Crohn's disease: Small bowel motility impairment correlates with inflammatory-related markers C-reactive protein and calprotectin

Neurogastroenterology and Motility

Volumn 25, Issue 6, 2013, Pages 467-e363

  Bickelhaupt, S ^a   Pazahr, S ^a   Chuck, N ^a   Blume, I ^a   Froehlich, J M ^a   Cattin, R ^b   Raible, S ^b   Bouquet, H ^c   Bill, U ^c   Rogler, G ^a   Frei, P ^a   Boss, A ^a   Patak, M A ^a,d  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b BERN UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

^c Sohard AG   (Switzerland)

^d Neuro Zentrum Hirslanden Klinik   (Switzerland)

Author keywords

C reactive protein; Calprotectin; Crohn's disease; Inflammatory markers; Small bowel motility.

Indexed keywords

C REACTIVE PROTEIN; CALGRANULIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CROHN DISEASE; FECES ANALYSIS; FEMALE; HUMAN; INTESTINAL DYSMOTILITY; INTESTINE CONTRACTION; INTESTINE MOTILITY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 84878019827     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12088     Document Type: Article

References (32)

1. Maglinte DD, Gourtsoyiannis N, Rex D, Howard TJ, Kelvin FM. Classification of small bowel Crohn's subtypes based on multimodality imaging. Radiol Clin North Am 2003; 4: 285-303.
2. Marmo R, Rotondano G, Piscopo R et al. Capsule endoscopy versus enteroclysis in the detection of small-bowel involvement in crohn's disease: a prospective trial. Clin Gastroenterol and Hepatol 2005; 3: 772-6.
3. Steinhardt HJ, Loeschke K, Kasper H, Holtermüller KH, Schäfer H. European Cooperative Crohn's Disease Study (ECCDS): clinical features and natural history. Digestion 1985; 31: 97-108.
4. Schoepfer AM, Beglinger C, Straumann A et al. Fecal calprotectin correlates more closely with the simple endoscopic score for Crohn's disease (SES-CD) than CRP, blood leukocytes, and the CDAI. Am J Gastroenterol 2009; 105: 162-9.
5. Sipponen T, Savilahti E, Kolho K-L, Nuutinen H, Turunen U, Färkkilä M. Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic findings. Inflamm Bowel Dis 2008; 14: 40-6.
6. Tilakaratne S, Lemberg D, Leach S, Day A. C-Reactive Protein and Disease Activity in Children with Crohn's Disease. Dig Dis Sci 2010; 55: 131-6.
7. Judd TA, Day AS, Lemberg DA, Turner D, Leach ST. Update of fecal markers of inflammation in inflammatory bowel disease. J Gastroenterol Hepatol 2011; 26: 1493-9.
8. Fiorino G, Bonifacio C, Malesci A, Balzarini L, Danese S. MRI in Crohn's disease-current and future clinical applications. Nat Rev Gastroenterol Hepatol 2011; 9: 23-31.
9. Sinha R, Murphy P, Hawker P, Sanders S, Rajesh A, Verma R. Role of MRI in Crohn's disease. Clin Radiol 2009; 64: 341-52.
10. Gourtsoyiannis NC, Grammatikakis J, Papamastorakis G et al. Imaging of small intestinal Crohn's disease: comparison between MR enteroclysis and conventional enteroclysis. Eur Radiol 2006; 16: 1915-25.
11. Froehlich JM, Patak MA, von Weymarn C, Juli CF, Zollikofer CL, Wentz K-U. Small bowel motility assessment with magnetic resonance imaging. J Magn Reson Imaging 2005; 21: 370-5.
12. Froehlich JM, Waldherr C, Stoupis C, Erturk SM, Patak MA. MR motility imaging in Crohn's disease improves lesion detection compared with standard MR imaging. Eur Radiol 2010; 20: 1945-51.
13. Menys A, Atkinson D, Odille F et al. Quantified terminal ileal motility during MR enterography as a potential biomarker of Crohn's disease activity: a preliminary study. Eur Radiol 2012; 22: 2494-501.
14. Königsrainer I, Türck MH, Eisner F et al. The Gut is not only the Target but a Source of Inflammatory Mediators Inhibiting Gastrointestinal Motility During Sepsis. Cell Physiol Biochem 2011; 28: 753-60.
15. Hierholzer C, Kalff JC, Chakraborty A et al. Impaired Gut Contractility Following Hemorrhagic Shock is Accompanied by IL-6 and G-CSF Production and Neutrophil Infiltration. Dig Dis Sci 2001; 46: 230-41.
16. Akiho H. Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders. World J Gastrointest Pathophysiol 2011; 2: 72.
17. Eda S, Kaufmann J, Roos W, Pohl S. Development of a new microparticle-enhanced turbidimetric assay for C-reactive protein with superior features in analytical sensitivity and dynamic range. J Clin Lab Anal 1998; 12: 137-44.
18. Poullis A, Foster R, Mendall MA, Fagerhol MK. Emerging role of calprotectin in gastroenterology. J Gastroenterol Hepatol 2003; 18: 756-62.
19. García-Sánchez V, Iglesias-Flores E, González R et al. Does fecal calprotectin predict relapse in patients with Crohn's disease and ulcerative colitis? J Crohns Colitis 2010; 4: 144-52.
20. Gaya DR, Mackenzie JF. Faecal calprotectin: a bright future for assessing disease activity in Crohn's disease. QJM 2002; 95: 557-8.
21. Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998; 316: 1236-8.
22. Rothman KJ. No Adjustments Are Needed for Multiple Comparisons. Epidemiology 1990; 1: 43-6.
23. Gutzeit A, Binkert C, Koh D-M et al. Evaluation of the anti-peristaltic effect of glucagon and hyoscine on the small bowel: comparison of intravenous and intramuscular drug administration. Eur Radiol 2012; 22: 1186-94.
24. Bickelhaupt S, Cattin R, Raible S, Bill U, Bouquet H. Correlation between global small-bowel motility in MRI and local disease activity in patients with Crohn's disease in: proceedings of ESGAR 2012 Book of Abstracts. Insights Imaging 2012; 3: 455-503.
25. Makanyanga J, Punwani S, Taylor SA. Assessment of wall inflammation and fibrosis in Crohn's disease: value of T1-weighted gadolinium-enhanced MR imaging. Abdom Imaging 2011; 37: 933-43.
26. Wright CD, Mülsch A, Busse R, Osswald H. Generation of nitric oxide by human neutrophils. Biochem Biophys Res Commun 1989; 160: 813-9.
27. Salzman AL. Nitric oxide in the gut. New Horiz 1995; 3: 33-45.
28. Bani D, Caterina Baccari M, Quattrone S et al. Relaxin Depresses Small Bowel Motility Through a Nitric Oxide-Mediated Mechanism. Studies in Mice. Biol Reprod 2002; 66: 778-84.
29. Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ. Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology 2000; 118: 316-27.
30. Ünlüer EE, Alican İ, Yeǧen C, Yeǧen BÇ. The delays in intestinal motility and neutrophil infiltration following burn injury in rats involve endogenous endothelins. Burns 2000; 26: 335-40.
31. Cao SG, Wu WC, Han Z, Wang MY. Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice. World J Gastroenterol 2005; 11: 737-40.
32. Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 1996; 111: 1683-99.