Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas

Journal of Immunology

Volumn 164, Issue 1, 2000, Pages 191-200

  Nugent, C Thomas ^b   Morgan, David J ^b   Biggs, Judith A ^b   Ko, Alice ^b   Pilip, Ingrid M ^a   Pamer, Eric G ^a   Sherman, Linda A ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR; VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; DIABETOGENESIS; IMMUNOLOGICAL TOLERANCE; INFLUENZA VIRUS; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 0033976066     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.1.191     Document Type: Article

References (72)

1. Bevan, M. J. 1977. In a radiation chimera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269:417.
2. Zinkernagel, R. M., G. N. Callahan, J. Klein, and G. Dennert. 1978. Cytotoxic T cells learn specificity for self-H-2 during differentiation in the thymus. Nature 271:251.
3. Tanchot, C., F. A. Lemonnier, B. Perarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
4. Kappler, J. W., N. Roehm, and P. Marrack. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49:273.
5. Webb, S., C. Morris, and J. Sprent. 1990. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249.
6. Moskophidis, D., F. Lechner, H. Pircher, and R. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:728.
7. + T cells in mice tolerant to Staphylococcus aureaus entero-toxin B. Nature 349:245.
8. Rocha, B., and H. v. Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
9. Bevan, M. J. 1976. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143:1283.
10. Oehen, S. U., P. S. Ohashi, K. Burki, H. Hengartner, R. M. Zinkernagel, and P. Aichele. 1994. Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels. Cell. Immunol. 158:342.
11. Liu, G. Y., P. J. Fairchild, R. M. Smith, J. R. Prowle, D. Kioussis, and D. C. Wraith. 1995. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3:407.
12. Kawai, K., and P. S. Ohashi. 1995. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature 374:68.
13. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
14. Oldstone, M. B. A., M. Nerenberg, P. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65:319.
15. + T cells. Eur. J. Immunol. 22:1013.
16. Morgan, D. J., C. Kurts, H. T. C. Kreuwel, H. K.L., W. R. Heath, and L. A. Sherman. 1999. Ontogeny of T cell tolerance to peripherally expressed antigens. Proc. Natl. Acad. Sci. USA 96:3854.
17. + T cell tolerance to peripherally expressed antigens. J. Immunol. 163:723.
18. Morgan, D. J., T. C. Kreuwel, S. Fleck, H. I. Levitsky, D. M. Pardoll, and L. A. Sherman. 1998. Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity. J. Immunol. 160:643.
19. Miller, J. F. A. P., and W. R. Heath. 1993. Self-ignorance in the peripheral T cell pool. Immunol. Rev. 133:131.
20. Zhang, L. 1996. The fate of adoptively transferred antigen-specific T cells in vivo. Eur. J. Immunol. 26:2208.
21. Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.
22. Padovan, E., G. Casorali, P. Dellatona, S. Meyer, M. Brockhaus, and A. Lanzavecchia. 1993. Expression of two T cell receptor α chains: dual receptor T cells. Science 262:422.
23. Heath, W. R., F. R. Carbone, P. Bertolino, J. Kelly, S. Cose, and J. F. A. P. Miller. 1995. Expression of two T cell receptor α chains on the surface of normal murine T cells. Eur. J. Immunol. 25:1617.
24. Blichfeldt, E., L. A. Munthe, J. S. Rotnes, and B. Bogen. 1996. Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor. Eur. J. Immunol. 26:2876.
25. Zal, T., S. Weiss, A. Mellor, and B. Stockinger. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93:9102.
26. Sarukhan, A., C. Garcia, A. Lanoue, and H. von Boehmer. 1998. Allelic inclusion of T cell receptor a genes poses an autoimmune hazard due to low-level expression of autospecific receptors. Immunity 8:563.
27. Hämmerling, G. J., G. Schönrich, I. Ferber, and B. Arnold. 1993. Peripheral tolerance as a multi-step mechanism. Immunol. Rev. 133:93.
28. + T cell deletion. Immunity 3:321.
29. Rocha, B., A. Grandien, and A. A. Freitas. 1995. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181:993.
30. Rocha, B., C. Tanchot, and H. v. Boehmer. 1993. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 177:1517.
31. Dubois, P. M., M. P. M. M. Tomkowiak, M. V. Mechelen, and J. Marvel. 1998. Tolerant CD8 T cells induced by multiple injections of peptide antigen show impaired TCR signaling and altered proliferative responses in vitro and in vivo. J. Immunol. 161:5260.
32. Falk, K., O. Rötzschke, K. Deres, J. Metzger, G. Jung, and H. G. Rammensee. 1991. Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast. J. Exp. Med. 174:425.
33. Alexander-Miller, M. A., G. R. Leggatt, and J. A. Berzofsky. 1996. Selective expansion of high-or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 93:4102.
34. Alexander-Miller, M. A., G. R. Leggatt, A. Sarin, and J. A. Berzofsky. 1996. Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. J. Exp. Med. 184:485.
35. Walsh, C. M., A. A. Glass, V. Chiu, and W. R. Clark. 1994. The role of the Fas lytic pathway in a perforin-less CTL hybridoma. J. Immunol. 153:2506.
36. Zisman, E., M. Sela, A. Ben-Nun, and E. Mozes. 1994. Dichotomy between the T and the B cell epitopes of the synthetic polypeptide (T,G)-A-L *. Eur. J. Immunol. 24:2497.
37. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. Lipman. 1990. A basic local alignment search tool. J. Mol. Biol. 215:403.
38. Wilson, R. K., B. F. Koop, C. Chen, N. Halloran, R. Sciammis, and L. Hood. 1992. Nucleotide sequence analysis of 95 kb near the 3′ end of the murine T-cell receptor α/δ chain locus: strategy and methodology. Genomics 13:1198.
39. Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Protein of Immunological Interest. U.S. Department of Health and Human Services, Bethesda.
40. Busch, D. H., I. M. Pilip, S. Vijh, and E. G. Pamer. 1998. Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity 8:353.
41. Chervonsky, A. V., Y. Wang, R. A. Flavell, C. A. Janeway, and L. A. Matis. 1997. The role of Fas in autoimmune diabetes. Cell 89:17.
42. + T cell-mediated insulin-dependent diabetes mellitus. J. Immunol. 163:4335.
43. + T cells by a self-derived peptide. Nature 378:295.
44. Brossart, P., and M. Bevan. 1996. Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide. J. Exp. Med. 183:2449.
45. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
46. Schönrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Scmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extra-thymic tolerance induction. Cell 65:293.
47. Renner, C., W. Jung, U. Sahin, R. v. Lier, and M. Pfreundschuh. 1995. The role of lymphocyte subsets and adhesion molecules in T cell-dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies. Eur. J. Immunol. 25:2027.
48. Dailey, M. O. 1998. Expression of T lymphocyte adhesion molecules: regulation during antigen-induced T cell activation and differentiation. Crit. Rev. Immunol. 18:153.
49. + T cells. J. Immunol. 154: 6306.
50. Casanova, J.-L., P. Romero, C. Widmann, P. Kourilsky, and J. L. Maryanski. 1991. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for a T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174:1371.
51. + cell-mediated spontaneous diabetes in neonatal mice. J. Immunol. 157:978.
52. Herrath, M. G. V., and M. B. A. Oldstone. 1997. Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:531.
53. Crawford, F., H. Kozono, J. White, P. Marrack, and J. Kappler. 1998. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 8:675.
54. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
55. Genain, C. P., D. Lee-Parritz, M.-H. Nguyen, L. Massacesi, N. Joshi, R. Ferrante, K. Hoffman, M. Moseley, N. L. Letvin, and S. L. Hauser. 1994. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J. Clin. Invest. 94:1339.
56. Malissen, M., J. Trucy, E. Jouvin-Marche, P. A. Cazenave, R. Scollay, and B. Malissen. 1992. Regulation of TCR α and β give allelic exclusion during T cell development. Immunol. Today 13:315.
57. Savage, P., J. J. Boniface, and M. M. Davis. 1999. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10:485.
58. Busch, D. H., and E. G. Pamer. 1999. T cell affinity maturation by selective expansion during infection. J. Exp. Med. 189:701.
59. Gallimore, A., J. Hombach, T. Dumrese, H. G. Rammensee, R. M. Zinkernagel, and H. Hengartner. 1998. A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells. Eur. J. Immunol. 10:3301.
60. Poplonski, L., B. Vukusic, J. Pawling, S. Clapoff, J. Roder, N. Hozumi, and J. Whither. 1996. Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells. Eur. J. Immunol. 26:601.
61. Cibotti, R., J.-P. Cabaniols, C. Pannetier, C. Delarbre, I. Vergnon, J. M. Kanellopoulos, and P. Kourilsky. 1994. Public and private Vβ T cell receptor repertoires against hen egg white lysozyme (HEL) in non-transgenic versus HEL transgenic mice. J. Exp. Med. 180:861.
62. Itoh, N., A. Imagawa, T. Hanafusa, M. Waguri, K. Yamamoto, H. Iwahashi, M. Moriwaki, H. Nakajima, J. Miyagawa, M. Namba, et al. 1997. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 186:613.
63. Arnold, B., G. Schönrich, and G. J. Hammerling. 1993. Multiple levels of peripheral tolerance. Immunol. Today 14:12.
64. + T cells can persist and function in vivo. J. Immunol. 163:155.
65. Gallimore, A., A. Glithero, A. Godkin, A. C. Tissot, A. Pluckthun, T. Elliott, H. Hengartner, and R. Zinkernagel. 1998. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 187:1383.
66. Yee, C., P. A. Savage, P. P. Lee, M. M. Davis, and P. D. Greenberg. 1999. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 162:2227.
67. Matzinger, P. 1994. Tolerance, danger, and the extended family. In Annual Review of Immunology, Vol. 12. W. E. Paul, ed. Annual Reviews, Palo Alto.
68. Vyse, T. J., and J. A. Todd. 1996. Genetic analysis of autoimmune disease. Cell 85:311.
69. Benoist, C., and D. Mathis. 1998. Autoimmunity: the pathogen connection. Nature 394:227.
70. Nicholson, L. B., H. Waldner, A. M. Carrizosa, A. Sette, M. Collins, and V. K. Kuchroo. 1998. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc. Natl. Acad. Sci. USA 95:264.
71. Windhagen, A., C. Scholz, P. Hollsberg, H. Fukaura, A. Sette, and D. A. Hafler. 1995. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 2:373.
72. Hernandez, J., P. P. Lee, M. M. Davis, and L. A. Sherman. 2000. The impact of self tolerance on the TCR repertoire. J. Immunol., In press.