Comparative study of the neurotoxicological effects of tramadol and tapentadol in SH-SY5Y cells

Toxicology

Volumn 359-360, Issue , 2016, Pages 1-10

  Faria, Juliana ^a,b,c   Barbosa, Joana ^a,b,c   Queirós, Odília ^a,d   Moreira, Roxana ^a,d   Carvalho, Félix ^b   Dinis Oliveira, Ricardo Jorge ^a,b,c  

^a UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c University of Porto   (Portugal)

^d UNIVERSITY OF MINHO   (Portugal)

Author keywords

Bioenergetics; In vitro; Neurotoxicity; Tapentadol; Tramadol

Indexed keywords

CYTOCHROME C; TAPENTADOL; TRAMADOL; ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 9; GLUCOSE; LACTIC ACID; NARCOTIC ANALGESIC AGENT; PHENOL DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; ENERGY METABOLISM; ENZYME RELEASE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROBLASTOMA CELL LINE; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; NECROSIS; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ANALGESICS, OPIOID; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; GLUCOSE; HUMANS; LACTIC ACID; MEMBRANE POTENTIAL, MITOCHONDRIAL; NECROSIS; PHENOLS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRAMADOL;

EID: 84975527349     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2016.06.010     Document Type: Article

References (45)

1. Atici, S., Cinel, L., Cinel, I., Doruk, N., Aktekin, M., Akca, A., Camdeviren, H., Oral, U., Opioid neurotoxicity: comparison of morphine and tramadol in an experimental rat model. Int. J. Neurosci. 114 (2004), 1001–1011.
2. Barbosa, D.J., Capela, J.P., Silva, R., Ferreira, L.M., Branco, P.S., Fernandes, E., Bastos, M.L., Carvalho, F., Ecstasy-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. Arch. Toxicol. 88 (2014), 515–531.
3. Berson, A., Fau, D., Fornacciari, R., Degove-Goddard, P., Sutton, A., Descatoire, V., Haouzi, D., Letteron, P., Moreau, A., Feldmann, G., Pessayre, D., Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation. J. Hepatol. 34 (2001), 261–269.
4. Bonelli, R.M., Hofmann, P., Aschoff, A., Niederwieser, G., Heuberger, C., Jirikowski, G., Kapfhammer, H.P., The influence of psychotropic drugs on cerebral cell death: female neurovulnerability to antipsychotics. Int. Clin. Psychopharmacol. 20 (2005), 145–149.
5. Boostani, R., Derakhshan, S., Tramadol induced seizure: a 3-year study. Casp. J. Intern. Med. 3 (2012), 484–487.
6. Bruce, R.D., Winkle, P., Custodio, J.M., Wei, X., Rhee, M.S., Kearney, B.P., Ramanathan, S., Friedland, G.H., Investigation of the interactions between methadone and elvitegravir-cobicistat in subjects receiving chronic methadone maintenance. Antimicrob. Agents Chemother. 57 (2013), 6154–6157.
7. Buege, J.A., Aust, S.D., Microsomal lipid peroxidation. Methods Enzymol. 52 (1978), 302–310.
8. Caputi, F.F., Carretta, D., Tzschentke, T.M., Candeletti, S., Romualdi, P., Opioid receptor gene expression in human neuroblastoma SH-SY5Y cells following tapentadol exposure. J. Mol. Neurosci.: MN 53 (2014), 669–676.
9. Chen, X.L., Lu, G., Gong, Y.X., Zhao, L.C., Chen, J., Chi, Z.Q., Yang, Y.M., Chen, Z., Li, Q.L., Liu, J.G., Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment. Cell Res. 17 (2007), 689–700.
10. Choi, S.B., Jang, J.S., Park, S., Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats. Brain Res. Bull. 67 (2005), 77–86.
11. Clarkson, J.E., Lacy, J.M., Fligner, C.L., Thiersch, N., Howard, J., Harruff, R.C., Logan, B.K., Tramadol (Ultram) concentrations in death investigation and impaired driving cases and their significance. J. Forensic Sci. 49 (2004), 1101–1105.
12. Costa, I., Oliveira, A., Guedes de Pinho, P., Teixeira, H.M., Moreira, R., Carvalho, F., Dinis-Oliveira, R.J., Postmortem redistribution of tramadol and O-desmethyltramadol. J. Anal. Toxicol. 37 (2013), 670–675.
13. Costa, I., Carvalho, F., Magalhaes, T., Guedes de Pinho, P., Silvestre, R., Dinis-Oliveira, R.J., Promising blood-derived biomarkers for estimation of the postmortem interval. Toxicol. Res. 4:6 (2015), 1443–1452.
14. Cunha-Oliveira, T., Rego, A.C., Oliveira, C.R., Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res. Rev. 58 (2008), 192–208.
15. De Backer, B., Renardy, F., Denooz, R., Charlier, C., Quantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication. J. Anal. Toxicol. 34 (2010), 599–604.
16. Di Daniel, E., Mudge, A.W., Maycox, P.R., Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons. Bipolar Disord. 7 (2005), 33–41.
17. Dinis-Oliveira, R.J., Carvalho, F., Moreira, R., Duarte, J.A., Proenca, J.B., Santos, A., Magalhaes, T., Clinical and forensic signs related to opioids abuse. Curr. Drug Abuse Rev. 5 (2012), 273–290.
18. Dinis-Oliveira, R.J., Santos, A., Magalhaes, T., Foam Cone exuding from the mouth and nostrils following heroin overdose. Toxicol. Mech. Methods 22 (2012), 159–160.
19. Fournier, J.P., Azoulay, L., Yin, H., Montastruc, J.L., Suissa, S., Tramadol use and the risk of hospitalization for hypoglycemia in patients with noncancer pain. JAMA Intern. Med. 175 (2015), 186–193.
20. Grond, S., Sablotzki, A., Clinical pharmacology of tramadol. Clin. Pharmacokinet. 43 (2004), 879–923.
21. Hartrick, C.T., Rozek, R.J., Tapentadol in pain management: a mu-opioid receptor agonist and noradrenaline reuptake inhibitor. CNS Drugs 25 (2011), 359–370.
22. Hong, M.S., Hong, S.J., Barhoumi, R., Burghardt, R.C., Donnelly, K.C., Wild, J.R., Venkatraj, V., Tiffany-Castiglioni, E., Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol. Appl. Pharmacol. 186 (2003), 110–118.
23. Iyer, S.K., Mohan, G., Ramakrishnan, S., Theodore, S., Comparison of tapentadol with tramadol for analgesia after cardiac surgery. Ann. Card. Anaesth. 18 (2015), 352–360.
24. Kemp, W., Schlueter, S., Smalley, E., Death due to apparent intravenous injection of tapentadol. J. Forensic Sci. 58 (2013), 288–291.
25. Larson, S.J., Pestaner, J., Prashar, S.K., Bayard, C., Zarwell, L.W., Pierre-Louis, M., Postmortem distribution of tapentadol and N-desmethyltapentadol. J. Anal. Toxicol. 36 (2012), 440–443.
26. Levine, R.L., Williams, J.A., Stadtman, E.R., Shacter, E., Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 233 (1994), 346–357.
27. Lu, C.W., Lin, S.C., Chen, K.F., Lai, Y.Y., Tsai, S.J., Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J. Biol. Chem. 283 (2008), 28106–28114.
28. Meske, D.S., Xie, J.Y., Oyarzo, J., Badghisi, H., Ossipov, M.H., Porreca, F., Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neurosci. Lett., 2013.
29. Perez-Alvarez, S., Cuenca-Lopez, M.D., de Mera, R.M., Puerta, E., Karachitos, A., Bednarczyk, P., Kmita, H., Aguirre, N., Galindo, M.F., Jordan, J., Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis. Biochim. Biophys. Acta 1802 (2010), 1036–1047.
30. Pfefferle, A.D., Warner, L.R., Wang, C.W., Nielsen, W.J., Babbitt, C.C., Fedrigo, O., Wray, G.A., Comparative expression analysis of the phosphocreatine circuit in extant primates: implications for human brain evolution. J. Hum. Evol. 60 (2011), 205–212.
31. Pinho, S., Oliveira, A., Costa, I., Gouveia, C.A., Carvalho, F., Moreira, R.F., Dinis-Oliveira, R.J., Simultaneous quantification of tramadol and O-desmethyltramadol in hair samples by gas chromatography-electron impact/mass spectrometry. Biomed. Chromatogr.: BMC 27 (2013), 1003–1011.
32. Raffa, R.B., Buschmann, H., Christoph, T., Eichenbaum, G., Englberger, W., Flores, C.M., Hertrampf, T., Kogel, B., Schiene, K., Strassburger, W., Terlinden, R., Tzschentke, T.M., Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opin. Pharmacother. 13 (2012), 1437–1449.
33. Ryan, N.M., Isbister, G.K., Tramadol overdose causes seizures and respiratory depression but serotonin toxicity appears unlikely. Clin. Toxicol. 53 (2015), 545–550.
34. Sansone, R.A., Sansone, L.A., Tramadol: seizures serotonin syndrome, and coadministered antidepressants. Psychiatry (Edgmont) 6 (2009), 17–21.
35. Shadnia, S., Soltaninejad, K., Heydari, K., Sasanian, G., Abdollahi, M., Tramadol intoxication: a review of 114 cases. Hum. Expe. Toxicol. 27 (2008), 201–205.
36. Streck, E.L., Amboni, G., Scaini, G., Di-Pietro, P.B., Rezin, G.T., Valvassori, S.S., Luz, G., Kapczinski, F., Quevedo, J., Brain creatine kinase activity in an animal model of mania. Life Sci. 82 (2008), 424–429.
37. Tsujimoto, Y., Apoptosis and necrosis: intracellular ATP level as a determinant for cell death modes. Cell Death Differ. 4 (1997), 429–434.
38. Valdiglesias, V., Costa, C., Sharma, V., Kilic, G., Pasaro, E., Teixeira, J.P., Dhawan, A., Laffon, B., Comparative study on effects of two different types of titanium dioxide nanoparticles on human neuronal cells. Food Chem. Toxic: Int. J. Pub. Br. Ind. Biol. Res. Assoc. 57 (2013), 352–361.
39. Walczak-Drzewiecka, A., Ratajewski, M., Wagner, W., Dastych, J., HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. J. Immunol. 181 (2008), 1665–1672.
40. Xie, H.R., Hu, L.S., Li, G.Y., SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. Chin. Med. J. (Engl.) 123 (2010), 1086–1092.
41. Yang, M., Zhong, J., Zhao, M., Wang, J., Gu, Y., Yuan, X., Sang, J., Huang, C., Overexpression of nuclear apoptosis-inducing factor 1 altered the proteomic profile of human gastric cancer cell MKN45 and induced cell cycle arrest at G1/S phase. PLoS One, 9, 2014, e100216.
42. Yu, Y., Liao, M., Liu, R., Chen, J., Feng, H., Fu, Z., Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment. World J. Surg. Oncol., 12, 2014, 78.
43. Zhou, S.F., Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin. Pharmacokinet. 48 (2009), 761–804.
44. Zhuo, H.Q., Huang, L., Huang, H.Q., Cai, Z., Effects of chronic tramadol exposure on the zebrafish brain: a proteomic study. J. Proteomics 75 (2012), 3351–3364.
45. da Silva, D.D., Silva, E., Carmo, H., Combination effects of amphetamines under hyperthermia − the role played by oxidative stress. J. Appl. Toxicol.: JAT 34 (2014), 637–650.