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Volumn 10, Issue 6, 2016, Pages 685-697

Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches

(24)  Lund Palau, Helena a   Turnbull, Andrew R a,b   Bush, Andrew a,b   Bardin, Emmanuelle c   Cameron, Loren c   Soren, Odel d   Wierre Gore, Natasha a   Alton, Eric W F W a   Bundy, Jacob G a   Connett, Gary e   Faust, Saul N e   Filloux, Alain f   Freemont, Paul c   Jones, Andy g   Khoo, Valerie a   Morales, Sandra h   Murphy, Ronan a   Pabary, Rishi a   Simbo, Ameze a   Schelenz, Silke g   more..


Author keywords

airway; antibiotic; biofilm; cystic fibrosis; persistence; Pseudomonas aeruginosa; sputum

Indexed keywords

ANTIBIOTIC AGENT; MONOCLONAL ANTIBODY; ANTIINFECTIVE AGENT;

EID: 84975316985     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1080/17476348.2016.1177460     Document Type: Review
Times cited : (116)

References (144)
  • 1
    • 19644371239 scopus 로고    scopus 로고
    • Pathogen-host interactions in Pseudomonas aeruginosa pneumonia
    • R.T.Sadikot, T.S.Blackwell, J.W.Christman, et al. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2005;171(11):1209–1223.
    • (2005) Am J Respir Crit Care Med , vol.171 , Issue.11 , pp. 1209-1223
    • Sadikot, R.T.1    Blackwell, T.S.2    Christman, J.W.3
  • 2
    • 84863328241 scopus 로고    scopus 로고
    • From environment to man: genome evolution and adaptation of human opportunistic bacterial pathogens
    • F.Aujoulat, F.Roger, A.Bourdier, et al. From environment to man: genome evolution and adaptation of human opportunistic bacterial pathogens. Genes (Basel). 2012;3(2):191–232.
    • (2012) Genes (Basel) , vol.3 , Issue.2 , pp. 191-232
    • Aujoulat, F.1    Roger, F.2    Bourdier, A.3
  • 3
    • 33745029052 scopus 로고    scopus 로고
    • Real-time PCR detection of Pseudomonas aeruginosa in clinical and municipal wastewater and genotyping of the ciprofloxacin-resistant isolates
    • T.Schwartz, H.Volkmann, S.Kirchen, et al. Real-time PCR detection of Pseudomonas aeruginosa in clinical and municipal wastewater and genotyping of the ciprofloxacin-resistant isolates. FEMS Microbiol Ecol. 2006;57(1):158–167.
    • (2006) FEMS Microbiol Ecol , vol.57 , Issue.1 , pp. 158-167
    • Schwartz, T.1    Volkmann, H.2    Kirchen, S.3
  • 4
    • 77956624070 scopus 로고    scopus 로고
    • How Pseudomonas aeruginosa adapts to various environments: a metabolomic approach
    • E.Frimmersdorf, S.Horatzek, A.Pelnikevich, et al. How Pseudomonas aeruginosa adapts to various environments: a metabolomic approach. Environ Microbiol. 2010;12(6):1734–1747.
    • (2010) Environ Microbiol , vol.12 , Issue.6 , pp. 1734-1747
    • Frimmersdorf, E.1    Horatzek, S.2    Pelnikevich, A.3
  • 5
    • 0034739007 scopus 로고    scopus 로고
    • Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
    • C.K.Stover, X.Q.Pham, A.L.Erwin, et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000;406(6799):959–964.•• The first complete sequence of a P. aeruginosa genome from the PAO1 laboratory strain, revealing genetic insights into its environmental adaptability and pathogenicity.
    • (2000) Nature , vol.406 , Issue.6799 , pp. 959-964
    • Stover, C.K.1    Pham, X.Q.2    Erwin, A.L.3
  • 6
    • 0035253464 scopus 로고    scopus 로고
    • Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis
    • J.L.Burns, R.L.Gibson, S.McNamara, et al. Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. J Infect Dis. 2001;183(3):444–452.
    • (2001) J Infect Dis , vol.183 , Issue.3 , pp. 444-452
    • Burns, J.L.1    Gibson, R.L.2    McNamara, S.3
  • 7
    • 0034764166 scopus 로고    scopus 로고
    • Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis
    • M.Rosenfeld, R.L.Gibson, S.McNamara, et al. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr Pulmonol. 2001;32(5):356–366.
    • (2001) Pediatr Pulmonol , vol.32 , Issue.5 , pp. 356-366
    • Rosenfeld, M.1    Gibson, R.L.2    McNamara, S.3
  • 8
    • 0030001433 scopus 로고    scopus 로고
    • Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis
    • D.S.Armstrong, K.Grimwood, J.B.Carlin, et al. Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis. Pediatr Pulmonol. 1996;21(5):267–275.
    • (1996) Pediatr Pulmonol , vol.21 , Issue.5 , pp. 267-275
    • Armstrong, D.S.1    Grimwood, K.2    Carlin, J.B.3
  • 9
    • 85018646181 scopus 로고    scopus 로고
    • Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
    • S.C.Langton Hewer, A.R.Smyth Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Database Syst Rev. 2014;11:Cd004197.
    • (2014) Cochrane Database Syst Rev , vol.11 , pp. Cd004197
    • Langton Hewer, S.C.1    Smyth, A.R.2
  • 10
    • 84975199041 scopus 로고    scopus 로고
    • Available from
    • UK Cystic Fibrosis Registry. Annual data report 2013: Cystic Fibrosis Trust; 2014. Available from: http://www.cysticfibrosis.org.uk/media/598466/annual-data-report-2013-jul14.pdf.
    • (2014) Annual data report 2013: Cystic Fibrosis Trust
  • 11
    • 84959336559 scopus 로고    scopus 로고
    • Bethesda, Maryland: Available from
    • Cystic Fibrosis Foundation Patient Registry. 2013 annual data report to the center directors. Bethesda, Maryland; 2014. Available from: https://www.cff.org/2013_CFF_Annual_Data_Report_to_the_Center_Directors.pdf.
    • (2014) 2013 annual data report to the center directors
  • 12
    • 34447530328 scopus 로고    scopus 로고
    • Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis
    • M.W.Konstan, W.J.Morgan, S.M.Butler, et al. Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis. J Pediatr. 2007;151(2):134–139, 9.e1.
    • (2007) J Pediatr , vol.151 , Issue.2 , pp. 134-139
    • Konstan, M.W.1    Morgan, W.J.2    Butler, S.M.3
  • 13
    • 0036320272 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis
    • J.Emerson, M.Rosenfeld, S.McNamara, et al. Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr Pulmonol. 2002;34(2):91–100.
    • (2002) Pediatr Pulmonol , vol.34 , Issue.2 , pp. 91-100
    • Emerson, J.1    Rosenfeld, M.2    McNamara, S.3
  • 14
    • 0035002870 scopus 로고    scopus 로고
    • Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis
    • G.M.Nixon, D.S.Armstrong, R.Carzino, et al. Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis. J Pediatr. 2001;138(5):699–704.
    • (2001) J Pediatr , vol.138 , Issue.5 , pp. 699-704
    • Nixon, G.M.1    Armstrong, D.S.2    Carzino, R.3
  • 15
    • 0142043977 scopus 로고    scopus 로고
    • Pathophysiology and management of pulmonary infections in cystic fibrosis
    • R.L.Gibson, J.L.Burns, B.W.Ramsey. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med. 2003;168(8):918–951.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.8 , pp. 918-951
    • Gibson, R.L.1    Burns, J.L.2    Ramsey, B.W.3
  • 16
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • H.Matsui, B.R.Grubb, R.Tarran, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell. 1998;95(7):1005–1015.
    • (1998) Cell , vol.95 , Issue.7 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3
  • 17
    • 27444444705 scopus 로고    scopus 로고
    • Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections
    • R.Tarran, B.Button, M.Picher, et al. Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. J Biol Chem. 2005;280(42):35751–35759.
    • (2005) J Biol Chem , vol.280 , Issue.42 , pp. 35751-35759
    • Tarran, R.1    Button, B.2    Picher, M.3
  • 18
    • 33845309114 scopus 로고    scopus 로고
    • A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms
    • H.Matsui, V.E.Wagner, D.B.Hill, et al. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2006;103(48):18131–18136.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.48 , pp. 18131-18136
    • Matsui, H.1    Wagner, V.E.2    Hill, D.B.3
  • 19
    • 77952974496 scopus 로고    scopus 로고
    • Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    • D.A.Stoltz, D.K.Meyerholz, A.A.Pezzulo, et al. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med. 2010;2(29):29ra31.
    • (2010) Sci Transl Med , vol.2 , Issue.29 , pp. 29ra31
    • Stoltz, D.A.1    Meyerholz, D.K.2    Pezzulo, A.A.3
  • 20
    • 84930409897 scopus 로고    scopus 로고
    • Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs
    • N.W.Keiser, S.E.Birket, I.A.Evans, et al. Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs. Am J Respir Cell Mol Biol. 2015;52(6):683–694.
    • (2015) Am J Respir Cell Mol Biol , vol.52 , Issue.6 , pp. 683-694
    • Keiser, N.W.1    Birket, S.E.2    Evans, I.A.3
  • 21
    • 84863476402 scopus 로고    scopus 로고
    • Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
    • A.A.Pezzulo, X.X.Tang, M.J.Hoegger, et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature. 2012;487(7405):109–113.
    • (2012) Nature , vol.487 , Issue.7405 , pp. 109-113
    • Pezzulo, A.A.1    Tang, X.X.2    Hoegger, M.J.3
  • 22
    • 84924565068 scopus 로고    scopus 로고
    • pH modulates the activity and synergism of the airway surface liquid antimicrobials beta-defensin-3 and LL-37
    • M.H.Abou Alaiwa, L.R.Reznikov, N.D.Gansemer, et al. pH modulates the activity and synergism of the airway surface liquid antimicrobials beta-defensin-3 and LL-37. Proc Natl Acad Sci U S A. 2014;111(52):18703–18708.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.52 , pp. 18703-18708
    • Abou Alaiwa, M.H.1    Reznikov, L.R.2    Gansemer, N.D.3
  • 23
    • 84902333159 scopus 로고    scopus 로고
    • Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study
    • M.H.Abou Alaiwa, A.M.Beer, A.A.Pezzulo, et al. Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study. J Cyst Fibros. 2014;13(4):373–377.
    • (2014) J Cyst Fibros , vol.13 , Issue.4 , pp. 373-377
    • Abou Alaiwa, M.H.1    Beer, A.M.2    Pezzulo, A.A.3
  • 24
    • 0037252641 scopus 로고    scopus 로고
    • Airway surface pH in subjects with cystic fibrosis
    • D.McShane, J.C.Davies, M.G.Davies, et al. Airway surface pH in subjects with cystic fibrosis. Eur Respir J. 2003;21(1):37–42.
    • (2003) Eur Respir J , vol.21 , Issue.1 , pp. 37-42
    • McShane, D.1    Davies, J.C.2    Davies, M.G.3
  • 25
    • 0037076416 scopus 로고    scopus 로고
    • CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation
    • T.H.Schroeder, M.M.Lee, P.W.Yacono, et al. CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proc Natl Acad Sci U S A. 2002;99(10):6907–6912.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.10 , pp. 6907-6912
    • Schroeder, T.H.1    Lee, M.M.2    Yacono, P.W.3
  • 26
    • 0030021470 scopus 로고    scopus 로고
    • Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections
    • G.B.Pier, M.Grout, T.S.Zaidi, et al. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science. 1996;271(5245):64–67.
    • (1996) Science , vol.271 , Issue.5245 , pp. 64-67
    • Pier, G.B.1    Grout, M.2    Zaidi, T.S.3
  • 27
    • 0011680902 scopus 로고
    • Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids
    • H.C.Krivan, D.D.Roberts, V.Ginsburg. Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids. Proc Natl Acad Sci U S A. 1988;85(16):6157–6161.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , Issue.16 , pp. 6157-6161
    • Krivan, H.C.1    Roberts, D.D.2    Ginsburg, V.3
  • 28
    • 0027428606 scopus 로고
    • Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells
    • L.Saiman, A.Prince. Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells. J Clin Invest. 1993;92(4):1875–1880.
    • (1993) J Clin Invest , vol.92 , Issue.4 , pp. 1875-1880
    • Saiman, L.1    Prince, A.2
  • 29
    • 0031156473 scopus 로고    scopus 로고
    • CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium
    • J.C.Davies, M.Stern, A.Dewar, et al. CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium. Am J Respir Cell Mol Biol. 1997;16(6):657–663.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , Issue.6 , pp. 657-663
    • Davies, J.C.1    Stern, M.2    Dewar, A.3
  • 30
    • 0024835905 scopus 로고
    • Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration
    • R.S.Baltimore, C.D.Christie, G.J.Smith. Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration. Am Rev Respir Dis. 1989;140(6):1650–1661.
    • (1989) Am Rev Respir Dis , vol.140 , Issue.6 , pp. 1650-1661
    • Baltimore, R.S.1    Christie, C.D.2    Smith, G.J.3
  • 31
    • 0036167851 scopus 로고    scopus 로고
    • Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
    • D.Worlitzsch, R.Tarran, M.Ulrich, et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest. 2002;109(3):317–325.
    • (2002) J Clin Invest , vol.109 , Issue.3 , pp. 317-325
    • Worlitzsch, D.1    Tarran, R.2    Ulrich, M.3
  • 32
    • 34248402460 scopus 로고    scopus 로고
    • Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients
    • L.Jelsbak, H.K.Johansen, A.L.Frost, et al. Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients. Infect Immun. 2007;75(5):2214–2224.
    • (2007) Infect Immun , vol.75 , Issue.5 , pp. 2214-2224
    • Jelsbak, L.1    Johansen, H.K.2    Frost, A.L.3
  • 33
    • 84937516045 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years
    • T.J.Kidd, K.A.Ramsay, S.Vidmar, et al. Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years. Journal of Cystic Fibrosis. 2015;14(3):361–369.•• Longitudinal study of P. aeruginosa acquisition, eradication success, and concordance of oropharyngeal and bronchoalveolar lavage (BAL) samples in preschool children with CF.
    • (2015) Journal of Cystic Fibrosis , vol.14 , Issue.3 , pp. 361-369
    • Kidd, T.J.1    Ramsay, K.A.2    Vidmar, S.3
  • 34
    • 84870341542 scopus 로고    scopus 로고
    • Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis
    • N.Cramer, L.Wiehlmann, O.Ciofu, et al. Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis. PLoS One. 2012;7(11):e50731.• Study comparing the molecular epidemiology of P. aeruginosa isolates from environmental and non-CF sources with cross-sectional and longitudinal isolates from CF patients in centers in Germany and Sweden.
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e50731
    • Cramer, N.1    Wiehlmann, L.2    Ciofu, O.3
  • 35
    • 84946497714 scopus 로고    scopus 로고
    • Proximity to blue spaces and risk of infection with Pseudomonas aeruginosa in cystic fibrosis: a case-control analysis
    • P.C.Goeminne, T.S.Nawrot, K.De Boeck, et al. Proximity to blue spaces and risk of infection with Pseudomonas aeruginosa in cystic fibrosis: a case-control analysis. J Cyst Fibros. 2015;14(6):741–747.
    • (2015) J Cyst Fibros , vol.14 , Issue.6 , pp. 741-747
    • Goeminne, P.C.1    Nawrot, T.S.2    De Boeck, K.3
  • 36
    • 84943744505 scopus 로고    scopus 로고
    • Association of meteorological and geographical factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis
    • K.J.Psoter, A.J.Der, J.Wakefield, et al. Association of meteorological and geographical factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis. Epidemiol Infect. 2016;144(5):1075–1083.
    • (2016) Epidemiol Infect , vol.144 , Issue.5 , pp. 1075-1083
    • Psoter, K.J.1    Der, A.J.2    Wakefield, J.3
  • 37
    • 0030573808 scopus 로고    scopus 로고
    • Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic
    • K.Cheng, R.L.Smyth, J.R.Govan, et al. Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic. Lancet. 1996;348(9028):639–642.
    • (1996) Lancet , vol.348 , Issue.9028 , pp. 639-642
    • Cheng, K.1    Smyth, R.L.2    Govan, J.R.3
  • 38
    • 0035908770 scopus 로고    scopus 로고
    • Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic
    • A.M.Jones, J.R.Govan, C.J.Doherty, et al. Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic. Lancet. 2001;358(9281):557–558.
    • (2001) Lancet , vol.358 , Issue.9281 , pp. 557-558
    • Jones, A.M.1    Govan, J.R.2    Doherty, C.J.3
  • 39
    • 0036796762 scopus 로고    scopus 로고
    • Detection of a widespread clone of Pseudomonas aeruginosa in a pediatric cystic fibrosis clinic
    • D.S.Armstrong, G.M.Nixon, R.Carzino, et al. Detection of a widespread clone of Pseudomonas aeruginosa in a pediatric cystic fibrosis clinic. Am J Respir Crit Care Med. 2002;166(7):983–987.
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.7 , pp. 983-987
    • Armstrong, D.S.1    Nixon, G.M.2    Carzino, R.3
  • 40
    • 0020533146 scopus 로고
    • Epidemiology of Pseudomonas aeruginosa infection and the role of contamination of the environment in a cystic fibrosis clinic
    • J.Zimakoff, N.Hoiby, K.Rosendal, et al. Epidemiology of Pseudomonas aeruginosa infection and the role of contamination of the environment in a cystic fibrosis clinic. J Hosp Infect. 1983;4(1):31–40.
    • (1983) J Hosp Infect , vol.4 , Issue.1 , pp. 31-40
    • Zimakoff, J.1    Hoiby, N.2    Rosendal, K.3
  • 41
    • 3142780517 scopus 로고    scopus 로고
    • Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales
    • F.W.Scott, T.L.Pitt. Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales. J Med Microbiol. 2004;53(Pt 7):609–615.
    • (2004) J Med Microbiol , vol.53 , pp. 609-615
    • Scott, F.W.1    Pitt, T.L.2
  • 42
    • 78349270511 scopus 로고    scopus 로고
    • Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis
    • S.D.Aaron, K.L.Vandemheen, K.Ramotar, et al. Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. Jama. 2010;304(19):2145–2153.
    • (2010) Jama , vol.304 , Issue.19 , pp. 2145-2153
    • Aaron, S.D.1    Vandemheen, K.L.2    Ramotar, K.3
  • 43
    • 0038808903 scopus 로고    scopus 로고
    • Identification of airborne dissemination of epidemic multiresistant strains of Pseudomonas aeruginosa at a CF centre during a cross infection outbreak
    • A.M.Jones, J.R.Govan, C.J.Doherty, et al. Identification of airborne dissemination of epidemic multiresistant strains of Pseudomonas aeruginosa at a CF centre during a cross infection outbreak. Thorax. 2003;58(6):525–527.
    • (2003) Thorax , vol.58 , Issue.6 , pp. 525-527
    • Jones, A.M.1    Govan, J.R.2    Doherty, C.J.3
  • 44
    • 11244272694 scopus 로고    scopus 로고
    • Environmental contamination with an epidemic strain of Pseudomonas aeruginosa in a Liverpool cystic fibrosis centre, and study of its survival on dry surfaces
    • S.Panagea, C.Winstanley, M.J.Walshaw, et al. Environmental contamination with an epidemic strain of Pseudomonas aeruginosa in a Liverpool cystic fibrosis centre, and study of its survival on dry surfaces. J Hosp Infect. 2005;59(2):102–107.
    • (2005) J Hosp Infect , vol.59 , Issue.2 , pp. 102-107
    • Panagea, S.1    Winstanley, C.2    Walshaw, M.J.3
  • 45
    • 84904055679 scopus 로고    scopus 로고
    • Viability of Pseudomonas aeruginosa in cough aerosols generated by persons with cystic fibrosis
    • L.D.Knibbs, G.R.Johnson, T.J.Kidd, et al. Viability of Pseudomonas aeruginosa in cough aerosols generated by persons with cystic fibrosis. Thorax. 2014;69(8):740–745.• Study demonstrating viable P. aeruginosa in cough aerosols, which travel further and persist for longer than previously recognized, challenging the perceived wisdom on infection control.
    • (2014) Thorax , vol.69 , Issue.8 , pp. 740-745
    • Knibbs, L.D.1    Johnson, G.R.2    Kidd, T.J.3
  • 46
    • 12844270608 scopus 로고    scopus 로고
    • Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis
    • Z.Li, M.R.Kosorok, P.M.Farrell, et al. Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis. Jama. 2005;293(5):581–588.
    • (2005) Jama , vol.293 , Issue.5 , pp. 581-588
    • Li, Z.1    Kosorok, M.R.2    Farrell, P.M.3
  • 47
    • 67249139656 scopus 로고    scopus 로고
    • Concordant genotype of upper and lower airways P. aeruginosa and S. aureus isolates in cystic fibrosis
    • J.G.Mainz, L.Naehrlich, M.Schien, et al. Concordant genotype of upper and lower airways P. aeruginosa and S. aureus isolates in cystic fibrosis. Thorax. 2009;64(6):535–540.
    • (2009) Thorax , vol.64 , Issue.6 , pp. 535-540
    • Mainz, J.G.1    Naehrlich, L.2    Schien, M.3
  • 48
    • 84355161775 scopus 로고    scopus 로고
    • Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
    • S.K.Hansen, M.H.Rau, H.K.Johansen, et al. Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection. ISME J. 2012;6(1):31–45.
    • (2012) ISME J , vol.6 , Issue.1 , pp. 31-45
    • Hansen, S.K.1    Rau, M.H.2    Johansen, H.K.3
  • 49
    • 84884366610 scopus 로고    scopus 로고
    • Bacterial sinusitis can be a focus for initial lung colonisation and chronic lung infection in patients with cystic fibrosis
    • K.Aanaes. Bacterial sinusitis can be a focus for initial lung colonisation and chronic lung infection in patients with cystic fibrosis. J Cyst Fibros. 2013;12(Suppl 2):S1–S20.
    • (2013) J Cyst Fibros , vol.12 , pp. S1-S20
    • Aanaes, K.1
  • 50
    • 84929359373 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa and periodontal pathogens in the oral cavity and lungs of cystic fibrosis patients: a case-control study
    • R.Rivas Caldas, F.Le Gall, K.Revert, et al. Pseudomonas aeruginosa and periodontal pathogens in the oral cavity and lungs of cystic fibrosis patients: a case-control study. J Clin Microbiol. 2015;53(6):1898–1907.
    • (2015) J Clin Microbiol , vol.53 , Issue.6 , pp. 1898-1907
    • Rivas Caldas, R.1    Le Gall, F.2    Revert, K.3
  • 51
    • 84918773770 scopus 로고    scopus 로고
    • Upper aero-digestive contamination by Pseudomonas aeruginosa and implications in cystic fibrosis
    • R.Rivas Caldas, S.Boisramé. Upper aero-digestive contamination by Pseudomonas aeruginosa and implications in cystic fibrosis. Journal of Cystic Fibrosis. 2015;14(1):6–15.
    • (2015) Journal of Cystic Fibrosis , vol.14 , Issue.1 , pp. 6-15
    • Rivas Caldas, R.1    Boisramé, S.2
  • 52
    • 84858280044 scopus 로고    scopus 로고
    • Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation
    • J.G.Mainz, J.Hentschel, C.Schien, et al. Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation. J Cyst Fibros. 2012;11(2):158–161.
    • (2012) J Cyst Fibros , vol.11 , Issue.2 , pp. 158-161
    • Mainz, J.G.1    Hentschel, J.2    Schien, C.3
  • 53
    • 34547531757 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor, initiator of inflammation and target for effective immunity
    • G.B.Pier. Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor, initiator of inflammation and target for effective immunity. Int J Med Microbiol. 2007;297(5):277–295.
    • (2007) Int J Med Microbiol , vol.297 , Issue.5 , pp. 277-295
    • Pier, G.B.1
  • 54
    • 0033584935 scopus 로고    scopus 로고
    • Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa
    • R.K.Ernst, E.C.Yi, L.Guo, et al. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science. 1999;286(5444):1561–1565.
    • (1999) Science , vol.286 , Issue.5444 , pp. 1561-1565
    • Ernst, R.K.1    Yi, E.C.2    Guo, L.3
  • 55
    • 0031975347 scopus 로고    scopus 로고
    • Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection
    • M.Feldman, R.Bryan, S.Rajan, et al. Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection. Infect Immun. 1998;66(1):43–51.
    • (1998) Infect Immun , vol.66 , Issue.1 , pp. 43-51
    • Feldman, M.1    Bryan, R.2    Rajan, S.3
  • 56
    • 0031724115 scopus 로고    scopus 로고
    • Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
    • G.A.O’Toole, R.Kolter. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol. 1998;30(2):295–304.
    • (1998) Mol Microbiol , vol.30 , Issue.2 , pp. 295-304
    • O’Toole, G.A.1    Kolter, R.2
  • 57
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by toll-like receptor 5
    • F.Hayashi, K.D.Smith, A.Ozinsky, et al. The innate immune response to bacterial flagellin is mediated by toll-like receptor 5. Nature. 2001;410(6832):1099–1103.
    • (2001) Nature , vol.410 , Issue.6832 , pp. 1099-1103
    • Hayashi, F.1    Smith, K.D.2    Ozinsky, A.3
  • 58
    • 2342630062 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients
    • M.C.Wolfgang, J.Jyot, A.L.Goodman, et al. Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients. Proc Natl Acad Sci U S A. 2004;101(17):6664–6668.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.17 , pp. 6664-6668
    • Wolfgang, M.C.1    Jyot, J.2    Goodman, A.L.3
  • 59
    • 78549236798 scopus 로고    scopus 로고
    • Protein secretion systems in Pseudomonas aeruginosa: a wealth of pathogenic weapons
    • S.Bleves, V.Viarre, R.Salacha, et al. Protein secretion systems in Pseudomonas aeruginosa: a wealth of pathogenic weapons. Int J Med Microbiol. 2010;300(8):534–543.• A comprehensive review of P. aeruginosa secretion systems and their role in pathogenicity.
    • (2010) Int J Med Microbiol , vol.300 , Issue.8 , pp. 534-543
    • Bleves, S.1    Viarre, V.2    Salacha, R.3
  • 60
    • 0024797909 scopus 로고
    • Functional importance of cystic fibrosis immunoglobulin G fragments generated by Pseudomonas aeruginosa elastase
    • T.Bainbridge, R.B.FickJr. Functional importance of cystic fibrosis immunoglobulin G fragments generated by Pseudomonas aeruginosa elastase. J Lab Clin Med. 1989;114(6):728–733.
    • (1989) J Lab Clin Med , vol.114 , Issue.6 , pp. 728-733
    • Bainbridge, T.1    Fick, R.B.2
  • 61
    • 0037383984 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa elastase degrades surfactant proteins A and D
    • W.I.Mariencheck, J.F.Alcorn, S.M.Palmer, et al. Pseudomonas aeruginosa elastase degrades surfactant proteins A and D. Am J Respir Cell Mol Biol. 2003;28(4):528–537.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , Issue.4 , pp. 528-537
    • Mariencheck, W.I.1    Alcorn, J.F.2    Palmer, S.M.3
  • 62
    • 0032699215 scopus 로고    scopus 로고
    • Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia
    • K.Kurahashi, O.Kajikawa, T.Sawa, et al. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest. 1999;104(6):743–750.
    • (1999) J Clin Invest , vol.104 , Issue.6 , pp. 743-750
    • Kurahashi, K.1    Kajikawa, O.2    Sawa, T.3
  • 63
    • 84873161425 scopus 로고    scopus 로고
    • Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections
    • B.Rada, T.L.Leto. Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections. Trends Microbiol. 2013;21(2):73–81.
    • (2013) Trends Microbiol , vol.21 , Issue.2 , pp. 73-81
    • Rada, B.1    Leto, T.L.2
  • 64
    • 84938086626 scopus 로고    scopus 로고
    • Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function
    • C.Nair, A.Shoemark, M.Chan, et al. Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function. Eur Respir J. 2014;44(5):1253–1261.
    • (2014) Eur Respir J , vol.44 , Issue.5 , pp. 1253-1261
    • Nair, C.1    Shoemark, A.2    Chan, M.3
  • 65
    • 0023108150 scopus 로고
    • Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro
    • R.Wilson, T.Pitt, G.Taylor, et al. Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. J Clin Invest. 1987;79(1):221–229.
    • (1987) J Clin Invest , vol.79 , Issue.1 , pp. 221-229
    • Wilson, R.1    Pitt, T.2    Taylor, G.3
  • 66
    • 84864578935 scopus 로고    scopus 로고
    • Protein secretion systems in Pseudomonas aeruginosa: an essay on diversity, evolution, and function
    • A.Filloux. Protein secretion systems in Pseudomonas aeruginosa: an essay on diversity, evolution, and function. Front Microbiol. 2011;2:155.
    • (2011) Front Microbiol , vol.2 , pp. 155
    • Filloux, A.1
  • 67
    • 33744728373 scopus 로고    scopus 로고
    • Acquisition and evolution of the exoU locus in Pseudomonas aeruginosa
    • B.R.Kulasekara, H.D.Kulasekara, M.C.Wolfgang, et al. Acquisition and evolution of the exoU locus in Pseudomonas aeruginosa. J Bacteriol. 2006;188(11):4037–4050.
    • (2006) J Bacteriol , vol.188 , Issue.11 , pp. 4037-4050
    • Kulasekara, B.R.1    Kulasekara, H.D.2    Wolfgang, M.C.3
  • 68
    • 0038153119 scopus 로고    scopus 로고
    • Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa
    • M.C.Wolfgang, B.R.Kulasekara, X.Liang, et al. Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2003;100(14):8484–8489.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.14 , pp. 8484-8489
    • Wolfgang, M.C.1    Kulasekara, B.R.2    Liang, X.3
  • 69
    • 34249664460 scopus 로고    scopus 로고
    • A genotypic and phenotypic comparison of type III secretion profiles of Pseudomonas aeruginosa cystic fibrosis and bacteremia isolates
    • D.W.Wareham, M.A.Curtis. A genotypic and phenotypic comparison of type III secretion profiles of Pseudomonas aeruginosa cystic fibrosis and bacteremia isolates. Int J Med Microbiol. 2007;297(4):227–234.
    • (2007) Int J Med Microbiol , vol.297 , Issue.4 , pp. 227-234
    • Wareham, D.W.1    Curtis, M.A.2
  • 70
    • 69249157248 scopus 로고    scopus 로고
    • The type III secretion system of Pseudomonas aeruginosa: infection by injection
    • A.R.Hauser. The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat Rev Microbiol. 2009;7(9):654–665.
    • (2009) Nat Rev Microbiol , vol.7 , Issue.9 , pp. 654-665
    • Hauser, A.R.1
  • 71
    • 33744974779 scopus 로고    scopus 로고
    • A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus
    • J.D.Mougous, M.E.Cuff, S.Raunser, et al. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science. 2006;312(5779):1526–1530.
    • (2006) Science , vol.312 , Issue.5779 , pp. 1526-1530
    • Mougous, J.D.1    Cuff, M.E.2    Raunser, S.3
  • 72
    • 84907296644 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes
    • N.Mayer-Hamblett, M.Rosenfeld, R.L.Gibson, et al. Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes. Am J Respir Crit Care Med. 2014;190(3):289–297.
    • (2014) Am J Respir Crit Care Med , vol.190 , Issue.3 , pp. 289-297
    • Mayer-Hamblett, N.1    Rosenfeld, M.2    Gibson, R.L.3
  • 73
    • 0027267656 scopus 로고
    • Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients
    • D.W.Martin, M.J.Schurr, M.H.Mudd, et al. Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Proc Natl Acad Sci U S A. 1993;90(18):8377–8381.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.18 , pp. 8377-8381
    • Martin, D.W.1    Schurr, M.J.2    Mudd, M.H.3
  • 74
    • 0033056054 scopus 로고    scopus 로고
    • Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung
    • K.Mathee, O.Ciofu, C.Sternberg, et al. Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung. Microbiology. 1999;145(Pt 6):1349–1357.
    • (1999) Microbiology , vol.145 , pp. 1349-1357
    • Mathee, K.1    Ciofu, O.2    Sternberg, C.3
  • 75
    • 0034878704 scopus 로고    scopus 로고
    • Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function
    • M.Hentzer, G.M.Teitzel, G.J.Balzer, et al. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function. J Bacteriol. 2001;183(18):5395–5401.
    • (2001) J Bacteriol , vol.183 , Issue.18 , pp. 5395-5401
    • Hentzer, M.1    Teitzel, G.M.2    Balzer, G.J.3
  • 76
    • 0034641962 scopus 로고    scopus 로고
    • Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
    • P.K.Singh, A.L.Schaefer, M.R.Parsek, et al. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature. 2000;407(6805):762–764.
    • (2000) Nature , vol.407 , Issue.6805 , pp. 762-764
    • Singh, P.K.1    Schaefer, A.L.2    Parsek, M.R.3
  • 77
    • 67249099362 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients
    • T.Bjarnsholt, P.O.Jensen, M.J.Fiandaca, et al. Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr Pulmonol. 2009;44(6):547–558.
    • (2009) Pediatr Pulmonol , vol.44 , Issue.6 , pp. 547-558
    • Bjarnsholt, T.1    Jensen, P.O.2    Fiandaca, M.J.3
  • 78
    • 84920982557 scopus 로고    scopus 로고
    • The problems of antibiotic resistance in cystic fibrosis and solutions
    • C.Lopez-Causape, E.Rojo-Molinero, M.D.Macia, et al. The problems of antibiotic resistance in cystic fibrosis and solutions. Expert Rev Respir Med. 2015;9(1):73–88.
    • (2015) Expert Rev Respir Med , vol.9 , Issue.1 , pp. 73-88
    • Lopez-Causape, C.1    Rojo-Molinero, E.2    Macia, M.D.3
  • 79
    • 77049122482 scopus 로고    scopus 로고
    • Antibiotic resistance of bacterial biofilms
    • N.Hoiby, T.Bjarnsholt, M.Givskov, et al. Antibiotic resistance of bacterial biofilms. Int J Antimicrob Agents. 2010;35(4):322–332.
    • (2010) Int J Antimicrob Agents , vol.35 , Issue.4 , pp. 322-332
    • Hoiby, N.1    Bjarnsholt, T.2    Givskov, M.3
  • 81
    • 82155202495 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling
    • J.A.Moscoso, H.Mikkelsen, S.Heeb, et al. The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling. Environ Microbiol. 2011;13(12):3128–3138.
    • (2011) Environ Microbiol , vol.13 , Issue.12 , pp. 3128-3138
    • Moscoso, J.A.1    Mikkelsen, H.2    Heeb, S.3
  • 82
    • 41949122329 scopus 로고    scopus 로고
    • In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections
    • L.Yang, J.A.Haagensen, L.Jelsbak, et al. In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections. J Bacteriol. 2008;190(8):2767–2776.
    • (2008) J Bacteriol , vol.190 , Issue.8 , pp. 2767-2776
    • Yang, L.1    Haagensen, J.A.2    Jelsbak, L.3
  • 83
    • 0347777343 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis
    • S.S.Yoon, R.F.Hennigan, G.M.Hilliard, et al. Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev Cell. 2002;3(4):593–603.
    • (2002) Dev Cell , vol.3 , Issue.4 , pp. 593-603
    • Yoon, S.S.1    Hennigan, R.F.2    Hilliard, G.M.3
  • 84
    • 0025755803 scopus 로고
    • Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression
    • M.J.Gambello, B.H.Iglewski. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol. 1991;173(9):3000–3009.
    • (1991) J Bacteriol , vol.173 , Issue.9 , pp. 3000-3009
    • Gambello, M.J.1    Iglewski, B.H.2
  • 85
    • 0028012702 scopus 로고
    • Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
    • J.P.Pearson, K.M.Gray, L.Passador, et al. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci U S A. 1994;91(1):197–201.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.1 , pp. 197-201
    • Pearson, J.P.1    Gray, K.M.2    Passador, L.3
  • 86
    • 0027299747 scopus 로고
    • Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
    • L.Passador, J.M.Cook, M.J.Gambello, et al. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science. 1993;260(5111):1127–1130.
    • (1993) Science , vol.260 , Issue.5111 , pp. 1127-1130
    • Passador, L.1    Cook, J.M.2    Gambello, M.J.3
  • 87
    • 0028349371 scopus 로고
    • Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
    • U.A.Ochsner, A.K.Koch, A.Fiechter, et al. Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J Bacteriol. 1994;176(7):2044–2054.
    • (1994) J Bacteriol , vol.176 , Issue.7 , pp. 2044-2054
    • Ochsner, U.A.1    Koch, A.K.2    Fiechter, A.3
  • 88
    • 0030985995 scopus 로고    scopus 로고
    • Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa
    • E.C.Pesci, J.P.Pearson, P.C.Seed, et al. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol. 1997;179(10):3127–3132.
    • (1997) J Bacteriol , vol.179 , Issue.10 , pp. 3127-3132
    • Pesci, E.C.1    Pearson, J.P.2    Seed, P.C.3
  • 89
    • 0031865630 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis
    • D.G.Storey, E.E.Ujack, H.R.Rabin, et al. Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis. Infect Immun. 1998;66(6):2521–2528.
    • (1998) Infect Immun , vol.66 , Issue.6 , pp. 2521-2528
    • Storey, D.G.1    Ujack, E.E.2    Rabin, H.R.3
  • 90
    • 0036126980 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis
    • D.L.Erickson. Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect Immun. 2002;70(4):1783–1790.
    • (2002) Infect Immun , vol.70 , Issue.4 , pp. 1783-1790
    • Erickson, D.L.1
  • 91
    • 0033598693 scopus 로고    scopus 로고
    • Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
    • M.Whiteley, K.M.Lee, E.P.Greenberg. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 1999;96(24):13904–13909.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.24 , pp. 13904-13909
    • Whiteley, M.1    Lee, K.M.2    Greenberg, E.P.3
  • 92
    • 0037325045 scopus 로고    scopus 로고
    • aeruginosa quorum-sensing systems and virulence
    • R.P.Smith. aeruginosa quorum-sensing systems and virulence. Curr Opin Microbiol. 2003;6(1):56–60.
    • (2003) Curr Opin Microbiol , vol.6 , Issue.1 , pp. 56-60
    • Smith, R.P.1
  • 93
    • 63749104134 scopus 로고    scopus 로고
    • Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules
    • P.Williams, M.Camara. Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules. Curr Opin Microbiol. 2009;12(2):182–191.
    • (2009) Curr Opin Microbiol , vol.12 , Issue.2 , pp. 182-191
    • Williams, P.1    Camara, M.2
  • 94
    • 0037325045 scopus 로고    scopus 로고
    • P. aeruginosa quorum-sensing systems and virulence
    • R.S.Smith, B.H.Iglewski. P. aeruginosa quorum-sensing systems and virulence. Curr Opin Microbiol. 2003;6(1):56–60.
    • (2003) Curr Opin Microbiol , vol.6 , Issue.1 , pp. 56-60
    • Smith, R.S.1    Iglewski, B.H.2
  • 95
    • 0033613179 scopus 로고    scopus 로고
    • Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
    • E.C.Pesci, J.B.Milbank, J.P.Pearson, et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 1999;96(20):11229–11234.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.20 , pp. 11229-11234
    • Pesci, E.C.1    Milbank, J.B.2    Pearson, J.P.3
  • 96
    • 33744814106 scopus 로고    scopus 로고
    • Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
    • E.E.Smith, D.G.Buckley, Z.Wu, et al. Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A. 2006;103(22):8487–8492.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.22 , pp. 8487-8492
    • Smith, E.E.1    Buckley, D.G.2    Wu, Z.3
  • 97
    • 57649178876 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression
    • L.R.Hoffman, H.D.Kulasekara, J.Emerson, et al. Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression. J Cyst Fibros. 2009;8(1):66–70.
    • (2009) J Cyst Fibros , vol.8 , Issue.1 , pp. 66-70
    • Hoffman, L.R.1    Kulasekara, H.D.2    Emerson, J.3
  • 98
    • 77954649223 scopus 로고    scopus 로고
    • Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients
    • T.Bjarnsholt, P.O.Jensen, T.H.Jakobsen, et al. Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients. PLoS One. 2010;5(4):e10115.
    • (2010) PLoS One , vol.5 , Issue.4 , pp. e10115
    • Bjarnsholt, T.1    Jensen, P.O.2    Jakobsen, T.H.3
  • 99
    • 84901330446 scopus 로고    scopus 로고
    • The mucoid switch in Pseudomonas aeruginosa represses quorum sensing systems and leads to complex changes to stationary phase virulence factor regulation
    • B.Ryall, M.Carrara, J.E.Zlosnik, et al. The mucoid switch in Pseudomonas aeruginosa represses quorum sensing systems and leads to complex changes to stationary phase virulence factor regulation. PLoS One. 2014;9(5):e96166.
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e96166
    • Ryall, B.1    Carrara, M.2    Zlosnik, J.E.3
  • 100
    • 77954718693 scopus 로고    scopus 로고
    • Beta-lactamases identified in clinical isolates of Pseudomonas aeruginosa
    • W.H.Zhao, Z.Q.Hu. Beta-lactamases identified in clinical isolates of Pseudomonas aeruginosa. Crit Rev Microbiol. 2010;36(3):245–258.
    • (2010) Crit Rev Microbiol , vol.36 , Issue.3 , pp. 245-258
    • Zhao, W.H.1    Hu, Z.Q.2
  • 101
    • 84857660045 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa: resistance to the max
    • K.Poole. Pseudomonas aeruginosa: resistance to the max. Front Microbiol. 2011;2:65.
    • (2011) Front Microbiol , vol.2 , pp. 65
    • Poole, K.1
  • 102
    • 70350313477 scopus 로고    scopus 로고
    • Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa
    • J.M.Rodriguez-Martinez, L.Poirel, P.Nordmann. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2009;53(11):4783–4788.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.11 , pp. 4783-4788
    • Rodriguez-Martinez, J.M.1    Poirel, L.2    Nordmann, P.3
  • 103
    • 28344451370 scopus 로고    scopus 로고
    • Lower airway inflammation in infants with cystic fibrosis detected by newborn screening
    • D.S.Armstrong, S.M.Hook, K.M.Jamsen, et al. Lower airway inflammation in infants with cystic fibrosis detected by newborn screening. Pediatr Pulmonol. 2005;40(6):500–510.
    • (2005) Pediatr Pulmonol , vol.40 , Issue.6 , pp. 500-510
    • Armstrong, D.S.1    Hook, S.M.2    Jamsen, K.M.3
  • 104
    • 84900315796 scopus 로고    scopus 로고
    • Lung inflammation in cystic fibrosis: pathogenesis and novel therapies
    • B.Dhooghe, S.Noel, F.Huaux, et al. Lung inflammation in cystic fibrosis: pathogenesis and novel therapies. Clin Biochem. 2014;47(7–8):539–546.
    • (2014) Clin Biochem , vol.47 , Issue.7-8 , pp. 539-546
    • Dhooghe, B.1    Noel, S.2    Huaux, F.3
  • 105
    • 33748654201 scopus 로고    scopus 로고
    • CFTR expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis
    • R.G.Painter, V.G.Valentine, N.A.LansonJr., et al. CFTR expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis. Biochemistry. 2006;45(34):10260–10269.
    • (2006) Biochemistry , vol.45 , Issue.34 , pp. 10260-10269
    • Painter, R.G.1    Valentine, V.G.2    Lanson, N.A.3
  • 106
    • 80052373194 scopus 로고    scopus 로고
    • Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR
    • R.L.Young, K.C.Malcolm, J.E.Kret, et al. Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR. PLoS One. 2011;6(9):e23637.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e23637
    • Young, R.L.1    Malcolm, K.C.2    Kret, J.E.3
  • 107
    • 36849020586 scopus 로고    scopus 로고
    • Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
    • D.Hartl, P.Latzin, P.Hordijk, et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med. 2007;13(12):1423–1430.
    • (2007) Nat Med , vol.13 , Issue.12 , pp. 1423-1430
    • Hartl, D.1    Latzin, P.2    Hordijk, P.3
  • 108
    • 84887488043 scopus 로고    scopus 로고
    • Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications
    • M.Cohen-Cymberknoh, E.Kerem, T.Ferkol, et al. Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications. Thorax. 2013;68(12):1157–1162.
    • (2013) Thorax , vol.68 , Issue.12 , pp. 1157-1162
    • Cohen-Cymberknoh, M.1    Kerem, E.2    Ferkol, T.3
  • 109
    • 84923273698 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity
    • E.Pernet, L.Guillemot, P.R.Burgel, et al. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun. 2014;5:5105.
    • (2014) Nat Commun , vol.5 , pp. 5105
    • Pernet, E.1    Guillemot, L.2    Burgel, P.R.3
  • 110
    • 0027476965 scopus 로고
    • Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease
    • E.Kessler, M.Safrin, J.C.Olson, et al. Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease. J Biol Chem. 1993;268(10):7503–7508.
    • (1993) J Biol Chem , vol.268 , Issue.10 , pp. 7503-7508
    • Kessler, E.1    Safrin, M.2    Olson, J.C.3
  • 111
    • 84940857494 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa inhibits the growth of Scedosporium aurantiacum, an opportunistic fungal pathogen isolated from the lungs of cystic fibrosis patients
    • J.Kaur, B.P.Pethani, S.Kumar, et al. Pseudomonas aeruginosa inhibits the growth of Scedosporium aurantiacum, an opportunistic fungal pathogen isolated from the lungs of cystic fibrosis patients. Front Microbiol. 2015;6:866.
    • (2015) Front Microbiol , vol.6 , pp. 866
    • Kaur, J.1    Pethani, B.P.2    Kumar, S.3
  • 112
    • 84941199899 scopus 로고    scopus 로고
    • Aspergillus fumigatus enhances elastase production in Pseudomonas aeruginosa co-cultures
    • K.Smith, R.Rajendran, S.Kerr, et al. Aspergillus fumigatus enhances elastase production in Pseudomonas aeruginosa co-cultures. Med Mycol. 2015;53(7):645–655.
    • (2015) Med Mycol , vol.53 , Issue.7 , pp. 645-655
    • Smith, K.1    Rajendran, R.2    Kerr, S.3
  • 113
    • 84940748160 scopus 로고    scopus 로고
    • Candida albicans inhibits Pseudomonas aeruginosa virulence through suppression of pyochelin and pyoverdine biosynthesis
    • E.Lopez-Medina, D.Fan, L.A.Coughlin, et al. Candida albicans inhibits Pseudomonas aeruginosa virulence through suppression of pyochelin and pyoverdine biosynthesis. PLoS Pathog. 2015;11(8):e1005129.
    • (2015) PLoS Pathog , vol.11 , Issue.8 , pp. e1005129
    • Lopez-Medina, E.1    Fan, D.2    Coughlin, L.A.3
  • 114
    • 79953002944 scopus 로고    scopus 로고
    • Rhinovirus infection liberates planktonic bacteria from biofilm and increases chemokine responses in cystic fibrosis airway epithelial cells
    • S.S.Chattoraj, S.Ganesan, A.M.Jones, et al. Rhinovirus infection liberates planktonic bacteria from biofilm and increases chemokine responses in cystic fibrosis airway epithelial cells. Thorax. 2011;66(4):333–339.
    • (2011) Thorax , vol.66 , Issue.4 , pp. 333-339
    • Chattoraj, S.S.1    Ganesan, S.2    Jones, A.M.3
  • 115
    • 79960151730 scopus 로고    scopus 로고
    • Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial
    • C.E.Wainwright, S.Vidmar, D.S.Armstrong, et al. Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial. JAMA. 2011;306(2):163–171.
    • (2011) JAMA , vol.306 , Issue.2 , pp. 163-171
    • Wainwright, C.E.1    Vidmar, S.2    Armstrong, D.S.3
  • 116
    • 33646375158 scopus 로고    scopus 로고
    • Are lower airway or throat cultures predictive of sinus bacteriology in cystic fibrosis?
    • M.S.Muhlebach, M.B.Miller, C.Moore, et al. Are lower airway or throat cultures predictive of sinus bacteriology in cystic fibrosis? Pediatr Pulmonol. 2006;41(5):445–451.
    • (2006) Pediatr Pulmonol , vol.41 , Issue.5 , pp. 445-451
    • Muhlebach, M.S.1    Miller, M.B.2    Moore, C.3
  • 117
    • 78149361309 scopus 로고    scopus 로고
    • Value of serology in predicting Pseudomonas aeruginosa infection in young children with cystic fibrosis
    • T.A.Douglas, S.Brennan, L.Berry, et al. Value of serology in predicting Pseudomonas aeruginosa infection in young children with cystic fibrosis. Thorax. 2010;65(11):985–990.
    • (2010) Thorax , vol.65 , Issue.11 , pp. 985-990
    • Douglas, T.A.1    Brennan, S.2    Berry, L.3
  • 118
    • 84925936295 scopus 로고    scopus 로고
    • Predictive values of antibodies against Pseudomonas aeruginosa in patients with cystic fibrosis one year after early eradication treatment
    • M.Kappler, F.Nagel, M.Feilcke, et al. Predictive values of antibodies against Pseudomonas aeruginosa in patients with cystic fibrosis one year after early eradication treatment. J Cyst Fibros. 2014;13(5):534–541.
    • (2014) J Cyst Fibros , vol.13 , Issue.5 , pp. 534-541
    • Kappler, M.1    Nagel, F.2    Feilcke, M.3
  • 119
    • 84959927544 scopus 로고    scopus 로고
    • Does mass spectrometric breath analysis detect Pseudomonas aeruginosa in cystic fibrosis?
    • R.Pabary, J.Huang, S.Kumar, et al. Does mass spectrometric breath analysis detect Pseudomonas aeruginosa in cystic fibrosis? Eur Respir J. 2016;47(3):994–997.
    • (2016) Eur Respir J , vol.47 , Issue.3 , pp. 994-997
    • Pabary, R.1    Huang, J.2    Kumar, S.3
  • 120
    • 84878795516 scopus 로고    scopus 로고
    • Hydrogen cyanide concentrations in the breath of adult cystic fibrosis patients with and without Pseudomonas aeruginosa infection
    • F.J.Gilchrist, R.J.Bright-Thomas, A.M.Jones, et al. Hydrogen cyanide concentrations in the breath of adult cystic fibrosis patients with and without Pseudomonas aeruginosa infection. J Breath Res. 2013;7(2):026010.
    • (2013) J Breath Res , vol.7 , Issue.2 , pp. 026010
    • Gilchrist, F.J.1    Bright-Thomas, R.J.2    Jones, A.M.3
  • 121
    • 0141631811 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa and Burkholderia cepacia cannot be detected by PCR in the breath condensate of patients with cystic fibrosis
    • C.Vogelberg, T.Hirsch, A.Rosen-Wolff, et al. Pseudomonas aeruginosa and Burkholderia cepacia cannot be detected by PCR in the breath condensate of patients with cystic fibrosis. Pediatr Pulmonol. 2003;36(4):348–352.
    • (2003) Pediatr Pulmonol , vol.36 , Issue.4 , pp. 348-352
    • Vogelberg, C.1    Hirsch, T.2    Rosen-Wolff, A.3
  • 122
    • 84903733662 scopus 로고    scopus 로고
    • Characterization and identification of clinically relevant microorganisms using rapid evaporative ionization mass spectrometry
    • N.Strittmatter, M.Rebec, E.A.Jones, et al. Characterization and identification of clinically relevant microorganisms using rapid evaporative ionization mass spectrometry. Anal Chem. 2014;86(13):6555–6562.
    • (2014) Anal Chem , vol.86 , Issue.13 , pp. 6555-6562
    • Strittmatter, N.1    Rebec, M.2    Jones, E.A.3
  • 123
    • 84891372431 scopus 로고    scopus 로고
    • Halting the spread of epidemic Pseudomonas aeruginosa in an adult cystic fibrosis centre: a prospective cohort study
    • A.Ashish, M.Shaw, C.Winstanley, et al. Halting the spread of epidemic Pseudomonas aeruginosa in an adult cystic fibrosis centre: a prospective cohort study. JRSM Short Rep. 2013;4(1):1.
    • (2013) JRSM Short Rep , vol.4 , Issue.1 , pp. 1
    • Ashish, A.1    Shaw, M.2    Winstanley, C.3
  • 124
    • 84859576702 scopus 로고    scopus 로고
    • Decade-long bacterial community dynamics in cystic fibrosis airways
    • J.Zhao, P.D.Schloss, L.M.Kalikin, et al. Decade-long bacterial community dynamics in cystic fibrosis airways. Proc Natl Acad Sci U S A. 2012;109(15):5809–5814.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.15 , pp. 5809-5814
    • Zhao, J.1    Schloss, P.D.2    Kalikin, L.M.3
  • 125
    • 84961291390 scopus 로고    scopus 로고
    • Comparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis
    • S.Boutin, S.Y.Graeber, M.Weitnauer, et al. Comparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis. PLoS One. 2015;10(1):e0116029.
    • (2015) PLoS One , vol.10 , Issue.1 , pp. e0116029
    • Boutin, S.1    Graeber, S.Y.2    Weitnauer, M.3
  • 126
    • 84920412587 scopus 로고    scopus 로고
    • Cystic fibrosis foundation pulmonary guideline. Pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection
    • P.J.MogayzelJr., E.T.Naureckas, K.A.Robinson, et al. Cystic fibrosis foundation pulmonary guideline. Pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection. Ann Am Thorac Soc. 2014;11(10):1640–1650.
    • (2014) Ann Am Thorac Soc , vol.11 , Issue.10 , pp. 1640-1650
    • Mogayzel, P.J.1    Naureckas, E.T.2    Robinson, K.A.3
  • 127
    • 77950914953 scopus 로고    scopus 로고
    • Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial
    • F.Ratjen, A.Munck, P.Kho, et al. Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial. Thorax. 2010;65(4):286–291.• Randomized trial comparing 28 and 56 days of inhaled tobramycin for eradication of early P. aeruginosa infection, showing comparable efficacy.
    • (2010) Thorax , vol.65 , Issue.4 , pp. 286-291
    • Ratjen, F.1    Munck, A.2    Kho, P.3
  • 128
    • 77957195625 scopus 로고    scopus 로고
    • Controlled trial of cycled antibiotic prophylaxis to prevent initial Pseudomonas aeruginosa infection in children with cystic fibrosis
    • G.A.Tramper-Stranders, T.F.Wolfs, S.Van Haren Noman, et al. Controlled trial of cycled antibiotic prophylaxis to prevent initial Pseudomonas aeruginosa infection in children with cystic fibrosis. Thorax. 2010;65(10):915–920.
    • (2010) Thorax , vol.65 , Issue.10 , pp. 915-920
    • Tramper-Stranders, G.A.1    Wolfs, T.F.2    Van Haren Noman, S.3
  • 129
    • 84863453860 scopus 로고    scopus 로고
    • Effect of pulmonary exacerbations on long-term lung function decline in cystic fibrosis
    • V.Waters, S.Stanojevic, E.G.Atenafu, et al. Effect of pulmonary exacerbations on long-term lung function decline in cystic fibrosis. Eur Respir J. 2012;40(1):61–66.
    • (2012) Eur Respir J , vol.40 , Issue.1 , pp. 61-66
    • Waters, V.1    Stanojevic, S.2    Atenafu, E.G.3
  • 130
    • 79960586834 scopus 로고    scopus 로고
    • Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis
    • K.De Boer, K.L.Vandemheen, E.Tullis, et al. Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis. Thorax. 2011;66(8):680–685.
    • (2011) Thorax , vol.66 , Issue.8 , pp. 680-685
    • De Boer, K.1    Vandemheen, K.L.2    Tullis, E.3
  • 131
    • 77957694293 scopus 로고    scopus 로고
    • Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbation
    • D.B.Sanders, R.C.Bittner, M.Rosenfeld, et al. Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbation. Am J Respir Crit Care Med. 2010;182(5):627–632.
    • (2010) Am J Respir Crit Care Med , vol.182 , Issue.5 , pp. 627-632
    • Sanders, D.B.1    Bittner, R.C.2    Rosenfeld, M.3
  • 132
    • 84855864416 scopus 로고    scopus 로고
    • Chronic Stenotrophomonas maltophilia infection and exacerbation outcomes in cystic fibrosis
    • V.Waters, E.G.Atenafu, J.G.Salazar, et al. Chronic Stenotrophomonas maltophilia infection and exacerbation outcomes in cystic fibrosis. J Cyst Fibros. 2012;11(1):8–13.
    • (2012) J Cyst Fibros , vol.11 , Issue.1 , pp. 8-13
    • Waters, V.1    Atenafu, E.G.2    Salazar, J.G.3
  • 133
    • 23444457294 scopus 로고    scopus 로고
    • Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial
    • S.D.Aaron, K.L.Vandemheen, W.Ferris, et al. Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial. Lancet. 2005;366(9484):463–471.
    • (2005) Lancet , vol.366 , Issue.9484 , pp. 463-471
    • Aaron, S.D.1    Vandemheen, K.L.2    Ferris, W.3
  • 134
    • 0038102859 scopus 로고    scopus 로고
    • Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients
    • T.W.R.Lee, K.G.Brownlee, S.P.Conway, et al. Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. Journal of Cystic Fibrosis. 2003;2(1):29–34.
    • (2003) Journal of Cystic Fibrosis , vol.2 , Issue.1 , pp. 29-34
    • Lee, T.W.R.1    Brownlee, K.G.2    Conway, S.P.3
  • 135
    • 0037190575 scopus 로고    scopus 로고
    • Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial
    • A.Equi, I.M.Balfour-Lynn, A.Bush, et al. Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial. Lancet. 2002;360(9338):978–984.
    • (2002) Lancet , vol.360 , Issue.9338 , pp. 978-984
    • Equi, A.1    Balfour-Lynn, I.M.2    Bush, A.3
  • 136
    • 77950573969 scopus 로고    scopus 로고
    • Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis–a pilot randomized controlled trial
    • A.R.Smyth, P.M.Cifelli, C.A.Ortori, et al. Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis–a pilot randomized controlled trial. Pediatr Pulmonol. 2010;45(4):356–362.
    • (2010) Pediatr Pulmonol , vol.45 , Issue.4 , pp. 356-362
    • Smyth, A.R.1    Cifelli, P.M.2    Ortori, C.A.3
  • 137
    • 33750479893 scopus 로고    scopus 로고
    • Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa
    • N.Barraud, D.J.Hassett, S.H.Hwang, et al. Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa. J Bacteriol. 2006;188(21):7344–7353.
    • (2006) J Bacteriol , vol.188 , Issue.21 , pp. 7344-7353
    • Barraud, N.1    Hassett, D.J.2    Hwang, S.H.3
  • 138
    • 84865851455 scopus 로고    scopus 로고
    • Cephalosporin-3ʹ-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms
    • N.Barraud, B.G.Kardak, N.R.Yepuri, et al. Cephalosporin-3ʹ-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms. Angew Chem Int Ed Engl. 2012;51(36):9057–9060.
    • (2012) Angew Chem Int Ed Engl , vol.51 , Issue.36 , pp. 9057-9060
    • Barraud, N.1    Kardak, B.G.2    Yepuri, N.R.3
  • 139
    • 68349154135 scopus 로고    scopus 로고
    • A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy
    • A.Wright, C.H.Hawkins, E.E.Anggard, et al. A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin Otolaryngol. 2009;34(4):349–357.
    • (2009) Clin Otolaryngol , vol.34 , Issue.4 , pp. 349-357
    • Wright, A.1    Hawkins, C.H.2    Anggard, E.E.3
  • 140
    • 84957900614 scopus 로고    scopus 로고
    • Anti-pseudomonal bacteriophage reduces infective burden and inflammatory response in murine lung
    • R.Pabary, C.Singh, S.Morales, et al. Anti-pseudomonal bacteriophage reduces infective burden and inflammatory response in murine lung. Antimicrob Agents Chemother. 2015;60(2):744–751.
    • (2015) Antimicrob Agents Chemother , vol.60 , Issue.2 , pp. 744-751
    • Pabary, R.1    Singh, C.2    Morales, S.3
  • 141
    • 77749315460 scopus 로고    scopus 로고
    • Bacteriophages can treat and prevent Pseudomonas aeruginosa lung infections
    • L.Debarbieux, D.Leduc, D.Maura, et al. Bacteriophages can treat and prevent Pseudomonas aeruginosa lung infections. J Infect Dis. 2010;201(7):1096–1104.
    • (2010) J Infect Dis , vol.201 , Issue.7 , pp. 1096-1104
    • Debarbieux, L.1    Leduc, D.2    Maura, D.3
  • 142
    • 84896473918 scopus 로고    scopus 로고
    • The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem
    • T.Secher, S.Fas, L.Fauconnier, et al. The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. PLoS One. 2013;8(9):e73396.
    • (2013) PLoS One , vol.8 , Issue.9 , pp. e73396
    • Secher, T.1    Fas, S.2    Fauconnier, L.3
  • 143
    • 84891705714 scopus 로고    scopus 로고
    • Vaccines for preventing infection with Pseudomonas aeruginosa in cystic fibrosis
    • H.K.Johansen, P.C.Gotzsche. Vaccines for preventing infection with Pseudomonas aeruginosa in cystic fibrosis. Cochrane Database Syst Rev. 2013;6:Cd001399.
    • (2013) Cochrane Database Syst Rev , vol.6 , pp. Cd001399
    • Johansen, H.K.1    Gotzsche, P.C.2
  • 144
    • 84935511737 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa in cystic fibrosis patients with G551D-CFTR treated with ivacaftor
    • S.L.Heltshe, N.Mayer-Hamblett, J.L.Burns, et al. Pseudomonas aeruginosa in cystic fibrosis patients with G551D-CFTR treated with ivacaftor. Clin Infect Dis. 2015;60(5):703–712.
    • (2015) Clin Infect Dis , vol.60 , Issue.5 , pp. 703-712
    • Heltshe, S.L.1    Mayer-Hamblett, N.2    Burns, J.L.3


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