Tramadol induced seizure: A 3-year study

Caspian Journal of Internal Medicine

Volumn 3, Issue 3, 2012, Pages 484-487

  Boostani, Reza ^a   Derakhshan, Siavash ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Electroencephalograms; Seizure; Tramadol

Indexed keywords

TRAMADOL;

ADOLESCENT; AGED; ARTICLE; CLINICAL ARTICLE; DRUG USE; ELECTROENCEPHALOGRAM; FEMALE; FOLLOW UP; HUMAN; IRAN; MALE; NEUROIMAGING; NEUROTOXICITY; SEIZURE; TONIC CLONIC SEIZURE; WHITE MATTER;

EID: 84865286483     PISSN: 20086164     EISSN: 20086172     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Raffa RB, Friderichs E, Reimann W, et al. Opioid and non-opioid components independently contribute to the mechanism of action of tramadol, an "atypical" opioid analgesic. J pharmacol Exp Ther 1992; 260: 275-5.
2. Dayer P, Collart L, Desmeules J. The pharmacology of tramadol. Drugs 1994; 47: 3-7.
3. Bamigbade T, Langford R. The clinical use of tramadol hydrochloride. Pain Rev 1998; 5: 155-2.
4. Jick H, Derby LE, Vasilakis C, Fife D. The risk of seizure associated with tramadol. Pharmacotherapy 1998; 18: 607-11.
5. Grond S, Sablotzki A. Clinical Pharmacology of Tramadol. Clin Pharmacokinet 2004; 43: 879-923.
6. Garcia-Quetglas E, Azana JR, Sadaba B, et al. Pharmakokinetics of tramadol enantiomers and the respective phase 1 metabolites in relation CYP2D6 phenotype. Pharmacol Res 2007; 55: 122-13.
7. Mason BJ, Blackburn KH. Possible serotonin syndrome associated with tramadol and sertraline coadministration. Ann Pharmacother 1997; 31: 175-7.
8. Boyd IW. Tramadol and seizures. Med J Aust 2005; 182: 595-6.
9. Javanovic-cupic V, Martinovic Z, Nesic N. Seizures associated with intoxication and abuse of tramadol. J Clin Toxicol (phila) 2006; 44: 143-6.
10. Petramfar P, Borhani H. Tramadol induced seizure: Report of 106 patients. Iran Red Crescent Med J 2010; 12: 49-51.
11. Gasse C, Derby L, Vasilakis-scaramozza C, Jick H. Incidence of first time idiopathic seizures in users of tramadol. Pharmacotherapy 2000; 20: 629-34.