, Al Edreesi M, Hasosah M, Alanazi A, Al Mofarreh M, Asery A, Al Qourain A, Nouli K, Al Hussaini A, Telmesani A, AlReheili K, Alghamdi S, Alrobiaa N, Alzaben A, Mehmadi A, Al Hebbi H, Al Sarkhy A, Al Mehaidib A, Al Saleem B, Assiri A, Wali S: Incidence of pediatric inflammatory bowel disease in Saudi Arabia: A multicenter national study. Inflamm Bowel Dis 2014; 20: 1085-1090.
-
(2014)
Inflamm Bowel Dis
, vol.20
, pp. 1085-1090
-
-
El Mouzan, M.I.1
Saadah, O.2
Al-Saleem, K.3
Al Edreesi, M.4
Hasosah, M.5
Alanazi, A.6
Al Mofarreh, M.7
Asery, A.8
Al Qourain, A.9
Nouli, K.10
Al Hussaini, A.11
Telmesani, A.12
AlReheili, K.13
Alghamdi, S.14
Alrobiaa, N.15
Alzaben, A.16
Mehmadi, A.17
Al Hebbi, H.18
Al Sarkhy, A.19
Al Mehaidib, A.20
Al Saleem, B.21
Assiri, A.22
Wali, S.23
more..
-
3
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
Lesage, S.4
Cezard, J.P.5
Belaiche, J.6
Almer, S.7
Tysk, C.8
O'Morain, C.A.9
Gassull, M.10
Binder, V.11
Finkel, Y.12
Cortot, A.13
Modigliani, R.14
Laurent-Puig, P.15
Gower-Rousseau, C.16
Macry, J.17
Colombel, J.F.18
Sahbatou, M.19
Thomas, G.20
more..
-
4
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-606.
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
Nicolae, D.L.4
Chen, F.F.5
Ramos, R.6
Britton, H.7
Moran, T.8
Karaliuskas, R.9
Duerr, R.H.10
Achkar, J.P.11
Brant, S.R.12
Bayless, T.M.13
Kirschner, B.S.14
Hanauer, S.B.15
Nunez, G.16
Cho, J.H.17
-
5
-
-
84898685253
-
Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses
-
Lecuyer E, Rakotobe S, Lengline-Garnier H, Lebreton C, Picard M, Juste C, Fritzen R, Eberl G, McCoy KD, Macpherson AJ, Reynaud CA, Cerf-Bensussan N, Gaboriau-Routhiau V: Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity 2014; 40: 608-620.
-
(2014)
Immunity
, vol.40
, pp. 608-620
-
-
Lecuyer, E.1
Rakotobe, S.2
Lengline-Garnier, H.3
Lebreton, C.4
Picard, M.5
Juste, C.6
Fritzen, R.7
Eberl, G.8
McCoy, K.D.9
Macpherson, A.J.10
Reynaud, C.A.11
Cerf-Bensussan, N.12
Gaboriau-Routhiau, V.13
-
6
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR: Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139: 485-498.
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
Atarashi, K.2
Manel, N.3
Brodie, E.L.4
Shima, T.5
Karaoz, U.6
Wei, D.7
Goldfarb, K.C.8
Santee, C.A.9
Lynch, S.V.10
Tanoue, T.11
Imaoka, A.12
Itoh, K.13
Takeda, K.14
Umesaki, Y.15
Honda, K.16
Littman, D.R.17
-
7
-
-
84901979873
-
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
-
Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR: Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature 2014; 510: 152-156.
-
(2014)
Nature
, vol.510
, pp. 152-156
-
-
Yang, Y.1
Torchinsky, M.B.2
Gobert, M.3
Xiong, H.4
Xu, M.5
Linehan, J.L.6
Alonzo, F.7
Ng, C.8
Chen, A.9
Lin, X.10
Sczesnak, A.11
Liao, J.J.12
Torres, V.J.13
Jenkins, M.K.14
Lafaille, J.J.15
Littman, D.R.16
-
8
-
-
84943638660
-
An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses
-
Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR: An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses. Cell 2015; 163: 381-393.
-
(2015)
Cell
, vol.163
, pp. 381-393
-
-
Sano, T.1
Huang, W.2
Hall, J.A.3
Yang, Y.4
Chen, A.5
Gavzy, S.J.6
Lee, J.Y.7
Ziel, J.W.8
Miraldi, E.R.9
Domingos, A.I.10
Bonneau, R.11
Littman, D.R.12
-
9
-
-
0030297089
-
The indigenous gastrointestinal microflora
-
Berg RD: The indigenous gastrointestinal microflora. Trends Microbiol 1996; 4: 430-435.
-
(1996)
Trends Microbiol
, vol.4
, pp. 430-435
-
-
Berg, R.D.1
-
10
-
-
84921786777
-
Regional specialization within the intestinal immune system
-
Mowat AM, Agace WW: Regional specialization within the intestinal immune system. Nat Rev Immunol 2014; 14: 667-685.
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 667-685
-
-
Mowat, A.M.1
Agace, W.W.2
-
11
-
-
80054122238
-
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
-
Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV: The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 2011; 334: 255-258.
-
(2011)
Science
, vol.334
, pp. 255-258
-
-
Vaishnava, S.1
Yamamoto, M.2
Severson, K.M.3
Ruhn, K.A.4
Yu, X.5
Koren, O.6
Ley, R.7
Wakeland, E.K.8
Hooper, L.V.9
-
12
-
-
33745327007
-
Antibiotics and probiotics in treatment of inflammatory bowel disease
-
Gionchetti P, Rizzello F, Lammers KM, Morselli C, Sollazzi L, Davies S, Tambasco R, Calabrese C, Campieri M: Antibiotics and probiotics in treatment of inflammatory bowel disease. World J Gastroenterol 2006; 12: 3306-3313.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 3306-3313
-
-
Gionchetti, P.1
Rizzello, F.2
Lammers, K.M.3
Morselli, C.4
Sollazzi, L.5
Davies, S.6
Tambasco, R.7
Calabrese, C.8
Campieri, M.9
-
13
-
-
0033551085
-
Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging
-
He G, Shankar RA, Chzhan M, Samouilov A, Kuppusamy P, Zweier JL: Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging. Proc Natl Acad Sci U S A 1999; 96: 4586-4591.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4586-4591
-
-
He, G.1
Shankar, R.A.2
Chzhan, M.3
Samouilov, A.4
Kuppusamy, P.5
Zweier, J.L.6
-
14
-
-
84908306828
-
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota
-
Albenberg L, Esipova TV, Judge CP, Bittinger K, Chen J, Laughlin A, Grunberg S, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov SA, Wu GD: Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology 2014; 147: 1055-1063.e8.
-
(2014)
Gastroenterology
, vol.147
, pp. 1055e8-1063e8
-
-
Albenberg, L.1
Esipova, T.V.2
Judge, C.P.3
Bittinger, K.4
Chen, J.5
Laughlin, A.6
Grunberg, S.7
Baldassano, R.N.8
Lewis, J.D.9
Li, H.10
Thom, S.R.11
Bushman, F.D.12
Vinogradov, S.A.13
Wu, G.D.14
-
15
-
-
84905482236
-
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
-
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA: Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest 2014; 124: 3617-3633.
-
(2014)
J Clin Invest
, vol.124
, pp. 3617-3633
-
-
Haberman, Y.1
Tickle, T.L.2
Dexheimer, P.J.3
Kim, M.O.4
Tang, D.5
Karns, R.6
Baldassano, R.N.7
Noe, J.D.8
Rosh, J.9
Markowitz, J.10
Heyman, M.B.11
Griffiths, A.M.12
Crandall, W.V.13
Mack, D.R.14
Baker, S.S.15
Huttenhower, C.16
Keljo, D.J.17
Hyams, J.S.18
Kugathasan, S.19
Walters, T.D.20
Aronow, B.21
Xavier, R.J.22
Gevers, D.23
Denson, L.A.24
more..
-
16
-
-
84880924622
-
Dysbiosis in inflammatory bowel diseases: The oxygen hypothesis
-
Rigottier-Gois L: Dysbiosis in inflammatory bowel diseases: The oxygen hypothesis. ISME J 2013; 7: 1256-1261.
-
(2013)
ISME J
, vol.7
, pp. 1256-1261
-
-
Rigottier-Gois, L.1
-
17
-
-
84896092821
-
The treatment-naive microbiome in new-onset Crohn's disease
-
Gevers D, Kugathasan S, Denson LA, Vazquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, Gonzalez A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ: The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe 2014; 15: 382-392.
-
(2014)
Cell Host Microbe
, vol.15
, pp. 382-392
-
-
Gevers, D.1
Kugathasan, S.2
Denson, L.A.3
Vazquez-Baeza, Y.4
Van Treuren, W.5
Ren, B.6
Schwager, E.7
Knights, D.8
Song, S.J.9
Yassour, M.10
Morgan, X.C.11
Kostic, A.D.12
Luo, C.13
Gonzalez, A.14
McDonald, D.15
Haberman, Y.16
Walters, T.17
Baker, S.18
Rosh, J.19
Stephens, M.20
Heyman, M.21
Markowitz, J.22
Baldassano, R.23
Griffiths, A.24
Sylvester, F.25
Mack, D.26
Kim, S.27
Crandall, W.28
Hyams, J.29
Huttenhower, C.30
Knight, R.31
Xavier, R.J.32
more..
-
18
-
-
84878019827
-
Crohn's disease: Small bowel motility impairment correlates with inflammatory-related markers C-reactive protein and calprotectin
-
Bickelhaupt S, Pazahr S, Chuck N, Blume I, Froehlich JM, Cattin R, Raible S, Bouquet H, Bill U, Rogler G, Frei P, Boss A, Patak MA: Crohn's disease: small bowel motility impairment correlates with inflammatory-related markers C-reactive protein and calprotectin. Neurogastroenterol Motil 2013; 25: 467-473.
-
(2013)
Neurogastroenterol Motil
, vol.25
, pp. 467-473
-
-
Bickelhaupt, S.1
Pazahr, S.2
Chuck, N.3
Blume, I.4
Froehlich, J.M.5
Cattin, R.6
Raible, S.7
Bouquet, H.8
Bill, U.9
Rogler, G.10
Frei, P.11
Boss, A.12
Patak, M.A.13
-
19
-
-
56649107785
-
Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients
-
Ohama T, Hori M, Fujisawa M, Kiyosue M, Hashimoto M, Ikenoue Y, Jinno Y, Miwa H, Matsumoto T, Murata T, Ozaki H: Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients. J Gastroenterol 2008; 43: 858-865.
-
(2008)
J Gastroenterol
, vol.43
, pp. 858-865
-
-
Ohama, T.1
Hori, M.2
Fujisawa, M.3
Kiyosue, M.4
Hashimoto, M.5
Ikenoue, Y.6
Jinno, Y.7
Miwa, H.8
Matsumoto, T.9
Murata, T.10
Ozaki, H.11
-
20
-
-
0022634567
-
Human interdigestive motility: Variations in patterns from esophagus to colon
-
Kellow JE, Borody TJ, Phillips SF, Tucker RL, Haddad AC: Human interdigestive motility: variations in patterns from esophagus to colon. Gastroenterology 1986; 91: 386-395.
-
(1986)
Gastroenterology
, vol.91
, pp. 386-395
-
-
Kellow, J.E.1
Borody, T.J.2
Phillips, S.F.3
Tucker, R.L.4
Haddad, A.C.5
-
21
-
-
80054767981
-
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation
-
Larsson JM, Karlsson H, Crespo JG, Johansson ME, Eklund L, Sjovall H, Hansson GC: Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. Inflamm Bowel Dis 2011; 17: 2299-2307.
-
(2011)
Inflamm Bowel Dis
, vol.17
, pp. 2299-2307
-
-
Larsson, J.M.1
Karlsson, H.2
Crespo, J.G.3
Johansson, M.E.4
Eklund, L.5
Sjovall, H.6
Hansson, G.C.7
-
22
-
-
84906707282
-
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus
-
Schutte A, Ermund A, Becker-Pauly C, Johansson ME, Rodriguez-Pineiro AM, Backhed F, Muller S, Lottaz D, Bond JS, Hansson GC: Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus. Proc Natl Acad Sci U S A 2014; 111: 12396-12401.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 12396-12401
-
-
Schutte, A.1
Ermund, A.2
Becker-Pauly, C.3
Johansson, M.E.4
Rodriguez-Pineiro, A.M.5
Backhed, F.6
Muller, S.7
Lottaz, D.8
Bond, J.S.9
Hansson, G.C.10
-
23
-
-
54449083567
-
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
-
Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC: The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A 2008; 105: 15064-15069.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 15064-15069
-
-
Johansson, M.E.1
Phillipson, M.2
Petersson, J.3
Velcich, A.4
Holm, L.5
Hansson, G.C.6
-
24
-
-
74249101114
-
Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease
-
Fyderek K, Strus M, Kowalska-Duplaga K, Gosiewski T, Wedrychowicz A, Jedynak-Wasowicz U, Sladek M, Pieczarkowski S, Adamski P, Kochan P, Heczko PB: Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease. World J Gastroenterol 2009; 15: 5287-5294.
-
(2009)
World J Gastroenterol
, vol.15
, pp. 5287-5294
-
-
Fyderek, K.1
Strus, M.2
Kowalska-Duplaga, K.3
Gosiewski, T.4
Wedrychowicz, A.5
Jedynak-Wasowicz, U.6
Sladek, M.7
Pieczarkowski, S.8
Adamski, P.9
Kochan, P.10
Heczko, P.B.11
-
25
-
-
84885711264
-
Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota
-
Kashyap PC, Marcobal A, Ursell LK, Smits SA, Sonnenburg ED, Costello EK, Higginbottom SK, Domino SE, Holmes SP, Relman DA, Knight R, Gordon JI, Sonnenburg JL: Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota. Proc Natl Acad Sci U S A 2013; 110: 17059-17064.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 17059-17064
-
-
Kashyap, P.C.1
Marcobal, A.2
Ursell, L.K.3
Smits, S.A.4
Sonnenburg, E.D.5
Costello, E.K.6
Higginbottom, S.K.7
Domino, S.E.8
Holmes, S.P.9
Relman, D.A.10
Knight, R.11
Gordon, J.I.12
Sonnenburg, J.L.13
-
26
-
-
77955398591
-
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
-
McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI; International IBD Genetics Consortium: Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet 2010; 19: 3468-3476.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3468-3476
-
-
International IBD Genetics Consortium1
McGovern, D.P.2
Jones, M.R.3
Taylor, K.D.4
Marciante, K.5
Yan, X.6
Dubinsky, M.7
Ippoliti, A.8
Vasiliauskas, E.9
Berel, D.10
Derkowski, C.11
Dutridge, D.12
Fleshner, P.13
Shih, D.Q.14
Melmed, G.15
Mengesha, E.16
King, L.17
Pressman, S.18
Haritunians, T.19
Guo, X.20
Targan, S.R.21
Rotter, J.I.22
more..
-
27
-
-
82755168804
-
Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (secretor) genotype
-
Rausch P, Rehman A, Kunzel S, Hasler R, Ott SJ, Schreiber S, Rosenstiel P, Franke A, Baines JF: Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (secretor) genotype. Proc Natl Acad Sci U S A 2011; 108: 19030-19035.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 19030-19035
-
-
Rausch, P.1
Rehman, A.2
Kunzel, S.3
Hasler, R.4
Ott, S.J.5
Schreiber, S.6
Rosenstiel, P.7
Franke, A.8
Baines, J.F.9
-
28
-
-
84886280379
-
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals
-
Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A: Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 2013; 342: 447-453.
-
(2013)
Science
, vol.342
, pp. 447-453
-
-
Shan, M.1
Gentile, M.2
Yeiser, J.R.3
Walland, A.C.4
Bornstein, V.U.5
Chen, K.6
He, B.7
Cassis, L.8
Bigas, A.9
Cols, M.10
Comerma, L.11
Huang, B.12
Blander, J.M.13
Xiong, H.14
Mayer, L.15
Berin, C.16
Augenlicht, L.H.17
Velcich, A.18
Cerutti, A.19
-
29
-
-
84862862332
-
Epithelial antimicrobial defence of the skin and intestine
-
Gallo RL, Hooper LV: Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol 2012; 12: 503-516.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 503-516
-
-
Gallo, R.L.1
Hooper, L.V.2
-
30
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th: A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456: 259-263.
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
Miyoshi, H.4
Loh, J.5
Lennerz, J.K.6
Kishi, C.7
Kc, W.8
Carrero, J.A.9
Hunt, S.10
Stone, C.D.11
Brunt, E.M.12
Xavier, R.J.13
Sleckman, B.P.14
Li, E.15
Mizushima, N.16
Stappenbeck, T.S.17
Virgin, I.V.H.W.18
-
31
-
-
77953904042
-
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
-
Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW: Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010; 141: 1135-1145.
-
(2010)
Cell
, vol.141
, pp. 1135-1145
-
-
Cadwell, K.1
Patel, K.K.2
Maloney, N.S.3
Liu, T.C.4
Ng, A.C.5
Storer, C.E.6
Head, R.D.7
Xavier, R.8
Stappenbeck, T.S.9
Virgin, H.W.10
-
32
-
-
84901660514
-
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
-
Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ: Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci U S A 2014; 111: 7741-7746.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 7741-7746
-
-
Lassen, K.G.1
Kuballa, P.2
Conway, K.L.3
Patel, K.K.4
Becker, C.E.5
Peloquin, J.M.6
Villablanca, E.J.7
Norman, J.M.8
Liu, T.C.9
Heath, R.J.10
Becker, M.L.11
Fagbami, L.12
Horn, H.13
Mercer, J.14
Yilmaz, O.H.15
Jaffe, J.D.16
Shamji, A.F.17
Bhan, A.K.18
Carr, S.A.19
Daly, M.J.20
Virgin, H.W.21
Schreiber, S.L.22
Stappenbeck, T.S.23
Xavier, R.J.24
more..
-
33
-
-
84896730900
-
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3
-
Murthy A, Li Y, Peng I, Reichelt M, Katakam AK, Noubade R, Roose-Girma M, DeVoss J, Diehl L, Graham RR, van Lookeren Campagne M: A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 2014; 506: 456-462.
-
(2014)
Nature
, vol.506
, pp. 456-462
-
-
Murthy, A.1
Li, Y.2
Peng, I.3
Reichelt, M.4
Katakam, A.K.5
Noubade, R.6
Roose-Girma, M.7
DeVoss, J.8
Diehl, L.9
Graham, R.R.10
Van Lookeren Campagne, M.11
-
34
-
-
35348857386
-
Molecularphylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
-
Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR: Molecularphylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 2007; 104: 13780-13785.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 13780-13785
-
-
Frank, D.N.1
St Amand, A.L.2
Feldman, R.A.3
Boedeker, E.C.4
Harpaz, N.5
Pace, N.R.6
-
35
-
-
78649686679
-
A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
-
Willing BP, Dicksved J, Halfvarson J, Andersson AF, Lucio M, Zheng Z, Jarnerot G, Tysk C, Jansson JK, Engstrand L: A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 2010; 139: 1844-1854.e1.
-
(2010)
Gastroenterology
, vol.139
, pp. 1844e1-1854e1
-
-
Willing, B.P.1
Dicksved, J.2
Halfvarson, J.3
Andersson, A.F.4
Lucio, M.5
Zheng, Z.6
Jarnerot, G.7
Tysk, C.8
Jansson, J.K.9
Engstrand, L.10
-
36
-
-
84866549438
-
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
-
Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, LeLeiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C: Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol 2012; 13:R79.
-
(2012)
Genome Biol
, vol.13
, pp. R79
-
-
Morgan, X.C.1
Tickle, T.L.2
Sokol, H.3
Gevers, D.4
Devaney, K.L.5
Ward, D.V.6
Reyes, J.A.7
Shah, S.A.8
LeLeiko, N.9
Snapper, S.B.10
Bousvaros, A.11
Korzenik, J.12
Sands, B.E.13
Xavier, R.J.14
Huttenhower, C.15
-
37
-
-
84881477044
-
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
-
Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K: Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 2013; 500: 232-236.
-
(2013)
Nature
, vol.500
, pp. 232-236
-
-
Atarashi, K.1
Tanoue, T.2
Oshima, K.3
Suda, W.4
Nagano, Y.5
Nishikawa, H.6
Fukuda, S.7
Saito, T.8
Narushima, S.9
Hase, K.10
Kim, S.11
Fritz, J.V.12
Wilmes, P.13
Ueha, S.14
Matsushima, K.15
Ohno, H.16
Olle, B.17
Sakaguchi, S.18
Taniguchi, T.19
Morita, H.20
Hattori, M.21
Honda, K.22
more..
-
38
-
-
84964313180
-
Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia
-
Narushima S, Sugiura Y, Oshima K, Atarashi K, Hattori M, Suematsu M, Honda K: Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia. Gut Microbes 2014; 5: 333-339.
-
(2014)
Gut Microbes
, vol.5
, pp. 333-339
-
-
Narushima, S.1
Sugiura, Y.2
Oshima, K.3
Atarashi, K.4
Hattori, M.5
Suematsu, M.6
Honda, K.7
-
39
-
-
70350666634
-
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
-
Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D, Xavier RJ, Teixeira MM, Mackay CR: Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009; 461: 1282-1286.
-
(2009)
Nature
, vol.461
, pp. 1282-1286
-
-
Maslowski, K.M.1
Vieira, A.T.2
Ng, A.3
Kranich, J.4
Sierro, F.5
Yu, D.6
Schilter, H.C.7
Rolph, M.S.8
Mackay, F.9
Artis, D.10
Xavier, R.J.11
Teixeira, M.M.12
Mackay, C.R.13
-
40
-
-
84890550163
-
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
-
Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY: Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013; 504: 451-455.
-
(2013)
Nature
, vol.504
, pp. 451-455
-
-
Arpaia, N.1
Campbell, C.2
Fan, X.3
Dikiy, S.4
Van Der Veeken, J.5
DeRoos, P.6
Liu, H.7
Cross, J.R.8
Pfeffer, K.9
Coffer, P.J.10
Rudensky, A.Y.11
-
41
-
-
84890564250
-
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
-
Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013; 504: 446-450.
-
(2013)
Nature
, vol.504
, pp. 446-450
-
-
Furusawa, Y.1
Obata, Y.2
Fukuda, S.3
Endo, T.A.4
Nakato, G.5
Takahashi, D.6
Nakanishi, Y.7
Uetake, C.8
Kato, K.9
Kato, T.10
Takahashi, M.11
Fukuda, N.N.12
Murakami, S.13
Miyauchi, E.14
Hino, S.15
Atarashi, K.16
Onawa, S.17
Fujimura, Y.18
Lockett, T.19
Clarke, J.M.20
Topping, D.L.21
Tomita, M.22
Hori, S.23
Ohara, O.24
Morita, T.25
Koseki, H.26
Kikuchi, J.27
Honda, K.28
Hase, K.29
Ohno, H.30
more..
-
42
-
-
84881068658
-
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
-
Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly YM, Glickman JN, Garrett WS: The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569-573.
-
(2013)
Science
, vol.341
, pp. 569-573
-
-
Smith, P.M.1
Howitt, M.R.2
Panikov, N.3
Michaud, M.4
Gallini, C.A.5
Bohlooly, Y.M.6
Glickman, J.N.7
Garrett, W.S.8
-
43
-
-
84892449521
-
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
-
Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V: Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 2014; 40: 128-139.
-
(2014)
Immunity
, vol.40
, pp. 128-139
-
-
Singh, N.1
Gurav, A.2
Sivaprakasam, S.3
Brady, E.4
Padia, R.5
Shi, H.6
Thangaraju, M.7
Prasad, P.D.8
Manicassamy, S.9
Munn, D.H.10
Lee, J.R.11
Offermanns, S.12
Ganapathy, V.13
-
44
-
-
22144490199
-
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
-
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL: An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005; 122: 107-118.
-
(2005)
Cell
, vol.122
, pp. 107-118
-
-
Mazmanian, S.K.1
Liu, C.H.2
Tzianabos, A.O.3
Kasper, D.L.4
-
45
-
-
79956311926
-
The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
-
Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK: The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011; 332: 974-977.
-
(2011)
Science
, vol.332
, pp. 974-977
-
-
Round, J.L.1
Lee, S.M.2
Li, J.3
Tran, G.4
Jabri, B.5
Chatila, T.A.6
Mazmanian, S.K.7
-
46
-
-
84888252464
-
Relevance of commensal microbiota in the treatment and prevention of inflammatory bowel disease
-
Dasgupta S, Kasper DL: Relevance of commensal microbiota in the treatment and prevention of inflammatory bowel disease. Inflamm Bowel Dis 2013; 19: 2478-2489.
-
(2013)
Inflamm Bowel Dis
, vol.19
, pp. 2478-2489
-
-
Dasgupta, S.1
Kasper, D.L.2
-
47
-
-
44449106055
-
A microbial symbiosis factor prevents intestinal inflammatory disease
-
Mazmanian SK, Round JL, Kasper DL: A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008; 453: 620-625.
-
(2008)
Nature
, vol.453
, pp. 620-625
-
-
Mazmanian, S.K.1
Round, J.L.2
Kasper, D.L.3
-
48
-
-
84892774558
-
Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells
-
An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL: Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 2014; 156: 123-133.
-
(2014)
Cell
, vol.156
, pp. 123-133
-
-
An, D.1
Oh, S.F.2
Olszak, T.3
Neves, J.F.4
Avci, F.Y.5
Erturk-Hasdemir, D.6
Lu, X.7
Zeissig, S.8
Blumberg, R.S.9
Kasper, D.L.10
-
49
-
-
84880941717
-
Production of α-galactosylceramide by a prominent member of the human gut microbiota
-
Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA: Production of α-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol 2013; 11:e1001610.
-
(2013)
PLoS Biol
, vol.11
, pp. e1001610
-
-
Wieland Brown, L.C.1
Penaranda, C.2
Kashyap, P.C.3
Williams, B.B.4
Clardy, J.5
Kronenberg, M.6
Sonnenburg, J.L.7
Comstock, L.E.8
Bluestone, J.A.9
Fischbach, M.A.10
-
50
-
-
84897053496
-
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
-
Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M: Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science 2014; 343: 1249288.
-
(2014)
Science
, vol.343
, pp. 1249288
-
-
Mortha, A.1
Chudnovskiy, A.2
Hashimoto, D.3
Bogunovic, M.4
Spencer, S.P.5
Belkaid, Y.6
Merad, M.7
-
51
-
-
84861964286
-
Interactions between commensal fungi and the C-type lectin receptor dectin-1 influence colitis
-
Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM: Interactions between commensal fungi and the C-type lectin receptor dectin-1 influence colitis. Science 2012; 336: 1314-1317.
-
(2012)
Science
, vol.336
, pp. 1314-1317
-
-
Iliev, I.D.1
Funari, V.A.2
Taylor, K.D.3
Nguyen, Q.4
Reyes, C.N.5
Strom, S.P.6
Brown, J.7
Becker, C.A.8
Fleshner, P.R.9
Dubinsky, M.10
Rotter, J.I.11
Wang, H.L.12
McGovern, D.P.13
Brown, G.D.14
Underhill, D.M.15
-
52
-
-
32944459814
-
Abundant and diverse fungal microbiota in the murine intestine
-
Scupham AJ, Presley LL, Wei B, Bent E, Griffith N, McPherson M, Zhu F, Oluwadara O, Rao N, Braun J, Borneman J: Abundant and diverse fungal microbiota in the murine intestine. Appl Environ Microbiol 2006; 72: 793-801.
-
(2006)
Appl Environ Microbiol
, vol.72
, pp. 793-801
-
-
Scupham, A.J.1
Presley, L.L.2
Wei, B.3
Bent, E.4
Griffith, N.5
McPherson, M.6
Zhu, F.7
Oluwadara, O.8
Rao, N.9
Braun, J.10
Borneman, J.11
-
53
-
-
84922245262
-
Disease-specific alterations in the enteric virome in inflammatory bowel disease
-
Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW: Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell 2015; 160: 447-460.
-
(2015)
Cell
, vol.160
, pp. 447-460
-
-
Norman, J.M.1
Handley, S.A.2
Baldridge, M.T.3
Droit, L.4
Liu, C.Y.5
Keller, B.C.6
Kambal, A.7
Monaco, C.L.8
Zhao, G.9
Fleshner, P.10
Stappenbeck, T.S.11
McGovern, D.P.12
Keshavarzian, A.13
Mutlu, E.A.14
Sauk, J.15
Gevers, D.16
Xavier, R.J.17
Wang, D.18
Parkes, M.19
Virgin, H.W.20
more..
-
54
-
-
55249105923
-
Clostridium difficile-more difficult than ever
-
Kelly CP, LaMont JT: Clostridium difficile-more difficult than ever. N Engl J Med 2008; 359: 1932-1940.
-
(2008)
N Engl J Med
, vol.359
, pp. 1932-1940
-
-
Kelly, C.P.1
LaMont, J.T.2
-
55
-
-
84873019302
-
Duodenal infusion of donor feces for recurrent Clostridium difficile
-
van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG, Speelman P, Dijkgraaf MG, Keller JJ: Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013; 368: 407-415.
-
(2013)
N Engl J Med
, vol.368
, pp. 407-415
-
-
Van Nood, E.1
Vrieze, A.2
Nieuwdorp, M.3
Fuentes, S.4
Zoetendal, E.G.5
De Vos, W.M.6
Visser, C.E.7
Kuijper, E.J.8
Bartelsman, J.F.9
Tijssen, J.G.10
Speelman, P.11
Dijkgraaf, M.G.12
Keller, J.J.13
-
56
-
-
84877020842
-
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut
-
Petrof EO, Gloor GB, Vanner SJ, Weese SJ, Carter D, Daigneault MC, Brown EM, Schroeter K, Allen-Vercoe E: Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut. Microbiome 2013; 1: 3.
-
(2013)
Microbiome
, vol.1
, pp. 3
-
-
Petrof, E.O.1
Gloor, G.B.2
Vanner, S.J.3
Weese, S.J.4
Carter, D.5
Daigneault, M.C.6
Brown, E.M.7
Schroeter, K.8
Allen-Vercoe, E.9
-
57
-
-
84925500413
-
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
-
Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, Gobourne A, No D, Liu H, Kinnebrew M, Viale A, Littmann E, van den Brink MR, Jenq RR, Taur Y, Sander C, Cross JR, Toussaint NC, Xavier JB, Pamer EG: Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 2015; 517: 205-208.
-
(2015)
Nature
, vol.517
, pp. 205-208
-
-
Buffie, C.G.1
Bucci, V.2
Stein, R.R.3
McKenney, P.T.4
Ling, L.5
Gobourne, A.6
No, D.7
Liu, H.8
Kinnebrew, M.9
Viale, A.10
Littmann, E.11
Van Den Brink, M.R.12
Jenq, R.R.13
Taur, Y.14
Sander, C.15
Cross, J.R.16
Toussaint, N.C.17
Xavier, J.B.18
Pamer, E.G.19
-
58
-
-
84916229815
-
Fecal microbiota transplantation in inflammatory bowel disease: Beyond the excitement
-
Ianiro G, Bibbo S, Scaldaferri F, Gasbarrini A, Cammarota G: Fecal microbiota transplantation in inflammatory bowel disease: beyond the excitement. Medicine (Baltimore) 2014; 93:e97.
-
(2014)
Medicine (Baltimore)
, vol.93
, pp. e97
-
-
Ianiro, G.1
Bibbo, S.2
Scaldaferri, F.3
Gasbarrini, A.4
Cammarota, G.5
-
59
-
-
46749119859
-
Molecular analysis of the gut microbiota of identical twins with Crohn's disease
-
Dicksved J, Halfvarson J, Rosenquist M, Jarnerot G, Tysk C, Apajalahti J, Engstrand L, Jansson JK: Molecular analysis of the gut microbiota of identical twins with Crohn's disease. ISME J 2008; 2: 716-727.
-
(2008)
ISME J
, vol.2
, pp. 716-727
-
-
Dicksved, J.1
Halfvarson, J.2
Rosenquist, M.3
Jarnerot, G.4
Tysk, C.5
Apajalahti, J.6
Engstrand, L.7
Jansson, J.K.8
-
60
-
-
84884543925
-
Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis
-
Tyler AD, Knox N, Kabakchiev B, Milgrom R, Kirsch R, Cohen Z, McLeod RS, Guttman DS, Krause DO, Silverberg MS: Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis. PLoS One 2013; 8:e66934.
-
(2013)
PLoS One
, vol.8
, pp. e66934
-
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Tyler, A.D.1
Knox, N.2
Kabakchiev, B.3
Milgrom, R.4
Kirsch, R.5
Cohen, Z.6
McLeod, R.S.7
Guttman, D.S.8
Krause, D.O.9
Silverberg, M.S.10
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