메뉴 건너뛰기




Volumn 272, Issue 1, 2016, Pages 8-16

Nowhere to hide: unconventional translation yields cryptic peptides for immune surveillance

Author keywords

antigen presentation; antigen processing; cytotoxic T cells; major histocompatibility complex; protein synthesis

Indexed keywords

CELL PROTEIN; CRYPTIC PEPTIDE; DNA FRAGMENT; GENOMIC DNA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; PEPTIDE; TRANSFER RNA; UNCLASSIFIED DRUG;

EID: 84975476964     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12434     Document Type: Review
Times cited : (52)

References (83)
  • 2
    • 26244467481 scopus 로고    scopus 로고
    • All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen-processing pathway
    • Shastri N, Cardinaud S, Schwab SR, Serwold T, Kunisawa J. All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen-processing pathway. Immunol Rev 2005;207:31–41.
    • (2005) Immunol Rev , vol.207 , pp. 31-41
    • Shastri, N.1    Cardinaud, S.2    Schwab, S.R.3    Serwold, T.4    Kunisawa, J.5
  • 3
    • 0024383535 scopus 로고
    • Antigen recognition by class I-restricted T lymphocytes
    • Townsend A, Bodmer H. Antigen recognition by class I-restricted T lymphocytes. Annu Rev Immunol 1989;7:601–624.
    • (1989) Annu Rev Immunol , vol.7 , pp. 601-624
    • Townsend, A.1    Bodmer, H.2
  • 4
    • 0027980319 scopus 로고
    • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
    • Rock KL, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994;78:761–771.
    • (1994) Cell , vol.78 , pp. 761-771
    • Rock, K.L.1
  • 5
    • 0036017391 scopus 로고    scopus 로고
    • Protein degradation and the generation of MHC class I-presented peptides
    • Rock KL, York IA, Saric T, Goldberg AL. Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol 2002;80:1–70.
    • (2002) Adv Immunol , vol.80 , pp. 1-70
    • Rock, K.L.1    York, I.A.2    Saric, T.3    Goldberg, A.L.4
  • 6
    • 0026524392 scopus 로고
    • A molecular model for MHC class I-restricted antigen processing
    • Monaco JJ. A molecular model for MHC class I-restricted antigen processing. Immunol Today 1992;13:173–179.
    • (1992) Immunol Today , vol.13 , pp. 173-179
    • Monaco, J.J.1
  • 7
    • 0026593016 scopus 로고
    • Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex
    • Kelly A, et al. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature 1992;355:641–644.
    • (1992) Nature , vol.355 , pp. 641-644
    • Kelly, A.1
  • 8
    • 0029917002 scopus 로고    scopus 로고
    • Processing and delivery of peptides presented by MHC class I molecules
    • Lehner PJ, Cresswell P. Processing and delivery of peptides presented by MHC class I molecules. Curr Opin Immunol 1996;8:59–67.
    • (1996) Curr Opin Immunol , vol.8 , pp. 59-67
    • Lehner, P.J.1    Cresswell, P.2
  • 10
    • 0034643348 scopus 로고    scopus 로고
    • The major substrates for TAP in vivo are derived from newly synthesized proteins
    • Reits EA, Vos JC, Gromme M, Neefjes J. The major substrates for TAP in vivo are derived from newly synthesized proteins. Nature 2000;404:774–778.
    • (2000) Nature , vol.404 , pp. 774-778
    • Reits, E.A.1    Vos, J.C.2    Gromme, M.3    Neefjes, J.4
  • 11
    • 0034700088 scopus 로고    scopus 로고
    • Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2
    • Schubert U, et al. Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2. Proc Natl Acad Sci USA 2000;97:13057–13062.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13057-13062
    • Schubert, U.1
  • 12
    • 0030239693 scopus 로고    scopus 로고
    • Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?
    • Yewdell JW, Anton LC, Bennink JR. Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules? J Immunol 1996;157:1823–1826.
    • (1996) J Immunol , vol.157 , pp. 1823-1826
    • Yewdell, J.W.1    Anton, L.C.2    Bennink, J.R.3
  • 13
    • 33745833084 scopus 로고    scopus 로고
    • The DRiP hypothesis decennial: support, controversy, refinement and extension
    • Yewdell JW, Nicchitta CV. The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends Immunol 2006;27:368–373.
    • (2006) Trends Immunol , vol.27 , pp. 368-373
    • Yewdell, J.W.1    Nicchitta, C.V.2
  • 14
    • 84867655637 scopus 로고    scopus 로고
    • Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides
    • Farfan-Arribas DJ, Stern LJ, Rock KL. Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides. Proc Natl Acad Sci USA 2012;109:16998–17003.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16998-17003
    • Farfan-Arribas, D.J.1    Stern, L.J.2    Rock, K.L.3
  • 16
    • 0036218697 scopus 로고    scopus 로고
    • Producing nature's gene-chips. The generation of peptides for display by MHC class I molecules
    • Shastri N, Schwab S, Serwold T. Producing nature's gene-chips. The generation of peptides for display by MHC class I molecules. Annu Rev Immunol 2002;20:463–493.
    • (2002) Annu Rev Immunol , vol.20 , pp. 463-493
    • Shastri, N.1    Schwab, S.2    Serwold, T.3
  • 17
    • 33845457635 scopus 로고    scopus 로고
    • Alternative translational products and cryptic T cell epitopes: expecting the unexpected
    • Ho O, Green WR. Alternative translational products and cryptic T cell epitopes: expecting the unexpected. J Immunol 2006;177:8283–8289.
    • (2006) J Immunol , vol.177 , pp. 8283-8289
    • Ho, O.1    Green, W.R.2
  • 18
    • 79958769095 scopus 로고    scopus 로고
    • Non-conventional sources of peptides presented by MHC class I
    • Starck SR, Shastri N. Non-conventional sources of peptides presented by MHC class I. Cell Mol Life Sci 2011;68:1471–1479.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1471-1479
    • Starck, S.R.1    Shastri, N.2
  • 19
    • 84953260622 scopus 로고    scopus 로고
    • Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
    • Laumont CM, et al. Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames. Nat Commun 2016;7:10238.
    • (2016) Nat Commun , vol.7 , pp. 10238
    • Laumont, C.M.1
  • 20
    • 0024492716 scopus 로고
    • T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis
    • Boon T, Van Pel A. T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis. Immunogenetics 1989;29:75–79.
    • (1989) Immunogenetics , vol.29 , pp. 75-79
    • Boon, T.1    Van Pel, A.2
  • 21
    • 0002527782 scopus 로고
    • Cytotoxic T cell recognition of the SV40 Tumor antigen: a note of caution
    • In, Pernis B, Silverstein S, Vogel H, eds., New York, Academic Press
    • Gooding LR, O'Connell KA, Geib RW, Pipas JM. Cytotoxic T cell recognition of the SV40 Tumor antigen: a note of caution. In: Pernis B, Silverstein S, Vogel H eds. Processing and presentation of antigens. New York: Academic Press, 1988:87–95.
    • (1988) Processing and presentation of antigens , pp. 87-95
    • Gooding, L.R.1    O'Connell, K.A.2    Geib, R.W.3    Pipas, J.M.4
  • 22
    • 0025925355 scopus 로고
    • A frameshift mutation at the NH2 terminus of the nucleoprotein gene does not affect generation of cytotoxic T lymphocyte epitopes
    • Fetten JV, Roy N, Gilboa E. A frameshift mutation at the NH2 terminus of the nucleoprotein gene does not affect generation of cytotoxic T lymphocyte epitopes. J Immunol 1991;147:2697–2705.
    • (1991) J Immunol , vol.147 , pp. 2697-2705
    • Fetten, J.V.1    Roy, N.2    Gilboa, E.3
  • 23
    • 0028817871 scopus 로고
    • A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells
    • Malarkannan S, Afkarian M, Shastri N. A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells. J Exp Med 1995;182:1739–1750.
    • (1995) J Exp Med , vol.182 , pp. 1739-1750
    • Malarkannan, S.1    Afkarian, M.2    Shastri, N.3
  • 24
    • 0033151592 scopus 로고    scopus 로고
    • Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism
    • Malarkannan S, Horng T, Shih PP, Schwab S, Shastri N. Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. Immunity 1999;10:681–690.
    • (1999) Immunity , vol.10 , pp. 681-690
    • Malarkannan, S.1    Horng, T.2    Shih, P.P.3    Schwab, S.4    Shastri, N.5
  • 25
    • 0042471944 scopus 로고    scopus 로고
    • Constitutive display of cryptic translation products by MHC class I molecules
    • Schwab SR, Li KC, Kang C, Shastri N. Constitutive display of cryptic translation products by MHC class I molecules. Science 2003;301:1367–1371.
    • (2003) Science , vol.301 , pp. 1367-1371
    • Schwab, S.R.1    Li, K.C.2    Kang, C.3    Shastri, N.4
  • 27
    • 0031882090 scopus 로고    scopus 로고
    • An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus
    • Mayrand SM, Schwarz DA, Green WR. An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus. J Immunol 1998;160:39–50.
    • (1998) J Immunol , vol.160 , pp. 39-50
    • Mayrand, S.M.1    Schwarz, D.A.2    Green, W.R.3
  • 28
    • 32044446285 scopus 로고    scopus 로고
    • Cytolytic CD8+ T cells directed against a cryptic epitope derived from a retroviral alternative reading frame confer disease protection
    • Ho O, Green WR. Cytolytic CD8+ T cells directed against a cryptic epitope derived from a retroviral alternative reading frame confer disease protection. J Immunol 2006;176:2470–2475.
    • (2006) J Immunol , vol.176 , pp. 2470-2475
    • Ho, O.1    Green, W.R.2
  • 29
    • 35748966715 scopus 로고    scopus 로고
    • AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape
    • Maness NJ, et al. AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. J Exp Med 2007;204:2505–2512.
    • (2007) J Exp Med , vol.204 , pp. 2505-2512
    • Maness, N.J.1
  • 30
    • 2442540999 scopus 로고    scopus 로고
    • Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames
    • Cardinaud S, et al. Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames. J Exp Med 2004;199:1053–1063.
    • (2004) J Exp Med , vol.199 , pp. 1053-1063
    • Cardinaud, S.1
  • 31
    • 73949119237 scopus 로고    scopus 로고
    • Robust, vaccine-induced CD8(+) T lymphocyte response against an out-of-frame epitope
    • Maness NJ, et al. Robust, vaccine-induced CD8(+) T lymphocyte response against an out-of-frame epitope. J Immunol 2010;184:67–72.
    • (2010) J Immunol , vol.184 , pp. 67-72
    • Maness, N.J.1
  • 32
    • 69749109840 scopus 로고    scopus 로고
    • Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses
    • Garrison KE, et al. Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses. Clin Vaccine Immunol 2009;16:1369–1371.
    • (2009) Clin Vaccine Immunol , vol.16 , pp. 1369-1371
    • Garrison, K.E.1
  • 33
    • 76149099253 scopus 로고    scopus 로고
    • Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences
    • Berger CT, et al. Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences. J Exp Med 2010;207:61–75.
    • (2010) J Exp Med , vol.207 , pp. 61-75
    • Berger, C.T.1
  • 34
    • 76149107149 scopus 로고    scopus 로고
    • CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription
    • Bansal A, et al. CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription. J Exp Med 2010;207:51–59.
    • (2010) J Exp Med , vol.207 , pp. 51-59
    • Bansal, A.1
  • 35
    • 84863093421 scopus 로고    scopus 로고
    • Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection
    • Champiat S, et al. Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection. PLoS ONE 2012;7:e39311.
    • (2012) PLoS ONE , vol.7
    • Champiat, S.1
  • 36
    • 84939782737 scopus 로고    scopus 로고
    • Enhanced recognition of HIV-1 cryptic epitopes restricted by HLA class I salleles associated with a favorable clinical outcome
    • Bansal A, et al. Enhanced recognition of HIV-1 cryptic epitopes restricted by HLA class I salleles associated with a favorable clinical outcome. J Acquir Immune Defic Syndr 2015;70:1–8.
    • (2015) J Acquir Immune Defic Syndr , vol.70 , pp. 1-8
    • Bansal, A.1
  • 37
    • 84898771549 scopus 로고    scopus 로고
    • Cryptic MHC class I-binding peptides are revealed by aminoglycoside-induced stop codon read-through into the 3’ UTR
    • Goodenough E, et al. Cryptic MHC class I-binding peptides are revealed by aminoglycoside-induced stop codon read-through into the 3’ UTR. Proc Natl Acad Sci USA 2014;111:5670–5675.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 5670-5675
    • Goodenough, E.1
  • 38
    • 67649817113 scopus 로고    scopus 로고
    • Cellular immune response to cryptic epitopes during therapeutic gene transfer
    • Li C, et al. Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proc Natl Acad Sci USA 2009;106:10770–10774.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10770-10774
    • Li, C.1
  • 39
    • 0034643336 scopus 로고    scopus 로고
    • Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
    • Schubert U, Anton LC, Gibbs J, Norbury CC, Yewdell JW, Bennink JR. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 2000;404:770–774.
    • (2000) Nature , vol.404 , pp. 770-774
    • Schubert, U.1    Anton, L.C.2    Gibbs, J.3    Norbury, C.C.4    Yewdell, J.W.5    Bennink, J.R.6
  • 40
    • 0029003999 scopus 로고
    • Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1
    • Levitskaya J, et al. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 1995;375:685–688.
    • (1995) Nature , vol.375 , pp. 685-688
    • Levitskaya, J.1
  • 41
    • 0030775380 scopus 로고    scopus 로고
    • Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1
    • Levitskaya J, Sharipo A, Leonchiks A, Ciechanover A, Masucci MG. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci USA 1997;94:12616–12621.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12616-12621
    • Levitskaya, J.1    Sharipo, A.2    Leonchiks, A.3    Ciechanover, A.4    Masucci, M.G.5
  • 42
    • 0033015741 scopus 로고    scopus 로고
    • Expression of EBNA-1 mRNA is regulated by cell cycle during Epstein-Barr virus type I latency
    • Davenport MG, Pagano JS. Expression of EBNA-1 mRNA is regulated by cell cycle during Epstein-Barr virus type I latency. J Virol 1999;73:3154–3161.
    • (1999) J Virol , vol.73 , pp. 3154-3161
    • Davenport, M.G.1    Pagano, J.S.2
  • 43
    • 34547119036 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing
    • Kwun HJ, da Silva SR, Shah IM, Blake N, Moore PS, Chang Y. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing. J Virol 2007;81:8225–8235.
    • (2007) J Virol , vol.81 , pp. 8225-8235
    • Kwun, H.J.1    da Silva, S.R.2    Shah, I.M.3    Blake, N.4    Moore, P.S.5    Chang, Y.6
  • 44
    • 79958766636 scopus 로고    scopus 로고
    • Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
    • Dolan BP, Bennink JR, Yewdell JW. Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands. Cell Mol Life Sci 2011;68:1481–1489.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1481-1489
    • Dolan, B.P.1    Bennink, J.R.2    Yewdell, J.W.3
  • 45
    • 77749249463 scopus 로고    scopus 로고
    • The synthesis of truncated polypeptides for immune surveillance and viral evasion
    • Cardinaud S, Starck SR, Chandra P, Shastri N. The synthesis of truncated polypeptides for immune surveillance and viral evasion. PLoS ONE 2010;5:e8692.
    • (2010) PLoS ONE , vol.5
    • Cardinaud, S.1    Starck, S.R.2    Chandra, P.3    Shastri, N.4
  • 46
    • 42049116319 scopus 로고    scopus 로고
    • A cryptic vascular endothelial growth factor T-cell epitope: identification and characterization by mass spectrometry and T-cell assays
    • Weinzierl AO, et al. A cryptic vascular endothelial growth factor T-cell epitope: identification and characterization by mass spectrometry and T-cell assays. Cancer Res 2008;68:2447–2454.
    • (2008) Cancer Res , vol.68 , pp. 2447-2454
    • Weinzierl, A.O.1
  • 47
    • 0023660877 scopus 로고
    • At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells
    • Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 1987;196:947–950.
    • (1987) J Mol Biol , vol.196 , pp. 947-950
    • Kozak, M.1
  • 48
    • 0037121050 scopus 로고    scopus 로고
    • Pushing the limits of the scanning mechanism for initiation of translation
    • Kozak M. Pushing the limits of the scanning mechanism for initiation of translation. Gene 2002;299:1–34.
    • (2002) Gene , vol.299 , pp. 1-34
    • Kozak, M.1
  • 49
    • 0000091608 scopus 로고    scopus 로고
    • The pathway and mechanism of initiation of protein synthesis
    • In, Sonenberg N, Hershey JWB, Mathews MB, eds., Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press
    • Hershey JWB, Merrick WC. The pathway and mechanism of initiation of protein synthesis. In: Sonenberg N, Hershey JWB, Mathews MB eds. Translational Control of Gene Expression. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2000:33–88.
    • (2000) Translational Control of Gene Expression , pp. 33-88
    • Hershey, J.W.B.1    Merrick, W.C.2
  • 50
    • 0034065158 scopus 로고    scopus 로고
    • The structure and function of initiation factors in eukaryotic protein synthesis
    • Pestova TV, Hellen CU. The structure and function of initiation factors in eukaryotic protein synthesis. Cell Mol Life Sci 2000;57:651–674.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 651-674
    • Pestova, T.V.1    Hellen, C.U.2
  • 51
    • 17144424622 scopus 로고    scopus 로고
    • Translational control in stress and apoptosis
    • Holcik M, Sonenberg N. Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 2005;6:318–327.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 318-327
    • Holcik, M.1    Sonenberg, N.2
  • 53
    • 0343069798 scopus 로고    scopus 로고
    • Statistical analysis of the 5’ untranslated region of human mRNA using ‘Oligo-Capped’ cDNA libraries
    • Suzuki Y, et al. Statistical analysis of the 5’ untranslated region of human mRNA using ‘Oligo-Capped’ cDNA libraries. Genomics 2000;64:286–297.
    • (2000) Genomics , vol.64 , pp. 286-297
    • Suzuki, Y.1
  • 54
    • 0034781576 scopus 로고    scopus 로고
    • Presence of ATG triplets in 5’ untranslated regions of eukaryotic cDNAs correlates with a ‘weak’ context of the start codon
    • Rogozin IB, Kochetov AV, Kondrashov FA, Koonin EV, Milanesi L. Presence of ATG triplets in 5’ untranslated regions of eukaryotic cDNAs correlates with a ‘weak’ context of the start codon. Bioinformatics 2001;17:890–900.
    • (2001) Bioinformatics , vol.17 , pp. 890-900
    • Rogozin, I.B.1    Kochetov, A.V.2    Kondrashov, F.A.3    Koonin, E.V.4    Milanesi, L.5
  • 55
    • 62549134121 scopus 로고    scopus 로고
    • Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling
    • Ingolia NT, Ghaemmaghami S, Newman JR, Weissman JS. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science 2009;324:218–223.
    • (2009) Science , vol.324 , pp. 218-223
    • Ingolia, N.T.1    Ghaemmaghami, S.2    Newman, J.R.3    Weissman, J.S.4
  • 56
    • 81055155799 scopus 로고    scopus 로고
    • Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes
    • Ingolia NT, Lareau LF, Weissman JS. Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell 2011;147:789–802.
    • (2011) Cell , vol.147 , pp. 789-802
    • Ingolia, N.T.1    Lareau, L.F.2    Weissman, J.S.3
  • 58
    • 84922489184 scopus 로고    scopus 로고
    • Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes
    • Ingolia NT, et al. Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes. Cell Rep 2014;8:1365–1379.
    • (2014) Cell Rep , vol.8 , pp. 1365-1379
    • Ingolia, N.T.1
  • 59
    • 84956597493 scopus 로고    scopus 로고
    • Translation from the 5’ untranslated region shapes the integrated stress response
    • Starck SR, et al. Translation from the 5’ untranslated region shapes the integrated stress response. Science 2016;351:aad3867.
    • (2016) Science , vol.351 , pp. aad3867
    • Starck, S.R.1
  • 60
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: from stress pathway to homeostatic regulation
    • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011;334:1081–1086.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 61
    • 0036498599 scopus 로고    scopus 로고
    • Identification of BING-4 cancer antigen translated from an alternative open reading frame of a gene in the extended MHC class II region using lymphocytes from a patient with a durable complete regression following immunotherapy
    • Rosenberg SA, et al. Identification of BING-4 cancer antigen translated from an alternative open reading frame of a gene in the extended MHC class II region using lymphocytes from a patient with a durable complete regression following immunotherapy. J Immunol 2002;168:2402–2407.
    • (2002) J Immunol , vol.168 , pp. 2402-2407
    • Rosenberg, S.A.1
  • 63
    • 52649143709 scopus 로고    scopus 로고
    • C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients
    • Tykodi SS, et al. C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients. Clin Cancer Res 2008;14:5260–5269.
    • (2008) Clin Cancer Res , vol.14 , pp. 5260-5269
    • Tykodi, S.S.1
  • 64
    • 0029854328 scopus 로고    scopus 로고
    • Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames
    • Bullock TNJ, Eisenlohr LC. Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames. J Exp Med 1996;184:1319–1329.
    • (1996) J Exp Med , vol.184 , pp. 1319-1329
    • Bullock, T.N.J.1    Eisenlohr, L.C.2
  • 65
    • 0037017382 scopus 로고    scopus 로고
    • +1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10
    • Saulquin X, et al. +1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10. J Exp Med 2002;195:353–358.
    • (2002) J Exp Med , vol.195 , pp. 353-358
    • Saulquin, X.1
  • 66
    • 33646867918 scopus 로고    scopus 로고
    • Epitopes derived by incidental translational frameshifting give rise to a protective CTL response
    • Zook MB, Howard MT, Sinnathamby G, Atkins JF, Eisenlohr LC. Epitopes derived by incidental translational frameshifting give rise to a protective CTL response. J Immunol 2006;176:6928–6934.
    • (2006) J Immunol , vol.176 , pp. 6928-6934
    • Zook, M.B.1    Howard, M.T.2    Sinnathamby, G.3    Atkins, J.F.4    Eisenlohr, L.C.5
  • 68
    • 3843117589 scopus 로고    scopus 로고
    • Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
    • Vattem KM, Wek RC. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci USA 2004;101:11269–11274.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11269-11274
    • Vattem, K.M.1    Wek, R.C.2
  • 69
    • 84880512422 scopus 로고    scopus 로고
    • Reinitiation and other unconventional posttermination events during eukaryotic translation
    • Skabkin MA, Skabkina OV, Hellen CU, Pestova TV. Reinitiation and other unconventional posttermination events during eukaryotic translation. Mol Cell 2013;51:249–264.
    • (2013) Mol Cell , vol.51 , pp. 249-264
    • Skabkin, M.A.1    Skabkina, O.V.2    Hellen, C.U.3    Pestova, T.V.4
  • 70
    • 84866267681 scopus 로고    scopus 로고
    • Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution
    • Lee S, Liu B, Lee S, Huang SX, Shen B, Qian SB. Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proc Natl Acad Sci USA 2012;109:E2424–E2432.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E2424-E2432
    • Lee, S.1    Liu, B.2    Lee, S.3    Huang, S.X.4    Shen, B.5    Qian, S.B.6
  • 71
    • 84869806462 scopus 로고    scopus 로고
    • Decoding human cytomegalovirus
    • Stern-Ginossar N, et al. Decoding human cytomegalovirus. Science 2012;338:1088–1093.
    • (2012) Science , vol.338 , pp. 1088-1093
    • Stern-Ginossar, N.1
  • 72
    • 84893766839 scopus 로고    scopus 로고
    • KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features
    • Arias C, et al. KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features. PLoS Pathog 2014;10:e1003847.
    • (2014) PLoS Pathog , vol.10
    • Arias, C.1
  • 73
    • 33845627785 scopus 로고    scopus 로고
    • Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
    • Garcia MA, et al. Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev 2006;70:1032–1060.
    • (2006) Microbiol Mol Biol Rev , vol.70 , pp. 1032-1060
    • Garcia, M.A.1
  • 74
    • 33847409304 scopus 로고    scopus 로고
    • Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine. A possible means to regulate gene expression
    • Nemeth AL, et al. Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine. A possible means to regulate gene expression. FEBS J 2007;274:1610–1620.
    • (2007) FEBS J , vol.274 , pp. 1610-1620
    • Nemeth, A.L.1
  • 75
    • 84900300350 scopus 로고    scopus 로고
    • PTENalpha, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism
    • Liang H, et al. PTENalpha, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Cell Metab 2014;19:836–848.
    • (2014) Cell Metab , vol.19 , pp. 836-848
    • Liang, H.1
  • 76
    • 84894318608 scopus 로고    scopus 로고
    • Ribosome profiling: new views of translation, from single codons to genome scale
    • Ingolia NT. Ribosome profiling: new views of translation, from single codons to genome scale. Nat Rev Genet 2014;15:205–213.
    • (2014) Nat Rev Genet , vol.15 , pp. 205-213
    • Ingolia, N.T.1
  • 77
    • 0034682720 scopus 로고    scopus 로고
    • Initiation of protein synthesis from the A site of the ribosome
    • Wilson JE, Pestova TV, Hellen CUT, Sarnow P. Initiation of protein synthesis from the A site of the ribosome. Cell 2000;102:511–520.
    • (2000) Cell , vol.102 , pp. 511-520
    • Wilson, J.E.1    Pestova, T.V.2    Hellen, C.U.T.3    Sarnow, P.4
  • 78
    • 0034652349 scopus 로고    scopus 로고
    • Methionine-independent initiation of translation in the capsid protein of an insect RNA virus
    • Sasaki J, Nakashima N. Methionine-independent initiation of translation in the capsid protein of an insect RNA virus. Proc Natl Acad Sci USA 2000;97:1512–1515.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1512-1515
    • Sasaki, J.1    Nakashima, N.2
  • 79
    • 21344441236 scopus 로고    scopus 로고
    • Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites
    • Pisarev AV, Shirokikh NE, Hellen CU. Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites. C R Biol 2005;328:589–605.
    • (2005) C R Biol , vol.328 , pp. 589-605
    • Pisarev, A.V.1    Shirokikh, N.E.2    Hellen, C.U.3
  • 80
    • 0032502748 scopus 로고    scopus 로고
    • Virus-induced host gene shutoff in animals and plants
    • Aranda M, Maule A. Virus-induced host gene shutoff in animals and plants. Virology 1998;243:261–267.
    • (1998) Virology , vol.243 , pp. 261-267
    • Aranda, M.1    Maule, A.2
  • 81
    • 84996773946 scopus 로고    scopus 로고
    • Translation of 5’ leaders is pervasive in genes resistant to eIF2 repression
    • Andreev DE, et al. Translation of 5’ leaders is pervasive in genes resistant to eIF2 repression. Elife 2015;4:e03971.
    • (2015) Elife , vol.4
    • Andreev, D.E.1
  • 82
    • 54949134074 scopus 로고    scopus 로고
    • A distinct translation initiation mechanism generates cryptic peptides for immune surveillance
    • Starck SR, et al. A distinct translation initiation mechanism generates cryptic peptides for immune surveillance. PLoS ONE 2008;3:e3460.
    • (2008) PLoS ONE , vol.3
    • Starck, S.R.1
  • 83
    • 84862991256 scopus 로고    scopus 로고
    • Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I
    • Starck SR, et al. Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I. Science 2012;336:1719–1723.
    • (2012) Science , vol.336 , pp. 1719-1723
    • Starck, S.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.