Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons

Genome Biology

Volumn 17, Issue 1, 2016, Pages

  van den Bos, Hilda ^a   Spierings, Diana C J ^a   Taudt, Aaron S ^a,b   Bakker, Bjorn ^a   Porubský, David ^a   Falconer, Ester ^c   Novoa, Carolina ^c   Halsema, Nancy ^a   Kazemier, Hinke G ^a   Hoekstra Wakker, Karina ^a   Guryev, Victor ^a   den Dunnen, Wilfred F A ^a   Foijer, Floris ^a   Tatché, Maria Colomé ^a,b   Boddeke, Hendrikus W G M ^a   Lansdorp, Peter M ^a,c,d  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer's disease; Aneuploidy; Brain; Neurons; Single cell sequencing

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ANEUPLOIDY; ARTICLE; BRAIN NERVE CELL; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME 16; CHROMOSOME 17; CHROMOSOME 21; CHROMOSOME 22; CHROMOSOME 3; CHROMOSOME 4; CHROMOSOME 6; CHROMOSOME ANALYSIS; CHROMOSOME NUMBER; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS; SINGLE CELL WHOLE GENOME SEQUENCING; TRISOMY 21; VERY ELDERLY; BRAIN; DNA SEQUENCE; GENETICS; HUMAN GENOME; METABOLISM; NERVE CELL; PATHOLOGY; PROCEDURES; SINGLE CELL ANALYSIS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANEUPLOIDY; BRAIN; FEMALE; GENOME, HUMAN; HUMANS; MALE; MIDDLE AGED; NEURONS; SEQUENCE ANALYSIS, DNA; SINGLE-CELL ANALYSIS;

EID: 84975705643     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-0976-2     Document Type: Article

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