메뉴 건너뛰기




Volumn 272, Issue 1, 2016, Pages 169-182

Antigen-specific impairment of adoptive T-cell therapy against cancer: players, mechanisms, solutions and a hypothesis

Author keywords

antigen presentation; cancer; cytotoxic T cells; dendritic cells; immunotherapy; myeloid derived suppressor cells

Indexed keywords

OVALBUMIN; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN;

EID: 84975501563     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12433     Document Type: Review
Times cited : (10)

References (65)
  • 1
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: harnessing the T cell response
    • Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012;12:269–281.
    • (2012) Nat Rev Immunol , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 3
    • 84877575144 scopus 로고    scopus 로고
    • Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors
    • Kochenderfer JN, Rosenberg SA. Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. Nat Rev Clin Oncol 2013;10:267–276.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 267-276
    • Kochenderfer, J.N.1    Rosenberg, S.A.2
  • 6
    • 84906850813 scopus 로고    scopus 로고
    • T-cell immunotherapy: looking forward
    • Corrigan-Curay J, et al. T-cell immunotherapy: looking forward. Mol Ther 2014;22:1564–1574.
    • (2014) Mol Ther , vol.22 , pp. 1564-1574
    • Corrigan-Curay, J.1
  • 8
    • 84934292391 scopus 로고    scopus 로고
    • Adoptive T cell therapy targeting CD1 and MR1
    • Guo T, Chamoto K, Hirano N. Adoptive T cell therapy targeting CD1 and MR1. Front Immunol 2015;6:247.
    • (2015) Front Immunol , vol.6 , pp. 247
    • Guo, T.1    Chamoto, K.2    Hirano, N.3
  • 9
    • 80051873375 scopus 로고    scopus 로고
    • CD8(+) T cells: foot soldiers of the immune system
    • Zhang N, Bevan MJ. CD8(+) T cells: foot soldiers of the immune system. Immunity 2011;35:161–168.
    • (2011) Immunity , vol.35 , pp. 161-168
    • Zhang, N.1    Bevan, M.J.2
  • 10
    • 79958772781 scopus 로고    scopus 로고
    • The role of the proteasome in the generation of MHC class I ligands and immune responses
    • Sijts EJ, Kloetzel PM. The role of the proteasome in the generation of MHC class I ligands and immune responses. Cell Mol Life Sci 2011;68:1491–1502.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1491-1502
    • Sijts, E.J.1    Kloetzel, P.M.2
  • 12
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565–1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 13
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science 2015;348:69–74.
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 14
    • 79958770296 scopus 로고    scopus 로고
    • Insights into the processing of MHC class I ligands gained from the study of human tumor epitopes
    • Vigneron N, Van den Eynde BJ. Insights into the processing of MHC class I ligands gained from the study of human tumor epitopes. Cell Mol Life Sci 2011;68:1503–1520.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1503-1520
    • Vigneron, N.1    Van den Eynde, B.J.2
  • 15
    • 84955660741 scopus 로고    scopus 로고
    • Quantifying epitope presentation using mass spectrometry
    • Croft NP, Purcell AW, Tscharke DC. Quantifying epitope presentation using mass spectrometry. Mol Immunol 2015;68:77–80.
    • (2015) Mol Immunol , vol.68 , pp. 77-80
    • Croft, N.P.1    Purcell, A.W.2    Tscharke, D.C.3
  • 16
    • 84880730689 scopus 로고    scopus 로고
    • Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
    • Linette GP, et al. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood 2013;122:863–871.
    • (2013) Blood , vol.122 , pp. 863-871
    • Linette, G.P.1
  • 17
    • 84873991752 scopus 로고    scopus 로고
    • Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
    • Morgan RA, et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother 2013;36:133–151.
    • (2013) J Immunother , vol.36 , pp. 133-151
    • Morgan, R.A.1
  • 19
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015;348:62–68.
    • (2015) Science , vol.348 , pp. 62-68
    • Rosenberg, S.A.1    Restifo, N.P.2
  • 20
    • 84890230340 scopus 로고    scopus 로고
    • The use of endogenous T cells for adoptive transfer
    • Yee C. The use of endogenous T cells for adoptive transfer. Immunol Rev 2014;257:250–263.
    • (2014) Immunol Rev , vol.257 , pp. 250-263
    • Yee, C.1
  • 21
    • 84954236800 scopus 로고    scopus 로고
    • Prospects for gene-engineered T cell immunotherapy for solid cancers
    • Klebanoff CA, Rosenberg SA, Restifo NP. Prospects for gene-engineered T cell immunotherapy for solid cancers. Nat Med 2016;22:26–36.
    • (2016) Nat Med , vol.22 , pp. 26-36
    • Klebanoff, C.A.1    Rosenberg, S.A.2    Restifo, N.P.3
  • 23
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov 2013;3:388–398.
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 24
    • 84890181067 scopus 로고    scopus 로고
    • Design and development of therapies using chimeric antigen receptor-expressing T cells
    • Dotti G, Gottschalk S, Savoldo B, Brenner MK. Design and development of therapies using chimeric antigen receptor-expressing T cells. Immunol Rev 2014;257:107–126.
    • (2014) Immunol Rev , vol.257 , pp. 107-126
    • Dotti, G.1    Gottschalk, S.2    Savoldo, B.3    Brenner, M.K.4
  • 25
    • 84890149044 scopus 로고    scopus 로고
    • Engineering T cells for cancer: our synthetic future
    • Vonderheide RH, June CH. Engineering T cells for cancer: our synthetic future. Immunol Rev 2014;257:7–13.
    • (2014) Immunol Rev , vol.257 , pp. 7-13
    • Vonderheide, R.H.1    June, C.H.2
  • 26
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985;318:533–538.
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1
  • 27
    • 79959933130 scopus 로고    scopus 로고
    • Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma
    • Prato S, Mintern JD, Lahoud MH, Huang DC, Villadangos JA. Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma. Immunol Cell Biol 2011;89:595–603.
    • (2011) Immunol Cell Biol , vol.89 , pp. 595-603
    • Prato, S.1    Mintern, J.D.2    Lahoud, M.H.3    Huang, D.C.4    Villadangos, J.A.5
  • 28
    • 84974803146 scopus 로고    scopus 로고
    • Target density, not affinity or avidity of antigen recognition, determines adoptive T cell therapy outcomes in a mouse lymphoma model
    • Segal G, Prato S, Zehn D, Mintern JD, Villadangos JA. Target density, not affinity or avidity of antigen recognition, determines adoptive T cell therapy outcomes in a mouse lymphoma model. J Immunol 2016. pii: 1502187. [Epub ahead of print].
    • (2016) J Immunol
    • Segal, G.1    Prato, S.2    Zehn, D.3    Mintern, J.D.4    Villadangos, J.A.5
  • 29
    • 84935086452 scopus 로고    scopus 로고
    • Impaired T-cell function in B-cell lymphoma: a direct consequence of events at the immunological synapse?
    • Nassef Kadry Naguib Roufaiel M, Wells JW, Steptoe RJ. Impaired T-cell function in B-cell lymphoma: a direct consequence of events at the immunological synapse? Front Immunol 2015;6:258.
    • (2015) Front Immunol , vol.6 , pp. 258
    • Nassef Kadry Naguib Roufaiel, M.1    Wells, J.W.2    Steptoe, R.J.3
  • 31
    • 62649151799 scopus 로고    scopus 로고
    • Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance
    • Parish IA, et al. Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance. Proc Natl Acad Sci USA 2009;106:3901–3906.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3901-3906
    • Parish, I.A.1
  • 32
    • 84885121180 scopus 로고    scopus 로고
    • Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold
    • Prato S, Zhan Y, Mintern JD, Villadangos JA. Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold. J Immunol 2013;191:3534–3544.
    • (2013) J Immunol , vol.191 , pp. 3534-3544
    • Prato, S.1    Zhan, Y.2    Mintern, J.D.3    Villadangos, J.A.4
  • 33
    • 84870280593 scopus 로고    scopus 로고
    • Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
    • Enouz S, Carrie L, Merkler D, Bevan MJ, Zehn D. Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med 2012;209:1769–1779.
    • (2012) J Exp Med , vol.209 , pp. 1769-1779
    • Enouz, S.1    Carrie, L.2    Merkler, D.3    Bevan, M.J.4    Zehn, D.5
  • 34
    • 0029965055 scopus 로고    scopus 로고
    • Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
    • Alexander-Miller MA, Leggatt GR, Berzofsky JA. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc Natl Acad Sci USA 1996;93:4102–4107.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4102-4107
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Berzofsky, J.A.3
  • 35
    • 0035423121 scopus 로고    scopus 로고
    • Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity
    • Dutoit V, et al. Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity. Cancer Res 2001;61:5850–5856.
    • (2001) Cancer Res , vol.61 , pp. 5850-5856
    • Dutoit, V.1
  • 36
    • 84879619273 scopus 로고    scopus 로고
    • Functional differences between low- and high-affinity CD8(+) T cells in the tumor environment
    • Bos R, Marquardt KL, Cheung J, Sherman LA. Functional differences between low- and high-affinity CD8(+) T cells in the tumor environment. Oncoimmunology 2012;1:1239–1247.
    • (2012) Oncoimmunology , vol.1 , pp. 1239-1247
    • Bos, R.1    Marquardt, K.L.2    Cheung, J.3    Sherman, L.A.4
  • 37
    • 84888065568 scopus 로고    scopus 로고
    • Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity
    • Dougan SK, et al. Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity. Cancer Immunol Res 2013;1:99–111.
    • (2013) Cancer Immunol Res , vol.1 , pp. 99-111
    • Dougan, S.K.1
  • 38
    • 84876859096 scopus 로고    scopus 로고
    • T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
    • Zhong S, et al. T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy. Proc Natl Acad Sci USA 2013;110:6973–6978.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 6973-6978
    • Zhong, S.1
  • 39
    • 0035286588 scopus 로고    scopus 로고
    • Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
    • Kalergis AM, et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat Immunol 2001;2:229–234.
    • (2001) Nat Immunol , vol.2 , pp. 229-234
    • Kalergis, A.M.1
  • 40
    • 79960455299 scopus 로고    scopus 로고
    • Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen
    • Thomas S, Xue SA, Bangham CR, Jakobsen BK, Morris EC, Stauss HJ. Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen. Blood 2011;118:319–329.
    • (2011) Blood , vol.118 , pp. 319-329
    • Thomas, S.1    Xue, S.A.2    Bangham, C.R.3    Jakobsen, B.K.4    Morris, E.C.5    Stauss, H.J.6
  • 41
    • 84864058737 scopus 로고    scopus 로고
    • High avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairment
    • Brentville VA, Metheringham RL, Gunn B, Durrant LG. High avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairment. PLoS ONE 2012;7:e41112.
    • (2012) PLoS ONE , vol.7
    • Brentville, V.A.1    Metheringham, R.L.2    Gunn, B.3    Durrant, L.G.4
  • 42
    • 0036219008 scopus 로고    scopus 로고
    • Characterization of two TCR transgenic mouse lines specific for herpes simplex virus
    • Mueller SN, Heath W, McLain JD, Carbone FR, Jones CM. Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol Cell Biol 2002;80:156–163.
    • (2002) Immunol Cell Biol , vol.80 , pp. 156-163
    • Mueller, S.N.1    Heath, W.2    McLain, J.D.3    Carbone, F.R.4    Jones, C.M.5
  • 43
    • 2942541735 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    • Heath WR, et al. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev 2004;199:9–26.
    • (2004) Immunol Rev , vol.199 , pp. 9-26
    • Heath, W.R.1
  • 44
    • 33746052871 scopus 로고    scopus 로고
    • The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
    • Schnorrer P, et al. The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture. Proc Natl Acad Sci USA 2006;103:10729–10734.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10729-10734
    • Schnorrer, P.1
  • 45
    • 56449097442 scopus 로고    scopus 로고
    • Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    • Hildner K, et al. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008;322:1097–1100.
    • (2008) Science , vol.322 , pp. 1097-1100
    • Hildner, K.1
  • 46
    • 0035059416 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cells, tolerance and immunity
    • Heath WR, Carbone FR. Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 2001;19:47–64.
    • (2001) Annu Rev Immunol , vol.19 , pp. 47-64
    • Heath, W.R.1    Carbone, F.R.2
  • 47
    • 84923688050 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell impact on endogenous and adoptively transferred T cells
    • Arina A, Bronte V. Myeloid-derived suppressor cell impact on endogenous and adoptively transferred T cells. Curr Opin Immunol 2015;33:120–125.
    • (2015) Curr Opin Immunol , vol.33 , pp. 120-125
    • Arina, A.1    Bronte, V.2
  • 48
    • 84959542771 scopus 로고    scopus 로고
    • The nature of myeloid-derived suppressor cells in the tumor microenvironment
    • Kumar V, Patel S, Tcyganov E, Gabrilovich DI. The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol 2016;37:208–220.
    • (2016) Trends Immunol , vol.37 , pp. 208-220
    • Kumar, V.1    Patel, S.2    Tcyganov, E.3    Gabrilovich, D.I.4
  • 49
    • 25444456369 scopus 로고    scopus 로고
    • Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells
    • Kusmartsev S, Nagaraj S, Gabrilovich DI. Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells. J Immunol 2005;175:4583–4592.
    • (2005) J Immunol , vol.175 , pp. 4583-4592
    • Kusmartsev, S.1    Nagaraj, S.2    Gabrilovich, D.I.3
  • 50
    • 1642536454 scopus 로고    scopus 로고
    • Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species
    • Kusmartsev S, Nefedova Y, Yoder D, Gabrilovich DI. Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J Immunol 2004;172:989–999.
    • (2004) J Immunol , vol.172 , pp. 989-999
    • Kusmartsev, S.1    Nefedova, Y.2    Yoder, D.3    Gabrilovich, D.I.4
  • 53
    • 15244355148 scopus 로고    scopus 로고
    • Peripheral tolerance of CD8 T lymphocytes
    • Redmond WL, Sherman LA. Peripheral tolerance of CD8 T lymphocytes. Immunity 2005;22:275–284.
    • (2005) Immunity , vol.22 , pp. 275-284
    • Redmond, W.L.1    Sherman, L.A.2
  • 54
    • 0028446546 scopus 로고
    • How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
    • von Herrath MG, Dockter J, Oldstone MB. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1994;1:231–242.
    • (1994) Immunity , vol.1 , pp. 231-242
    • von Herrath, M.G.1    Dockter, J.2    Oldstone, M.B.3
  • 55
    • 0033976066 scopus 로고    scopus 로고
    • Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas
    • Nugent CT, et al. Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas. J Immunol 2000;164:191–200.
    • (2000) J Immunol , vol.164 , pp. 191-200
    • Nugent, C.T.1
  • 56
    • 33747092627 scopus 로고    scopus 로고
    • T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
    • Zehn D, Bevan MJ. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 2006;25:261–270.
    • (2006) Immunity , vol.25 , pp. 261-270
    • Zehn, D.1    Bevan, M.J.2
  • 57
    • 84866555886 scopus 로고    scopus 로고
    • From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
    • Banchereau J, Pascual V, O'Garra A. From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol 2012;13:925–931.
    • (2012) Nat Immunol , vol.13 , pp. 925-931
    • Banchereau, J.1    Pascual, V.2    O'Garra, A.3
  • 58
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6:345–352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 59
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. T cell exhaustion. Nat Immunol 2011;12:492–499.
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 60
    • 84958101717 scopus 로고    scopus 로고
    • In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity
    • Halle S, et al. In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity. Immunity 2016;44:233–245.
    • (2016) Immunity , vol.44 , pp. 233-245
    • Halle, S.1
  • 61
    • 76249116978 scopus 로고    scopus 로고
    • Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice
    • James SE, et al. Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood 2009;114:5454–5463.
    • (2009) Blood , vol.114 , pp. 5454-5463
    • James, S.E.1
  • 62
    • 76249092898 scopus 로고    scopus 로고
    • Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function
    • Kenna TJ, et al. Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function. J Immunol 2010;184:598–606.
    • (2010) J Immunol , vol.184 , pp. 598-606
    • Kenna, T.J.1
  • 63
    • 84903456590 scopus 로고    scopus 로고
    • Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses
    • Tay SS, et al. Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proc Natl Acad Sci USA 2014;111:E2540–E2549.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E2540-E2549
    • Tay, S.S.1
  • 64
    • 84941938736 scopus 로고    scopus 로고
    • Immune outcomes in the liver: Is CD8 T cell fate determined by the environment?
    • Wong YC, Tay SS, McCaughan GW, Bowen DG, Bertolino P. Immune outcomes in the liver: Is CD8 T cell fate determined by the environment? J Hepatol 2015;63:1005–1014.
    • (2015) J Hepatol , vol.63 , pp. 1005-1014
    • Wong, Y.C.1    Tay, S.S.2    McCaughan, G.W.3    Bowen, D.G.4    Bertolino, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.