Freeze-dried mucoadhesive polymeric system containing pegylated lipoplexes: Towards a vaginal sustained released system for siRNA

Journal of Controlled Release

Volumn 236, Issue , 2016, Pages 68-78

  Furst, Tania ^a   Dakwar, George R ^b   Zagato, Elisa ^b   Lechanteur, Anna ^a   Remaut, Katrien ^b   Evrard, Brigitte ^a   Braeckmans, Kevin ^b   Piel, Geraldine ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Diffusion; Freeze drying; Lipoplexes; Mucoadhesion; Stability; Vaginal drug delivery

Indexed keywords

BODY FLUIDS; CONVERGENCE OF NUMERICAL METHODS; DIFFUSION; DIFFUSION IN LIQUIDS; FLUORESCENCE MICROSCOPY; HYDROGELS; LOW TEMPERATURE DRYING;

DRUG DELIVERY SYSTEM; FREEZE DRYING; HYDROXYETHYL CELLULOSES (HEC); LIPOPLEXES; MECHANICAL CHARACTERISTICS; MUCOADHESION; MUCOADHESIVE PROPERTIES; VAGINAL DRUG DELIVERY;

POLYMERS;

HYDROXYETHYLCELLULOSE; LIPOPLEX; MACROGOL; PEGYLATED LIPOPLEXES; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-METHOXY-POLY(ETHYLENE GLYCOL 2000); CELLULOSE; CERAMIDE; LIPOSOME; MACROGOL DERIVATIVE; NANOPARTICLE; PHOSPHATIDYLETHANOLAMINE;

ARTICLE; COMPLEX FORMATION; DRUG EFFICACY; DRUG FORMULATION; DRUG STABILITY; FLUORESCENCE CORRELATION SPECTROSCOPY; FREEZE DRYING; HARDNESS; LIPOSOMAL DELIVERY; MUCOADHESION; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; VAGINA MUCOSA; X RAY ANALYSIS; ZETA POTENTIAL; ADHESION; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; FEMALE; GENE TRANSFER; HUMAN; HYDROGEL; INTRAVAGINAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; MUCOSA; SURFACE PROPERTY; VAGINA;

ADHESIVENESS; ADMINISTRATION, INTRAVAGINAL; CELLULOSE; CERAMIDES; CHEMISTRY, PHARMACEUTICAL; FEMALE; FREEZE DRYING; GENE TRANSFER TECHNIQUES; HUMANS; HYDROGELS; LIPOSOMES; MUCOUS MEMBRANE; NANOPARTICLES; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; SURFACE PROPERTIES; VAGINA;

EID: 84976254187     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.06.028     Document Type: Article

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