Vaginal inserts based on chitosan and carboxymethylcellulose complexes for local delivery of chlorhexidine: Preparation, characterization and antimicrobial activity

International Journal of Pharmaceutics

Volumn 478, Issue 2, 2015, Pages 456-463

  Bigucci, Federica ^a   Abruzzo, Angela ^a   Vitali, Beatrice ^a   Saladini, Bruno ^b   Cerchiara, Teresa ^a   Gallucci, Maria Caterina ^c   Luppi, Barbara ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b PolyCrystalLine Srl   (Italy)

^c UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Antimicrobial activity; Carboxymethylcellulose; Chitosan; Chlorhexidine digluconate; Polyelectrolyte complexes; Vaginal inserts

Indexed keywords

CARBOXYMETHYLCELLULOSE; CHITOSAN; CHLORHEXIDINE GLUCONATE; CHLORHEXIDINE; DRUG DOSAGE FORM; TOPICAL ANTIINFECTIVE AGENT; WATER;

ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; COMPLEX FORMATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ESCHERICHIA COLI; MORPHOLOGY; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; WATER TRANSPORT; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG DOSAGE FORM; DRUG EFFECTS; DRUG FORMULATION; GROWTH, DEVELOPMENT AND AGING; INTRAVAGINAL DRUG ADMINISTRATION;

ADMINISTRATION, INTRAVAGINAL; ANTI-INFECTIVE AGENTS, LOCAL; CANDIDA ALBICANS; CARBOXYMETHYLCELLULOSE SODIUM; CHITOSAN; CHLORHEXIDINE; DOSAGE FORMS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; ESCHERICHIA COLI; WATER;

EID: 84920860886     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.12.008     Document Type: Article

References (37)

1. A. Abruzzo, F. Bigucci, T. Cerchiara, B. Saladini, M. Gallucci, F. Cruciani, B. Vitali, and B. Luppi Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate Carbohydr. Polym. 91 2013 651 658
2. V. Ambrogi, P. Perioli, F. Marmottini, M. Moretti, E. Lollini, and C. Rossi Chlorhexidine MCM-41 mucoadhesive tablets for topical use J. Pharm. Innov. 4 2009 156 164
3. J. Berger, M. Reist, J.M. Mayer, O. Felt, N.A. Peppas, and R. Gurny Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications Eur. J. Pharm. Biopharm. 57 2004 35 52
4. M.C. Bonferoni, G. Sandri, S. Rossi, F. Ferrari, S. Gibin, and C. Caramella Chitosan citrate as multifunctional polymer for vaginal delivery. Evaluation of penetration enhancement and peptidase inhibition properties Eur. J. Pharm. Sci. 33 2008 166 176
5. N. Dobaria, R. Mashru, and N.H. Vadia Vaginal drug delivery systems: a review of current status East Cent. Afr. J. Pharm. Sci. 10 2007 3 13
6. P.K. Dutta, J. Dutta, and V.S. Tripathi Chitin and chitosan: chemistry, properties and applications J. Sci. Ind. Res. 63 2004 20 31
7. A. Ellepola, and L. Samaranayake Adjunctive use of chlorhexidine in oral candidoses: a review Oral Dis. 7 2001 11 17
8. A. García, D. Leonardi, G.N. Piccirilli, M.E. Mamprin, A.C. Olivieri, and M.C. Lamas Spray drying formulation of albendazole microspheres by experimental design. In vitro-in vivo studies Drug Dev. Ind. Pharm. 2013 10.3109/03639045.2013.858737
9. G. Giuliana, G. Pizo, M.E. Milici, G.C. Musotto, and R. Giangreco In vitro antifungal properties of mouthrinses containing antimicrobial agents J. Periodontol. 68 1997 729 733
10. M. Gomez-Burgaz, B. GarcIa-Ochoa, and S. Torrado-Santiago Chitosan-carboxymethylcellulose interpolymer complexes for gastric-specific delivery of clarithromycin Int. J. Pharm. 359 2008 135 143
11. J.H. Hamman Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems Mar. Drugs 8 2010 1305 1322
12. I.M. Helander, E.L. Nurmiaho-Lassila, R. Ahvenainen, J. Rhoades, and S. Roller Chitosan disrupts the barrier properties of the outer membrane of gram-negative bacteria Int. J. Food Microbiol. 71 2001 235 244
13. C. Juliano, M. Cossu, P. Pigozzi, G. Rassu, and P. Giunchedi Preparation, in vitro characterization and preliminary in vivo evaluation of buccal polymeric films containing chlorhexidine AAPS PharmSciTech 9 2008 1153 1158
14. S. Karki, and A.C. Cheng Impact of non-rinse skin cleansing with chlorhexidine gluconate on prevention of healthcare-associated infections and colonization with multi-resistant organisms: a systematic review J. Hosp. Infect. 82 2012 71 84
15. M.N.V. Kumar Ravi A review of chitin and chitosan applications React. Funct. Polym. 46 2000 1 27
16. H. Liu, Y. Du, X. Wang, and L. Sun Chitosan kills bacteria through cell membrane damage Int. J. Food Microbiol. 95 2004 147 155
17. N. Liu, X.G. Chen, H.J. Park, C.G. Liu, C.S. Liu, and X.H. Meng Effect of MW and concentration of chitosan on antibacterial activity of Escherichia coli Carbohydr. Polym. 64 2006 60 65
18. B. Luppi, F. Bigucci, A. Abruzzo, G. Corace, T. Cerchiara, and V. Zecchi Freeze-dried chitosan/pectin nasal inserts for antipsychotic drug delivery Eur. J. Pharm. Biopharm. 75 2010 381 387
19. B. Luppi, F. Bigucci, T. Cerchiara, and V. Zecchi Chitosan-based hydrogels for nasal drug delivery: from inserts to nanoparticles Expert Opin. Drug Deliv. 7 2010 811 828
20. B. Luppi, F. Bigucci, L. Mercolini, A. Musenga, M. Sorrenti, L. Catenacci, and V. Zecchi Novel mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes for peptide and protein delivery J. Pharm. Pharmacol. 61 2009 151 157
21. M.M. Meshali, and K.E. Gabr Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behaviour of chlorpromazine HCl Int. J. Pharm. 89 1993 177 181
22. B. Molteni, A. D'Antuono, P. Bandini, G. Sintini, E. Barcellona, A. Agnello, and M. Milani Efficacy and tolerability of a new chlorhexidine-based vaginal gel in vaginal infections Curr. Med. Res. Opin. 20 2004 849 853
23. R.A.A. Muzzarelli Human enzymatic activities related to the therapeutic administration of chitin derivatives Cell. Mol. Life Sci. 53 1997 131 140
24. R.A.A. Muzzarelli Chitins and chitosans as immune adjuvants and non-allergenic drug carriers Mar. Drugs 8 2010 292 312
25. K. Padpois, V. Bertholle, F. Pirot, T.T. Hyunh, A. Rossi, P. Colombo, and F. Sonvico Chlorexidine salt-loaded polyurethane orthodontic chains: in vitro releases and antibacterial activity studies AAPS PharmSciTech 13 2012 1446 1450
26. D. Palmer, M. Levina, A. Nokhodchi, D. Douroumis, T. Farrell, and A. Rajabi-Siahboomi The influence of sodium carboxymethylcellulose on drug release from polyethylene oxide extended release matrices AAPS PharmSciTech 12 3 2011 10.1208/s12249-011-9648-4
27. D. Palmer, M. Levina, D. Douroumis, M.J. Maniruzzaman, D. Morganc, T.P. Farrell, A.R. Rajabi-Siahboomi, and A. Nokhodchi Mechanism of synergistic interactions and its influence on drug release from extended release matrices manufactured using binary mixtures of polyethylene oxide and sodium carboxymethylcellulose Colloids Surf. B Biointerfaces 104 2013 174 180
28. L. Perioli, V. Ambrogi, L. Venezia, C. Pagano, M. Ricci, and C. Rossi Chitosan and modified chitosan as agents to improve performances of mucoadhesive vaginal gels Colloids Surf. B Biointerfaces 66 2008 141 145
29. C.G. Pupe, M. Villardi, C.R. Rodrigues, H.V. Antunes, L.C. Maia, V.P. De Dousa, and L.M. Cabral Preparation and evaluation of antimicrobial activity of nanosystems for the control of oral pathogens Streptococcus mutans and Candida albicans Int. J. Nanomed. 6 2011 2581 2590
30. L.G. Ribeiro, L.N. Hashizume, and M. Maltz The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature J. Dent. 35 2007 359 370
31. C. Rosca, M.I. Popa, G. Lisa, and G.C. Chitanu Interaction of chitosan with natural or synthetic anionic polyelectrolytes. 1. The chitosan-carboxymethylcellulose complex Carbohydr. Polym. 62 2005 35 41
32. S. Rossi, G. Sandri, F. Ferrari, M.C. Bonferoni, and C. Caramella Development of films and matrices based on chitosan and polyacrylic acid for vaginal delivery of acyclovir STP Pharm. Sci. 13 2003 183 190
33. D.J. Rouse, and S. Cliver Clinical trial of chlorhexidine vaginal irrigation to prevent peripartal infection in nulliparous women Am. J. Obstet. Gynecol. 189 2003 166 170
34. A.M. Salem, D. Adams, H.N. Newman, and L.W. Rawle Antimicrobial properties of two aliphatic amines and chlorhexidine in vitro and in saliva J. Clin. Periodontol. 14 1987 44 47
35. H. Tang, P. Zhang, T.L. Kieft, S.J. Ryan, S.M. Baker, and W.P. Wiesmann Snezna Rogelj Antibacterial action of a novel functionalized chitosan-arginine against gram-negative bacteria Acta Biomater. 6 2010 2562 2571
36. C. Valenta The use of mucoadhesive polymers in vaginal delivery Adv. Drug Deliv. Rev. 57 2005 1692 1712
37. Q. Zhao, J. Qiana, Q. Ana, C. Gaob, Z. Guia, Jina, and Huangtao Synthesis and characterization of soluble chitosan/sodium carboxymethyl cellulose polyelectrolyte complexes and the pervaporation dehydration of their homogeneous membranes J. Membr. Sci. 333 2009 168 178